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Jack Feldman, Ph.D.

Email Address:
feldman@ucla.edu

Work Address:
Office
CHS
Los Angeles, CA 90095
UNITED STATES

Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES

Work Phone Number:
(310) 825-1586
310-825-0954



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Department / Division Affiliations
Distinguished Professor, Neurobiology
Member, ACCESS Program: Dept. of Neurobiology, Neuroengineering Training Program, Neuroscience Graduate Program, Brain Research Institute
ACCESS Affinity - Neurobiology

Publications:

Shao XM, Tan W, Xiu J, Puskar N, Fonck C, Lester HA, Feldman JL. Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm.. J Neurosci. 2008; 28(2): 519-28.
Tan W, Janczewski WA, Yang P, Shao XM, Callaway EM, Feldman JL. Silencing preBotzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat.. Nat Neurosci. 2008; 11(5): 538-40.
Morgado-Valle C, Beltran-Parrazal L, Difranco M, Vergara JL, Feldman JL. Somatic Ca2+ transients do not contribute to inspiratory drive in preBotzinger Complex neurons.. J Physiol. 2008; .
McKay LC, Feldman JL. Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not during wakefulness.. Am J Respir Crit Care Med. 2008; 178(1): 89-95.
Shao XM, Feldman JL. Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC.. J Neurosci Methods 2007; 160(2): 256-63.
Neverova NV, Saywell SA, Nashold LJ, Mitchell GS, Feldman JL. Episodic stimulation of alpha 1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability.. J Neurosci 2007; 27(16): 4435-42.
Pace RW, Mackay DD, Feldman JL, Del Negro CA. Inspiratory bursts in the preBotzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice.. J Physiol 2007; 582(Pt 1): 113-25.
Shao XM, Feldman JL. Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials.. J Neurosci Methods 2007; 159(1): 108-15.
Morgado-Valle C, Feldman JL. NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptors.. J Physiol 2007; 582(Pt 1): 359-68.
Pace RW, Mackay DD, Feldman JL, Del Negro CA. Role of persistent sodium current in mouse preBotzinger Complex neurons and respiratory rhythm generation.. J Physiol 2007; 580(Pt 2): 485-96.
Feldman JL, Geimer S, Marshall WF. The mother centriole plays an instructive role in defining cell geometry.. PLoS Biol 2007; 5(6): e149.
Janczewski, WA Feldman, JL Distinct rhythm generators for inspiration and expiration in the juvenile rat. J. Physiol.. 2006; 570: 407-420.
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Janczewski WA, Feldman JL. Distinct rhythm generators for inspiration and expiration in the juvenile rat.. J Physiol 2006; 570(Pt 2): 407-20.
Feldman, JL Del Negro, CA Looking for inspiration: New perspectives on the generation of respiratory rhythm.. Nature Reviews Neuroscience. 2006; 7: 232-242.
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Feldman JL, Del Negro CA. Looking for inspiration: new perspectives on respiratory rhythm.. Nat Rev Neurosci 2006; 7(3): 232-42.
Janczewski WA, Feldman JL. Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on "respiratory-related rhythmic activity in the rostral medulla of newborn rats".. J Neurophysiol 2006; 96(1): 1-2.
Feldman JL, Janczewski WA. Point: Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBotC is the primary site of respiratroy rhythm generation in the mammal.. J Appl Physiol 2006; 100(6): 2096-7.
Feldman JL, Janczewski WA. The Last Word: Point: Counterpoint authors respond to commentaries on "the parafacial respiratory group (pFRG)/ pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal".. J Appl Physiol 2006; 101(2): 689.
Shao XM, Feldman JL. Cholinergic neurotransmission in the preBotzinger Complex modulates excitability of inspiratory neurons and regulates respiratory rhythm.. Neuroscience 2005; 130(4): 1069-81.
Feldman JL, Neverova NV, Saywell SA. Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades.. Respir Physiol Neurobiol 2005; 147(2-3): 131-43.
Keegan BR, Feldman JL, Begemann G, Ingham PW, Yelon D. Retinoic acid signaling restricts the cardiac progenitor pool.. Science 2005; 30(5707): 247-9.
McKay LC, Janczewski WA, Feldman JL Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons. Nature Neuroscience. 2005; 8(9): 1142-1144.
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McKay LC, Janczewski WA, Feldman JL. Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons.. Nat Neurosci 2005; 8(9): 1142-4.
Del Negro CA, Morgado-Valle C, Hayes JA, Mackay DD, Pace RW, Crowder EA, Feldman JL. Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation.. J Neurosci 2005; 25(2): 446-53.
