Mailing Address:
Neuroscience Research Building, Rm. 545 635 Charles E. Young Dr. South University of California, Los Angeles Los Angeles , CA 90095 UNITED STATES
Fax Number:
310-983-1133
Lab Number:
310-983-1126
Office Phone Number:
310-794-9421
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Andrews received her B.S. in Chemistry from the Pennsylvania State University. She carried out her dissertation research under the direction of Dr. Dennis Murphy at the National Institute of Mental Health (NIMH) and was awarded her Ph.D. in Chemistry from the American University. She also attended the George Washington University, Sino-Soviet Institute for Russian Area Studies. Andrews was a United States Department of Education Fellow and an NIH Predoctoral Intramural Research Training Awardee. Andrews continued as a Postdoctoral IRTA Fellow and a Senior Staff Fellow at the NIMH. In 1998, she joined the faculty at the Pennsylvania State University in the Departments of Chemistry and Veterinary and Biomedical Sciences and was affiliated with the Huck Institutes Neuroscience and Molecular Toxicology Programs. Andrews is an Eli Lilly Outstanding Analytical Chemist Awardee and the recipient of a NARSAD Independent Investigator Award, among others. She is a fellow of the Collegium Internationale Neuropsychopharmacologicum and a Serotonin Club councilor. Andrews serves on multiple review panels for the National Institute of Mental Health and the National Institute on Neurological Disorders and Stroke.
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Vaish A, Shuster MJ, Cheunkar S, Weiss PS, Andrews AM Tuning stamp surface energy for soft lithography of polar molecules to fabricate bioactive small-molecule microarrays.
Small.
2011; 7(10):
1471-9.
Yogesh S. Singh, Lauren E. Sawarynski, Heather M. Michael, Robert E. Ferrell, Michael A. Murphey-Corb, Greg M. Swain, Bhavik A. Patel and Anne M. Andrews Boron-Doped Diamond Microelectrodes Reveal Reduced Serotonin Uptake Rates in Lymphocytes from Adult Rhesus Monkeys Carrying the Short Allele of the 5-HTTLPR.
ACS Chem. Neurosci..
2010; 1(1):
49?64.
Daws, L. C., Andrews, A. M., Gerhardt, G. A. Electrochemical techniques and advances in psychopharmacology.
Encyclopedia of Psychopharmacology
2010; I.P.Stolerman, Ed., in press, Springer: New York:
.
Vaish, A.
Shuster, M. J.
Cheunkar, S.
Singh, Y. S.
Weiss, P. S.
Andrews, A. M. Native serotonin membrane receptors recognize 5-hydroxytryptophan-functionalized substrates: Enabling small-molecule recognition.
ACS Chemical Neuroscience.
2010; 1(7):
495-504.
Luellen, B. A., Gillman, T. L., and Andrews, A. M. Presynaptic adaptive responses to constitutive versus adult pharmacologic inhibition of serotonin uptake.
Experimental Models in Serotonin Transporter Research.
2010; A. V. Kalueff and J. L. LaPorte, Eds. Cambridge University Press: Cambridge:
1-42.
Andrews, A. M. Does chronic antidepressant treatment increase extracellular serotonin?.
Frontiers in Neuroscience
2009; 3(2):
p. 246-247.
Shuster, M. J., Vaish, A., Szapacs, M. E., Anderson, M. E., Weiss, P. S., and Andrews, A. M. Biospecific recognition of tethered small molecules diluted in self-assembled monolayers.
Advanced Materials .
2008; 20:
p. 164-167.
Guiard, B. P., David, D. J., Deltheil, T., Chenu, F., Le Maitre, E., Renoir, T., Leroux-Nicollet, I., Sokoloff, P., Lanfumey, L., Hamon, M., Andrews, A. M., Hen, R., and Gardier, A. M. Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal hyperserotonergic phenotype.
The International Journal of Neuropsychopharmacology.
2008; 11(1):
p. 79-92.
