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Sophie Sokolow, Ph.D.

Email Address:
ssokolow@sonnet.ucla.edu
Work Email Address:
ssokolow@sonnet.ucla.edu

Mailing Address:
BOX 956919, 5-946 Factor Bldg
Los Angeles, CA 90095
UNITED STATES

Fax Number:
310-206-7703
Work Phone Number:
310-206-3390



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Department / Division Affiliations
Assistant Professor, School of Nursing
Member, Brain Research Institute, CTSI

Research Interest:

Molecular mechanisms involved in cellular calcium homeostasis dysregulation occurring in neurodegeneration, with a particular focus on Alzheimer?s disease

Exploring the molecular mechanisms involved in cellular calcium homeostasis dysregulation occurring in neurodegeneration, with a particular focus on Alzheimer's disease. The Sokolow laboratory focuses on understanding the molecular mechanisms involved in the pathogenesis of neurodegenerative disorders. This includes Alzheimer's disease (AD), Parkinson's disease and ischemia. The laboratory has special expertise in AD and calcium signaling. Our group investigates the calcium hypothesis in synaptic amyloid-beta protein (Abeta) buildup and tau phosphorylation. Abeta and p-tau are the major AD pathological characteristics. Using post-mortem human brain regions affected by Abeta and different mouse models of AD, we are studying specific proteins involved in the calciumopathy of AD pathology in order to identify key player that could yield insights into new AD therapies.

Bio:

Dr. Sokolow earned a pharmacy degree and a PhD in in Biomedical sciences from the Free University of Brussels, Belgium. Dr Sokolow also earned the FPGEC (Foreign Pharmacy Equivalency Examination Certificate) from the American Association Board of Pharmacy and is a registered intern pharmacist of the California Board of Pharmacy. In Belgium, Dr Sokolow worked as a community pharmacist and was also a consultant to the Belgian Ministry of Public Health where she provided drug monitoring and reporting services. Her graduate work included the production and characterization of a new mouse model lacking the sodium-calcium exchangers 3 (Ncx3-/-). Dr Sokolow is currenlty Assistant Professor at UCLA School of Nursing where she teaches Pharmacology and Therapeutics (N115) and Advanced Pharmacology (N225) to undergraduate and graduate in nursing students. Her research laboratory focuses on understanding the molecular mechanisms involved in the pathogenesis of neurodegenerative disorders (e.g. Alzheimer’s disease and Parkinson's disease). Her laboratory has special expertise in AD and calcium signaling. Her team investigates the calcium hypothesis in synaptic amyloid-beta protein (Abeta) buildup and and neurodegeneration. Dr Sokolow also has a particular interest in AD pharmacogenomics.

Publications:

