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Paul Mischel, M.D.

Work Email Address:
pmischel@mednet.ucla.edu

Work Address:
University of California San Diego
CA
UNITED STATES




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Department / Division Affiliations
Professor, Pathology and Laboratory Medicine, Surgical Pathology, Neuropathology
Lya and Harrison Latta Professor, Molecular & Medical Pharmacology
Member, ACCESS Program: Dept. of Cellular & Molecular Pathology, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, JCCC Signal Transduction and Therapeutics Program Area, Neuroscience IDP
Faculty, Cellular and Molecular Pathology PhD Program

Bio:

Dr. Paul Mischel is the Lya and Harrison Latta Professor of Pathology and Laboratory Medicine and holds a joint appointment in the Department of Molecular and Medical Pharmacology at the David Geffen School of Medicine at UCLA. Dr. Mischel graduated Alpha Omega Alpha with an M.D. from Cornell University Medical College and trained in Anatomic Pathology and Neuropathology at UCLA. Dr. Mischel obtained his post-doctoral research training in the laboratory of Dr. Louis F. Reichardt at the Howard Hughes Medical Institute at UCSF and joined the UCLA faculty in 1998. Dr. Mischel has received a number of awards, including the Farber Award in 2007, the top brain tumor research award given jointly by the Society for Neuro-Oncology and the American Association of Neurosurgery. Dr. Mischel's work was profiled by the Journal of Cell Biology in June 2008. Dr. Mischel was inducted into the American Society for Clinical Investigation (ASCI) in 2007 and was elected to serve on their council. Dr. Mischel is currently the President-elect of the ASCI. Expertise: Dr. Mischel is a board certified neuropathologist with expertise in signal transduction biology. His laboratory focuses on the development and application of molecularly targeted therapies for glioblastoma and on the application of emerging technologies to identify the patients most likely to benefit from these new treatments.
Please visit the Mischel Lab Click here:

Visit the UCLA Pathology Site here: Pathology

Visit the Jonnson Cancer Center here: JCCC

Visit UCLA Molecular & Medical Pharmacology Site here: Pharmacology

Visit the UCLA ACCESS Faculty page here: ACCESS

Publications:

Mellinghoff IK, Wang MY, Vivanco I, Haas-Kogan DA, Zhu S, Dia EQ, Lu KV, Yoshimoto K, Huang JH, Chute DJ, Riggs BL, Horvath S, Liau LM, Cavenee WK, Rao PN, Beroukhim R, Peck TC, Lee JC, Sellers WR, Stokoe D, Prados M, Cloughesy TF, Sawyers CL, Mischel PS Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. N Engl J Med. 2006; 353(19): 2012-24.
Tso CL, Freije WA, Day A, Chen Z, Merriman B, Perlina A, Lee Y, Dia EQ, Yoshimoto K, Mischel PS, Liau LM, Cloughesy TF, Nelson SF. Distinct Transcription Profiles of Primary and Secondary Glioblastoma Subgroups. Cancer Research. 2006; 66(1): 159-67.
Carlson MR, Zhang B, Fang Z, Mischel PS, Horvath S, Nelson SF. Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks. BMC Genomics. 2006; 7(1): 40.
Wang C-C, Liao Y-P, Mischel PS, Iwamoto KS, Cacalano NA, McBride WH. HDJ-2 as a target for radiosensitization of glioblastoma multiforme cells by the farnesyltransferase inhibitor, R115777 and the role of the p53/p21 pathway. Cancer Research. 2006; in press: .
Pope WB, Lai A, Nghiemphu P, Mischel P, Cloughesy TF MRI in patients with high-grade gliomas treated with bevacizumab and chemotherapy. Neurology. 2006; 66(8): 1258-60.
Mischel PS, Cloughesy TF, Mellinghoff IK. PTEN loss as a mechanism of resistance to EGFR tyrosine kinases inhibitors. Clinical Cancer Research. 2006; Invited Review: .
Wang C-C, Liao Y-P, Mischel PS, Iwamoto KS, Cacalano NA, McBride WH. Primary gioblastoma express mesenchymal stem-like properties. 2006; In press: .
Tso CL, Shintaku P, Chen J, Chen Z, Yoshimoto K, Mischel PS, Cloughesy TF, Liau LM, Nelson SF Primary gioblastoma express mesenchymal stem-like properties. Molecular Cancer Research. 2006; In Press: .
Mischel PS and Cloughesy TF. Using Molecular information to guide brain tumor therapy. Nature Clinical Practice Neurology. 2006; (2): 232-233.
Wang M, Lu K, Zhu S, Dia E, Vivanco I, Shackleford G, Cavenee W, Mellinghoff I, Cloughesy TF, Sawyers C, Mischel PS. mTOR inhibition promotes response to EGFR kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells. Cancer Research. 2006; In Press: .
Liau LM, Prins RM, Kiertscher SM, Odesa SK, Kremen TJ, Giovannone AJ, Lin JW, Chute DJ, Mischel PS, Cloughesy TF, Roth MD Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment. Clin Cancer Res. 2005; 1,11(15): 5515-25.
Chen W, Cloughesy T, Kamdar N, Satyamurthy N, Bergsneider M, Liau L, Mischel P, Czernin J, Phelps ME, Silverman DH Imaging proliferation in brain tumors with 18F-FLT PET: comparison with 18F-FDG. J Nucl Med. . 2005; 46(6): 945-52.
Liau LM, Prins RM, Kiertscher SM, Odesa SK, Kremen TJ, Giovannone AJ, Lin JW, Chute DJ, Mischel PS, Cloughesy TF and Roth MD Dendritic Cell Vaccination in Glioblastoma Patients Induces Systemic and Intracranial T-cell Responses Modulated by the Local CNS Tumor Microenvironment. Clinical Cancer Research. 2005; 11(15): 5515-5525.
Lu KV, Jong KA, Kim GY, Singh J, Dia EQ, Yoshimoto K, Wang MY, Cloughesy TF, Nelson SF and Mischel PS Differential induction of glioblastoma migration and growth by two forms of pleiotrophin. Journal of Biological Chemistry. 2005; 280(29): 26953-64.