Murphy, D. L., Fox, M. A., Timpano, K. R., Moya, P. R., Ren-Patterson, R., Andrews, A. M., Holmes, A., Lesch, K. P., and Wendland, J. R. How the serotonin story is being rewritten by new gene-based discoveries principally related to SLC6A4, the serotonin transporter gene, which functions to influence all cellular serotonin systems.
Neuropharmacology.
2008; 55(6):
932-960.
Mullen, T. J., Srinivasan, C., Shuster, M. J., Horn, M. W., Andrews, A. M., and Weiss, P. S. Hybrid approaches to nanometer-scale patterning: Exploiting tailored intermolecular interactions.
Journal of Nanoparticle Research.
2008; 10(8):
1231-1240.
Fox, M. A., Andrews, A. M., Wendland, J. R., Lesch, K. P., Holmes, A., and Murphy, D. L. A pharmacological analysis of mice with a targeted disruption of the serotonin transporter.
Pychopharmacology (Berl).
2007; 195(2):
147-166.
Luellen, B. A., Bianco, L. E., Schneider, L. M., and Andrews, A. M. Reduced brain-derived neurotrophic factor is associated with a loss of serotonergic innervation in the hippocampus of aging mice.
Genes Brain and Behavior.
2007; 6:
p. 482-490.
Perez, X. A., Bressler, A. J., and Andrews, A. M. Determining serotonin and dopamine uptake rates in synaptosomes using high-speed chronoamperometry.
Electrochemical Methods of Neurotransmitter Analysis.
2007;
A.C. Michael and L.M. Borland, Eds.,CRC Press LLC: Boca Raton.
Andrews, A. M. The use of 2'-NH2-MPTP as a tool to probe central serotonin and norepinephrine neurotransmitter systems.
Neurotransmissions
2000; 16:
p.18-21.
Jayanthi, S., Ladenheim, B., Andrews, A. M., and Cadet, J. L. Overexpression of human copper/zinc superoxide dismutase in transgenic mice attenuates oxidative stress caused by methylenedioxymethamphetamine (Ecstasy).
Neuroscience.
1999; 91(4):
p.1379-1387.
Bengel, D., Murphy, D. L., Andrews, A. M., Wichems, C. H., Feltner, D., Heils, A., Mossner, R., Westphal, H., and Lesch, K. P. Altered brain serotonin homeostasis and locomotor insensitivity to 3,4-methylenedioxymethamphetamine ("Ecstasy") in serotonin transporter-deficient mice.
Molecular Pharmacology.
1998; 53(4):
p. 649-655.
Murphy, D. L., Andrews, A. M., Wichems, C. H., Li, Q., Tohda, M., and Greenberg, B. Brain serotonin neurotransmission: An overview and update with an emphasis on serotonin subsystem heterogeneity, multiple receptors, interactions with other neurotransmitter systems, and consequent implications for understanding the actions of serotonergic drugs.
Journal of Clinical Psychiatry.
1998; 59(Suppl 15):
p.4-12.
Tsao, L. I., Ladenheim, B., Andrews, A. M., Chiueh, C. C., Cadet, J. L., and Su, T. P. Delta opioid peptide [D-Ala2,D-leu5]enkephalin blocks the long-term loss of dopamine transporters induced by multiple administrations of methamphetamine: involvement of opioid receptors and reactive oxygen species.
Journal of Pharmacology and Experimental Therapeutics.
1998; 287(1):
322-331.
Bengel, D., Jöhren, O., Andrews, A. M., Heils, A., Mössner, R., Sanvitto, G. L., Saavedra, J. M., Lesch, K.-P., and Murphy, D. L. Cellular localization and expression of the serotonin transporter in mouse brain.
Brain Research.
1997; 778(2):
p. 338-345.
Bengel, D., Heils, A., Petri, S., Seemann, M., Glatz, K., Andrews, A., Murphy, D. L., and Lesch, K. P. Gene structure and 5'-flanking regulatory region of the murine serotonin transporter.
Brain Research: Molecular Brain Research.
1997; 44(2):
286-92.
