Site Search



Albert Lai, M.D., Ph.D.

Work Email Address:
albertlai@ mednet.ucla.edu

Mailing Address:
BOX 957334, Neuroscience Research
Building 1, Room 575B
Los Angeles, CA 90095
UNITED STATES

Office Address:
635 Charles E. Young Drive
Los Angeles, CA 90095
UNITED STATES

Fax Number:
310-825-0644
Office Phone Number:
310-825-5321



Login to the Faculty Database

Department / Division Affiliations
Associate Professor In-Residence, Neurology

Research Interest:

Identification of genes influencing glioblastoma response to therapy using microarray technology

The focus of our research is to identify genes influencing glioblastoma response to therapy using microarray technology. In collaboration with Dr. Stan Nelson, we are developing a microarray based procedure to determine global methylation patterns found in glioblastoma. We anticipate that correlation of methylation array data with gene expression and SNP array data will help identify genes critical in determining response to agents such as temozolomide and bevacizumab. These techniques will be applied to frozen glioblastoma patient tissue archived in the UCLA Neuro-oncology Tumor Bank. All stored tissue is complemented by detailed clinical response, survival and imaging data. Identified genes will be expressed in glioblastoma cell lines and subjected to functional assays for validation. Validated genes may be candidate biomarkers of prognosis or response. As a secondary focus, I am continuing research initiated with Dr. Andrew Charles examining the role of Connexin 43 in glioma migration. We have expressed Cx43-eYFP fusion proteins in polarized MDCK cells as a model of Cx43 expression in brain endothelial cells. We are determining the cellular localization of Cx43-eYFP using a variety of fluorescent based techniques.

Publications:

