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Patricia Dickson, M.D.

Email Address:
pdickson@ucla.edu
Work Email Address:
pdickson@ucla.edu

Work Address:
1124 West Carson Street
Torrance, CA
UNITED STATES

Fax Number:
(310) 328-9921
(310) 782-2999
Work Phone Number:
(310) 222-3756
(310) 222-4145



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Department / Division Affiliations
Associate Professor In-Residence, David Geffen School of Medicine at UCLA
Assistant Professor, MEDICAL GENETICS
Member, ACCESS Program, Access Neuroscience Home Area, CTSI, Committee on Maternal, Child and Adolescent Health
Assistant Professor In-Residence, Brain Research Institute, Neuroscience IDP

Research Interest:

Therapy for Pediatric Neurodegenerative Diseases

Dr. Dickson’s laboratory focuses on finding treatments for the brain in the mucopolysaccharidoses. The mucopolysaccharidoses (MPS) are a group of rare genetic diseases which cause physical and neurological degeneration and early death. Current projects include intrathecal enzyme replacement therapy for mucopolysaccharidosis type I, the immune response to recombinant enzyme, and developing therapy for the brain in mucopolysaccharidosis type III. The goal is to work towards new treatments and better use of existing treatments for the benefit of people living with MPS.

Publications:

Vite Charles H, Nestrasil Igor, Mlikotic Anton, Jens Jackie K, Snella Elizabeth M, Gross William, Shapiro Elsa G, Kovac Victor, Provenzale James M, Chen Steven, Le Steven Q, Kan Shih-hsin, Banakar Shida, Wang Raymond Y, Haskins Mark E, Ellinwood N Matthew, Dickson Patricia I Features of brain MRI in dogs with treated and untreated mucopolysaccharidosis type I. Comparative medicine. 2013; 63(2): 163-73.
Vera Moin, Lester Thomas, Zhao Bin, Tiger Pascale, Clarke Scott, Tippin Brigette L, Passage Merry B, Le Steven Q, Femenia Javier, Lemontt Jeffrey F, Kakkis Emil D, Dickson Patricia I Mannose 6-phosphate conjugation is not sufficient to allow induction of immune tolerance to phenylalanine ammonia-lyase in dogs. JIMD reports. 2013; 8(2): 63-72.
Tippin Brigette L, Troitskaya Larisa, Kan Shih-hsin, Todd Amanda K, Le Steven Q, Dickson Patricia I Biochemical characterization of fluorescent-labeled recombinant human alpha-L-iduronidase in vitro. Biotechnology and applied biochemistry. 2012; 58(6): 391-6.
Dickson Patricia I, Ellinwood N Matthew, Brown Jillian R, Witt Robert G, Le Steven Q, Passage Merry B, Vera Moin U, Crawford Brett E Specific antibody titer alters the effectiveness of intrathecal enzyme replacement therapy in canine mucopolysaccharidosis I. Molecular genetics and metabolism. 2012; 106(1): 68-72.
Chen Agnes, Vogler Carole, McEntee Michael, Hanson Stephen, Ellinwood N Matthew, Jens Jackie, Snella Elizabeth, Passage Merry, Le Steven, Guerra Catalina, Dickson Patricia Glycosaminoglycan storage in neuroanatomical regions of mucopolysaccharidosis I dogs following intrathecal recombinant human iduronidase. APMIS : acta pathologica, microbiologica, et immunologica Scandinavica. 2011; 119(8): 513-21.
Dickson Patricia I, Chen Agnes H Intrathecal enzyme replacement therapy for mucopolysaccharidosis I: translating success in animal models to patients. Current pharmaceutical biotechnology. 2011; 12(6): 946-55.