Andrews, A. M., Ladenheim, B., Epstein, C. J., Cadet, J. L., and Murphy, D. L. Transgenic mice with high levels of superoxide dismutase activity are protected from the neurotoxic effects of 2'-NH2-MPTP on serotonergic and noradrenergic nerve terminals.
Molecular Pharmacology.
1996; 50(6):
p. 1511-1519.
Andrews, A. M. and Murphy, D. L. 2'-NH2-MPTP in Swiss Webster mice: evidence for long-term (6-month) depletions in cortical and hippocampal serotonin and norepinephrine, differential protection by selective uptake inhibitors or clorgyline and functional changes in central serotonin neurotransmission..
Journal of Pharmacology and Experimental Therapeutics.
1993; 267(3):
p. 1432-1439.
Andrews, A. M. and Murphy, D. L. Sustained depletion of cortical and hippocampal serotonin and norepinephrine but not striatal dopamine by 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine (2'-NH2-MPTP): a comparative study with 2'-CH3-MPTP and MPTP.
Journal of Neurochemistry.
1993; 60(3):
p. 1167-1170.
Shuster M J, Vaish A, Cao H H, Guttentag A I, McManigle J E, Gibb A L, Martinez M M, Nezarati R M, Hinds J M, Liao W-S, Weiss P S, Andrews A M Patterning small-molecule biocapture surfaces: microcontact insertion
printing vs. photolithography..
Chemical communications (Cambridge, England).
2011; 47(38):
10641-3.
Vaish Amit, Liao Wei-Ssu, Shuster Mitchell J, Hinds Jennifer M, Weiss Paul S, Andrews Anne M Thin gold film-assisted fluorescence spectroscopy for biomolecule
sensing..
Analytical chemistry.
2011; 83(19):
7451-6.
Singh Yogesh S, Sawarynski Lauren E, Dabiri Pasha D, Choi Wonwoo R, Andrews Anne M Head-to-head comparisons of carbon fiber microelectrode coatings for
sensitive and selective neurotransmitter detection by voltammetry..
Analytical chemistry.
2011; 83(17):
6658-66.
Leuchter Andrew F, Cook Ian A, Hamilton Steven P, Narr Katherine L, Toga Arthur, Hunter Aimee M, Faull Kym, Whitelegge Julian, Andrews Anne M, Loo Joseph, Way Baldwin, Nelson Stanley F, Horvath Steven, Lebowitz Barry D Biomarkers to predict antidepressant response.
Current psychiatry reports.
2010; 12(6):
553-62.
Liu Yansheng, Zhang Jing, Xu Xiaomi, Zhao Moe K, Andrews Anne M, Weber Stephen G Capillary Ultrahigh Performance Liquid Chromatography with Elevated Temperature for Sub-One Minute Separations of Basal Serotonin in Submicroliter Brain Microdialysate Samples.
Analytical chemistry.
2010; 82(23):
9611-6.
Shen Qiuying, Lal Rachnanjali, Luellen Beth A, Earnheart John C, Andrews Anne Milasincic, Luscher Bernhard gamma-Aminobutyric acid-type A receptor deficits cause hypothalamic-pituitary-adrenal axis hyperactivity and antidepressant drug sensitivity reminiscent of melancholic forms of depression.
Biological psychiatry.
2010; 68(6):
512-20.
Singh Yogesh S, Sawarynski Lauren E, Michael Heather M, Ferrell Robert E, Murphey-Corb Michael A, Swain Greg M, Patel Bhavik A, Andrews Anne M Boron-Doped Diamond Microelectrodes Reveal Reduced Serotonin Uptake
Rates in Lymphocytes from Adult Rhesus Monkeys Carrying the Short
Allele of the 5-HTTLPR..
ACS chemical neuroscience.
2010; 1(1):
49-64.
Murphy Dennis L, Fox Meredith A, Timpano Kiara R, Moya Pablo R, Ren-Patterson Renee, Andrews Anne M, Holmes Andrew, Lesch Klaus-Peter, Wendland Jens R How the serotonin story is being rewritten by new gene-based
discoveries principally related to SLC6A4, the serotonin transporter
gene, which functions to influence all cellular serotonin systems..