Chen W, Cloughesy TF, Kamdar N, Satyamurthy, Bergscheider M, Liau L, Mischel P, Czernin J, Phelps ME, Silverman DHS. Imaging Proliferation in Brain Tumors with FLT-PET. Journal of Nuclear Medicine. 2005; 46(6): 945-952.
Pope WB, Sayre J, Perlina A, Villablanca P, Mischel PS, Cloughesy TF MR imaging correlates of survival in patients with high grade gliomas. American Journal of Neuroradiology . American Journal of Neuroradiology. 2005; 26(10): 2466-2474.
Pope WB, Sayer J, Perlina A, Villablanca JP, Mischel PS, Cloughesy TF. Magnetic Resonance Imaging Correlates of Survival in Patients with High Grade Gliomas. American Journal of Neuroradiology. 2005; 26(10): 2466-2474.
Mellinghoff IK, Wang MY, Vivanco I, Haas-Kogan DA, Zhu S, Dia EQ, Lu KV, Yoshimoto K, Huang JHY, Chute DJ, Riggs BL, Horvath S, Liau LM, Cavenee WK, Rao PN, Beroukhim R, Peck TC, Lee JC, Sellers WR, StokoeD , Prados M, Cloughesy TF, Sawyers CL and Mischel PS. Molecular determinants of EGFR kinase inhibitor response in glioblastoma. New England Journal of Medicine. 2005; 353(19): 2012-2024.
Stillman BN, Mischel PS, Baum LG. New Roles for Galectins in Brain Tumors-From Prognostic Markers to Therapeutic Targets. 2005; (15): 124-132.
Mehrian Shai R, Reichardt JK, Ya-Hsuan H, Kremen TJ, Liau LM, Cloughesy TF, Mischel PS, Nelson SF Robustness of gene expression profiling in glioma specimen samplings and derived cell lines. . 2005; 20(136 (1-2)): 99-103.
Lu KV, Jong KA, Rajasekaran AK, Cloughesy TF, Mischel PS Upregulation of tissue inhibitor of metalloproteinases (TIMP)-2 promotes matrix metalloproteinase (MMP)-2 activation and cell invasion in a human glioblastoma cell line. Lab Invest. 2004; 84(1): 8-20.
Mischel PS, Cloughesy TF, Nelson SF DNA-microarray analysis of brain cancer: molecular classification for therapy. Nat Rev Neurosci. 2004; 5(10): 782-92.
Frieje WA, Castro-Vargas FE, Fang Z, Horvath S, Cloughesy TF, Liau LM, Mischel PS, Nelson SF. Gene Expression Profiling of Gliomas Strongly Predicts Survival. Cancer Res. . 2004; 15, 64(18): 6503-6510.
Lu KV, Jong K, Rajasekaran AK, Cloughesy TF, Mischel PS. Upregulation of Tissue Inhibitor of Metalloproteinases (TIMP)-2 Promotes Matrix Metalloproteinase (MMP)-2 Activation and Cell Invasion in Human Glioblastoma Cell Line. 2004; 84(1): 8-20.
Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, Inge L, Smith BL, Sawyers CL, Mischel PS Analysis of the phosphatidylinositol 3'-kinase signaling pathway in glioblastoma patients in vivo. Cancer Res. . 2003; 1;63(11): 2742-6.
Shai R, Shi T, Kremen TJ, Horvath S, Liau LM, Cloughesy TF, Mischel PS, Nelson SF Gene expression profiling identifies molecular subtypes of gliomas. Oncogene. . 2003; 31,22(31): 4918-23.
Choe G, Horvath S, Cloughesy TF, Crosby K, Seligson D, Palotie A, Inge L, Smith B, Sawyers CL, Mischel PS. Analysis of the P13K Signaling Pathway in Glioblastoma Patients. 2003; 63(11): 2742-2746.
Shai R, Shi T, Kremen TJ, Horvath S, Liau LM, Cloughesy TF, Mischel PS*, Nelson SF*, (*Co-Senior authors) Gene Expression Profiling Identites Distinct Subtypes of Glioblastoma. 2003; 22(31): 4918-4923.
Mischel PS, Shai R, Shi T, Horvath S, Lu KV, Choe G, Seligson D, Kremen TJ, Palotie A, Liau L, Cloughesy T, Nelson SF Identification of Molecular Subtypes of Glioblastoma by Gene Expression Profiling . Oncogene. . 2003; 217;2(15): 2361-2372.
Mischel PS, Nelson SF, Cloughesy TF Molecular analysis of glioblastoma: pathway profiling and its implications for patient therapy. Cancer biology & therapy. . 2003; 2(3): 242-7.
Mischel PS, Cloughesy TF Targeted molecular therapy of GBM. Brain Pathol. 2003; 13(1): 52-61.
Mischel PS, Umbach JA, Eskandari S, Smith SG, Gundersen CB, Zampighi GA. Nerve growth factor signals via pre-existing TrkA receptor oligomers. Biophysical Journal 2002; 83(2): 968-976.
Liau LM, Black KL, Martin NA, Sykes SN, Brontstein JM, Joubin-Steele L, Mischel PS, Belldegrun A, Cloughesy TF Treatment of a glioblastoma patient by vaccination with autologous dendritic cells pulsed with allogenic major histocompatibility complex class I-matched tumor peptides. Neurosurgical Focus . 2001; (9): 1-5.
Vinters HV, Park SH, Johnson MW, Mischel PS, Catania M, Kerfoot C Cortical dysplasia, genetic abnormalities and neurocutaneous syndromes. Dev. Neuroscience . 1999; (21): 248-59.
Bakshi R, Mazziotta JC, Mischel PS, Jahan R, Seligson DB, Vinters HV Lymphomatosis cerebri presenting as a rapidly progressive dementia: clinical, neuroimaging and pathologic findings. Dement Geriatr Cogn Disord. 1999; 10(2): 152-7.
Vinters HV, Farrell MA, Mischel PS, Anders KA Diagnostic Neuropathology. 1998; .
Mischel PS, Vinters HV Focal Cortical Dysplasia. Neurobase 1998; .
