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Whitney Pope, M.D., Ph.D.

Email Address:
wpope@mednet.ucla.edu
Email Address:
wpope@ucla.edu

Mailing Address:
BL-428 CHS
Campus Mail Code 172115
CA
UNITED STATES

Fax Number:
3108251776
Work Phone Number:
(310) 267-9783
3107947923



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Research Interest:

Imaging of brain tumors

My research focuses on the imaging of brain tumors, using advanced magnetic resonance imaging (MRI) techniques such as perfusion and diffusion MRI, spectroscopy and positron emission tomography (PET). Additionally, I am interested in the relationship between gene expression and physiologic MRI-based biomarkers in glioblastoma that are predictive of prognosis and response to specific therapies such as bevacizumab (Avastin).

Publications:

Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Pope Whitney B Cell invasion, motility, and proliferation level estimate (CIMPLE) maps derived from serial diffusion MR images in recurrent glioblastoma treated with bevacizumab. Journal of neuro-oncology. 2011; 105(1): 91-101.
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Mischel Paul S, Nghiemphu Phioanh L, Lalezari Shadi, Schmainda Kathleen M, Pope Whitney B Graded functional diffusion map-defined characteristics of apparent diffusion coefficients predict overall survival in recurrent glioblastoma treated with bevacizumab. Neuro-oncology. 2011; 105(1): .
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Liau Linda M, Pope Whitney B High order diffusion tensor imaging in human glioblastoma. Academic radiology. 2011; 18(8): 947-54.
Pope Whitney B, Young Jonathan R, Ellingson Benjamin M Advances in MRI assessment of gliomas and response to anti-VEGF therapy. Current neurology and neuroscience reports. 2011; 11(3): 336-44.
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Pope Whitney B Nonlinear registration of diffusion-weighted images improves clinical sensitivity of functional diffusion maps in recurrent glioblastoma treated with bevacizumab. Magnetic resonance in medicine : official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 2011; 18(8): .
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Lalezari Shadi, Zaw Taryar, Motevalibashinaeini Kourosh, Mischel Paul S, Pope Whitney B Quantification of edema reduction using differential quantitative T2 (DQT2) relaxometry mapping in recurrent glioblastoma treated with bevacizumab. Journal of neuro-oncology. 2011; 18(8): .
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Mischel Paul S, Pope Whitney B Quantitative volumetric analysis of conventional MRI response in recurrent glioblastoma treated with bevacizumab. Neuro-oncology. 2011; 13(4): 401-9.
Lai Albert, Tran Anh, Nghiemphu Phioanh L, Pope Whitney B, Solis Orestes E, Selch Michael, Filka Emese, Yong William H, Mischel Paul S, Liau Linda M, Phuphanich Surasak, Black Keith, Peak Scott, Green Richard M, Spier Cynthia E, Kolevska Tatjana, Polikoff Jonathan, Fehrenbacher Louis, Elashoff Robert, Cloughesy Timothy Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2011; 29(2): 142-8.
Ringman John Matthew, Pope Whitney, Salamon Noriko Insensitivity of visual assessment of hippocampal atrophy in familial Alzheimer's disease. Journal of neurology. 2010; 257(5): 839-42.
Kappadakunnel Melanie, Eskin Ascia, Dong Jun, Nelson Stanley F, Mischel Paul S, Liau Linda M, Ngheimphu Phioanh, Lai Albert, Cloughesy Timothy F, Goldin Jonathan, Pope Whitney B Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. Journal of neuro-oncology. 2010; 96(3): 359-67.
Harley Erin M, Pope Whitney B, Villablanca J Pablo, Mumford Jeanette, Suh Robert, Mazziotta John C, Enzmann Dieter, Engel Stephen A Engagement of fusiform cortex and disengagement of lateral occipital cortex in the acquisition of radiological expertise. Cerebral cortex (New York, N.Y. : 1991). 2009; 19(11): 2746-54.
Ledezma Carlos J, Chen Wei, Sai Victor, Freitas Bonnie, Cloughesy Tim, Czernin Johannes, Pope Whitney 18F-FDOPA PET/MRI fusion in patients with primary/recurrent gliomas: initial experience. European journal of radiology. 2009; 71(2): 242-8.
