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Itzhak Fried, M.D.

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Mailing Address:
UCLA Med-Neuro
BOX 957039, 18-225 NPI
Los Angeles, CA 90095

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Department / Division Affiliations
Director, Epilepsy Surgery
Professor, Psychiatry and Biobehavioral Sciences, Surgery
Professor in Residence, Semel Institute for Neuroscience and Human Behavior
Member, Brain Research Institute, Neuroscience IDP


Suthana Nanthia, Fried Itzhak Percepts to recollections: insights from single neuron recordings in the human brain. Trends in cognitive sciences. 2012; .
Medvedovsky Mordekhay, Taulu Samu, Gaily Eija, Metsähonkala Eeva-Liisa, Mäkelä Jyrki P, Ekstein Dana, Kipervasser Svetlana, Neufeld Miri Y, Kramer Uri, Blomstedt Göran, Fried Itzhak, Karppinen Atte, Veshchev Igor, Roivainen Reina, Ben-Zeev Bruria, Goldberg-Stern Hadassah, Wilenius Juha, Paetau Ritva Sensitivity and specificity of seizure-onset zone estimation by ictal magnetoencephalography. Epilepsia. 2012; .
Engel Jerome, McDermott Michael P, Wiebe Samuel, Langfitt John T, Stern John M, Dewar Sandra, Sperling Michael R, Gardiner Irenita, Erba Giuseppe, Fried Itzhak, Jacobs Margaret, Vinters Harry V, Mintzer Scott, Kieburtz Karl, Kieburtz Karl Early surgical therapy for drug-resistant temporal lobe epilepsy: a randomized trial. JAMA : the journal of the American Medical Association. 2012; 307(9): 922-30.
Tankus Ariel, Fried Itzhak Visuomotor coordination and motor representation by human temporal lobe neurons. Journal of cognitive neuroscience. 2012; 24(3): 600-10.
Suthana Nanthia, Haneef Zulfi, Stern John, Mukamel Roy, Behnke Eric, Knowlton Barbara, Fried Itzhak Memory enhancement and deep-brain stimulation of the entorhinal area. The New England journal of medicine. 2012; 366(6): 502-10.
Staba Richard J, Ekstrom Arne D, Suthana Nanthia A, Burggren Alison, Fried Itzhak, Engel Jerome, Bookheimer Susan Y Gray matter loss correlates with mesial temporal lobe neuronal hyperexcitability inside the human seizure-onset zone. Epilepsia. 2012; 53(1): 25-34.
Mukamel Roy, Fried Itzhak Human intracranial recordings and cognitive neuroscience. Annual review of psychology. 2012; 63(6): 511-37.
Mukamel Roy, Nir Yuval, Harel Michal, Arieli Amos, Malach Rafael, Fried Itzhak Invariance of firing rate and field potential dynamics to stimulus modulation rate in human auditory cortex. Human brain mapping. 2011; 32(8): 1181-93.
Fried Itzhak, Mukamel Roy, Kreiman Gabriel Internally generated preactivation of single neurons in human medial frontal cortex predicts volition. Neuron. 2011; 69(3): 548-62.
Mukamel Roy, Ekstrom Arne D, Kaplan Jonas, Iacoboni Marco, Fried Itzhak Single-neuron responses in humans during execution and observation of actions. Current biology : CB. 2010; 20(8): 750-6.
Upchurch Kristen, Stern John M, Salamon Noriko, Dewar Sandra, Engel Jerome, Vinters Harry V, Fried Itzhak Epileptogenic temporal cavernous malformations: operative strategies and postoperative seizure outcomes. Seizure : the journal of the British Epilepsy Association. 2010; 19(2): 120-8.
Engel Jerome, Akhtari Massoud, Bragin Anatol, Fried Itzhak, Ogren Jennifer A, Staba Richard J, Salamon Noriko, Thompson Paul M New approaches to structural and functional imaging in focal epilepsy. Epilepsia. 2010; 51 Suppl 1(2): 83-6.
Viskontas Indre V, Quiroga Rodrigo Quian, Fried Itzhak Human medial temporal lobe neurons respond preferentially to personally relevant images. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(50): 21329-34.
Ogren Jennifer A, Wilson Charles L, Bragin Anatol, Lin Jack J, Salamon Noriko, Dutton Rebecca A, Luders Eileen, Fields Tony A, Fried Itzhak, Toga Arthur W, Thompson Paul M, Engel Jerome, Staba Richard J Three-dimensional surface maps link local atrophy and fast ripples in human epileptic hippocampus. Annals of neurology. 2009; 66(6): 783-91.
Tankus Ariel, Yeshurun Yehezkel, Fried Itzhak An automatic measure for classifying clusters of suspected spikes into single cells versus multiunits. Journal of neural engineering. 2009; 6(5): 056001.
Lerner Jason T, Salamon Noriko, Hauptman Jason S, Velasco Tonicarlo R, Hemb Marta, Wu Joyce Y, Sankar Raman, Donald Shields W, Engel Jerome, Fried Itzhak, Cepeda Carlos, Andre Veronique M, Levine Michael S, Miyata Hajime, Yong William H, Vinters Harry V, Mathern Gary W Assessment and surgical outcomes for mild type I and severe type II cortical dysplasia: a critical review and the UCLA experience. Epilepsia. 2009; 50(6): 1310-35.