Mischel PS, VInters HV Neuropathology of developmental disorders. Epilepsy: A comprehensive textbook 1998; .
Mathern GL, Babb TL, Mischel PS, Vinters HV, Pretorius JK, Leite JP and Peacock WJ Childhood generalized and mesial temporal epilepsies demonstrate different amounts and patterns of hippocampal neuron loss and mossy fiber synaptic reorganization. Brain. 1997; (119): 965-87.
Menchine M, Emelin JK, Mischel PS, Haag TA, Norman MG, Pepkowitz SH, Welsh CT, Townsend JJ, Vinters HV Tissue and cell-type specific expression of the Tuberous Sclerosis Gene, TSC2, in human tissues. . Modern Pathology. 1997; (9): 1071-80.
Kaufer D, Mendez MF, Mischel PS, Verity MA, Benson DF Alien hand syndrome in adult onset orthochromatic leukodystrophy. Behavioral Neurology . 1996; (9): 5-10.
Mischel PS, Nguyen L, Vinters HV Cerebral cortical dysplasia associated with pediatric epilepsy. Journal of Neuropathology and Experimental Neurology 1995; 54: 137-53.
Mischel PS, Vinters HV Coccidioidomycosis: Selected neuropathologic and vasculopathic manifestations and their clinical correlates. Clinical Infectious Diseases 1995; 20(2): 400-405.
McPherson SE, Kuratani JD, Cummings JL, Shih J, Mischel PS and Vinters HV Creutzfeldt-Jakob Disease with mixed transcortical aphasia. Behavioral Neurology . 1994; (7): 197-203.
Einhorn TA, Levine B and Mischel PS. Nutrition and bone. Orthopedic Clinics of North America. 1990; (21): 43-51.
Agnihotri Sameer, Gajadhar Aaron S, Ternamian Christian, Gorlia Thierry, Diefes Kristin L, Mischel Paul S, Kelly Joanna, McGown Gail, Thorncroft Mary, Carlson Brett L, Sarkaria Jann N, Margison Geoffrey P, Aldape Kenneth, Hawkins Cynthia, Hegi Monika, Guha Abhijit Alkylpurine-DNA-N-glycosylase confers resistance to temozolomide in xenograft models of glioblastoma multiforme and is associated with poor survival in patients. The Journal of clinical investigation. 2011; .
Liu Yue, Ye Fei, Yamada Kazunari, Tso Jonathan L, Zhang Yibei, Nguyen David H, Dong Qinghua, Soto Horacio, Choe Jinny, Dembo Anna, Wheeler Hayley, Eskin Ascia, Schmid Ingrid, Yong William H, Mischel Paul S, Cloughesy Timothy F, Kornblum Harley I, Nelson Stanley F, Liau Linda M, Tso Cho-Lea Autocrine endothelin-3/endothelin receptor B signaling maintains cellular and molecular properties of glioblastoma stem cells. Molecular cancer research : MCR. 2011; 9(12): 1668-85.
Lai Albert, Kharbanda Samir, Pope Whitney B, Tran Anh, Solis Orestes E, Peale Franklin, Forrest William F, Pujara Kanan, Carrillo Jose A, Pandita Ajay, Ellingson Benjamin M, Bowers Chauncey W, Soriano Robert H, Schmidt Nils O, Mohan Sankar, Yong William H, Seshagiri Somasekar, Modrusan Zora, Jiang Zhaoshi, Aldape Kenneth D, Mischel Paul S, Liau Linda M, Escovedo Cameron J, Chen Weidong, Nghiemphu Phioanh Leia, James C David, Prados Michael D, Westphal Manfred, Lamszus Katrin, Cloughesy Timothy, Phillips Heidi S Evidence for Sequenced Molecular Evolution of IDH1 Mutant Glioblastoma From a Distinct Cell of Origin. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2011; 29(34): 4482-90.
Woerner B Mark, Luo Jingqin, Brown Kristin R, Jackson Erin, Dahiya Sonika M, Mischel Paul, Benovic Jeffrey L, Piwnica-Worms David, Rubin Joshua B Suppression of G-protein-Coupled Receptor Kinase 3 Expression Is a Feature of Classical GBM that Is Required for Maximal Growth. Molecular cancer research : MCR. 2011; .
Tanaka Kazuhiro, Babic Ivan, Nathanson David, Akhavan David, Guo Deliang, Gini Beatrice, Dang Julie, Zhu Shaojun, Yang Huijun, de Jesus Jason, Amzajerdi Ali Nael, Zhang Yinan, Dibble Christian C, Dan Hancai, Rinkenbaugh Amanda, Yong William H, Vinters Harry V, Gera Joseph F, Cavenee Webster K, Cloughesy Timothy F, Manning Brendan D, Baldwin Albert S, Mischel Paul S Oncogenic EGFR signaling activates an mTORC2-NF-κB pathway that promotes chemotherapy resistance. Cancer discovery. 2011; 1(6): 524-538.
Masui Kenta, Cloughesy Timothy F, Mischel Paul S Review: Molecular pathology in adult high-grade gliomas: from molecular diagnostics to target therapies. Neuropathology and applied neurobiology. 2011; 9(12): .
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Mischel Paul S, Nghiemphu Phioanh L, Lalezari Shadi, Schmainda Kathleen M, Pope Whitney B Graded functional diffusion map-defined characteristics of apparent diffusion coefficients predict overall survival in recurrent glioblastoma treated with bevacizumab. Neuro-oncology. 2011; 13(10): 1151-61.
Mellinghoff Ingo K, Schultz Nikolaus, Mischel Paul S, Cloughesy Timothy F Will Kinase Inhibitors Make it as Glioblastoma Drugs?. Current topics in microbiology and immunology. 2011; 1(6): .
Cvrljevic Anna N, Akhavan David, Wu Min, Martinello Paul, Furnari Frank B, Johnston Amelia J, Guo Deliang, Pike Lisa, Cavenee Webster K, Scott Andrew M, Mischel Paul S, Hoogenraad Nick J, Johns Terrance G Activation of Src induces mitochondrial localisation of de2-7EGFR (EGFRvIII) in glioma cells: implications for glucose metabolism. Journal of cell science. 2011; 124(Pt 17): 2938-50.
