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William Melega, Ph.D.

Work Email Address:

Work Address:
Los Angeles, CA 90095

Lab Number:
(310) 206-8811

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Department / Division Affiliations
Professor, Biomedical Physics IDP, Semel Institute for Neuroscience and Human Behavior
Professor in Residence, Molecular & Medical Pharmacology
Member, ACCESS Program: Dept. of Molecular & Medical Pharmacology, Access Molecular Pharmacology: Therapeutics, Diagnostics, and Biology of Disease Home Area, Access Neuroscience Home Area, Brain Research Institute, Pharmacology Home Area
Faculty, Molecular Toxicology IDP


Melega WP, Lacan G, Gorgulho AA, Behnke EJ, De Salles AA Hypothalamic deep brain stimulation reduces weight gain in an obesity-animal model. PLoS ONE . 2012; 7(1): e30672, 1-8.
Yong J, Lacan G, Dang H, Hsieh T, Middleton B, Wasserfall C, Tian J, Melega WP, Kaufman DL BCG vaccine-induced neuroprotection in a mouse model of Parkinson's Disease. PLoS ONE. 2011; 6(1): e16610.
Kuczenski R, Segal DS, Melega WP, Lacan G, McCunney SJ Human methamphetamine pharmacokinetics simulated in the rat: behavioral and neurochemical effects of a 72-hour binge. Neuropsychopharmacology. 2009; 34: 24302441.
Lacan G, Plenevaux A, Rubins D, Way BM, Defraiteur C, Gillet S, Lemaire C, Aerts J, Luxen, A, Cherry SR, Melega WP. Cyclosporine, a p-glycoprotein modulator, increases 18F-MPPF binding in rat brain and peripheral tissues: Micropet and ex vivo studies. Eur. J. Nuc. Med. Mol. Imaging 2008; .
Chin MH, Qian W-J, Wang H, Petyuk VA, Bloom JS, Sforza DM, Lacan G, Liu D, Khan AH, Cantor RM, Bigelow DJ, Melega WP, Camp II DG, Richard D. Smith RD, Smith DJ. miRNAs and codon usage regulate striatal gene and protein expression in two mouse models of Parkinson's disease. J Proteome Res 2008; 7: 666-677.
Melega WP, Cho AK, Harvey DC, Lacan G Methamphetamine blood concentrations in human abusers: application to pharmacokinetic modeling. Synapse 2007; 61: 216-220.
O'Neil ML,Kuczenski R, Segal DS, Cho AK, Lacan G, Melega WP Escalating dose pretreatment induces pharmacodynamic and not pharmacokinetic tolerance to a subsequent high-dose methamphetamine binge. Synapse 2006; 60: 465-473.
Segal DS, Kuczenski R, O'Neil ML, Melega WP, Cho AK Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterization. Psychopharmacology (Berl) 2005; 180: 501-512.
Segal DS, Kuczenski R, ONeil ML, Melega WP, Cho AK. Escalating dose methamphetamine pretreatment alters the behavioral and neurochemical profiles associated with exposure to a high dose methamphetamine binge. Neuropsychopharmacology 2003; 28: 1730-40.
Cho AK, Melega WP Patterns of methamphetamine abuse and their consequences. Journal of addictive diseases . 2002; 21(1): 21-34.
Segal, DS Kuczenski, R O'Neil, ML Melega, WP Cho, AK Prolonged exposure of rats to intravenous methamphetamine: behavioral and neurochemical characterization. Psychopharmacology. 2005; 180(3): 501-12.
Rubins, DJ Melega, WP Lacan, G Way, B Plenevaux, A Luxen, A Cherry, SR Development and evaluation of an automated atlas-based image analysis method for microPET studies of the rat brain. NeuroImage. 2003; 20(4): 2100-18.
Brown, VM Ossadtchi, A Khan, AH Yee, S Lacan, G Melega, WP Cherry, SR Leahy, RM Smith, DJ Multiplex three-dimensional brain gene expression mapping in a mouse model of Parkinson's disease. Genome research. 2002; 12(6): 868-84.
Cho, AK Melega, WP Kuczenski, R Segal, DS Relevance of pharmacokinetic parameters in animal models of methamphetamine abuse. Synapse (New York, N.Y.) . 2001; 39(2): 161-6.
Harvey, DC Lacan, G Tanious, SP Melega, WP Recovery from methamphetamine induced long-term nigrostriatal dopaminergic deficits without substantia nigra cell loss. Brain research. . 2000; 871(2): 259-70.
Cho, AK Melega, WP Kuczenski, R Segal, DS Schmitz, DA Caudate-putamen dopamine and stereotypy response profiles after intravenous and subcutaneous amphetamine. Synapse (New York, N.Y.) . 1999; 31(2): 125-33.
Melega, WP Cho, AK Schmitz, D Kuczenski, R Segal, DS l-methamphetamine pharmacokinetics and pharmacodynamics for assessment of in vivo deprenyl-derived l-methamphetamine. The Journal of pharmacology and experimental therapeutics. 1999; 288(2): 752-8.