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Molecular & Medical Pharmacology
ACCESS Program: MBI IDP,
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Brain Research Institute,
Center for Duchenne Muscular Dystrophy,
Center for Neurodegenerative Disease Studies,
Molecular, Cellular, and Integrative Physiology IDP
Ming Guo received her Ph.D. from Yuh Nung Jan's laboratory at the University of California, San Francisco for her work on how NUMB regulates NOTCH during asymmetric divisions in Drosophila neuronal stem cell development. After her residency training in Neurology at UCLA and a short postdoc in Larry Zipursky's laboratory, she became an assistant professor in neurology at the UCLA School of Medicine. She is an Alfred P. Sloan Foundation fellow, Larry Hillblom Foundation Startup Grantee, Ellison Medical Foundation New Scholar in Aging, McKnight Neuroscience Foundation Brain Disorder Awardee and Klingenstein Fellow. She also cares for patients with neurological disorders at the UCLA Medical Center and is a national Board Examiner for American Board of Psychiatry and Neurology. The Guo laboratory works on mechanisms of neurodegerative diseases using D. melanogaster as a model. Much of the focus is on studying molecular mechanisms of the two most common neurodegenerative disorders, Alzheimer disease and Parkinson's disease.
J.C. Rochet, B.A. Hay and M. Guo Molecular Insights into Parkinson's Disease.
Progress in Molecular Biology and Translational Science
2012; in press:
M.W. Dodson, T. Zhang, C. Jiang, S. Chen and M. Guo Roles of the Drosophila LRRK2 homolog in Rab7-dependent lysosomal positioning.
Human Molecular Genetics
2012; in press:
B.A. Hay, C.H. Chen, C. M. Ward, H. Huang. J. T.Su, and M. Guo Engineering the genomes of wild insect populations: Challenges, and opportunities provided by synthetic Medea selfish genetic elements.
J. Insect Physiol.
M. Guo What have we learned from Drosophila models of Parkinson?s disease.
Progress in Brain Research
Li, H. and
Guo, M. Protein Degradation in Parkinson Disease Revisited: It's Complex .
J. Clinical Invest
and Guo, M. Loss-of-function analysis suggests that Omi/HtrA2 is not an essential component of the pink1/parkin pathway in vivo.
Yu, H. and
Guo, M. Role of X11 and ubiquilin as in vivo regulators of the amyloid precursor protein in Drosophila.
Guo, M. The Parkinson's disease genes pink1 and parkin promote mitochondrial fission and/or fusion in Drosophila.
Ganguly, A.*, Feldman, R.* and Guo, M. ubiquilin antagonizes presenilin and promotes neurodegeneration.
Human Molecular Genetics
293-302. (Cover Story).
Chen, C., Huang, H., Ward, C., Su, J., Schaeffer, L., M. Guo and Hay, B.A. A Synthetic Maternal-Effect Selfish Genetic Element Drives Population Replacement in Drosophila .
Dodson, M.W. and Guo, M. Pink1, Parkin, DJ-1 and Mitochondrial Dysfunction in Parkinson's Disease.
Curr. Opin. Neurobiol
Clark, I.E*., Dodson, M.W.*, Jiang, C.*, Cao, J.H., Huh, J.R., Seol, J.H., Yoo, S.J., Hay, B.A. and Guo, M.
Drosophila pink1 is required for mitochondrial function and interacts genetically with parkin .
Xu P, Guo M, Hay BA. MicroRNAs and the regulation of cell death.
Guo, M., Hay, B. Cell proliferation and apoptosis.
Curr Opin Cell Biol.
Hay, BA, Huh, JR and Guo, M The genetics of cell death: approaches, insights and opportunities in Drosophila.
Nature Review Genetics
Guo, M Hong, EJ Fernandes, J Zipursky, SL Hay, BA A reporter for amyloid precursor protein gamma-secretase activity in Drosophila.
Human molecular genetics.
Hay, BA Guo, M Coupling cell growth, proliferation, and death. Hippo weighs in.
Xu, P Vernooy, SY Guo, M Hay, BA The Drosophila microRNA Mir-14 suppresses cell death and is required for normal fat metabolism.
Current biology :
Guo, M Jan, LY Jan, YN Control of daughter cell fates during asymmetric division: interaction of Numb and Notch.
Guo, M Bier, E Jan, LY Jan, YN tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the Drosophila PNS.