Molinaro Pasquale, Cataldi Mauro, Cuomo Ornella, Viggiano Davide, Pignataro Giuseppe, Sirabella Rossana, Secondo Agnese, Boscia Francesca, Pannaccione Anna, Scorziello Antonella, Sokolow Sophie, Herchuelz André, Di Renzo Gianfranco, Annunziato Lucio Genetically modified mice as a strategy to unravel the role played by the Na(+)/Ca (2+) exchanger in brain ischemia and in spatial learning and memory deficits. Advances in experimental medicine and biology. 2013; 961: 213-22.
Henkins Kristen M, Sokolow Sophie, Miller Carol A, Vinters Harry V, Poon Wayne W, Cornwell Lindsey B, Saing Tommy, Gylys Karen Hoppens Extensive p-tau pathology and SDS-stable p-tau oligomers in Alzheimer's cortical synapses. Brain pathology (Zurich, Switzerland). 2012; 22(6): 826-33.
Pannaccione Anna, Secondo Agnese, Molinaro Pasquale, D'Avanzo Carla, Cantile Maria, Esposito Alba, Boscia Francesca, Scorziello Antonella, Sirabella Rossana, Sokolow Sophie, Herchuelz André, Di Renzo Gianfranco, Annunziato Lucio A new concept: Aβ1-42 generates a hyperfunctional proteolytic NCX3 fragment that delays caspase-12 activation and neuronal death. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012; 32(31): 10609-17.
Sokolow Sophie, Henkins Kristen M, Bilousova Tina, Miller Carol A, Vinters Harry V, Poon Wayne, Cole Gregory M, Gylys Karen Hoppens AD synapses contain abundant Aβ monomer and multiple soluble oligomers, including a 56-kDa assembly. Neurobiology of aging. 2012; 33(8): 1545-55.
Boscia F, D'Avanzo C, Pannaccione A, Secondo A, Casamassa A, Formisano L, Guida N, Sokolow Sophie, Herchuelz André, Annunziato L Silencing or knocking out the Na(+)/Ca(2+) exchanger-3 (NCX3) impairs oligodendrocyte differentiation. Cell death and differentiation. 2012; 19(4): 562-72.
Sokolow Sophie, Henkins Kristen M, Williams Iris A, Vinters Harry V, Schmid Ingrid, Cole Gregory M, Gylys Karen H Isolation of synaptic terminals from Alzheimer's disease cortex. Cytometry. Part A : the journal of the International Society for Analytical Cytology. 2012; 81(3): 248-54.
Sokolow Sophie, Luu Sanh H, Nandy Karabi, Miller Carol A, Vinters Harry V, Poon Wayne W, Gylys Karen H Preferential accumulation of amyloid-beta in presynaptic glutamatergic terminals (VGluT1 and VGluT2) in Alzheimer's disease cortex. Neurobiology of disease. 2012; 45(1): 381-7.
Ringman John M, Schulman Howard, Becker Chris, Jones Ted, Bai Yuchen, Immermann Fred, Cole Gregory, Sokolow Sophie, Gylys Karen, Geschwind Daniel H, Cummings Jeffrey L, Wan Hong I Proteomic changes in cerebrospinal fluid of presymptomatic and affected persons carrying familial Alzheimer disease mutations. Archives of neurology. 2012; 69(1): 96-104.
Nguidjoe Evrard, Sokolow Sophie, Bigabwa Serge, Pachera Nathalie, D'Amico Eva, Allagnat Florent, Vanderwinden Jean-Marie, Sener Abdullah, Manto Mario, Depreter Marianne, Mast Jan, Joanny Geraldine, Montanya Eduard, Rahier Jacques, Cardozo Alessandra K, Eizirik Décio L, Schurmans Stéphane, Herchuelz André Heterozygous inactivation of the Na/Ca exchanger increases glucose-induced insulin release, β-cell proliferation, and mass. Diabetes. 2011; 60(8): 2076-85.
Molinaro Pasquale, Viggiano Davide, Nisticò Robert, Sirabella Rossana, Secondo Agnese, Boscia Francesca, Pannaccione Anna, Scorziello Antonella, Mehdawy Bisan, Sokolow Sophie, Herchuelz André, Di Renzo Gianfranco F, Annunziato Lucio Na+ -Ca2+ exchanger (NCX3) knock-out mice display an impairment in hippocampal long-term potentiation and spatial learning and memory. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(20): 7312-21.
Sokolow Sophie, Luu Sanh H, Headley Alison J, Hanson Alecia Y, Kim Taeree, Miller Carol A, Vinters Harry V, Gylys Karen H High levels of synaptosomal Na(+)-Ca(2+) exchangers (NCX1, NCX2, NCX3) co-localized with amyloid-beta in human cerebral cortex affected by Alzheimer's disease. Cell calcium. 2011; 49(4): 208-16.
Verwey N A, van der Flier W M, Blennow K, Clark C, Sokolow S, De Deyn P P, Galasko D, Hampel H, Hartmann T, Kapaki E, Lannfelt L, Mehta P D, Parnetti L, Petzold A, Pirttila T, Saleh L, Skinningsrud A, Swieten J C V, Verbeek M M, Wiltfang J, Younkin S, Scheltens P, Blankenstein M A A worldwide multicentre comparison of assays for cerebrospinal fluid biomarkers in Alzheimer's disease. Annals of clinical biochemistry. 2009; 46(Pt 3): 235-40.
Wehling-Henricks Michelle, Sokolow Sophie, Lee Jamie J, Myung Kyu H, Villalta S Armando, Tidball James G Major basic protein-1 promotes fibrosis of dystrophic muscle and attenuates the cellular immune response in muscular dystrophy. Human molecular genetics. 2008; 17(15): 2280-92.
Ringman J M, Younkin S G, Pratico D, Seltzer W, Cole G M, Geschwind D H, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, Rosario E R, Gylys K H, Varpetian A, Medina L D, Cummings J L Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology. 2008; 71(2): 85-92.
Fein Jeffrey A, Sokolow Sophie, Miller Carol A, Vinters Harry V, Yang Fusheng, Cole Gregory M, Gylys Karen Hoppens Co-localization of amyloid beta and tau pathology in Alzheimer's disease synaptosomes. The American journal of pathology. 2008; 172(6): 1683-92.
Jeffs Graham J, Meloni Bruno P, Sokolow Sophie, Herchuelz Andre, Schurmans Stéphane, Knuckey Neville W NCX3 knockout mice exhibit increased hippocampal CA1 and CA2 neuronal damage compared to wild-type mice following global cerebral ischemia. Experimental neurology. 2008; 210(1): 268-73.
Molinaro Pasquale, Cuomo Ornella, Pignataro Giuseppe, Boscia Francesca, Sirabella Rossana, Pannaccione Anna, Secondo Agnese, Scorziello Antonella, Adornetto Annagrazia, Gala Rosaria, Viggiano Davide, Sokolow Sophie, Herchuelz Andre, Schurmans Stèphane, Di Renzo Gianfranco, Annunziato Lucio Targeted disruption of Na+/Ca2+ exchanger 3 (NCX3) gene leads to a worsening of ischemic brain damage. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008; 28(5): 1179-84.
Sokolow Sophie, Manto Mario, Gailly Philippe, Molgó Jordi, Vandebrouck Clarisse, Vanderwinden Jean-Marie, Herchuelz Andre, Schurmans Stéphane Impaired neuromuscular transmission and skeletal muscle fiber necrosis in mice lacking Na/Ca exchanger 3. The Journal of clinical investigation. 2004; 113(2): 265-73.