Neuropharmacology.
2008; 55(6):
932-60.
Guiard Bruno P, David Denis J P, Deltheil Thierry, Chenu Franck, Le Maître Erwan, Renoir Thibault, Leroux-Nicollet Isabelle, Sokoloff Pierre, Lanfumey Laurence, Hamon Michel, Andrews Anne M, Hen René, Gardier Alain M Brain-derived neurotrophic factor-deficient mice exhibit a hippocampal
hyperserotonergic phenotype..
The international journal of neuropsychopharmacology / official scientific journal of the Collegium Internationale Neuropsychopharmacologicum (CINP).
2008; 11(1):
79-92.
Fox Meredith A, Andrews Anne M, Wendland Jens R, Lesch Klaus-Peter, Holmes Andrew, Murphy Dennis L A pharmacological analysis of mice with a targeted disruption of the
serotonin transporter..
Psychopharmacology.
2007; 195(2):
147-66.
Srinivasan Charan, Mullen Thomas J, Hohman J Nathan, Anderson Mary E, Dameron Arrelaine A, Andrews Anne M, Dickey Elizabeth C, Horn Mark W, Weiss Paul S Scanning electron microscopy of nanoscale chemical patterns..
ACS nano.
2007; 1(3):
191-201.
Mullen, T. J., Srinivasan, C., Hohman, J. N., Gillmor, S. D., Shuster, M. J., Horn, M. W., Andrews, A. M., and Weiss, P. S. Microcontact insertion printing.
Applied Physics Letters.
2007; 90(6):
p. 063114 (063111-063113).
Perez Xiomara A, Bianco Laura E, Andrews Anne M Filtration disrupts synaptosomes during radiochemical analysis of
serotonin uptake: comparison with chronoamperometry in SERT knockout
mice..
Journal of neuroscience methods.
2006; 154(1-2):
245-55.
Luellen Beth A, Szapacs Matthew E, Materese Christopher K, Andrews Anne M The neurotoxin 2'-NH2-MPTP degenerates serotonin axons and evokes
increases in hippocampal BDNF..
Neuropharmacology.
2006; 50(3):
297-308.
Perez, X. A., Bianco, L. E., and Andrews, A. M. Filtration disrupts synaptosomes during radiochemical analysis of serotonin uptake: Comparison with chronoamperometry in SERT knockout mice.
Journal of Neuroscience Methods.
2006; 154:
p. 245-255.
Unger Erica L, Eve David J, Perez Xiomara A, Reichenbach Dawn K, Xu Yanqun, Lee Michael K, Andrews Anne M Locomotor hyperactivity and alterations in dopamine neurotransmission
are associated with overexpression of A53T mutant human
alpha-synuclein in mice..
Neurobiology of disease.
2006; 21(2):
431-43.
Kim Dong-Kyu, Tolliver Teresa J, Huang Su-Jan, Martin Bradley J, Andrews Anne M, Wichems Christine, Holmes Andrew, Lesch Klaus-Peter, Murphy Dennis L Altered serotonin synthesis, turnover and dynamic regulation in
multiple brain regions of mice lacking the serotonin transporter..
Neuropharmacology.
2005; 49(6):
798-810.
Perez Xiomara A, Andrews Anne M Chronoamperometry to determine differential reductions in uptake in
brain synaptosomes from serotonin transporter knockout mice..
Analytical chemistry.
2005; 77(3):
818-26.
Szapacs Matthew E, Mathews Tiffany A, Tessarollo Lino, Ernest Lyons W, Mamounas Laura A, Andrews Anne M Exploring the relationship between serotonin and brain-derived
neurotrophic factor: analysis of BDNF protein and extraneuronal 5-HT
in mice with reduced serotonin transporter or BDNF expression..
Journal of neuroscience methods.
2004; 140(1-2):
81-92.
Mathews Tiffany A, Fedele Denise E, Coppelli Francesca M, Avila Amy M, Murphy Dennis L, Andrews Anne M Gene dose-dependent alterations in extraneuronal serotonin but not
dopamine in mice with reduced serotonin transporter expression..