Zamora I, Feldman JL, Marshall WF. PCR-based assay for mating type and diploidy in Chlamydomonas.. Biotechniques 2004; 37(4): 534-6.
Feldman JL, Janczewski WA. Slip of the tongue.. Am J Respir Crit Care Med 2004; 170(6): 581-2.
Feldman, JL Mitchell, GS Nattie, EE Breathing: rhythmicity, plasticity, chemosensitivity.. Annual review of neuroscience. . 2003; 26: 239-66.
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Shao XM, Ge Q, Feldman JL Modulation of AMPA receptors by cAMP-dependent protein kinase in preBotzinger complex inspiratory neurons regulates respiratory rhythm in the rat.. J Physiol 2003; 545(Pt 2): 543-53.
Feldman, JL, McCrimmon DR Neural Control of Breathing. Fundamental Neuroscience 2002; Chapter 37: .
Chamberlin, NL Bocchiaro, CM Greene, RW Feldman, JL Nicotinic excitation of rat hypoglossal motoneurons.. Neuroscience. . 2002; 115(3): 861-70.
Alheid, GF Gray, PA Jiang, MC Feldman, JL McCrimmon, DR Parvalbumin in respiratory neurons of the ventrolateral medulla of the adult rat.. Journal of neurocytology. . 2002; 31(8-9): 693-717.
Shao XM, Feldman JL Pharmacology of nicotinic receptors in preBotzinger complex that mediate modulation of respiratory pattern.. J Neurophysiol 2002; 88(4): 1851-8.
Gray PA, Janczewski WA, Mellen N, McCrimmon DR, Feldman JL Normal breathing requires preBotzinger Complex neurokinin-1 receptor expressing neurons. Nature Neuroscience 2001; 4(9): 927-930.
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Lai J, Shao XM, Pan RW, Dy E, Huang CH, Feldman JL RT-PCR reveals muscarinic acetylcholine receptor mRNA in the pre-Botzinger complex.. Am J Physiol Lung Cell Mol Physiol 2001; 281(6): L1420-4.
Gray, PA, Rekling, JC, Bocchiaro, CM, Feldman, JL Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBotzinger complex. Science. 1999; 286: 1566-1568.
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Rekling, JC, Feldman, JL PreBotzinger Complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation. Annual Review of Physiology. 1998; 60: 385-405.
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Smith JC, Ellenberger, HH, Ballanyi, K, Richter, DW, Feldman, JL Pre-botzinger complex: A brain region that may generate respiratory rhythm in mammals. Science 1991; 254: 726-729.
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Del Negro, CA Morgado-Valle, C Hayes, JA Mackay, DD Pace, RW Crowder, EA Feldman, JL Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2005; 25(2): 446-53.
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Bocchiaro, CM Feldman, JL Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons.. Proceedings of the National Academy of Sciences of the United States of America. . 2004; 101(12): 4292-5.
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Saywell, SA Feldman, JL Dynamic interactions of excitatory and inhibitory inputs in hypoglossal motoneurones: respiratory phasing and modulation by PKA.. The Journal of physiology. . 2004; 554(Pt 3): 879-89.
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Parkis, MA Feldman, JL Robinson, DM Funk, GD Oscillations in endogenous inputs to neurons affect excitability and signal processing.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2003; 23(22): 8152-8.
Mellen, NM Janczewski, WA Bocchiaro, CM Feldman, JL Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation.. Neuron. . 2003; 37(5): 821-6.
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Bocchiaro, CM Saywell, SA Feldman, JL Dynamic modulation of inspiratory drive currents by protein kinase A and protein phosphatases in functionally active motoneurons.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2003; 23(4): 1099-103.
Janczewski, WA Onimaru, H Homma, I Feldman, JL Opioid-resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat.. The Journal of physiology. . 2002; 545(Pt 3): 1017-26.
Del Negro, CA Morgado-Valle, C Feldman, JL Respiratory rhythm: an emergent network property?. Neuron. . 2002; 34(5): 821-30.
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Mellen, NM Milsom, WK Feldman, JL Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation.. American journal of physiology. Regulatory, integrative and comparative physiology. . 2002; 282(2): R484-91.
Mellen, NM Feldman, JL Phasic vagal sensory feedback transforms respiratory neuron activity in vitro.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2001; 21(18): 7363-71.
Rekling, JC Funk, GD Bayliss, DA Dong, XW Feldman, JL Synaptic control of motoneuronal excitability.. Physiological reviews. . 2000; 80(2): 767-852.
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