Tankus Ariel, Yeshurun Yehezkel, Flash Tamar, Fried Itzhak Encoding of speed and direction of movement in the human supplementary motor area. Journal of neurosurgery. 2009; 110(6): 1304-16.
Ekstrom Arne, Suthana Nanthia, Behnke Eric, Salamon Noriko, Bookheimer Susan, Fried Itzhak High-resolution depth electrode localization and imaging in patients with pharmacologically intractable epilepsy. Journal of neurosurgery. 2008; 108(4): 812-5.
Staba Richard J, Frighetto Leonardo, Behnke Eric J, Mathern Gary W, Fields Tony, Bragin Anatol, Ogren Jennifer, Fried Itzhak, Wilson Charles L, Engel Jerome Increased fast ripple to ripple ratios correlate with reduced hippocampal volumes and neuron loss in temporal lobe epilepsy patients. Epilepsia. 2007; 48(11): 2130-8.
Viskontas Indre V, Ekstrom Arne D, Wilson Charles L, Fried Itzhak Characterizing interneuron and pyramidal cells in the human medial temporal lobe in vivo using extracellular recordings. Hippocampus. 2007; 17(1): 49-57.
Ekstrom Arne, Viskontas Indre, Kahana Michael, Jacobs Josh, Upchurch Kristen, Bookheimer Susan, Fried Itzhak Contrasting roles of neural firing rate and local field potentials in human memory. Hippocampus. 2007; 17(8): 606-17.
Viskontas Indre V, Knowlton Barbara J, Steinmetz Peter N, Fried Itzhak Differences in mnemonic processing by neurons in the human hippocampus and parahippocampal regions. Journal of cognitive neuroscience. 2006; 18(10): 1654-62.
Zeitzer Jamie M, Morales-Villagran Alberto, Maidment Nigel T, Behnke Eric J, Ackerson Larry C, Lopez-Rodriguez Faustino, Fried Itzhak, Engel Jerome, Wilson Charles L Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study. Sleep. 2006; 29(4): 455-61.
Schrader Lara M, Stern John M, Wilson Charles L, Fields Tony A, Salamon Noriko, Nuwer Marc R, Vespa Paul M, Fried Itzhak Low frequency electrical stimulation through subdural electrodes in a case of refractory status epilepticus. Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology. 2006; 117(4): 781-8.
Bragin Anatol, Wilson Charles L, Fields Tony, Fried Itzhak, Engel Jerome Analysis of seizure onset on the basis of wideband EEG recordings. Epilepsia. 2005; 46 Suppl 5(5736): 59-63.
Ekstrom Arne D, Caplan Jeremy B, Ho Emily, Shattuck Kirk, Fried Itzhak, Kahana Michael J Human hippocampal theta activity during virtual navigation. Hippocampus. 2005; 15(7): 881-9.
Frazee John, Fried Itzhak, Kawamoto Henry, Lazareff Jorge, Nieto Jaime, Patel Swati, Urata Mark, van de Wiele Barbara The separation of Guatemalan craniopagus twins. Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery. 2004; 20(8-9): 593-600.
Staba Richard J, Wilson Charles L, Bragin Anatol, Jhung Donald, Fried Itzhak, Engel Jerome High-frequency oscillations recorded in human medial temporal lobe during sleep. Annals of neurology. 2004; 56(1): 108-15.
Amador Nelly, Fried Itzhak Single-neuron activity in the human supplementary motor area underlying preparation for action. Journal of neurosurgery. 2004; 100(2): 250-9.
Cornford Eain M, Shamsa Kamran, Zeitzer Jamie M, Enriquez Cathleen M, Wilson Charles L, Behnke Eric J, Fried Itzhak, Engel Jerome Regional analyses of CNS microdialysate glucose and lactate in seizure patients. Epilepsia. 2002; 43(11): 1360-71.
Bragin Anatol, Wilson Charles L, Staba Richard J, Reddick Mark, Fried Itzhak, Engel Jerome Interictal high-frequency oscillations (80-500 Hz) in the human epileptic brain: entorhinal cortex. Annals of neurology. 2002; 52(4): 407-15.
Staba Richard J, Wilson Charles L, Bragin Anatol, Fried Itzhak, Engel Jerome Quantitative analysis of high-frequency oscillations (80-500 Hz) recorded in human epileptic hippocampus and entorhinal cortex. Journal of neurophysiology. 2002; 88(4): 1743-52.
Staba Richard J, Wilson Charles L, Bragin Anatol, Fried Itzhak, Engel Jerome Sleep states differentiate single neuron activity recorded from human epileptic hippocampus, entorhinal cortex, and subiculum. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002; 22(13): 5694-704.
Fried Itzhak, Cameron Katherine A, Yashar Sharona, Fong Raymond, Morrow Jack W Inhibitory and excitatory responses of single neurons in the human medial temporal lobe during recognition of faces and objects. Cerebral cortex (New York, N.Y. : 1991). 2002; 12(6): 575-84.
Staba Richard J, Wilson Charles L, Fried Itzhak, Engel Jerome Single neuron burst firing in the human hippocampus during sleep. Hippocampus. 2002; 12(6): 724-34.