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Daniel Silverman, M.D., Ph.D.

Work Email Address:
dsilver@ucla.edu

Work Address:
Office
Medical Center, MC694215
Los Angeles, CA 90095
UNITED STATES

Work Phone Number:
(310) 825-4257


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Department / Division Affiliations
Clinical Professor, Biomedical Physics IDP, Molecular & Medical Pharmacology
Member, ACCESS Program: Dept. of Molecular & Medical Pharmacology, Cancer Molecular Imaging, Brain Research Institute, Santa Monica Nuclear Medicine Services

Bio:

Daniel H. Silverman, M.D., Ph.D., is Head of the Neuronuclear Imaging Section of the Ahmanson Translational Imaging Division at UCLA Medical Center, on the Executive Committee of the UCLA Alzheimer's Disease Research Center, and a Professor in the Department of Molecular and Medical Pharmacology, University of California, Los Angeles. He obtained his Ph.D. in Biological Chemistry at Harvard University, and postdoctoral research training in Biochemistry and Molecular Pharmacology at Harvard Medical School. He obtained his M.D. from The Ohio State University College of Medicine, subsequently completed post-M.D. training at UCLA, and then obtained certification from both the American Board of Internal Medicine and the American Board of Nuclear Medicine.
Publications:

Seibyl JP, Chen W, and Silverman DHS 3,4-Dihydroxy-6-[F-18]-Fluoro-L-Phenylalanine Positron Emission Tomography in Patients with Central Motor Disorders and in Evaluation of Brain and Other Tumors. Seminars in Nuclear Medicine 2007; 37: 440-450.
Silverman DHS, Dy CJ, Castellon SA, Lai J, Pio BS, Abraham L, Waddell K, Petersen L, Phelps ME, Ganz PA Altered frontocortical, cerebellar, and basal ganglia activity in adjuvant-treated breast cancer survivors 5 to 10 years after chemotherapy.. Breast Cancer Res Treat. 2007; 103: 303-311.
Kesner AL, Hsueh W-A, Htet NL, Pio BS, Czernin J, Pegram MD, Phelps ME, Silverman DHS Biodistribution and predictive value of 18F-fluorocyclophosphamide in mice bearing human breast xenografts. J. Nucl. Med. 2007; 48: 2021-2027.
Chen W, Delaloye S, Silverman DHS, Geist C, Czernin J, Sayre J, Satyamurthy N, Pope W, Lai A, Phelps ME, Cloughesy T Predicting Treatment Response of Malignant Gliomas to Bevacizumab and Irinotecan by Imaging Proliferation with 18F-FLT PET. J. Clin. Oncol. 2007; 25: 4714-4721.
Silverman DHS and Thompson PM ) Structural and functional neuroimaging: focusing on mild cognitive impairment. Appl Neurol. 2006; 2: 10-22.
Chen W, Silverman DHS, DelaloyeS, Czernin J, Kamdar N, Pope W, Satyamurthy N, Schiepers C, Cloughesy T 18F-FDOPA PET Imaging of Brain Tumors: Comparison Study with 18F-FDG PET and Evaluation of Diagnostic Accuracy. J Nucl Med. 2006; 47: 904-911.
Silverman DHS, Geist CL, Rasgon NL Clinical Data on Estrogen Effects in the Central Nervous System. in Effects of Estrogen on Brain Function 2006; 79-94.
Small GW, Silverman DHS, Siddarth P, Ercoli LM, Miller KJ, Lavretsky H, Wright BC, Bookheimer, SY, Barrio JR, Phelps ME Effects of a 14-day healthy aging lifestyle program on cognition and brain function. Am J Geriatr Psychiatr. 2006; 14: 538-554.
Karen J. Miller, Thomas D. Parsons, Peter C. Whybrow, Katja Van Herle, Natalie Rasgon, Andre Van Herle, Dorothy Martinez, Dan H. Silverman, Michael Bauer Memory improvement with treatment of hypothyroidism. Int J Neuroscience 2006; 116: 895-906.
Hsueh W-A, Kesner AL, Gangloff A, Pegram MD, Beryt M, Czernin C, Phelps ME, and Silverman DHS Predicting Chemotherapy Response to Paclitaxel Using [18F]-Fluoropaclitaxel and PET. J. Nucl. Med. 2006; 47: 1995-1999.
