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Rhonda Voskuhl, M.D.

Email Address:
rvoskuhl@ucla.edu

Office Address:
635 Charles E. Young Drive South
NRB1 475D
Los Angeles, CA 90095
UNITED STATES

Work Phone Number:
(310) 206-4636



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Department / Division Affiliations
Professor, Neurology
Professor in Residence, Semel Institute for Neuroscience and Human Behavior
Member, ACCESS Program: Neuroscience IDP, Neuroscience IDP, Brain Research Institute, CTSI
Faculty, Molecular, Cellular, and Integrative Physiology IDP

Bio:

<p> Dr. Voskuhl attended Phillips University in Enid, Oklahoma on full basketball and academic scholarships. She received her M.D. from Vanderbilt Medical School and completed neurology residency at the University of Texas Southwestern. Her fellowship years were spent in the Neuroimmunology Branch, NINDS, NIH. Dr. Voskuhl joined UCLA as Assistant Professor of Neurology in 1995, was promoted to Associated Professor in 2000 and Professor in 2004. She is Director of the UCLA MS Program. She received the Jack H. Skirball Endowed Chair in Multiple Sclerosis in 2006. She has received numerous grants from both the NIH and the National Multiple Sclerosis Society. Dr. Voskuhl???s laboratory is focused upon understanding the immunopathogenesis of multiple sclerosis (MS) through use of the murine model experimental autoimmune encephalomyelitis (EAE). She does basic science and also novel clinical trial design. She has studied the effect of sex hormones and sex chromosomes on both inflammation and neurodegeneration. This basic research has led to two novel pilot treatment trials in MS, as well as a multicenter trial at several sites in the U.S. In summary, Dr. Voskuhl???s research focus is to make basic discoveries at the research bench and to move them to novel therapies at the bedside, a prototypic example of translational research. </p> <div> Her current titles include: </div> <div>Jack H. Skirball Chair in Multiple Sclerosis Research </div> <div>Director, UCLA Multiple Sclerosis Program </div> <div>Professor of Neurology </div> <div>David Geffen School of Medicine at UCLA </div>

Publications:

