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Patricia Dickson, M.D.

Email Address:
pdickson@ucla.edu
Work Email Address:
pdickson@ucla.edu

Work Address:
1124 West Carson Street
Torrance, CA
UNITED STATES

Fax Number:
(310) 328-9921
(310) 782-2999
Work Phone Number:
(310) 222-3756
(310) 222-4145


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Department / Division Affiliations
Associate Professor In-Residence, David Geffen School of Medicine at UCLA
Assistant Professor, MEDICAL GENETICS
Member, CTSI, Committee on Maternal, Child and Adolescent Health
Assistant Professor In-Residence, Neuroscience IDP, Brain Research Institute

Research Interest:

Therapy for Pediatric Neurodegenerative Diseases
Dr. Dickson’s laboratory focuses on finding treatments for the brain in the mucopolysaccharidoses. The mucopolysaccharidoses (MPS) are a group of rare genetic diseases which cause physical and neurological degeneration and early death. Current projects include intrathecal enzyme replacement therapy for mucopolysaccharidosis type I, the immune response to recombinant enzyme, and developing therapy for the brain in mucopolysaccharidosis type III. The goal is to work towards new treatments and better use of existing treatments for the benefit of people living with MPS.
Publications:

Dierenfeld AD, McEntee MF, Passage M, Le S, Jens JK, Snella EM, Kline KL, Parkes JD, Ware WA, Moran LE, Wengert JA, Whitley RD, Betts DM, Boal AM, Riedesel EA, Gross W, Ellinwood NM, Dickson PI Replacing the enzyme α-L-iduronidase at birth ameliorates symptoms in the brain and periphery of dogs with mucopolysaccharidosis type I. Science Translational Medicine 2010; 2(60): ra89.
Dickson Patricia I, Hanson Stephen, McEntee Michael F, Vite Charles H, Vogler Carole A, Mlikotic Anton, Chen Agnes H, Ponder Katherine P, Haskins Mark E, Tippin Brigette L, Le Steven Q, Passage Merry B, Guerra Catalina, Dierenfeld Ashley, Jens Jackie, Snella Elizabeth, Kan Shih-Hsin, Ellinwood N Matthew Early versus late treatment of spinal cord compression with long-term intrathecal enzyme replacement therapy in canine mucopolysaccharidosis type I.. Molecular genetics and metabolism. 2010; 101(2-3): 115-22.
Ezra Navid, Tetteh Beatrice, Diament Michael, Jonas Adam J, Dickson Patricia Hereditary multiple exostoses with spine involvement in a 4-year-old boy.. American journal of medical genetics. Part A. 2010; 152A(5): 1264-7.
Carlstrom Lucas P, Jens Jackie K, Dobyns Marley E, Passage Merry, Dickson Patricia I, Ellinwood N Matthew Inadvertent propagation of factor VII deficiency in a canine mucopolysaccharidosis type I research breeding colony.. Comparative medicine. 2009; 59(4): 378-82.
Passage M B, Krieger A W, Peinovich M C, Lester T, Le S Q, Dickson P I, Kakkis E D Continuous infusion of enzyme replacement therapy is inferior to weekly infusions in MPS I dogs.. Journal of inherited metabolic disease. 2009; 110(3): .
Munoz-Rojas Maria-Veronica, Vieira Taiane, Costa Ronaldo, Fagondes Simone, John Angela, Jardim Laura Bannach, Vedolin Leonardo M, Raymundo Marcia, Dickson Patricia I, Kakkis Emil, Giugliani Roberto Intrathecal enzyme replacement therapy in a patient with mucopolysaccharidosis type I and symptomatic spinal cord compression.. American journal of medical genetics. Part A. 2008; 146A(19): 2538-44.
Dickson Patricia, Peinovich Maryn, McEntee Michael, Lester Thomas, Le Steven, Krieger Aimee, Manuel Hayden, Jabagat Catherine, Passage Merry, Kakkis Emil D Immune tolerance improves the efficacy of enzyme replacement therapy in canine mucopolysaccharidosis I.. The Journal of clinical investigation. 2008; 118(8): 2868-76.
Dickson Patricia, McEntee Michael, Vogler Carole, Le Steven, Levy Beth, Peinovich Maryn, Hanson Stephen, Passage Merry, Kakkis Emil Intrathecal enzyme replacement therapy: successful treatment of brain disease via the cerebrospinal fluid.. Molecular genetics and metabolism. 2007; 91(1): 61-8.
Belichenko P V, Dickson P I, Passage M, Jungles S, Mobley W C, Kakkis E D Penetration, diffusion, and uptake of recombinant human alpha-L-iduronidase after intraventricular injection into the rat brain.. Molecular genetics and metabolism. 2005; 86(1-2): 141-9.
Dickson Patricia I, Briones Norman Y, Baylen Barry G, Jonas Adam J, French Samuel W, Lin Henry J Costello syndrome with pancreatic islet cell hyperplasia.. American journal of medical genetics. Part A. 2004; 130A(4): 402-5.
Kakkis E, McEntee M, Vogler C, Le S, Levy B, Belichenko P, Mobley W, Dickson P, Hanson S, Passage M Intrathecal enzyme replacement therapy reduces lysosomal storage in the brain and meninges of the canine model of MPS I.. Molecular genetics and metabolism. 2004; 83(1-2): 163-74.
Joyce James J, Dickson Patricia I, Qi Ning, Noble Julie E, Raj J Usha, Baylen Barry G Normal right and left ventricular mass development during early infancy.. The American journal of cardiology. 2004; 93(6): 797-801.