Mailing Address:
Add Office Info Here Add Office & Work Info Here UNITED STATES
Work Phone Number:
310-825-9546
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Dr. Williams' laboratory is interested primarily in two topics of retinal cell biology. In one, we are studying the photoreceptor cilium, which is extraordinarily modified to form the photoreceptor outer segment, and is affected by many ciliopathies. Projects include ciliogenesis, axonemal transport, barrier/filter functions, and 3-D ultrastructure. The second topic concerns the motor proteins involved in the motility of organelles in the retinal pigmented epithelium (RPE). We use a combination of mouse genetics, biochemistry, and different forms of microscopy, including live-cell imaging. We are also developing a gene therapy approach for the retinal degeneration associated with a form of Usher syndrome (inherited deaf-blindness, caused by mutations in an unconventional myosin gene), and are interested in relationships between retinal degenerations and other neurodegenerative disorders.
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