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Gary Mathern, M.D.

Work Email Address:
gmathern@ucla.edu

Mailing Address:
710 Westwood Plaza
Los Angeles, CA 90095
UNITED STATES




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Department / Division Affiliations
Director, Epilepsy Surgery, Pediatric Epilepsy Program
Professor, Neurosurgery
Professor in Residence, Surgery
Member, Brain Research Institute, Neuroscience IDP, Pediatric Neuro-oncology and Neural Tumors Center

Bio:

Gary W. Mathern, M.D. Professor in Residence and Director of the Pediatric Epilepsy Surgery Program and Pediatric Neurosurgery Program. Dr. Mathern works in conjunction with the Epilepsy Program to provide surgical treatment for children with epilepsy. HOSPITAL POSITION * Professor in Residence, UCLA Medical Center, Department of Neurosurgery o American Association of Neurological Surgeons o American Association for the Advancement of Science o American Clinical Neurophysiology Society, Long Range Planning Committee o American Epilepsy Society o American Epilepsy Society Scientific Program Committee o Brain Research Institute o Mental Retardation Research Center, UCLA Center for Health Sciences o Society for Neuroscience o Trauma Care Committee, Olive View/UCLA Medical Center MEMBERSHIP, MEDICAL ORGANIZATIONS

Publications:

Cepeda, C. Andre, V. M. Vinters, H. V. Levine, M. S. Mathern, G. W. Are cytomegalic neurons and balloon cells generators of epileptic activity in pediatric cortical dysplasia?. Epilepsia. 2005; 46 Suppl 5: 82-8.
Cepeda, C. Andre, V. M. Flores-Hernandez, J. Nguyen, O. K. Wu, N. Klapstein, G. J. Nguyen, S. Koh, S. Vinters, H. V. Levine, M. S. Mathern, G. W. Pediatric cortical dysplasia: correlations between neuroimaging, electrophysiology and location of cytomegalic neurons and balloon cells and glutamate/GABA synaptic circuits. Dev Neurosci. 2005; 27(1): 59-76.
Koh, S. Nguyen, S. Asarnow, R. F. LoPresti, C. Yudovin, S. Shields, W. D. Vinters, H. V. Mathern, G. W. Five or more acute postoperative seizures predict hospital course and long-term seizure control after hemispherectomy. Epilepsia. 2004; 45(5): 527-33.
Andre, V. M. Flores-Hernandez, J. Cepeda, C. Starling, A. J. Nguyen, S. Lobo, M. K. Vinters, H. V. Levine, M. S. Mathern, G. W. NMDA receptor alterations in neurons from pediatric cortical dysplasia tissue. Cereb Cortex. 2004; 14(6): 634-46.
Caplan, R. Siddarth, P. Mathern, G. Vinters, H. Curtiss, S. Levitt, J. Asarnow, R. Shields, W. D. Developmental outcome with and without successful intervention. Int Rev Neurobiol. 2002; 49: 269-84.
Mathern, GW Adelson, PD Cahan, LD Leite, JP Hippocampal neuron damage in human epilepsy: Meyer's hypothesis revisited. Progress in brain research. . 2002; 135: 237-51.
Mathern, GW Leiphart, JL De Vera, A Adelson, PD Seki, T Neder, L Leite, JP Seizures decrease postnatal neurogenesis and granule cell development in the human fascia dentata. Epilepsia. . 2002; 43 Suppl 5: 68-73.
Shusta, E. V. Boado, R. J. Mathern, G. W. Pardridge, W. M. Vascular genomics of the human brain. J Cereb Blood Flow Metab. 2002; 22(3): 245-52.
Mathern, GW Cepeda, C Hurst, RS Flores-Hernandez, J Mendoza, D Levine, MS Neurons recorded from pediatric epilepsy surgery patients with cortical dysplasia. Epilepsia. . 2000; 41 Suppl 6: S162-7.
Mathern, GW Babb, TL Micevych, PE Blanco, CE Pretorius, JK Granule cell mRNA levels for BDNF, NGF, and NT-3 correlate with neuron losses or supragranular mossy fiber sprouting in the chronically damaged and epileptic human hippocampus. Molecular and chemical neuropathology / sponsored by the International Society for Neurochemistry and the World Federation of Neurology and research groups on neurochemistry and cerebrospinal fluid. . 1997; 30(1-2): 53-76.
Babb, TL Mathern, GW Pretorius, JK Cifuentes, F Astrocytes may contribute to the latent period in progressive neuron loss, axon sprouting, and chronic seizures in rat kainate hippocampal epilepsy. Epilepsy research. Supplement. . 1996; 12: 343-54.
Mathern, G. W. Leite, J. P. Pretorius, J. K. Quinn, B. Peacock, W. J. Babb, T. L. Severe seizures in young children are associated with hippocampal neuron losses and aberrant mossy fiber sprouting during fascia dentata postnatal development. Epilepsy Res Suppl. 1996; 12: 33-43.
Babb, TL Pereira-Leite, J Mathern, GW Pretorius, JK Kainic acid induced hippocampal seizures in rats: comparisons of acute and chronic seizures using intrahippocampal versus systemic injections. Italian journal of neurological sciences. . 1995; 16(1-2): 39-44.
Mathern, G. W. Babb, T. L. Pretorius, J. K. Melendez, M. Levesque, M. F. The pathophysiologic relationships between lesion pathology, intracranial ictal EEG onsets, and hippocampal neuron losses in temporal lobe epilepsy. Epilepsy Res. 1995; 21(2): 133-47.
Babb, TL Pretorius, JK Mello, LE Mathern, GW Levesque, MF Synaptic reorganizations in epileptic human and rat kainate hippocampus may contribute to feedback and feedforward excitation. Epilepsy research. Supplement. . 1992; 9: 193-202; discussion 203.
Jonas, R Asarnow, RF LoPresti, C Yudovin, S Koh, S Wu, JY Sankar, R Shields, WD Vinters, HV Mathern, GW Surgery for symptomatic infant-onset epileptic encephalopathy with and without infantile spasms. Neurology. . 2005; 64(4): 746-50.
Andres, M Andre, VM Nguyen, S Salamon, N Cepeda, C Levine, MS Leite, JP Neder, L Vinters, HV Mathern, GW Human cortical dysplasia and epilepsy: an ontogenetic hypothesis based on volumetric MRI and NeuN neuronal density and size measurements. Cerebral cortex (New York, N.Y. : 1991) . 2005; 15(2): 194-210.
de Bode, S Firestine, A Mathern, GW Dobkin, B Residual motor control and cortical representations of function following hemispherectomy: effects of etiology. Journal of child neurology. . 2005; 20(1): 64-75.
Jonas, R Nguyen, S Hu, B Asarnow, RF LoPresti, C Curtiss, S de Bode, S Yudovin, S Shields, WD Vinters, HV Mathern, GW Cerebral hemispherectomy: hospital course, seizure, developmental, language, and motor outcomes. Neurology. . 2004; 62(10): 1712-21.
Najm, I Ying, Z Babb, T Crino, PB Macdonald, R Mathern, GW Spreafico, R Mechanisms of epileptogenicity in cortical dysplasias. Neurology. . 2004; 62(6 Suppl 3): S9-13.
Cook, SW Nguyen, ST Hu, B Yudovin, S Shields, WD Vinters, HV Van de Wiele, BM Harrison, RE Mathern, GW Cerebral hemispherectomy in pediatric patients with epilepsy: comparison of three techniques by pathological substrate in 115 patients. Journal of neurosurgery. . 2004; 100(2 Suppl Pediatrics): 125-41.
Stables, JP Bertram, E Dudek, FE Holmes, G Mathern, G Pitkanen, A White, HS Therapy discovery for pharmacoresistant epilepsy and for disease-modifying therapeutics: summary of the NIH/NINDS/AES models II workshop. Epilepsia. . 2003; 44(12): 1472-8.
Handforth, A Ondo, WG Tatter, S Mathern, GW Simpson, RK Walker, F Sutton, JP Hubble, JP Jankovic, J Vagus nerve stimulation for essential tremor: a pilot efficacy and safety trial. Neurology. . 2003; 61(10): 1401-5.
Bender, RA Soleymani, SV Brewster, AL Nguyen, ST Beck, H Mathern, GW Baram, TZ Enhanced expression of a specific hyperpolarization-activated cyclic nucleotide-gated cation channel (HCN) in surviving dentate gyrus granule cells of human and experimental epileptic hippocampus. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2003; 23(17): 6826-36.
Cepeda, C. Hurst, R. S. Flores-Hernandez, J. Hernandez-Echeagaray, E. Klapstein, G. J. Boylan, M. K. Calvert, C. R. Jocoy, E. L. Nguyen, O. K. Andre, V. M. Vinters, H. V. Ariano, M. A. Levine, M. S. Mathern, G. W. Morphological and electrophysiological characterization of abnormal cell types in pediatric cortical dysplasia. J Neurosci Res. 2003; 72(4): 472-86.
Curtiss, S de Bode, S Mathern, GW Spoken language outcomes after hemispherectomy: factoring in etiology. Brain and language. . 2001; 79(3): 379-96.
Leiphart, JW Peacock, WJ Mathern, GW Lobar and multilobar resections for medically intractable pediatric epilepsy. Pediatric neurosurgery. . 2001; 34(6): 311-8.
Katzir, H Mendoza, D Mathern, GW Effect of theophylline and trimethobenzamide when given during kainate-induced status epilepticus: an improved histopathologic rat model of human hippocampal sclerosis. Epilepsia. . 2000; 41(11): 1390-9.
Mathern, GW Giza, CC Yudovin, S Vinters, HV Peacock, WJ Shewmon, DA Shields, WD Postoperative seizure control and antiepileptic drug use in pediatric epilepsy surgery patients: the UCLA experience, 1986-1997. Epilepsia. . 1999; 40(12): 1740-9.
Kerfoot, C Vinters, HV Mathern, GW Cerebral cortical dysplasia: giant neurons show potential for increased excitation and axonal plasticity. Developmental neuroscience. . 1999; 21(3-5): 260-70.
Isokawa, M Mathern, GW Developmental changes in NMDA-induced intrinsic optical signals in the hippocampal dentate gyrus of children with medically intractable seizures. Developmental neuroscience. . 1999; 21(3-5): 215-22.
Cepeda, C Li, Z Cromwell, HC Altemus, KL Crawford, CA Nansen, EA Ariano, MA Sibley, DR Peacock, WJ Mathern, GW Levine, MS Electrophysiological and morphological analyses of cortical neurons obtained from children with catastrophic epilepsy: dopamine receptor modulation of glutamatergic responses. Developmental neuroscience. . 1999; 21(3-5): 223-35.
Bragin, A Engel, J Wilson, CL Vizentin, E Mathern, GW Electrophysiologic analysis of a chronic seizure model after unilateral hippocampal KA injection. Epilepsia. . 1999; 40(9): 1210-21.
Mathern, GW Pretorius, JK Mendoza, D Leite, JP Chimelli, L Born, DE Fried, I Assirati, JA Ojemann, GA Adelson, PD Cahan, LD Kornblum, HI Hippocampal N-methyl-D-aspartate receptor subunit mRNA levels in temporal lobe epilepsy patients. Annals of neurology. . 1999; 46(3): 343-58.
Mathern, GW Mendoza, D Lozada, A Pretorius, JK Dehnes, Y Danbolt, NC Nelson, N Leite, JP Chimelli, L Born, DE Sakamoto, AC Assirati, JA Fried, I Peacock, WJ Ojemann, GA Adelson, PD Hippocampal GABA and glutamate transporter immunoreactivity in patients with temporal lobe epilepsy. Neurology. . 1999; 52(3): 453-72.
Bragin, A Engel, J Wilson, CL Fried, I Mathern, GW Hippocampal and entorhinal cortex high-frequency oscillations (100--500 Hz) in human epileptic brain and in kainic acid--treated rats with chronic seizures. Epilepsia. . 1999; 40(2): 127-37.
Mathern, GW Pretorius, JK Mendoza, D Lozada, A Kornblum, HI Hippocampal AMPA and NMDA mRNA levels correlate with aberrant fascia dentata mossy fiber sprouting in the pilocarpine model of spontaneous limbic epilepsy. Journal of neuroscience research. . 1998; 54(6): 734-53.
Mathern, GW Pretorius, JK Kornblum, HI Mendoza, D Lozada, A Leite, JP Chimelli, L Born, DE Fried, I Sakamoto, AC Assirati, JA Peacock, WJ Ojemann, GA Adelson, PD Altered hippocampal kainate-receptor mRNA levels in temporal lobe epilepsy patients. Neurobiology of disease. . 1998; 5(3): 151-76.
Mathern, GW Pretorius, JK Leite, JP Kornblum, HI Mendoza, D Lozada, A Bertram, EH Hippocampal AMPA and NMDA mRNA levels and subunit immunoreactivity in human temporal lobe epilepsy patients and a rodent model of chronic mesial limbic epilepsy. Epilepsy research. . 1998; 32(1-2): 154-71.