Journal of neuroscience methods.
2004; 140(1-2):
169-81.
Numis Adam L, Unger Erica L, Sheridan Douglas L, Chisnell Angela C, Andrews Anne M The role of membrane and vesicular monoamine transporters in the
neurotoxic and hypothermic effects of
1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine
(2'-NH(2)-MPTP)..
Molecular pharmacology.
2004; 66(3):
718-27.
Szapacs Matthew E, Numis Adam L, Andrews Anne M Late onset loss of hippocampal 5-HT and NE is accompanied by increases
in BDNF protein expression in mice co-expressing mutant APP and PS1..
Neurobiology of disease.
2004; 16(3):
572-80.
Luellen Beth A, Miller Diane B, Chisnell Angela C, Murphy Dennis L, O'Callaghan James P, Andrews Anne Milasincic Neuronal and astroglial responses to the serotonin and norepinephrine
neurotoxin: 1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine..
The Journal of pharmacology and experimental therapeutics.
2003; 307(3):
923-31.
Unger Erica L, Mazzola-Pomietto Pascale, Murphy Dennis L, Andrews Anne M 2'-NH(2)-MPTP [1-methyl-4-(2'-aminophenyl)-1,2,3,6-tetrahydropyridine]
depletes serotonin and norepinephrine in rats: a comparison with
2'-CH(3)-MPTP
[1-methyl-4-(2'-methylphenyl)-1,2,3,6-tetrahydropyridine]..
The Journal of pharmacology and experimental therapeutics.
2002; 303(2):
527-33.
Murphy, D. L., Li, Q., Engel, S., Wichems, C., Andrews, A., Lesch, K. P., and Uhl, G. Genetic perspectives on the serotonin transporter.
Brain Research Bulletin.
2001; 56(5):
p. 487-494.
Sora, I., Hall, F. S., Andrews, A. M., Itokawa, M., Li, X. F., Wei, H. B., Wichems, C., Lesch, K. P., Murphy, D. L., and Uhl, G. R. Molecular mechanisms of cocaine reward: combined dopamine and serotonin transporter knockouts eliminate cocaine place preference.
Proceedings of the National Academy of Sciences of the United States of America.
2001; 98(9):
p. 5300-3055.
Tella, S. R., Ladenheim, B., Andrews, A. M., Goldberg, S. R., and Cadet, J. L. Differential reinforcing effects of cocaine and GBR-12909: biochemical evidence for divergent neuroadaptive changes in the mesolimbic dopaminergic system.
Journal Neuroscience.
1996; 16(23):
p. 7416-7427.
Andrews, A. M. and Murphy, D. L. Fluoxetine and desipramine selectively attenuate 2'-NH2-MPTP-induced depletions in serotonin and norepinephrine.
European Journal of Pharmacology.
1993; 250(2):
p. 215-221.
Andrews Anne M, Kantor Mark A Oxidative stress increases in overweight individuals following an
exercise test..
Military medicine.
2010; 175(12):
1014-9.
Schnall Barri L, Baum Brian S, Andrews Anne M Gait characteristics of a soldier with a traumatic hip
disarticulation..
Physical therapy.
2008; 88(12):
1568-77.
Srinivasan Charan, Mullen Thomas J, Hohman J Nathan, Anderson Mary E, Dameron Arrelaine A, Andrews Anne M, Dickey Elizabeth C, Horn Mark W, Weiss Paul S Scanning electron microscopy of nanoscale chemical patterns..
ACS nano.
2007; 1(3):
191-201.
Andrews Anne M, Wunderlich Benjaman, Linberg Alison Core temperature changes in service members with and without
amputations during the Army 10-Miler..
Military medicine.
2011; 176(6):
664-8.
Vaish Amit, Shuster Mitchell J, Cheunkar Sarawut, Weiss Paul S, Andrews Anne M Tuning stamp surface energy for soft lithography of polar molecules to
fabricate bioactive small-molecule microarrays..
Small (Weinheim an der Bergstrasse, Germany).
2011; 7(10):
1471-9.
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