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Jack Feldman, Ph.D.

Email Address:
feldman@ucla.edu

Work Address:
Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES

Office
CHS
Los Angeles, CA 90095
UNITED STATES

Lab Number:
(310) 825-1586
Office Phone Number:
310-825-0954



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Department / Division Affiliations
Distinguished Professor, Neurobiology
Member, ACCESS Program: Dept. of Neurobiology, Access Molecular, Cellular and Integrative Physiology Home Area, Access Neuroscience Home Area, Brain Research Institute, Neuroengineering Training Program, Neuroscience IDP

Publications:

Kam Kaiwen, Worrell Jason W, Janczewski Wiktor A, Cui Yan, Feldman Jack L Distinct inspiratory rhythm and pattern generating mechanisms in the preBötzinger complex. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013; 33(22): 9235-45.
Kam Kaiwen, Worrell Jason W, Ventalon Cathie, Emiliani Valentina, Feldman Jack L Emergence of population bursts from simultaneous activation of small subsets of preBötzinger complex inspiratory neurons. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013; 33(8): 3332-8.
Janczewski Wiktor A, Tashima Alexis, Hsu Paul, Cui Yan, Feldman Jack L Role of inhibition in respiratory pattern generation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2013; 33(13): 5454-65.
Babiec Walter E, Faull Kym F, Feldman Jack L Cyclothiazide-induced persistent increase in respiratory-related activity in vitro. The Journal of physiology. 2012; 590(Pt 19): 4897-915.
Shao Xuesi M, Xu Bin, Liang Jing, Xie Xinmin Simon, Zhu Yifang, Feldman Jack L Nicotine Delivery to Rats via Lung Alveolar Region-Targeted Aerosol Technology Produces Blood Pharmacokinetics Resembling Human Smoking. Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco. 2012; .
Tan Wenbin, Sherman David, Turesson Jenny, Shao Xuesi M, Janczewski Wiktor A, Feldman Jack L Reelin demarcates a subset of pre-Bötzinger complex neurons in adult rat. J. Comp. Neurol. 2012; 520(3): 606-19.
Feldman Jack L, Del Negro Christopher A, Gray Paul A Understanding the Rhythm of Breathing: So Near, Yet So Far. Annual review of physiology. 2012; .
Pagliardini Silvia, Janczewski Wiktor A, Tan Wenbin, Dickson Clayton T, Deisseroth Karl, