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Douglas Black, Ph.D.

Work Email Address:
dougb@microbio.ucla.edu

Laboratory Address:
Laboratory
MRL 6-567

UNITED STATES

Work Address:
Office
MRL 6-780
CAMPUS - 166222
CA
UNITED STATES

Work Phone Number:
(310) 794-7644



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Department / Division Affiliations
Professor, Microbiology, Immunology & Molecular Genetics
Member, ACCESS Program: Dept. of Microbiology, Immunology, & Molecular Genetics, Access Biochemistry, Biophysics, Structural Biology Home Area, Access Gene Regulation Home Area, Access Neuroscience Home Area, Brain Research Institute, Center for Duchenne Muscular Dystrophy, JCCC Gene Regulation Program Area
Faculty, Biomedical Engineering IDP, Molecular Biology IDP
Investigator, Howard Hughes Medical Institute

Bio:

Dr. Black is a Professor in the Department of Microbiology, Immunology, and Molecular Genetics at the University of California, Los Angeles, and the David Geffen School of Medicine at UCLA. His B.A. degree is in chemistry from the University of California, Santa Cruz. He received his Ph.D. degree in molecular biochemistry and biophysics at Yale University, working with Joan Steitz. Prior to his appointment at UCLA, he worked with David Baltimore and Donald Rio at the Whitehead Institute for Biomedical Research as a Helen Hay Whitney and American Cancer Society fellow. He was also a fellow of the David and Lucile Packard Foundation.

Publications:

Shalini Sharma, Lori A. Kohlstaedt, Andrey Damianov, Donald C. Rio, and Douglas L. Black Polypyrimidine tract binding protein controls the transition from exon definition to an intron defined spliceosome. Nature Structural and Molecular Biology 2008; In Press.: .
Lee J, Xing Y, Nguyen D, Xie J, Lee C. and Douglas L. Black Depolarization and CaM Kinase IV Modulate NMDA Receptor Splicing through Two Essential RNA Elements. PLoS Biology 2007; 5(2): e40.
Boutz P, Chawla G, Stoilov P, and Douglas L. Black MicroRNAs regulate the expression of the alternative splicing factor nPTB during muscle development. Genes and Development 2007; 21(1): 71-84.
Li, Qin, Lee, Ji-Ann, and Douglas L. Black Neuronal Regulation of Alternative Pre-messenger RNA Splicing. Nature Reviews Neuroscience 2007; 8(11): 819-31.
Boutz P, Stoilov P, Li Q, Lin C, Chawla G, Ostrow K, Shiue L, Manuel C. Ares and Douglas L. Black Post-transcriptional regulatory switch in polypyrimidine tract-binding proteins reprograms alternative splicing in developing neurons. Genes and Development 2007; 21(13): 1636-52.
Xie J, Jan C, Stoilov P, Park J, Black DL A concensus CaMK IV-responsive RNA sequence mediates regulation of alternative exons in neurons. RNA 2005; 11(12): 1825-1834.
Underwood J, Boutz P, Dougherty JD, Stoilov P, Black DL Homologues of the C. Elegans Fox-1 Protein are neuronal splicing regulators in mammals. MCB 2005; 25(22): 10005-16.
Black DL Mechanisms of alternative pre-messenger RNA splicing. Annual review of biochemistry. . 2003; 72: 291-336.
Grabowski PJ, Black DL Alternative RNA splicing in the nervous system. Progress in Neurobiology 2001; 65: 289-308.
Sharma S, Falick AM, Black DL Polypyrimidine tract binding protein blocks the 5' splice site-dependent assembly of U2AF and the prespliceosomal E complex. Molecular Cell . 2005; 19(4): 485-96.
Amir-Ahmady B, Boutz PL, Markovtsov V, Phillips ML, Black DL Exon repression by polypyrimidine tract binding protein. RNA (New York, N.Y.) . 2005; 11(5): 699-716.
Xie J, Black DL A CaMK IV responsive RNA element mediates depolarization-induced alternative splicing of ion channels. Nature. . 2001; 410(6831): 936-9.