Guo Deliang, Reinitz Felicia, Youssef Mary, Hong Cynthia, Nathanson David, Akhavan David, Kuga Daisuke, Amzajerdi Ali Nael, Soto Horacio, Zhu Shaojun, Babic Ivan, Tanaka Kazuhiro, Dang Julie, Iwanami Akio, Gini Beatrice, Dejesus Jason, Lisiero Dominique D, Huang Tiffany T, Prins Robert M, Wen Patrick Y, Robins H Ian, Prados Michael D, Deangelis Lisa M, Mellinghoff Ingo K, Mehta Minesh P, James C David, Chakravarti Arnab, Cloughesy Timothy F, Tontonoz Peter, Mischel Paul S An LXR agonist promotes GBM cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer discovery. 2011; 1(5): 442-456.
Jijiwa Mayumi, Demir Habibe, Gupta Snehalata, Leung Crystal, Joshi Kaushal, Orozco Nicholas, Huang Tiffany, Yildiz Vedat O, Shibahara Ichiyo, de Jesus Jason A, Yong William H, Mischel Paul S, Fernandez Soledad, Kornblum Harley I, Nakano Ichiro CD44v6 regulates growth of brain tumor stem cells partially through the AKT-mediated pathway. PloS one. 2011; 6(9): e24217.
Vlashi Erina, Lagadec Chann, Vergnes Laurent, Matsutani Tomoo, Masui Kenta, Poulou Maria, Popescu Ruxandra, Della Donna Lorenza, Evers Patrick, Dekmezian Carmen, Reue Karen, Christofk Heather, Mischel Paul S, Pajonk Frank Metabolic state of glioma stem cells and nontumorigenic cells. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(38): 16062-7.
Atefi Mohammad, von Euw Erika, Attar Narsis, Ng Charles, Chu Connie, Guo Deliang, Nazarian Ramin, Chmielowski Bartosz, Glaspy John A, Comin-Anduix Begonya, Mischel Paul S, Lo Roger S, Ribas Antoni Reversing Melanoma Cross-Resistance to BRAF and MEK Inhibitors by Co-Targeting the AKT/mTOR Pathway. PloS one. 2011; 6(12): e28973.
Mischel Paul S Lost - and found - in translation. The Journal of clinical investigation. 2011; 121(8): 3357-9.
Niehr Franziska, von Euw Erika, Attar Narsis, Guo Deliang, Matsunaga Doug, Sazegar Hooman, Ng Charles, Glaspy John A, Recio Juan A, Lo Roger S, Mischel Paul S, Comin-Anduix Begonya, Ribas Antoni Combination therapy with vemurafenib (PLX4032/RG7204) and metformin in melanoma cell lines with distinct driver mutations. Journal of translational medicine. 2011; 9(6): 76.
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Lalezari Shadi, Zaw Taryar, Motevalibashinaeini Kourosh, Mischel Paul S, Pope Whitney B Quantification of edema reduction using differential quantitative T2 (DQT2) relaxometry mapping in recurrent glioblastoma treated with bevacizumab. Journal of neuro-oncology. 2011; 121(8): .
Nakano Ichiro, Joshi Kaushal, Visnyei Koppany, Hu Bin, Watanabe Momoko, Lam Diana, Wexler Eric, Saigusa Kuniyasu, Nakamura Yuko, Laks Dan R, Mischel Paul S, Viapiano Mariano, Kornblum Harley I Siomycin A targets brain tumor stem cells partially through a MELK-mediated pathway. Neuro-oncology. 2011; 13(6): 622-34.
Kawahara Hironori, Okada Yohei, Imai Takao, Iwanami Akio, Mischel Paul S, Okano Hideyuki Musashi1 cooperates in abnormal cell lineage protein 28 (Lin28)-mediated let-7 family microRNA biogenesis in early neural differentiation. The Journal of biological chemistry. 2011; 286(18): 16121-30.
Agnihotri Sameer, Wolf Amparo, Munoz Diana M, Smith Christopher J, Gajadhar Aaron, Restrepo Andres, Clarke Ian D, Fuller Gregory N, Kesari Santosh, Dirks Peter B, McGlade C Jane, Stanford William L, Aldape Kenneth, Mischel Paul S, Hawkins Cynthia, Guha Abhijit A GATA4-regulated tumor suppressor network represses formation of malignant human astrocytomas. The Journal of experimental medicine. 2011; 208(4): 689-702.
Pope Whitney B, Sayre James, Perlina Alla, Villablanca J Pablo, Mischel Paul S, Cloughesy Timothy F MR imaging correlates of survival in patients with high-grade gliomas. AJNR. American journal of neuroradiology. 2011; 26(10): 2466-74.
Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Nghiemphu Phioanh L, Mischel Paul S, Pope Whitney B Quantitative volumetric analysis of conventional MRI response in recurrent glioblastoma treated with bevacizumab. Neuro-oncology. 2011; 13(4): 401-9.
Nathanson David, Mischel Paul S Charting the course across the blood-brain barrier. The Journal of clinical investigation. 2011; 121(1): 31-3.
Cloughesy Timothy F, Mischel Paul S New strategies in the molecular targeting of glioblastoma: how do you hit a moving target?. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011; 17(1): 6-11.
Lai Albert, Tran Anh, Nghiemphu Phioanh L, Pope Whitney B, Solis Orestes E, Selch Michael, Filka Emese, Yong William H, Mischel Paul S, Liau Linda M, Phuphanich Surasak, Black Keith, Peak Scott, Green Richard M, Spier Cynthia E, Kolevska Tatjana, Polikoff Jonathan, Fehrenbacher Louis, Elashoff Robert, Cloughesy Timothy Phase II study of bevacizumab plus temozolomide during and after radiation therapy for patients with newly diagnosed glioblastoma multiforme. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2011; 29(2): 142-8.
Panosyan Eduard H, Laks Dan R, Masterman-Smith Michael, Mottahedeh Jack, Yong William H, Cloughesy Timothy F, Lazareff Jorge A, Mischel Paul S, Moore Theodore B, Kornblum Harley I Clinical outcome in pediatric glial and embryonal brain tumors correlates with in vitro multi-passageable neurosphere formation. Pediatric blood & cancer. 2010; 55(4): 644-51.
