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Bruce Kagan, M.D.

Work Email Address:
bkagan@mednet.ucla.edu

Mailing Address:
760 Westwood Plaza
Los Angeles, CA 90024
UNITED STATES

Work Phone Number:
310 206 2372



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Department / Division Affiliations
Director, Adult Partial Hospitalization Program
Professor, Psychiatry and Biobehavioral Sciences
Member, Adult Psychiatry, ACCESS Program, Access Neuroscience Home Area, Brain Research Institute, Neuroscience IDP

Bio:

Bruce L. Kagan is a psychiatrist and neurophysiologist who joined the UCLA faculty in 1986. He became a full professor in 1998 and served as Director of the Psychiatry Research Residency Track from 1994-2004. He has chaired the Medical Institutional Review Board for Neuropsychiatry since 2004. He is currently Chief of Staff of the Resnick Neuropsychiatric Hospital.
Dr. Kagan earned his BA cum laude in Molecular Biophysics and Biochemistry from Yale University. He received the MD and Ph.D. (physiology) degrees from the Albert Einstein College of Medicine. His laboratory research centers on channel forming toxins. He is currently studying channels formed by amyloid peptides in Alzheimer's and Parkinson's disease to elucidate the pathogenesis of these illnesses. He is also screening chemical libraries for channel blockers that could be used as therapeutic agents.

Publications:

Quist, A., Doudevski, I., Lin, H., Azimova, R., Ng, D., Frangione, B., Kagan, B., Ghiso, J., Lal, R. Amyloid ion channels: A common structural link for protein-misfolding disease. Proc Natl Acad Sci USA 2005; 102(30): 10427-32.
Kagan, B.L. Amyloidosis and protein folding. Science 2005; 307: 42-3.
Kagan, B.L., Azimova, R., Azimov, R. Amyloid peptide channels. J Memb Biol 2004; 202: 1-10.
Lin, M-C., Mirzabekov, T., Kagan, B.L. Electrophysiologic Properties of Alpha Beta 25-35 channels. Peptides 2002; 23(7): 1215-28.
Hirakura, Y., Lin, M-C., Kagan, B.L. The Channel hypothesis of Alzheimer's disease: current status. Peptides 2002; 23(7): 1311-5.
Hirakura, Y., Kagan, B.L. The channel hypothesis of amyloidosis. Cellular and Molecular Mechanics of Toxin Action 2002; Vol. 5, (in press): .
Kagan, BL Hirakura, Y Azimov, R Azimova, R The channel hypothesis of Huntington's disease. Brain research bulletin. . 2001; 56(3-4): 281-4.
Kagan Bruce L, Jang Hyunbum, Capone Ricardo, Teran Arce Fernando, Ramachandran Srinivasan, Lal Ratnesh, Nussinov Ruth Antimicrobial properties of amyloid peptides. Molecular pharmaceutics. 2012; 9(4): 708-17.
Connelly Laura, Jang Hyunbum, Arce Fernando Teran, Ramachandran Srinivasan, Kagan Bruce L, Nussinov Ruth, Lal Ratnesh Effects of point substitutions on the structure of toxic Alzheimer's β-amyloid channels: atomic force microscopy and molecular dynamics simulations. Biochemistry. 2012; 51(14): 3031-8.
Capone Ricardo, Jang Hyunbum, Kotler Samuel A, Connelly Laura, Teran Arce Fernando, Ramachandran Srinivasan, Kagan Bruce L, Nussinov Ruth, Lal Ratnesh All-d-Enantiomer of β-Amyloid Peptide Forms Ion Channels in Lipid Bilayers. Journal of chemical theory and computation. 2012; 8(3): 1143-1152.
Connelly Laura, Jang Hyunbum, Arce Fernando Teran, Capone Ricardo, Kotler Samuel A, Ramachandran Srinivasan, Kagan Bruce L, Nussinov Ruth, Lal Ratnesh Atomic force microscopy and MD simulations reveal pore-like structures of all-D-enantiomer of Alzheimer's β-amyloid peptide: relevance to the ion channel mechanism of AD pathology. The journal of physical chemistry. B. 2012; 116(5): 1728-35.
Kagan Bruce L Membrane pores in the pathogenesis of neurodegenerative disease. Progress in molecular biology and translational science. 2012; 107(3): 295-325.
Capone Ricardo, Jang Hyunbum, Kotler Samuel A, Kagan Bruce L, Nussinov Ruth, Lal Ratnesh Probing structural features of Alzheimer's amyloid-β pores in bilayers using site-specific amino acid substitutions. Biochemistry. 2012; 51(3): 776-85.
Kagan Bruce L Antimicrobial amyloids?. Biophysical journal. 2011; 100(7): 1597-8.
Kagan Bruce L, Thundimadathil Jyothi Amyloid peptide pores and the beta sheet conformation. Advances in experimental medicine and biology. 2010; 677(14): 150-67.
Jang Hyunbum, Arce Fernando Teran, Ramachandran Srinivasan, Capone Ricardo, Azimova Rushana, Kagan Bruce L, Nussinov Ruth, Lal Ratnesh Truncated beta-amyloid peptide channels provide an alternative mechanism for Alzheimer's Disease and Down syndrome. Proceedings of the National Academy of Sciences of the United States of America. 2010; 107(14): 6538-43.
Kagan Bruce L Amyloidosis and protein folding. Science (New York, N.Y.). 2005; 307(5706): 42-3; author reply 42-3.
Lin Meng-chin Allison, Kagan Bruce L Electrophysiologic properties of channels induced by Abeta25-35 in planar lipid bilayers. Peptides. 2002; 23(7): 1215-28.
Kagan Bruce L, Hirakura Yutaka, Azimov Rustam, Azimova Rushana, Lin Meng-Chin The channel hypothesis of Alzheimer's disease: current status. Peptides. 2002; 23(7): 1311-5.
Kagan, BL Hirakura, Y Azimov, R Azimova, R Lin, MC The channel hypothesis of Alzheimer's disease: current status. Peptides. . 2002; 23(7): 1311-5.
Hirakura Yutaka, Carreras Isabel, Sipe Jean D, Kagan Bruce L Channel formation by serum amyloid A: a potential mechanism for amyloid pathogenesis and host defense. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. 2002; 9(1): 13-23.
Hirakura, Y Kagan, BL Pore formation by beta-2-microglobulin: a mechanism for the pathogenesis of dialysis associated amyloidosis. Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis. . 2001; 8(2): 94-100.