Tran, Anh Escovedo, Cameron Migdall-Wilson, Justine Chou, Arthur P Chen, Weidong Cloughesy, Timothy Nelson, Stanley Lai, Albert In silico enhanced restriction enzyme based methylation analysis of the human glioblastoma genome using Agilent 244K CpG Island microarrays. Frontiers in Neurogenomics. 2010; .
Remington, M. Chtchetinin, J. Ancheta, K. Nghiemphu, P. L. Cloughesy, T. Lai, A. The L84F polymorphic variant of human O6-methylguanine-DNA methyltransferase alters stability in U87MG glioma cells but not temozolomide sensitivity. Neuro Oncol. 2009; 11(1): 22-32.
Pope, W. B. Chen, J. H. Dong, J. Carlson, M. R. Perlina, A. Cloughesy, T. F. Liau, L. M. Mischel, P. S. Nghiemphu, P. Lai, A. Nelson, S. F. Relationship between gene expression and enhancement in glioblastoma multiforme: exploratory DNA microarray analysis. Radiology. 2008; 249(1): 268-77.
Mareninov Sergey, De Jesus Jason, Sanchez Desiree E, Kay Andrew B, Wilson Ryan W, Babic Ivan, Chen Weidong, Telesca Donatello, Lou Jerry J, Mirsadraei Leili, Gardner Tracie P, Khanlou Negar, Vinters Harry V, Shafa Bob B, Lai Albert, Liau Linda M, Mischel Paul S, Cloughesy Timothy F, Yong William H Lyophilized brain tumor specimens can be used for histologic, nucleic acid, and protein analyses after 1 year of room temperature storage. Journal of neuro-oncology. 2013; 113(3): 365-73.
Naeini Kourosh M, Pope Whitney B, Cloughesy Timothy F, Harris Robert J, Lai Albert, Eskin Ascia, Chowdhury Reshmi, Phillips Heidi S, Nghiemphu Phioanh L, Behbahanian Yalda, Ellingson Benjamin M Identifying the mesenchymal molecular subtype of glioblastoma using quantitative volumetric analysis of anatomic magnetic resonance images. Neuro-oncology. 2013; 15(5): 626-34.
Harris Robert J, Cloughesy Timothy F, Pope Whitney B, Godinez Sergio, Natsuaki Yutaka, Nghiemphu Phioanh L, Meyer Heiko, Paul Dominik, Behbahanian Yalda, Lai Albert, Ellingson Benjamin M Pre- and post-contrast three-dimensional double inversion-recovery MRI in human glioblastoma. Journal of neuro-oncology. 2013; 112(2): 257-66.
Lalezari Shadi, Chou Arthur P, Tran Anh, Solis Orestes E, Khanlou Negar, Chen Weidong, Li Sichen, Carrillo Jose A, Chowdhury Reshmi, Selfridge Julia, Sanchez Desiree E, Wilson Ryan W, Zurayk Mira, Lalezari Jonathan, Lou Jerry J, Ormiston Laurel, Ancheta Karen, Hanna Robert, Miller Paul, Piccioni David, Ellingson Benjamin M, Buchanan Colin, Mischel Paul S, Nghiemphu Phioanh L, Green Richard, Wang He-Jing, Pope Whitney B, Liau Linda M, Elashoff Robert M, Cloughesy Timothy F, Yong William H, Lai Albert Combined analysis of O6-methylguanine-DNA methyltransferase protein expression and promoter methylation provides optimized prognostication of glioblastoma outcome. Neuro-oncology. 2013; 15(3): 370-81.
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Liau Linda M, Pope Whitney B Quantitative probabilistic functional diffusion mapping in newly diagnosed glioblastoma treated with radiochemotherapy. Neuro-oncology. 2013; 15(3): 382-90.
Prins Robert M, Wang Xiaoyan, Soto Horacio, Young Emma, Lisiero Dominique N, Fong Brendan, Everson Richard, Yong William H, Lai Albert, Li Gang, Cloughesy Timothy F, Liau Linda M Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients. Journal of immunotherapy (Hagerstown, Md. : 1997). 2013; 36(2): 152-7.
Li Sichen, Chou Arthur P, Chen Weidong, Chen Ruihuan, Deng Yuzhong, Phillips Heidi S, Selfridge Julia, Zurayk Mira, Lou Jerry J, Everson Richard G, Wu Kuan-Chung, Faull Kym F, Cloughesy Timothy, Liau Linda M, Lai Albert Overexpression of isocitrate dehydrogenase mutant proteins renders glioma cells more sensitive to radiation. Neuro-oncology. 2013; 15(1): 57-68.
Lazovic Jelena, Soto Horacio, Piccioni David, Lou Jerry R, Li Sichen, Mirsadraei Leili, Yong William, Prins Robert, Liau Linda M, Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Pope Whitney B Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase-1 mutation. Neuro-oncology. 2012; 14(12): 1465-72.
Nghiemphu Phioanh Leia, Lai Albert, Green Richard M, Reardon David A, Cloughesy Timothy A dose escalation trial for the combination of erlotinib and sirolimus for recurrent malignant gliomas. Journal of neuro-oncology. 2012; 110(2): 245-50.
Harris Robert J, Cloughesy Timothy F, Pope Whitney B, Nghiemphu Phioanh L, Lai Albert, Zaw Taryar, Czernin Johannes, Phelps Michael E, Chen Wei, Ellingson Benjamin M 18F-FDOPA and 18F-FLT positron emission tomography parametric response maps predict response in recurrent malignant gliomas treated with bevacizumab. Neuro-oncology. 2012; 14(8): 1079-89.
Piccioni David, Lai Albert, Nghiemphu Phioanh, Cloughesy Timothy Bevacizumab as first-line therapy for glioblastoma. Future oncology (London, England). 2012; 8(8): 929-38.
Pope Whitney B, Qiao Xin Joe, Kim Hyun J, Lai Albert, Nghiemphu Phioanh, Xue Xi, Ellingson Benjamin M, Schiff David, Aregawi Dawit, Cha Soonmee, Puduvalli Vinay K, Wu Jing, Yung Wai-Kwan A, Young Geoffrey S, Vredenburgh James, Barboriak Dan, Abrey Lauren E, Mikkelsen Tom, Jain Rajan, Paleologos Nina A, Rn Patricia Lada, Prados Michael, Goldin Jonathan, Wen Patrick Y, Cloughesy Timothy Apparent diffusion coefficient histogram analysis stratifies progression-free and overall survival in patients with recurrent GBM treated with bevacizumab: a multi-center study. Journal of neuro-oncology. 2012; 108(3): 491-8.
Ellingson Benjamin M, Zaw Taryar, Cloughesy Timothy F, Naeini Kourosh M, Lalezari Shadi, Mong Sandy, Lai Albert, Nghiemphu Phioanh L, Pope Whitney B Comparison between intensity normalization techniques for dynamic susceptibility contrast (DSC)-MRI estimates of cerebral blood volume (CBV) in human gliomas. Journal of magnetic resonance imaging : JMRI. 2012; 35(6): 1472-7.
White Carissa M, Pope Whitney B, Zaw Taryar, Qiao Joe, Naeini Kourosh M, Lai Albert, Nghiemphu Phioanh L, Wang J J, Cloughesy Timothy F, Ellingson Benjamin M Regional and Voxel-Wise Comparisons of Blood Flow Measurements Between Dynamic Susceptibility Contrast Magnetic Resonance Imaging (DSC-MRI) and Arterial Spin Labeling (ASL) in Brain Tumors. Journal of neuroimaging : official journal of the American Society of Neuroimaging. 2012; 108(3): .
Ellingson Benjamin M, Cloughesy Timothy F, Zaw Taryar, Lai Albert, Nghiemphu Phioanh L, Harris Robert, Lalezari Shadi, Wagle Naveed, Naeini Kourosh M, Carrillo Jose, Liau Linda M, Pope Whitney B Functional diffusion maps (fDMs) evaluated before and after radiochemotherapy predict progression-free and overall survival in newly diagnosed glioblastoma. Neuro-oncology. 2012; 14(3): 333-43.
Walter Franziska, Cloughesy Timothy, Walter Martin A, Lai Albert, Nghiemphu Phioanh, Wagle Naveed, Fueger Barbara, Satyamurthy Nagichettiar, Phelps Michael E, Czernin Johannes Impact of 3,4-dihydroxy-6-18F-fluoro-L-phenylalanine PET/CT on managing patients with brain tumors: the referring physician's perspective. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2012; 53(3): 393-8.
Pope Whitney B, Prins Robert M, Albert Thomas M, Nagarajan Rajakumar, Yen Katharine E, Bittinger Mark A, Salamon Noriko, Chou Arthur P, Yong William H, Soto Horacio, Wilson Neil, Driggers Edward, Jang Hyun G, Su Shinsan M, Schenkein David P, Lai Albert, Cloughesy Timothy F, Kornblum Harley I, Wu Hong, Fantin Valeria R, Liau Linda M Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy. Journal of neuro-oncology. 2012; 107(1): 197-205.
Ellingson Benjamin M, Cloughesy Timothy F, Pope Whitney B, Zaw Taryar M, Phillips Heidi, Lalezari Shadi, Nghiemphu Phioanh L, Ibrahim Hassana, Naeini Kourosh M, Harris Robert J, Lai Albert Anatomic localization of O6-methylguanine DNA methyltransferase (MGMT) promoter methylated and unmethylated tumors: a radiographic study in 358 de novo human glioblastomas. NeuroImage. 2012; 59(2): 908-16.