Sun Jing, Masterman-Smith Michael D, Graham Nicholas A, Jiao Jing, Mottahedeh Jack, Laks Dan R, Ohashi Minori, DeJesus Jason, Kamei Ken-ichiro, Lee Ki-Bum, Wang Hao, Yu Zeta T F, Lu Yi-Tsung, Hou Shuang, Li Keyu, Liu Max, Zhang Nangang, Wang Shutao, Angenieux Brigitte, Panosyan Eduard, Samuels Eric R, Park Jun, Williams Dirk, Konkankit Vera, Nathanson David, van Dam R Michael, Phelps Michael E, Wu Hong, Liau Linda M, Mischel Paul S, Lazareff Jorge A, Kornblum Harley I, Yong William H, Graeber Thomas G, Tseng Hsian-Rong A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens. Cancer research. 2010; 70(15): 6128-38.
Akhavan David, Cloughesy Timothy F, Mischel Paul S mTOR signaling in glioblastoma: lessons learned from bench to bedside. Neuro-oncology. 2010; 12(8): 882-9.
Søndergaard Jonas N, Nazarian Ramin, Wang Qi, Guo Deliang, Hsueh Teli, Mok Stephen, Sazegar Hooman, MacConaill Laura E, Barretina Jordi G, Kehoe Sarah M, Attar Narsis, von Euw Erika, Zuckerman Jonathan E, Chmielowski Bartosz, Comin-Anduix Begoña, Koya Richard C, Mischel Paul S, Lo Roger S, Ribas Antoni Differential sensitivity of melanoma cell lines with BRAFV600E mutation to the specific Raf inhibitor PLX4032. Journal of translational medicine. 2010; 8(4): 39.
Lee Yohan, Liu Jason, Patel Shilpa, Cloughesy Timothy, Lai Albert, Farooqi Haumith, Seligson David, Dong Jun, Liau Linda, Becker Donald, Mischel Paul, Shams Soheil, Nelson Stanley Genomic landscape of meningiomas. Brain pathology (Zurich, Switzerland). 2010; 20(4): 751-62.
Vivanco Igor, Rohle Daniel, Versele Matthias, Iwanami Akio, Kuga Daisuke, Oldrini Barbara, Tanaka Kazuhiro, Dang Julie, Kubek Sara, Palaskas Nicolaos, Hsueh Teli, Evans Michael, Mulholland David, Wolle Daniel, Rajasekaran Sigrid, Rajasekaran Ayyappan, Liau Linda M, Cloughesy Timothy F, Dikic Ivan, Brennan Cameron, Wu Hong, Mischel Paul S, Perera Timothy, Mellinghoff Ingo K The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(14): 6459-64.
Guo Deliang, Cloughesy Timothy F, Radu Caius G, Mischel Paul S AMPK: A metabolic checkpoint that regulates the growth of EGFR activated glioblastomas. Cell cycle (Georgetown, Tex.). 2010; 9(2): 211-2.
Tarcic Gabi, Boguslavsky Shlomit K, Wakim Jean, Kiuchi Tai, Liu Angela, Reinitz Felicia, Nathanson David, Takahashi Takamune, Mischel Paul S, Ng Tony, Yarden Yosef An unbiased screen identifies DEP-1 tumor suppressor as a phosphatase controlling EGFR endocytosis. Current biology : CB. 2009; 19(21): 1788-98.
Gregorian Caroline, Nakashima Jonathan, Dry Sarah M, Nghiemphu P Leia, Smith Kate Barzan, Ao Yan, Dang Julie, Lawson Gregory, Mellinghoff Ingo K, Mischel Paul S, Phelps Michael, Parada Luis F, Liu Xin, Sofroniew Michael V, Eilber Fritz C, Wu Hong PTEN dosage is essential for neurofibroma development and malignant transformation. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(46): 19479-84.
Veeriah, Taylor, Meng, Fang, Yilmaz, Vivanco, Janakiraman, Schultz, Hanrahan, Pao, Ladanyi, Sander, Heguy, Holland, Paty, Mischel, Liau, Cloughesy, Mellinghoff, Solit, Chan Somatic mutations of the Parkinson's disease-associated gene PARK2 in glioblastoma and other human malignancies. Nature genetics. 2009; .
Mischel Paul A case for a science-informed perspective on health care reform. The Journal of clinical investigation. 2009; 119(10): 2855.
Lu Kan V, Zhu Shaojun, Cvrljevic Anna, Huang Tiffany T, Sarkaria Shawn, Ahkavan David, Dang Julie, Dinca Eduard B, Plaisier Seema B, Oderberg Isaac, Lee Yohan, Chen Zugen, Caldwell Jeremy S, Xie Yongmin, Loo Joseph A, Seligson David, Chakravari Arnab, Lee Francis Y, Weinmann Roberto, Cloughesy Timothy F, Nelson Stanley F, Bergers Gabriele, Graeber Thomas, Furnari Frank B, James C David, Cavenee Webster K, Johns Terrance G, Mischel Paul S Fyn and SRC are effectors of oncogenic epidermal growth factor receptor signaling in glioblastoma patients. Cancer research. 2009; 69(17): 6889-98.
Liu Qinghai, Nguyen David H, Dong Qinghua, Shitaku Peter, Chung Kenneth, Liu On Ying, Tso Jonathan L, Liu Jason Y, Konkankit Veerauo, Cloughesy Timothy F, Mischel Paul S, Lane Timothy F, Liau Linda M, Nelson Stanley F, Tso Cho-Lea Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors. Journal of neuro-oncology. 2009; 94(1): 1-19.
Kappadakunnel Paul S, Eskin Paul S, Dong Paul S, Nelson Paul S, Mischel Paul S, Liau Paul S, Ngheimphu Paul S, Lai Paul S, Cloughesy Paul S, Goldin Paul S, Pope Paul S Stem cell associated gene expression in glioblastoma multiforme: relationship to survival and the subventricular zone. Journal of neuro-oncology. 2009; 69(17): .