Khanlou Négar, Mathern Gary W, Mitchell Wendy G, Salamon Noriko, Pope Whitney B, Yong William H, Vinters Harry V Cortical dysplasia with prominent Rosenthal fiber formation in a case of intractable pediatric epilepsy. Human pathology. 2009; 40(8): 1200-4.
Pope Whitney B, Kim Hyun J, Huo Jing, Alger Jeffry, Brown Matthew S, Gjertson David, Sai Victor, Young Jonathan R, Tekchandani Leena, Cloughesy Timothy, Mischel Paul S, Lai Albert, Nghiemphu Phioanh, Rahmanuddin Syed, Goldin Jonathan Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment. Radiology. 2009; 252(1): 182-9.
Pope Whitney B, Chen Jenny H, Dong Jun, Carlson Marc R J, Perlina Alla, Cloughesy Timothy F, Liau Linda M, Mischel Paul S, Nghiemphu Phioanh, Lai Albert, Nelson Stanley F Relationship between gene expression and enhancement in glioblastoma multiforme: exploratory DNA microarray analysis. Radiology. 2008; 249(1): 268-77.
Lai Albert, Filka Emese, McGibbon Bruce, Nghiemphu Phioanh Leia, Graham Carrie, Yong William H, Mischel Paul, Liau Linda M, Bergsneider Marvin, Pope Whitney, Selch Michael, Cloughesy Tim Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability. International journal of radiation oncology, biology, physics. 2008; 71(5): 1372-80.
Ananthnarayan Suchitra, Bahng Jennie, Roring James, Nghiemphu Phioanh, Lai Albert, Cloughesy Timothy, Pope Whitney B Time course of imaging changes of GBM during extended bevacizumab treatment. Journal of neuro-oncology. 2008; 88(3): 339-47.
Nghiemphu Phioanh Leia, Green Richard M, Pope Whitney B, Lai Albert, Cloughesy Timothy F Safety of anticoagulation use and bevacizumab in patients with glioma. Neuro-oncology. 2008; 10(3): 355-60.
Morioka Craig A, El-Saden Suzie, Pope Whitney, Sayre James, Duckwiler Gary, Meng Frank, Bui Alex, Kangarloo Hooshang A methodology to integrate clinical data for the efficient assessment of brain-tumor patients. Informatics for health & social care. 2008; 33(1): 55-68.
Nael Kambiz, Villablanca J Pablo, Mossaz Léonard, Pope Whitney, Juncosa Alex, Laub Gerhard, Finn J Paul 3-T contrast-enhanced MR angiography in evaluation of suspected intracranial aneurysm: comparison with MDCT angiography. AJR. American journal of roentgenology. 2008; 190(2): 389-95.
Chen Wei, Delaloye Sibylle, Silverman Daniel H S, Geist Cheri, Czernin Johannes, Sayre James, Satyamurthy Nagichettiar, Pope Whitney, Lai Albert, Phelps Michael E, Cloughesy Timothy Predicting treatment response of malignant gliomas to bevacizumab and irinotecan by imaging proliferation with [18F] fluorothymidine positron emission tomography: a pilot study. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2007; 25(30): 4714-21.
Carlson Marc R J, Pope Whitney B, Horvath Steve, Braunstein Jerome G, Nghiemphu Phioanh, Tso Cho-Lea, Mellinghoff Ingo, Lai Albert, Liau Linda M, Mischel Paul S, Dong Jun, Nelson Stanley F, Cloughesy Timothy F Relationship between survival and edema in malignant gliomas: role of vascular endothelial growth factor and neuronal pentraxin 2. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007; 13(9): 2592-8.
Nael Kambiz, Villablanca J Pablo, Pope Whitney B, McNamara Thomas O, Laub Gerhard, Finn J Paul Supraaortic arteries: contrast-enhanced MR angiography at 3.0 T--highly accelerated parallel acquisition for improved spatial resolution over an extended field of view. Radiology. 2007; 242(2): 600-9.
Chen Wei, Silverman Daniel H S, Delaloye Sibylle, Czernin Johannes, Kamdar Nirav, Pope Whitney, Satyamurthy Nagichettiar, Schiepers Christiaan, Cloughesy Timothy 18F-FDOPA PET imaging of brain tumors: comparison study with 18F-FDG PET and evaluation of diagnostic accuracy. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2006; 47(6): 904-11.
Nael Kambiz, Ruehm Stefan G, Michaely Henrik J, Pope Whitney, Laub Gerhard, Finn J Paul, Villablanca J Pablo High spatial-resolution CE-MRA of the carotid circulation with parallel imaging: comparison of image quality between 2 different acceleration factors at 3.0 Tesla. Investigative radiology. 2006; 41(4): 391-9.
Pope Whitney B, Sayre James, Perlina Alla, Villablanca J Pablo, Mischel Paul S, Cloughesy Timothy F MR imaging correlates of survival in patients with high-grade gliomas. AJNR. American journal of neuroradiology. 2006; 26(10): 2466-74.