Wu, J., Ohlsson, M., Warner, E.A., Loo, K.K., Hoang, T., Voskuhl, R.R., Havton, L.A. Glial Reactions and Degeneration of Myelinated Processes in Spinal Cord Gray Matter in Chronic Experimental Autoimmune Encephalomyelitis. Neuroscience, 156(3): 586-96 2008; .
Sicotte, N. L. Giesser, B. S. Tandon, V. Klutch, R. Steiner, B. Drain, A. E. Shattuck, D. W. Hull, L. Wang, H. J. Elashoff, R. M. Swerdloff, R. S. Voskuhl, R. R. Testosterone treatment in multiple sclerosis: a pilot study. Arch Neurol. 2007; 64(5): 683-8.
Gold, S. M. Voskuhl, R. R. Testosterone replacement therapy for the treatment of neurological and neuropsychiatric disorders. Curr Opin Investig Drugs. 2006; 7(7): 625-30.
Palaszynski, K. M. Loo, K. K. Ashouri, J. F. Liu, H. Voskuhl, R. R. Androgens are protective in experimental autoimmune encephalomyelitis: implications for multiple sclerosis. J Neuroimmunol. 2004; 146(1-2): 144-52.
Sicotte, N. L. Liva, S. M. Klutch, R. Pfeiffer, P. Bouvier, S. Odesa, S. Wu, T. C. Voskuhl, R. R. Treatment of multiple sclerosis with the pregnancy hormone estriol. Ann Neurol. 2002; 52(4): 421-8..
Voskuhl, R. R. Palaszynski, K. Sex hormones and experimental autoimmune encephalomyelitis:Implications for multiple sclerosis. The Neuroscientist 2001; 7(3): 258-270.
Liva, S.M. Voskuhl, R.R. Testosterone acts directly on CD4+ T-lymphocytes to increase IL10 production. Journal of Immunology 2001; 167: 2060-2067.
Ziehn Marina O, Avedisian Andrea A, Dervin Shannon M, Umeda Elizabeth A, O'Dell Thomas J, Voskuhl Rhonda R Therapeutic Testosterone Administration Preserves Excitatory Synaptic Transmission in the Hippocampus during Autoimmune Demyelinating Disease.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012; 32(36): 12312-24.
Gold Stefan M, Sasidhar Manda V, Lagishetty Venu, Spence Rory D, Umeda Elizabeth, Ziehn Marina O, Krieger Thorsten, Schulz Karl-Heinz, Heesen Christoph, Hewison Martin, Voskuhl Rhonda R Dynamic Development of Glucocorticoid Resistance during Autoimmune Neuroinflammation.. The Journal of clinical endocrinology and metabolism. 2012; 97(8): E1402-10.
Ziehn Marina O, Avedisian Andrea A, Dervin Shannon M, O'Dell Thomas J, Voskuhl Rhonda R Estriol preserves synaptic transmission in the hippocampus during autoimmune demyelinating disease.. Laboratory investigation; a journal of technical methods and pathology. 2012; 92(8): 1234-45.
Sasidhar Manda V, Itoh Noriko, Gold Stefan M, Lawson Gregory W, Voskuhl Rhonda R The XX sex chromosome complement in mice is associated with increased spontaneous lupus compared with XY.. Annals of the rheumatic diseases. 2012; 71(8): 1418-22.
MacKenzie-Graham Allan J, Rinek Gilda A, Avedisian Andrea, Morales Laurie B, Umeda Elizabeth, Boulat Benoit, Jacobs Russell E, Toga Arthur W, Voskuhl Rhonda R Estrogen treatment prevents gray matter atrophy in experimental autoimmune encephalomyelitis.. Journal of neuroscience research. 2012; 90(7): 1310-23.
Voskuhl Rhonda R, Gold Stefan M Sex-related factors in multiple sclerosis susceptibility and progression.. Nature reviews. Neurology. 2012; 8(5): 255-63.
MacKenzie-Graham Allan, Rinek Gilda A, Avedisian Andrea, Gold Stefan M, Frew Andrew J, Aguilar Cynthia, Lin David R, Umeda Elizabeth, Voskuhl Rhonda R, Alger Jeffry R Cortical atrophy in experimental autoimmune encephalomyelitis: in vivo imaging.. NeuroImage. 2012; 60(1): 95-104.
Daumer Martin, Weinshenker Brian G, Voskuhl Rhonda Pregnancy: a "modifiable" risk factor in MS?. Neurology. 2012; 78(12): 846-8.
Spence Rory D, Voskuhl Rhonda R Neuroprotective effects of estrogens and androgens in CNS inflammation and neurodegeneration.. Frontiers in neuroendocrinology. 2012; 33(1): 105-15.