Iwanami Akio, Cloughesy Timothy F, Mischel Paul S Striking the balance between PTEN and PDK1: it all depends on the cell context. Genes & development. 2009; 23(15): 1699-704.
Guo Deliang, Hildebrandt Isabel J, Prins Robert M, Soto Horacio, Mazzotta Mary M, Dang Julie, Czernin Johannes, Shyy John Y-J, Watson Andrew D, Phelps Michael, Radu Caius G, Cloughesy Timothy F, Mischel Paul S The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(31): 12932-7.
McGillicuddy Lauren T, Fromm Jody A, Hollstein Pablo E, Kubek Sara, Beroukhim Rameen, De Raedt Thomas, Johnson Bryan W, Williams Sybil M G, Nghiemphu Phioanh, Liau Linda M, Cloughesy Tim F, Mischel Paul S, Parret Annabel, Seiler Jeanette, Moldenhauer Gerd, Scheffzek Klaus, Stemmer-Rachamimov Anat O, Sawyers Charles L, Brennan Cameron, Messiaen Ludwine, Mellinghoff Ingo K, Cichowski Karen Proteasomal and genetic inactivation of the NF1 tumor suppressor in gliomagenesis. Cancer cell. 2009; 16(1): 44-54.
Pope Whitney B, Kim Hyun J, Huo Jing, Alger Jeffry, Brown Matthew S, Gjertson David, Sai Victor, Young Jonathan R, Tekchandani Leena, Cloughesy Timothy, Mischel Paul S, Lai Albert, Nghiemphu Phioanh, Rahmanuddin Syed, Goldin Jonathan Recurrent glioblastoma multiforme: ADC histogram analysis predicts response to bevacizumab treatment. Radiology. 2009; 252(1): 182-9.
Huang Tiffany T, Sarkaria Shawn M, Cloughesy Timothy F, Mischel Paul S Targeted therapy for malignant glioma patients: lessons learned and the road ahead. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2009; 6(3): 500-12.
Veeriah Selvaraju, Brennan Cameron, Meng Shasha, Singh Bhuvanesh, Fagin James A, Solit David B, Paty Philip B, Rohle Dan, Vivanco Igor, Chmielecki Juliann, Pao William, Ladanyi Marc, Gerald William L, Liau Linda, Cloughesy Timothy C, Mischel Paul S, Sander Chris, Taylor Barry, Schultz Nikolaus, Major John, Heguy Adriana, Fang Fang, Mellinghoff Ingo K, Chan Timothy A The tyrosine phosphatase PTPRD is a tumor suppressor that is frequently inactivated and mutated in glioblastoma and other human cancers. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(23): 9435-40.
Laks Dan R, Masterman-Smith Michael, Visnyei Koppany, Angenieux Brigitte, Orozco Nicholas M, Foran Ian, Yong William H, Vinters Harry V, Liau Linda M, Lazareff Jorge A, Mischel Paul S, Cloughesy Timothy F, Horvath Steve, Kornblum Harley I Neurosphere formation is an independent predictor of clinical outcome in malignant glioma. Stem cells (Dayton, Ohio). 2009; 27(4): 980-7.
Dumont Rebecca A, Hildebrandt Isabel, Su Helen, Haubner Roland, Reischl Gerald, Czernin Johannes G, Mischel Paul S, Weber Wolfgang A Noninvasive imaging of alphaVbeta3 function as a predictor of the antimigratory and antiproliferative effects of dasatinib. Cancer research. 2009; 69(7): 3173-9.
Kreisl Teri N, Lassman Andrew B, Mischel Paul S, Rosen Neal, Scher Howard I, Teruya-Feldstein Julie, Shaffer David, Lis Eric, Abrey Lauren E A pilot study of everolimus and gefitinib in the treatment of recurrent glioblastoma (GBM). Journal of neuro-oncology. 2009; 92(1): 99-105.
Guo Deliang, Prins Robert M, Dang Julie, Kuga Daisuke, Iwanami Akio, Soto Horacio, Lin Kelly Y, Huang Tiffany T, Akhavan David, Hock M Benjamin, Zhu Shaojun, Kofman Ava A, Bensinger Steve J, Yong William H, Vinters Harry V, Horvath Steve, Watson Andrew D, Kuhn John G, Robins H Ian, Mehta Minesh P, Wen Patrick Y, DeAngelis Lisa M, Prados Michael D, Mellinghoff Ingo K, Cloughesy Timothy F, Mischel Paul S EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy. Science signaling. 2009; 2(101): ra82.
Lee Yohan, Scheck Adrienne C, Cloughesy Timothy F, Lai Albert, Dong Jun, Farooqi Haumith K, Liau Linda M, Horvath Steve, Mischel Paul S, Nelson Stanley F Gene expression analysis of glioblastomas identifies the major molecular basis for the prognostic benefit of younger age. BMC medical genomics. 2008; 1(34): 52.
Brown Paul D, Krishnan Sunil, Sarkaria Jann N, Wu Wenting, Jaeckle Kurt A, Uhm Joon H, Geoffroy Francois J, Arusell Robert, Kitange Gaspar, Jenkins Robert B, Kugler John W, Morton Roscoe F, Rowland Kendrith M, Mischel Paul, Yong William H, Scheithauer Bernd W, Schiff David, Giannini Caterina, Buckner Jan C, Buckner Jan C Phase I/II trial of erlotinib and temozolomide with radiation therapy in the treatment of newly diagnosed glioblastoma multiforme: North Central Cancer Treatment Group Study N0177. Journal of clinical oncology : official journal of the American Society of Clinical Oncology. 2008; 26(34): 5603-9.
Pope Whitney B, Chen Jenny H, Dong Jun, Carlson Marc R J, Perlina Alla, Cloughesy Timothy F, Liau Linda M, Mischel Paul S, Nghiemphu Phioanh, Lai Albert, Nelson Stanley F Relationship between gene expression and enhancement in glioblastoma multiforme: exploratory DNA microarray analysis. Radiology. 2008; 249(1): 268-77.