Mathern, GW Pretorius, JK Mendoza, D Lozada, A Leite, JP Chimelli, L Fried, I Sakamoto, AC Assirati, JA Adelson, PD Increased hippocampal AMPA and NMDA receptor subunit immunoreactivity in temporal lobe epilepsy patients. Journal of neuropathology and experimental neurology. . 1998; 57(6): 615-34.
Mathern, GW Price, G Rosales, C Pretorius, JK Lozada, A Mendoza, D Anoxia during kainate status epilepticus shortens behavioral convulsions but generates hippocampal neuron loss and supragranular mossy fiber sprouting. Epilepsy research. . 1998; 30(2): 133-51.
Mathern, GW Pretorius, JK Kornblum, HI Mendoza, D Lozada, A Leite, JP Chimelli, LM Fried, I Sakamoto, AC Assirati, JA Lévesque, MF Adelson, PD Peacock, WJ Human hippocampal AMPA and NMDA mRNA levels in temporal lobe epilepsy patients. Brain : a journal of neurology. . 1997; 120 ( Pt 11): 1937-59.
Mathern, GW Bertram, EH Babb, TL Pretorius, JK Kuhlman, PA Spradlin, S Mendoza, D In contrast to kindled seizures, the frequency of spontaneous epilepsy in the limbic status model correlates with greater aberrant fascia dentata excitatory and inhibitory axon sprouting, and increased staining for N-methyl-D-aspartate, AMPA and GABA(A) receptors. Neuroscience. . 1997; 77(4): 1003-19.
Mathern, GW Kuhlman, PA Mendoza, D Pretorius, JK Human fascia dentata anatomy and hippocampal neuron densities differ depending on the epileptic syndrome and age at first seizure. Journal of neuropathology and experimental neurology. . 1997; 56(2): 199-212.
Babb, TL Mathern, GW Leite, JP Pretorius, JK Yeoman, KM Kuhlman, PA Glutamate AMPA receptors in the fascia dentata of human and kainate rat hippocampal epilepsy. Epilepsy research. . 1996; 26(1): 193-205.
Leite, JP Babb, TL Pretorius, JK Kuhlman, PA Yeoman, KM Mathern, GW Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainate in developing rats. Epilepsy research. . 1996; 26(1): 219-31.
Mathern, GW Babb, TL Leite, JP Pretorius, K Yeoman, KM Kuhlman, PA The pathogenic and progressive features of chronic human hippocampal epilepsy. Epilepsy research. . 1996; 26(1): 151-61.
Mathern, GW Babb, TL Mischel, PS Vinters, HV Pretorius, JK Leite, JP Peacock, WJ Childhood generalized and mesial temporal epilepsies demonstrate different amounts and patterns of hippocampal neuron loss and mossy fibre synaptic reorganization. Brain : a journal of neurology. . 1996; 119 ( Pt 3): 965-87.
Mathern, GW Leite, JP Babb, TL Pretorius, JK Kuhlman, PA Mendoza, D Fried, I Sakamoto, AC Assirati, JA Adelson, PD Peacock, WJ Aberrant hippocampal mossy fiber sprouting correlates with greater NMDAR2 receptor staining. Neuroreport. . 1996; 7(5): 1029-35.
Mathern, GW Babb, TL Pretorius, JK Leite, JP Reactive synaptogenesis and neuron densities for neuropeptide Y, somatostatin, and glutamate decarboxylase immunoreactivity in the epileptogenic human fascia dentata. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1995; 15(5 Pt 2): 3990-4004.
Mathern, GW Pretorius, JK Babb, TL Influence of the type of initial precipitating injury and at what age it occurs on course and outcome in patients with temporal lobe seizures. Journal of neurosurgery. . 1995; 82(2): 220-7.
Mathern, GW Pretorius, JK Babb, TL Quantified patterns of mossy fiber sprouting and neuron densities in hippocampal and lesional seizures. Journal of neurosurgery. . 1995; 82(2): 211-9.
Mathern, GW Babb, TL Vickrey, BG Melendez, M Pretorius, JK The clinical-pathogenic mechanisms of hippocampal neuron loss and surgical outcomes in temporal lobe epilepsy. Brain : a journal of neurology. . 1995; 118 ( Pt 1): 105-18.
Mathern, GW Pretorius, JK Babb, TL Quinn, B Unilateral hippocampal mossy fiber sprouting and bilateral asymmetric neuron loss with episodic postictal psychosis. Journal of neurosurgery. . 1995; 82(2): 228-33.
Mathern, GW Babb, TL Vickrey, BG Melendez, M Pretorius, JK Traumatic compared to non-traumatic clinical-pathologic associations in temporal lobe epilepsy. Epilepsy research. . 1994; 19(2): 129-39.
Mathern, GW Leite, JP Pretorius, JK Quinn, B Peacock, WJ Babb, TL Children with severe epilepsy: evidence of hippocampal neuron losses and aberrant mossy fiber sprouting during postnatal granule cell migration and differentiation. Brain research. Developmental brain research. . 1994; 78(1): 70-80.
Mathern, GW Cifuentes, F Leite, JP Pretorius, JK Babb, TL Hippocampal EEG excitability and chronic spontaneous seizures are associated with aberrant synaptic reorganization in the rat intrahippocampal kainate model. Electroencephalography and clinical neurophysiology. . 1993; 87(5): 326-39.
Schell, RE Mathern, GW Complication in nasogastric tube placement after a gunshot wound to the face. Oral surgery, oral medicine, and oral pathology. . 1990; 70(4): 525-6.
Mathern, GW Batzdorf, U Grisel's syndrome. Cervical spine clinical, pathologic, and neurologic manifestations. Clinical orthopaedics and related research. . 1989; (244): 131-46.