Dickson Patricia I, Hanson Stephen, McEntee Michael F, Vite Charles H, Vogler Carole A, Mlikotic Anton, Chen Agnes H, Ponder Katherine P, Haskins Mark E, Tippin Brigette L, Le Steven Q, Passage Merry B, Guerra Catalina, Dierenfeld Ashley, Jens Jackie, Snella Elizabeth, Kan Shih-Hsin, Ellinwood N Matthew Early versus late treatment of spinal cord compression with long-term intrathecal enzyme replacement therapy in canine mucopolysaccharidosis type I. Molecular genetics and metabolism. 2010; 101(2-3): 115-22.
Ezra Navid, Tetteh Beatrice, Diament Michael, Jonas Adam J, Dickson Patricia Hereditary multiple exostoses with spine involvement in a 4-year-old boy. American journal of medical genetics. Part A. 2010; 152A(5): 1264-7.
Chen Agnes, Dickson Patricia Intrathecal enzyme replacement therapy to treat spinal cord compression in mucopolysaccharidosis: Overview and rationale. Journal of pediatric rehabilitation medicine. 2010; 3(1): 7-11.
Dierenfeld AD, McEntee MF, Passage M, Le S, Jens JK, Snella EM, Kline KL, Parkes JD, Ware WA, Moran LE, Wengert JA, Whitley RD, Betts DM, Boal AM, Riedesel EA, Gross W, Ellinwood NM, Dickson PI Replacing the enzyme α-L-iduronidase at birth ameliorates symptoms in the brain and periphery of dogs with mucopolysaccharidosis type I. Science Translational Medicine 2010; 2(60): ra89.
Passage M B, Krieger A W, Peinovich M C, Lester T, Le S Q, Dickson P I, Kakkis E D Continuous infusion of enzyme replacement therapy is inferior to weekly infusions in MPS I dogs. Journal of inherited metabolic disease. 2009; 110(3): .
Carlstrom Lucas P, Jens Jackie K, Dobyns Marley E, Passage Merry, Dickson Patricia I, Ellinwood N Matthew Inadvertent propagation of factor VII deficiency in a canine mucopolysaccharidosis type I research breeding colony. Comparative medicine. 2009; 59(4): 378-82.
Dickson Patricia, Peinovich Maryn, McEntee Michael, Lester Thomas, Le Steven, Krieger Aimee, Manuel Hayden, Jabagat Catherine, Passage Merry, Kakkis Emil D Immune tolerance improves the efficacy of enzyme replacement therapy in canine mucopolysaccharidosis I. The Journal of clinical investigation. 2008; 118(8): 2868-76.
Munoz-Rojas Maria-Veronica, Vieira Taiane, Costa Ronaldo, Fagondes Simone, John Angela, Jardim Laura Bannach, Vedolin Leonardo M, Raymundo Marcia, Dickson Patricia I, Kakkis Emil, Giugliani Roberto Intrathecal enzyme replacement therapy in a patient with mucopolysaccharidosis type I and symptomatic spinal cord compression. American journal of medical genetics. Part A. 2008; 146A(19): 2538-44.
Dickson Patricia, McEntee Michael, Vogler Carole, Le Steven, Levy Beth, Peinovich Maryn, Hanson Stephen, Passage Merry, Kakkis Emil Intrathecal enzyme replacement therapy: successful treatment of brain disease via the cerebrospinal fluid. Molecular genetics and metabolism. 2007; 91(1): 61-8.
Belichenko P V, Dickson P I, Passage M, Jungles S, Mobley W C, Kakkis E D Penetration, diffusion, and uptake of recombinant human alpha-L-iduronidase after intraventricular injection into the rat brain. Molecular genetics and metabolism. 2005; 86(1-2): 141-9.
Dickson Patricia I, Briones Norman Y, Baylen Barry G, Jonas Adam J, French Samuel W, Lin Henry J Costello syndrome with pancreatic islet cell hyperplasia. American journal of medical genetics. Part A. 2004; 130A(4): 402-5.
Kakkis E, McEntee M, Vogler C, Le S, Levy B, Belichenko P, Mobley W, Dickson P, Hanson S, Passage M Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I. Molecular genetics and metabolism. 2004; 83(1-2): 163-74.
Joyce James J, Dickson Patricia I, Qi Ning, Noble Julie E, Raj J Usha, Baylen Barry G Normal right and left ventricular mass development during early infancy. The American journal of cardiology. 2004; 93(6): 797-801.