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Fred Sabb

Email Address:
fsabb@ucla.edu
Work Email Address:
fsabb@mednet.ucla.edu

Mailing Address:
C8-881 Semel

UNITED STATES

760 Westwood Plaza
Los Angeles, CA 90095
UNITED STATES

Fax Number:
(310) 206-8525
Work Phone Number:
(310) 844-6458



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Department / Division Affiliations
Assistant Professor, Psychiatry and Biobehavioral Sciences
Member, Brain Research Institute
Assistant Professor In-Residence, Neuroscience IDP

Research Interest:

Phenomics, the system-wide study of phenotypes for whole-genome analysis

My research is in phenomics, the system-wide study of phenotypes for whole-genome analysis. I am involved in the Consortium for Neuropsychiatric Phenomics, which aims to examine cognitive phenotypes in pursuit of novel genes for schizophrenia, bipolar disorder, and ADHD. I am specifically interested in high-throughput strategies to represent and refine latent cognitive, behavioral, and personality phenotypes used in pursuit of novel genes for these neuropsychiatric disorders. In particular, I am interested in the interaction between components of cognitive control, including working memory, response inhibition, and task switching, and how these processes are perturbed in psychiatric disorders. I employ neuro-informatics techniques to better represent and refine complex phenotypic constructs that ultimately drive directed behavioral and neuroimaging experiments.

Publications:

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Cohen Jessica R, Asarnow Robert F, Sabb Fred W, Bilder Robert M, Bookheimer Susan Y, Knowlton Barbara J, Poldrack Russell A Decoding continuous variables from neuroimaging data: basic and clinical applications. Frontiers in neuroscience. 2011; 5(9): 75.
Poldrack Russell A, Kittur Aniket, Kalar Donald, Miller Eric, Seppa Christian, Gil Yolanda, Parker D Stott, Sabb Fred W, Bilder Robert M The cognitive atlas: toward a knowledge foundation for cognitive neuroscience. Frontiers in neuroinformatics. 2011; 5(9): 17.
Bilder Robert M, Howe Andrew, Novak Nic, Sabb Fred W, Parker D Stott The genetics of cognitive impairment in schizophrenia: a phenomic perspective. Trends in cognitive sciences. 2011; 15(9): 428-35.
Cohen Jessica R, Asarnow Robert F, Sabb Fred W, Bilder Robert M, Bookheimer Susan Y, Knowlton Barbara J, Poldrack Russell A Decoding developmental differences and individual variability in response inhibition through predictive analyses across individuals. Frontiers in human neuroscience. 2010; 4(9): 47.
Cohen Jessica R, Asarnow Robert F, Sabb Fred W, Bilder Robert M, Bookheimer Susan Y, Knowlton Barbara J, Poldrack Russell A A unique adolescent response to reward prediction errors. Nature neuroscience. 2010; 13(6): 669-71.
Walshaw Patricia D, Alloy Lauren B, Sabb Fred W Executive function in pediatric bipolar disorder and attention-deficit hyperactivity disorder: in search of distinct phenotypic profiles. Neuropsychology review. 2010; 20(1): 103-20.
Sabb Fred W, van Erp Theo G M, Hardt Molly E, Dapretto Mirella, Caplan Rochelle, Cannon Tyrone D, Bearden Carrie E Language network dysfunction as a predictor of outcome in youth at clinical high risk for psychosis. Schizophrenia research. 2010; 116(2-3): 173-83.
Bilder Robert M, Sabb Fred W, Parker D Stott, Kalar Donald, Chu Wesley W, Fox Jared, Freimer Nelson B, Poldrack Russell A Cognitive ontologies for neuropsychiatric phenomics research. Cognitive neuropsychiatry. 2009; 14(4-5): 419-50.
Altshuler Lori, Bookheimer Susan, Townsend Jennifer, Proenza Manuel A, Sabb Fred, Mintz Jim, Cohen Mark S Regional brain changes in bipolar I depression: a functional magnetic resonance imaging study. Bipolar disorders. 2008; 10(6): 708-17.
Foerde Karin, Poldrack Russell A, Khan Barbara J, Sabb Fred W, Bookheimer Susan Y, Bilder Robert M, Guthrie Don, Granholm Eric, Nuechterlein Keith H, Marder Stephen R, Asarnow Robert F Selective corticostriatal dysfunction in schizophrenia: examination of motor and cognitive skill learning. Neuropsychology. 2008; 22(1): 100-9.
Sabb Fred W, Bilder Robert M, Chou Maggie, Bookheimer Susan Y Working memory effects on semantic processing: priming differences in pars orbitalis. NeuroImage. 2007; 37(1): 311-22.
Altshuler Lori L, Bookheimer Susan Y, Townsend Jennifer, Proenza Manuel A, Eisenberger Naomi, Sabb Fred, Mintz Jim, Cohen Mark S Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study. Biological psychiatry. 2005; 58(10): 763-9.
Altshuler Lori, Bookheimer Susan, Proenza Manuel A, Townsend Jennifer, Sabb Fred, Firestine Ann, Bartzokis George, Mintz Jim, Mazziotta John, Cohen Mark S Increased amygdala activation during mania: a functional magnetic resonance imaging study. The American journal of psychiatry. 2005; 162(6): 1211-3.
Poldrack Russell A, Sabb Fred W, Foerde Karin, Tom Sabrina M, Asarnow Robert F, Bookheimer Susan Y, Knowlton Barbara J The neural correlates of motor skill automaticity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005; 25(22): 5356-64.
Green Michael F, Glahn David, Engel Stephen A, Nuechterlein Keith H, Sabb Fred, Strojwas Magda, Cohen Mark S Regional brain activity associated with visual backward masking. Journal of cognitive neuroscience. 2005; 17(1): 13-23.
Kroger James K, Sabb Fred W, Fales Christina L, Bookheimer Susan Y, Cohen Mark S, Holyoak Keith J Recruitment of anterior dorsolateral prefrontal cortex in human reasoning: a parametric study of relational complexity. Cerebral cortex (New York, N.Y. : 1991). 2002; 12(5): 477-85.
Burggren Alison C, Small Gary W, Sabb Fred W, Bookheimer Susan Y Specificity of brain activation patterns in people at genetic risk for Alzheimer disease. The American journal of geriatric psychiatry : official journal of the American Association for Geriatric Psychiatry. 2002; 10(1): 44-51.