Lai Albert, Filka Emese, McGibbon Bruce, Nghiemphu Phioanh Leia, Graham Carrie, Yong William H, Mischel Paul, Liau Linda M, Bergsneider Marvin, Pope Whitney, Selch Michael, Cloughesy Tim Phase II pilot study of bevacizumab in combination with temozolomide and regional radiation therapy for up-front treatment of patients with newly diagnosed glioblastoma multiforme: interim analysis of safety and tolerability. International journal of radiation oncology, biology, physics. 2008; 71(5): 1372-80.
de la Iglesia Nria, Konopka Genevieve, Lim Kah-Leong, Nutt Catherine L, Bromberg Jacqueline F, Frank David A, Mischel Paul S, Louis David N, Bonni Azad Deregulation of a STAT3-interleukin 8 signaling pathway promotes human glioblastoma cell proliferation and invasiveness. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008; 28(23): 5870-8.
Jindra Peter T, Hsueh Aileen, Hong Longshen, Gjertson David, Shen Xiu-Da, Gao Feng, Dang Julie, Mischel Paul S, Baldwin William M, Fishbein Michael C, Kupiec-Weglinski Jerzy W, Reed Elaine F Anti-MHC class I antibody activation of proliferation and survival signaling in murine cardiac allografts. Journal of immunology (Baltimore, Md. : 1950). 2008; 180(4): 2214-24.
Cloughesy Tim F, Yoshimoto Koji, Nghiemphu Phioanh, Brown Kevin, Dang Julie, Zhu Shaojun, Hsueh Teli, Chen Yinan, Wang Wei, Youngkin David, Liau Linda, Martin Neil, Becker Don, Bergsneider Marvin, Lai Albert, Green Richard, Oglesby Tom, Koleto Michael, Trent Jeff, Horvath Steve, Mischel Paul S, Mellinghoff Ingo K, Sawyers Charles L Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS medicine. 2008; 5(1): e8.
Yoshimoto Koji, Dang Julie, Zhu Shaojun, Nathanson David, Huang Tiffany, Dumont Rebecca, Seligson David B, Yong William H, Xiong Zhenggang, Rao Nagesh, Winther Henrik, Chakravarti Arnab, Bigner Darell D, Mellinghoff Ingo K, Horvath Steve, Cavenee Webster K, Cloughesy Timothy F, Mischel Paul S Development of a real-time RT-PCR assay for detecting EGFRvIII in glioblastoma samples. Clinical cancer research : an official journal of the American Association for Cancer Research. 2008; 14(2): 488-93.
Nakano Ichiro, Masterman-Smith Michael, Saigusa Kuniyasu, Paucar Andres A, Horvath Steve, Shoemaker Lorelei, Watanabe Momoko, Negro Alejandra, Bajpai Ruchi, Howes Amy, Lelievre Vincent, Waschek James A, Lazareff Jorge A, Freije William A, Liau Linda M, Gilbertson Richard J, Cloughesy Timothy F, Geschwind Daniel H, Nelson Stanley F, Mischel Paul S, Terskikh Alexey V, Kornblum Harley I Maternal embryonic leucine zipper kinase is a key regulator of the proliferation of malignant brain tumors, including brain tumor stem cells. Journal of neuroscience research. 2008; 86(1): 48-60.
Beroukhim Rameen, Getz Gad, Nghiemphu Leia, Barretina Jordi, Hsueh Teli, Linhart David, Vivanco Igor, Lee Jeffrey C, Huang Julie H, Alexander Sethu, Du Jinyan, Kau Tweeny, Thomas Roman K, Shah Kinjal, Soto Horacio, Perner Sven, Prensner John, Debiasi Ralph M, Demichelis Francesca, Hatton Charlie, Rubin Mark A, Garraway Levi A, Nelson Stan F, Liau Linda, Mischel Paul S, Cloughesy Tim F, Meyerson Matthew, Golub Todd A, Lander Eric S, Mellinghoff Ingo K, Sellers William R Assessing the significance of chromosomal aberrations in cancer: methodology and application to glioma. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(50): 20007-12.
Weaver Jonathan D, Vinters Harry V, Koretz Brandon, Xiong Zhenggang, Mischel Paul, Kado Deborah Lymphomatosis cerebri presenting as rapidly progressive dementia. The neurologist. 2007; 13(3): 150-3.
Carlson Marc R J, Pope Whitney B, Horvath Steve, Braunstein Jerome G, Nghiemphu Phioanh, Tso Cho-Lea, Mellinghoff Ingo, Lai Albert, Liau Linda M, Mischel Paul S, Dong Jun, Nelson Stanley F, Cloughesy Timothy F Relationship between survival and edema in malignant gliomas: role of vascular endothelial growth factor and neuronal pentraxin 2. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007; 13(9): 2592-8.
Thomas Roman K, Baker Alissa C, Debiasi Ralph M, Winckler Wendy, Laframboise Thomas, Lin William M, Wang Meng, Feng Whei, Zander Thomas, MacConaill Laura, Macconnaill Laura E, Lee Jeffrey C, Nicoletti Rick, Hatton Charlie, Goyette Mary, Girard Luc, Majmudar Kuntal, Ziaugra Liuda, Wong Kwok-Kin, Gabriel Stacey, Beroukhim Rameen, Peyton Michael, Barretina Jordi, Dutt Amit, Emery Caroline, Greulich Heidi, Shah Kinjal, Sasaki Hidefumi, Gazdar Adi, Minna John, Armstrong Scott A, Mellinghoff Ingo K, Hodi F Stephen, Dranoff Glenn, Mischel Paul S, Cloughesy Tim F, Nelson Stan F, Liau Linda M, Mertz Kirsten, Rubin Mark A, Moch Holger, Loda Massimo, Catalona William, Fletcher Jonathan, Signoretti Sabina, Kaye Frederic, Anderson Kenneth C, Demetri George D, Dummer Reinhard, Wagner Stephan, Herlyn Meenhard, Sellers William R, Meyerson Matthew, Garraway Levi A High-throughput oncogene mutation profiling in human cancer. Nature genetics. 2007; 39(3): 347-51.