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Pope Whitney B Nonlinear registration of diffusion-weighted images improves clinical sensitivity of functional diffusion maps in recurrent glioblastoma treated with bevacizumab. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2012; 67(1): 237-45.
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Lalezari Shadi, Zaw Taryar, Motevalibashinaeini Kourosh, Mischel Paul S, Pope Whitney B Quantification of edema reduction using differential quantitative T2 (DQT2) relaxometry mapping in recurrent glioblastoma treated with bevacizumab. Journal of neuro-oncology. 2012; 106(1): 111-9.
Lai Albert, Kharbanda Samir, Pope Whitney B, Tran Anh, Solis Orestes E, Peale Franklin, Forrest William F, Pujara Kanan, Carrillo Jose A, Pandita Ajay, Ellingson Benjamin M, Bowers Chauncey W, Soriano Robert H, Schmidt Nils O, Mohan Sankar, Yong William H, Seshagiri Somasekar, Modrusan Zora, Jiang Zhaoshi, Aldape Kenneth D, Mischel Paul S, Liau Linda M, Escovedo Cameron J, Chen Weidong, Nghiemphu Phioanh Leia, James C David, Prados Michael D, Westphal Manfred, Lamszus Katrin, Cloughesy Timothy, Phillips Heidi S Evidence for sequenced molecular evolution of IDH1 mutant glioblastoma from a distinct cell of origin. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2011; 29(34): 4482-90.
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Pope Whitney B Cell invasion, motility, and proliferation level estimate (CIMPLE) maps derived from serial diffusion MR images in recurrent glioblastoma treated with bevacizumab. Journal of neuro-oncology. 2011; 105(1): 91-101.
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Mischel Paul S, Nghiemphu Phioanh L, Lalezari Shadi, Schmainda Kathleen M, Pope Whitney B Graded functional diffusion map-defined characteristics of apparent diffusion coefficients predict overall survival in recurrent glioblastoma treated with bevacizumab. Neuro-oncology. 2011; 13(10): 1151-61.
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Liau Linda M, Pope Whitney B High order diffusion tensor imaging in human glioblastoma. Academic radiology. 2011; 18(8): 947-54.
Solis Orestes E, Mehta Rupal I, Lai Albert, Mehta Rashi I, Farchoukh Lama O, Green Richard M, Cheng Jerry C, Natarajan Sathima, Vinters Harry V, Cloughesy Timothy, Yong William H Rosette-forming glioneuronal tumor: a pineal region case with IDH1 and IDH2 mutation analyses and literature review of 43 cases. Journal of neuro-oncology. 2011; 102(3): 477-84.
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Mischel Paul S, Pope Whitney B Quantitative volumetric analysis of conventional MRI response in recurrent glioblastoma treated with bevacizumab. Neuro-oncology. 2011; 13(4): 401-9.
Lai Albert, Tran Anh, Nghiemphu Phioanh L, Pope Whitney B, Solis Orestes E, Selch Michael, Filka Emese, Yong William H, Mischel Paul S, Liau Linda M, Phuphanich Surasak, Black Keith, Peak Scott, Green Richard M, Spier Cynthia E, Kolevska Tatjana, Polikoff Jonathan, Fehrenbacher Louis, Elashoff Robert, Cloughesy Timothy Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2011; 29(2): 142-8.
Wang Christina H, Rockhill Jason K, Mrugala Maciej, Peacock Danielle L, Lai Albert, Jusenius Katy, Wardlaw Joanna M, Cloughesy Timothy, Spence Alexander M, Rockne Russ, Alvord Ellsworth C, Swanson Kristin R Prognostic significance of growth kinetics in newly diagnosed glioblastomas revealed by combining serial imaging with a novel biomathematical model. Cancer research. 2009; 69(23): 9133-40.
Chtchetinin Jana, Gifford Wes D, Li Sichen, Paznekas William A, Jabs Ethylin Wang, Lai Albert Tyrosine-dependent basolateral targeting of human connexin43-eYFP in Madin-Darby canine kidney cells can be disrupted by the oculodentodigital dysplasia mutation L90V. The FEBS journal. 2009; 276(23): 6992-7005.
Lee Yohan, Liu Jason, Patel Shilpa, Cloughesy Timothy, Lai Albert, Farooqi Haumith, Seligson David, Dong Jun, Liau Linda, Becker Donald, Mischel Paul, Shams Soheil, Nelson Stanley Genomic Landscape of Meningiomas. Brain pathology (Zurich, Switzerland). 2009; 276(23): .