Spence Rory D, Hamby Mary E, Umeda Elizabeth, Itoh Noriko, Du Sienmi, Wisdom Amy J, Cao Yuan, Bondar Galyna, Lam Jeannie, Ao Yan, Sandoval Francisco, Suriany Silvie, Sofroniew Michael V, Voskuhl Rhonda R Neuroprotection mediated through estrogen receptor-alpha in astrocytes.. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(21): 8867-72.
Voskuhl Rhonda Sex differences in autoimmune diseases.. Biology of sex differences. 2011; 2(1): 1.
Du Sienmi, Sandoval Francisco, Trinh Pauline, Umeda Elizabeth, Voskuhl Rhonda Estrogen receptor-β ligand treatment modulates dendritic cells in the target organ during autoimmune demyelinating disease.. European journal of immunology. 2011; 41(1): 140-50.
Crawford Daniel K, Mangiardi Mario, Song Bingbing, Patel Rhusheet, Du Sienmi, Sofroniew Michael V, Voskuhl Rhonda R, Tiwari-Woodruff Seema K Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination.. Brain : a journal of neurology. 2010; 133(10): 2999-3016.
Ziehn Marina O, Avedisian Andrea A, Tiwari-Woodruff Seema, Voskuhl Rhonda R Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE.. Laboratory investigation; a journal of technical methods and pathology. 2010; 90(5): 774-86.
Du Sienmi, Sandoval Francisco, Trinh Pauline, Voskuhl Rhonda R Additive effects of combination treatment with anti-inflammatory and neuroprotective agents in experimental autoimmune encephalomyelitis.. Journal of neuroimmunology. 2010; 219(1-2): 64-74.
MacKenzie-Graham Allan, Tiwari-Woodruff Seema K, Sharma Gaurav, Aguilar Cynthia, Vo Kieumai T, Strickland Lauren V, Morales Laurie, Fubara Boma, Martin Melanie, Jacobs Russell E, Johnson G Allan, Toga Arthur W, Voskuhl Rhonda R Purkinje cell loss in experimental autoimmune encephalomyelitis.. NeuroImage. 2009; 48(4): 637-51.
Gold Stefan M, Voskuhl Rhonda R Estrogen treatment in multiple sclerosis.. Journal of the neurological sciences. 2009; 286(1-2): 99-103.
Tiwari-Woodruff Seema, Voskuhl Rhonda R Neuroprotective and anti-inflammatory effects of estrogen receptor ligand treatment in mice.. Journal of the neurological sciences. 2009; 286(1-2): 81-5.
Gold Stefan M, Sasidhar Manda V, Morales Laurie B, Du Sienmi, Sicotte Nancy L, Tiwari-Woodruff Seema K, Voskuhl Rhonda R Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERalpha).. Laboratory investigation; a journal of technical methods and pathology. 2009; 89(10): 1076-83.
Gold Stefan M, Voskuhl Rhonda R Estrogen and testosterone therapies in multiple sclerosis.. Progress in brain research. 2009; 175(37): 239-51.
Voskuhl Rhonda R, Peterson R Scott, Song Bingbing, Ao Yan, Morales Laurie Beth J, Tiwari-Woodruff Seema, Sofroniew Michael V Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009; 29(37): 11511-22.
Voskuhl Rhonda, Wu T C Jackson Do estroprogestinic hormones protect against chemotherapy-induced amenorrhea in multiple sclerosis?. Nature clinical practice. Neurology. 2009; 5(1): 18-9.
Smith-Bouvier Deborah L, Divekar Anagha A, Sasidhar Manda, Du Sienmi, Tiwari-Woodruff Seema K, King Jennifer K, Arnold Arthur P, Singh Ram Raj, Voskuhl Rhonda R A role for sex chromosome complement in the female bias in autoimmune disease.. The Journal of experimental medicine. 2008; 205(5): 1099-108.
Gold Stefan M, Chalifoux Sara, Giesser Barbara S, Voskuhl Rhonda R Immune modulation and increased neurotrophic factor production in multiple sclerosis patients treated with testosterone.. Journal of neuroinflammation. 2008; 5(1): 32.
Tiwari-Woodruff, S. Morales, L. B. Lee, R. Voskuhl, R. R. Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER){alpha} and ERbeta ligand treatment. Proc Natl Acad Sci U S A. 2007; 104(37): 14813-8.