Parsa Andrew T, Waldron James S, Panner Amith, Crane Courtney A, Parney Ian F, Barry Jeffrey J, Cachola Kristine E, Murray Joseph C, Tihan Tarik, Jensen Michael C, Mischel Paul S, Stokoe David, Pieper Russell O Loss of tumor suppressor PTEN function increases B7-H1 expression and immunoresistance in glioma. Nature medicine. 2007; 13(1): 84-8.
Mellinghoff Ingo K, Cloughesy Tim F, Mischel Paul S PTEN-mediated resistance to epidermal growth factor receptor kinase inhibitors. Clinical cancer research : an official journal of the American Association for Cancer Research. 2007; 13(2 Pt 1): 378-81.
Lee Jeffrey C, Vivanco Igor, Beroukhim Rameen, Huang Julie H Y, Feng Whei L, DeBiasi Ralph M, Yoshimoto Koji, King Jennifer C, Nghiemphu Phioanh, Yuza Yuki, Xu Qing, Greulich Heidi, Thomas Roman K, Paez J Guillermo, Peck Timothy C, Linhart David J, Glatt Karen A, Getz Gad, Onofrio Robert, Ziaugra Liuda, Levine Ross L, Gabriel Stacey, Kawaguchi Tomohiro, O'Neill Keith, Khan Haumith, Liau Linda M, Nelson Stanley F, Rao P Nagesh, Mischel Paul, Pieper Russell O, Cloughesy Tim, Leahy Daniel J, Sellers William R, Sawyers Charles L, Meyerson Matthew, Mellinghoff Ingo K Epidermal growth factor receptor activation in glioblastoma through novel missense mutations in the extracellular domain. PLoS medicine. 2006; 3(12): e485.
Tso Cho-Lea, Shintaku Peter, Chen James, Liu Qinghai, Liu Jason, Chen Zugen, Yoshimoto Koji, Mischel Paul S, Cloughesy Timothy F, Liau Linda M, Nelson Stanley F Primary glioblastomas express mesenchymal stem-like properties. Molecular cancer research : MCR. 2006; 4(9): 607-19.
Wang Maria Y, Lu Kan V, Zhu Shaojun, Dia Ederlyn Q, Vivanco Igor, Shackleford Gregory M, Cavenee Webster K, Mellinghoff Ingo K, Cloughesy Timothy F, Sawyers Charles L, Mischel Paul S Mammalian target of rapamycin inhibition promotes response to epidermal growth factor receptor kinase inhibitors in PTEN-deficient and PTEN-intact glioblastoma cells. Cancer research. 2006; 66(16): 7864-9.
Wang Chun-Chieh, Liao Yu-Pei, Mischel Paul S, Iwamoto Keisuke S, Cacalano Nicholas A, McBride William H HDJ-2 as a target for radiosensitization of glioblastoma multiforme cells by the farnesyltransferase inhibitor R115777 and the role of the p53/p21 pathway. Cancer research. 2006; 66(13): 6756-62.
Carlson Marc R J, Zhang Bin, Fang Zixing, Mischel Paul S, Horvath Steve, Nelson Stanley F Gene connectivity, function, and sequence conservation: predictions from modular yeast co-expression networks. BMC genomics. 2006; 7(5): 40.
Mischel Paul S, Cloughesy Timothy Using molecular information to guide brain tumor therapy. Nature clinical practice. Neurology. 2006; 2(5): 232-3.
Tso Cho-Lea, Freije William A, Day Allen, Chen Zugen, Merriman Barry, Perlina Ally, Lee Yohan, Dia Ederlyn Q, Yoshimoto Koji, Mischel Paul S, Liau Linda M, Cloughesy Timothy F, Nelson Stanley F Distinct transcription profiles of primary and secondary glioblastoma subgroups. Cancer research. 2006; 66(1): 159-67.
Mellinghoff Ingo K, Wang Maria Y, Vivanco Igor, Haas-Kogan Daphne A, Zhu Shaojun, Dia Ederlyn Q, Lu Kan V, Yoshimoto Koji, Huang Julie H Y, Chute Dennis J, Riggs Bridget L, Horvath Steve, Liau Linda M, Cavenee Webster K, Rao P Nagesh, Beroukhim Rameen, Peck Timothy C, Lee Jeffrey C, Sellers William R, Stokoe David, Prados Michael, Cloughesy Timothy F, Sawyers Charles L, Mischel Paul S Molecular determinants of the response of glioblastomas to EGFR kinase inhibitors. The New England journal of medicine. 2005; 353(19): 2012-24.
Wang Y, Zhu S, Cloughesy TF, Liau LM, Mischel PS p53 disruption profoundly alters the response of human glioblastoma cells to DNA topoisomerase I inhibition. Oncogene. . 2004; 12, 23(6): 1283-90.
Choe G, Park JK, Jouben-Steele L, Kremen TJ, Liau LM, Vinters HV, Cloughesy TF, Mischel PS Active matrix metalloproteinase 9 expression is associated with primary glioblastoma subtype. Clinical cancer research : an official journal of the American Association for Cancer Research. . 2002; 8(9): 2894-901.
Catania MG, Mischel PS, Vinters HV Hamartin and tuberin interaction with the G2/M cyclin-dependent kinase CDK1 and its regulatory cyclins A and B. Journal of neuropathology and experimental neurology. . 2001; 60(7): 711-23.
Mischel PS, Smith SG, Vining ER, Valletta JS, Mobley WC, Reichardt LF The extracellular domain of p75NTR is necessary to inhibit neurotrophin-3 signaling through TrkA. The Journal of biological chemistry. . 2001; 276(14): 11294-301.
Jahan R, Mischel PS, Curran JG, Peacock WJ, Shields DW, Vinters HV Bilateral neuropathologic changes in a child with hemimegalencephaly. Pediatric neurology. . 1997; 17(4): 344-9.
Farahani K, Mischel PS, Black KL, De Salles AA, Anzai Y, Lufkin RB Hyperacute thermal lesions: MR imaging evaluation of development in the brain. Radiology. . 1995; 196(2): 517-20.
Geschwind DH, FitzPatrick M, Mischel PS, Cummings JL Sneddon's syndrome is a thrombotic vasculopathy: neuropathologic and neuroradiologic evidence. Neurology. . 1995; 45(3 Pt 1): 557-60.