Kappadakunnel Melanie, Eskin Ascia, Dong Jun, Nelson Stanley F, Mischel Paul S, Liau Linda M, Ngheimphu Phioanh, Lai Albert, Cloughesy Timothy F, Goldin Jonathan, Pope Whitney B Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. Journal of neuro-oncology. 2009; 78(11): .
Pope Whitney B, Kim Hyun J, Huo Jing, Alger Jeffry, Brown Matthew S, Gjertson David, Sai Victor, Young Jonathan R, Tekchandani Leena, Cloughesy Timothy, Mischel Paul S, Lai Albert, Nghiemphu Phioanh, Rahmanuddin Syed, Goldin Jonathan Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment. Radiology. 2009; 252(1): 182-9.
Nghiemphu P L, Liu W, Lee Y, Than T, Graham C, Lai A, Green R M, Pope W B, Liau L M, Mischel P S, Nelson S F, Elashoff R, Cloughesy T F Bevacizumab and chemotherapy for recurrent glioblastoma: a single-institution experience. Neurology. 2009; 72(14): 1217-22.
Lee, Y. Scheck, A. C. Cloughesy, T. F. Lai, A. Dong, J. Farooqi, H. K. Liau, L. M. Horvath, S. Mischel, P. S. Nelson, S. F. Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age. BMC Med Genomics. 2008; 1(1): 52.
Lai Albert, Filka Emese, McGibbon Bruce, Nghiemphu Phioanh Leia, Graham Carrie, Yong William H, Mischel Paul, Liau Linda M, Bergsneider Marvin, Pope Whitney, Selch Michael, Cloughesy Tim Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability. International journal of radiation oncology, biology, physics. 2008; 71(5): 1372-80.
Ananthnarayan Suchitra, Bahng Jennie, Roring James, Nghiemphu Phioanh, Lai Albert, Cloughesy Timothy, Pope Whitney B Time course of imaging changes of GBM during extended bevacizumab treatment. Journal of neuro-oncology. 2008; 88(3): 339-47.
Nghiemphu Phioanh Leia, Green Richard M, Pope Whitney B, Lai Albert, Cloughesy Timothy F Safety of anticoagulation use and bevacizumab in patients with glioma. Neuro-oncology. 2008; 10(3): 355-60.
Cloughesy, T. F. Yoshimoto, K. Nghiemphu, P. Brown, K. Dang, J. Zhu, S. Hsueh, T. Chen, Y. Wang, W. Youngkin, D. Liau, L. Martin, N. Becker, D. Bergsneider, M. Lai, A. Green, R. Oglesby, T. Koleto, M. Trent, J. Horvath, S. Mischel, P. S. Mellinghoff, I. K. Sawyers, C. L. Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med. 2008; 5(1): e8.
Chen, W. Delaloye, S. Silverman, D. H. Geist, C. Czernin, J. Sayre, J. Satyamurthy, N. Pope, W. Lai, A. Phelps, M. E. Cloughesy, T. Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study. J Clin Oncol. 2007; 25(30): 4714-21.
Carlson, M. R. Pope, W. B. Horvath, S. Braunstein, J. G. Nghiemphu, P. Tso, C. L. Mellinghoff, I. Lai, A. Liau, L. M. Mischel, P. S. Dong, J. Nelson, S. F. Cloughesy, T. F. Relationship between survival and edema in malignant gliomas: role of vascular endothelial growth factor and neuronal pentraxin 2. Clin Cancer Res. 2007; 13(9): 2592-8.
Pope, W. B. Lai, A. Nghiemphu, P. Mischel, P. Cloughesy, T. F. MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy. Neurology. 2006; 66(8): 1258-60.
Lai, A. Le, D. N. Paznekas, W. A. Gifford, W. D. Jabs, E. W. Charles, A. C. Oculodentodigital dysplasia connexin43 mutations result in non-functional connexin hemichannels and gap junctions in C6 glioma cells. J Cell Sci. 2006; 119(Pt 3): 532-41.
Lai, A. Gibson, A. Hopkins, C. R. Trowbridge, I. S. Signal-dependent trafficking of beta-amyloid precursor protein-transferrin receptor chimeras in madin-darby canine kidney cells. J Biol Chem. 1998; 273(6): 3732-9.
Lai, A. Sisodia, S. S. Trowbridge, I. S. Characterization of sorting signals in the beta-amyloid precursor protein cytoplasmic domain. J Biol Chem. 1995; 270(8): 3565-73.
Collawn, J. F. Lai, A. Domingo, D. Fitch, M. Hatton, S. Trowbridge, I. S. YTRF is the conserved internalization signal of the transferrin receptor, and a second YTRF signal at position 31-34 enhances endocytosis. J Biol Chem. 1993; 268(29): 21686-92.