Kesner AL, Dahlbom M, Huang, S-C, Czernin J, Kreissl M, Wu H-M, Silverman DHS Semi-automated analysis of dynamic small animal PET data acquired for radiodosimetry determination.. J Nucl Med. 2006; 47: 1181-1186.
Azarian V, Gangloff A, Seimbille Y, Delaloye S, Czernin J, Phelps ME, Silverman DHS Synthesis and liposome encapsulation of a novel 18F-conjugate of omega-conotoxin GVIA for the potential imaging of N-type Ca2+ channels in the brain by positron emission tomography.. J Label Compd Radiopharm. 2006; 49: 269-283.
Pio BS, Park CK, Pietras R, Hsueh W-A, Satyamurthy N, Pegram MD, Czernin J, Phelps ME, Silverman DHS Usefulness of 3'-[F-18]fluoro-3'-deoxythymidine with positron emission tomography in predicting breast cancer response to therapy.. Mol. Imaging Biol. 2006; 8: 36-42.
Tran A, Pio BS, Khatibi B, Czernin J, Phelps ME, Silverman DH 18F-FDG PET for staging breast cancer in patients with inner-quadrant versus outer-quadrant tumors: comparison with long-term clinical outcome.. J Nucl Med. 2005; 46: 1455-1459..
Castellon SA, Silverman DH, Ganz PA. Breast cancer treatment and cognitive functioning: current status and future challenges in assessment.. Breast Cancer Res Treat. 2005; 92: 199-206.
Moulin-Romsee G, Maes A, Silverman D, Mortelmans L, Van Laere K. Cost-effectiveness of 18F-fluorodeoxyglucose positron emission tomography in the assessment of early dementia from a Belgian and European perspective.. Eur J Neurol. 2005; 12: 254-263.
Gangloff A, Hsueh W-A, Kesner AL, Kiesewetter DO, Pio BS, Pegram MD, Beryt M, Townsend A, Czernin J, Phelps ME, Silverman DHS Estimation of Paclitaxel Biodistribution and Uptake in Human-Derived Xenografts In Vivo with 18F-Fluoropaclitaxel.. J Nucl Med. 2005; 46: 1866-1871.
Rasgon NL, Silverman D, Siddarth P, Miller K, Ercoli LM, Elman S, Lavretsky H, Huang S-C, Phelps PE, Small GW Estrogen use and brain metabolic change in postmenopausal women with age-associated memory decline. Neurobiology of Aging 2005; 226: 229-235.
Seimbille Y, Phelps ME, Czernin J, Silverman DHS Fluorine-18 labeling of 6,7-disubstituted anilinoquinazoline derivatives for positron emission tomography (PET) imaging of tyrosine kinase receptors: synthesis of 18F-iressa and related molecular probes.. J Label Compd Radiopharm. 2005; 48: 829-843.
Chen W, Cloughesy T, Kamdar N, Satyamurthy N, Bergsneider M, Liau L, Mischel P, Czernin J, Phelps ME, Silverman DHS Imaging proliferation in brain tumors with 18F-FLT PET: comparison with FDG.. J Nucl Med. 2005; 46: 945-952.
Pan X-B, Wright TG, Leong FJ, Declerck JM, Silverman DHS Improving Influx Constant and Ratio Estimation in FDOPA Brain PET Analysis for Parkinson's Disease. J Nucl Med. 2005; 46: 1737-1744.
Silverman DHS Screening 18F-FDG Whole-Body Scanning: AWESOM-PET or FALSPOS-PET?. J. Nucl. Med. 2005; 46: 717.
Lacan G, Kesner AL, Gangloff A, Zheng L, Czernin J, Melega WP, Silverman DHS Synthesis of 2-[(2-Chloro-2'- [18F]fluoroethyl)amino]-2H-1,3,2-oxazaphosphorinane-2-oxide (18F-Fluorocyclo-phosphamide), a potential tracer for breast tumor prognostic imaging with PET. J Label Compd Radiopharm. 2005; 48: 635-643.
Seimbille Y, Czernin J, Phelps ME, Silverman DHS. 48:819-827 Synthesis of an 18F-fluorobenzoate idarubicin derivative as new potential PET radiotracer to predict chemotherapy resistance.. J Label Compd Radiopharm. 2005; .
Allen-Auerbach M, Quon A, Weber WA, Obrzut S, Crawford T, Silverman DH, Ratib O, Phelps ME, Czernin J Comparison between 2-deoxy-2-[18F]fluoro-D-Glucose positron emission tomography and positron emission tomography/computed tomography hardware fusion for staging of patients with lymphoma. Mol Imaging Biol. 2004; 6(6): 411-6.