Tiwari-Woodruff Seema, Morales Laurie Beth J, Lee Ruri, Voskuhl Rhonda R Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment.. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(37): 14813-8.
Sicotte Nancy L, Giesser Barbara S, Tandon Vinita, Klutch Ricki, Steiner Barbara, Drain Ann E, Shattuck David W, Hull Laura, Wang He-Jing, Elashoff Robert M, Swerdloff Ronald S, Voskuhl Rhonda R Testosterone treatment in multiple sclerosis: a pilot study.. Archives of neurology. 2007; 64(5): 683-8.
Smith Deborah L, Dong Xin, Du Sienmi, Oh Myungshin, Singh Ram Raj, Voskuhl Rhonda R A female preponderance for chemically induced lupus in SJL/J mice.. Clinical immunology (Orlando, Fla.). 2007; 122(1): 101-7.
MacKenzie-Graham Allan, Tinsley Matthew R, Shah Kaanan P, Aguilar Cynthia, Strickland Lauren V, Boline Jyl, Martin Melanie, Morales Laurie, Shattuck David W, Jacobs Russell E, Voskuhl Rhonda R, Toga Arthur W Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis.. NeuroImage. 2006; 32(3): 1016-23.
Gold Stefan M, Voskuhl Rhonda R Testosterone replacement therapy for the treatment of neurological and neuropsychiatric disorders.. Current opinion in investigational drugs (London, England : 2000). 2006; 7(7): 625-30.
Mackenzie-Graham, A. Tinsley, M. R. Shah, K. P. Aguilar, C. Strickland, L. V. Boline, J. Martin, M. Morales, L. Shattuck, D. W. Jacobs, R. E. Voskuhl, R. R. Toga, A. W. Cerebellar cortical atrophy in experimental autoimmune encephalomyelitis. Neuroimage. 2006; .
Morales, L. B. Loo, K. K. Liu, H. B. Peterson, C. Tiwari-Woodruff, S. Voskuhl, R. R. Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis. J Neurosci. 2006; 26(25): 6823-33.
Morales Laurie Beth J, Loo Kyi Kyi, Liu Hong-Biao, Peterson Cory, Tiwari-Woodruff Seema, Voskuhl Rhonda R Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006; 26(25): 6823-33.
Palaszynski Karen M, Smith Deborah L, Kamrava Shana, Burgoyne Paul S, Arnold Arthur P, Voskuhl Rhonda R A yin-yang effect between sex chromosome complement and sex hormones on the immune response.. Endocrinology. 2005; 146(8): 3280-5.
Palaszynski, K. M. Smith, D. L. Kamrava, S. Burgoyne, P. S. Arnold, A. P. Voskuhl, R. R. A Yin-Yang Effect Between Sex Chromosome Complement and Sex Hormones on the Immune Response. Endocrinology. 2005; .
Soldan Samantha S, Alvarez Retuerto Ana Isabel, Sicotte Nancy L, Voskuhl Rhonda R Dysregulation of IL-10 and IL-12p40 in secondary progressive multiple sclerosis.. Journal of neuroimmunology. 2004; 146(1-2): 209-15.
Liu, H. B. Loo, K. K. Palaszynski, K. Ashouri, J. Lubahn, D. B. Voskuhl, R. R. Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease. J Immunol. 2003; 171(12): 6936-40.
Liu Hong-biao, Loo Kyi Kyi, Palaszynski Karen, Ashouri Judith, Lubahn Dennis B, Voskuhl Rhonda R Estrogen receptor alpha mediates estrogen's immune protection in autoimmune disease.. Journal of immunology (Baltimore, Md. : 1950). 2003; 171(12): 6936-40.
Soldan Samantha S, Alvarez Retuerto Ana Isabel, Sicotte Nancy L, Voskuhl Rhonda R Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol.. Journal of immunology (Baltimore, Md. : 1950). 2003; 171(11): 6267-74.
Soldan, S. S. Retuerto, A. I. Sicotte, N. L. Voskuhl, R. R. Immune modulation in multiple sclerosis patients treated with the pregnancy hormone estriol. J Immunol. 2003; 171(11): 6267-74.
Sicotte Nancy L, Liva Stephanie M, Klutch Rochelle, Pfeiffer Paul, Bouvier Seth, Odesa Sylvia, Wu T C Jackson, Voskuhl Rhonda R Treatment of multiple sclerosis with the pregnancy hormone estriol.. Annals of neurology. 2002; 52(4): 421-8.
Liva, SM Voskuhl, RR Testosterone acts directly on CD4+ T lymphocytes to increase IL-10 production.. Journal of immunology (Baltimore, Md. : 1950) . 2001; 167(4): 2060-7.