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Cho-Lea Tso, Ph.D.

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13-260 Factor Building


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Department / Division Affiliations
Associate Professor, Surgical Oncology
Assistant Professor, Department of Medicine
Member, Brain Research Institute, JCCC Signal Transduction and Therapeutics Program Area

Research Interest:

Characterization of glioblastoma (GBM) stem cells

My research focuses on characterization of glioblastoma (GBM) stem cells, which are previously unrecognized subpopulation within tumors that are likely responsible for tumor initiation and tumor recurrence. We characterize the properties of GBM stem cell in cellular, molecular and genomic levels both in vitro and in vivo. We aim to identify key factors and potential pathways that trigger the dysregulated self-renewal, differentiation and sustained tumor growth. Findings from these studies will contribute fundamental information towards establishing the identity and possible role of GBM stem cells in tumorigenesis, progression and resistance to treatment. Ultimately, these knowledge and experimental results may translate into new strategies for developing and designing an effective GBM stem cell-targeted anti cancer therapy, which is not targeted in the current brain cancer therapy.