Filmont JE, Yap CS, Ko F, Vranjesevic D, Quon A, Margolis DJ, Safaei A, Emmanouilides C, Silverman DH, Phelps ME, Czernin J, Conventional imaging and 2-deoxy-2-[(18)F]fluoro-D-glucose positron emission tomography for predicting the clinical outcome of patients with previously treated Hodgkin's disease. Mol Imaging Biol. 2004; 6(1): 47-54.
Seritan AL, Mendez MF, Silverman DH, Hurley RA, Taber KH Functional imaging as a window to dementia: corticobasal degeneration. J Neuropsychiatry Clin Neurosci. 2004; 16: 393-399 (and front cover figure).
Silverman DHS Silverman DHS (2004) Brain F-18-FDG PET in the diagnosis of neurodegenerative dementias: comparison with perfusion SPECT and with clinical evaluations lacking nuclear imaging . J Nucl Med 2004; 45: 594-607.
Pio BS, Byrne FR, Aranda R, Boulay G, Spicher K, Song MH, Birnbaumer L, Phelps ME, Czernin J, Silverman DHS Non-invasive quantification of bowel inflammation through positron emission tomography imaging of 2-deoxy-2-[18F]fluoro-D-glucose-labeled white blood cells. Molec Imaging and Biol. 2003; 5: 271-277.
Silverman DHS, Truong CT, Kim SK, Chang CY, Chen W, Kowell AP, Cummings JL, Czernin J, Small GW, Phelps ME Prognostic value of regional cerebral metabolism in patients undergoing dementia evaluation: comparison to a quantifying parameter of subsequent cognitive performance and to prognostic assessment without PET. Molec Gen and Metab. 2003; 80: 350-355.
Silverman DH, Phelps ME Application of positron emission tomography for evaluation of metabolism and blood flow in human brain: normal development, aging, dementia, and stroke.. Molecular genetics and metabolism. . 2001; 74(1-2): 128-38.
Schoder H, Silverman DH, Campisi R, Karpman H, Phelps ME, Schelbert HR and Czernin J Effect of mental stress on myocardial blood flow and vasomotion in patients with coronary artery disease.. J. Nucl. Med. 2000; 41: 11-16.
Schoder H, Silverman DHS, Campisi R, Schelbert HR, Phelps ME and Czernin J Effects of age, gender, and hemodynamic parameters on the myocardial blood flow response to mental stress in healthy individuals.. American J. Physiol.: Heart and Circulatory Physiology 2000; 278: H360-H366.
Silverman DHS, Phelps ME Evaluating dementia with PET: how do we put into clinical perspective what we know to date? Invited Commentary.. J. Nucl. Med. 2000; 41: 1929-1932.
Silverman DH Cerebral Activity in the Perception of Visceral Pain.. Current Review of Pain. 1999; 3(4): 291-299.
Witzig TE, White CA, Wiseman GA, Gordon LI, Emmanouilides C, Raubitschek A, Janakiraman N, Gutheil J, Schilder RJ, Spies S, Silverman DH, Parker E, Grillo-Lopez AJ Phase I/II trial of IDEC-Y2B8 radioimmunotherapy for treatment of relapsed or refractory CD20-positive B-cell non-Hodgkin?s lymphoma.. J. Clin. Oncol. 1999; 17: 3793-3803.
Moon DH, Maddahi J, Silverman DHS, Glaspy JA, Phelps ME, Hoh CK Accuracy of whole body FDG PET for the detection of recurrent or metastatic breast carcinoma.. J. Nuclear Med 1998; 39: 431-435.
Silverman DHS, Hoh CK, Seltzer MA, Schiepers C, Cuan GS, Gambhir SS, Zheng L,Czernin J, Phelps ME Evaluating tumor biology and oncological disease with positron emission tomography.. Seminars in Radiation Oncology 1998; 8: 183-196.
Chen W, Cloughesy T, Kamdar N, Satyamurthy N, Bergsneider M, Liau L, Mischel P, Czernin J, Phelps ME, Silverman DH Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDG.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. . 2005; 46(6): 945-52.
Waldherr C, Mellinghoff IK, Tran C, Halpern BS, Rozengurt N, Safaei A, Weber WA, Stout D, Satyamurthy N, Barrio J, Phelps ME, Silverman DH, Sawyers CL, Czernin J Monitoring antiproliferative responses to kinase inhibitor therapy in mice with 3'-deoxy-3'-18F-fluorothymidine PET.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. . 2005; 46(1): 114-20.
Silverman DH, Alavi A PET imaging in the assessment of normal and impaired cognitive function.. Radiologic clinics of North America. . 2005; 43(1): 67-77, x.
Halpern BS, Dahlbom M, Quon A, Schiepers C, Waldherr C, Silverman DH, Ratib O, Czernin J Impact of patient weight and emission scan duration on PET/CT image quality and lesion detectability.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. . 2004; 45(5): 797-801.
Silverman DH, Delpassand ES, Torabi F, Goy A, McLaughlin P, Murray JL Radiolabeled antibody therapy in non-Hodgkins lymphoma: radiation protection, isotope comparisons and quality of life issues.. Cancer treatment reviews. . 2004; 30(2): 165-72.
Halpern BS, Dahlbom M, Waldherr C, Yap CS, Schiepers C, Silverman DH, Ratib O, Czernin J Cardiac pacemakers and central venous lines can induce focal artifacts on CT-corrected PET images.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. . 2004; 45(2): 290-3.
Vranjesevic D, Schiepers C, Silverman DH, Quon A, Villalpando J, Dahlbom M, Phelps ME, Czernin J Relationship between 18F-FDG uptake and breast density in women with normal breast tissue.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. . 2003; 44(8): 1238-42.
Silverman DH, Gambhir SS, Huang HW, Schwimmer J, Kim S, Small GW, Chodosh J, Czernin J, Phelps ME Evaluating early dementia with and without assessment of regional cerebral metabolism by PET: a comparison of predicted costs and benefits.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. . 2002; 43(2): 253-66.
Silverman DH, Small GW, Chang CY, Lu CS, Kung De, Aburto MA, Chen W, Czernin J, Rapoport SI, Pietrini P, Alexander GE, Schapiro MB, Jagust WJ, Hoffman JM, Welsh-Bohmer KA, Alavi A, Clark CM, Salmon E, de Leon MJ, Mielke R, Cummings JL, Kowell AP, Gambhir SS, Hoh CK, Phelps ME Positron emission tomography in evaluation of dementia: Regional brain metabolism and long-term outcome.. JAMA : the journal of the American Medical Association. . 2001; 286(17): 2120-7.
Small GW, Ercoli LM, Silverman DH, Huang SC, Komo S, Bookheimer SY, Lavretsky H, Miller K, Siddarth P, Rasgon NL, Mazziotta JC, Saxena S, Wu HM, Mega MS, Cummings JL, Saunders AM, Pericak-Vance MA, Roses AD, Barrio JR, Phelps ME Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease.. Proceedings of the National Academy of Sciences of the United States of America. . 2000; 97(11): 6037-42.
Brody AL, Saxena S, Silverman DH, Alborzian S, Fairbanks LA, Phelps ME, Huang SC, Wu HM, Maidment K, Baxter LR Brain metabolic changes in major depressive disorder from pre- to post-treatment with paroxetine.. Psychiatry research. . 1999; 91(3): 127-39.
Wiseman GA, White CA, Witzig TE, Gordon LI, Emmanouilides C, Raubitschek A, Janakiraman N, Gutheil J, Schilder RJ, Spies S, Silverman DH, Grillo-Lopez AJ Radioimmunotherapy of relapsed non-Hodgkin's lymphoma with zevalin, a 90Y-labeled anti-CD20 monoclonal antibody.. Clinical cancer research : an official journal of the American Association for Cancer Research. . 1999; 5(10 Suppl): 3281s-3286s.
Silverman DH, Small GW, Phelps ME Clinical Value of Neuroimaging in the Diagnosis of Dementia. Sensitivity and Specificity of Regional Cerebral Metabolic and Other Parameters for Early Identification of Alzheimer's Disease.. Clinical Positron Imaging. 1999; 2(3): 119-130.
Silverman DH, Munakata JA, Ennes H, Mandelkern MA, Hoh CK, Mayer EA Regional cerebral activity in normal and pathological perception of visceral pain.. Gastroenterology. . 1997; 112(1): 64-72.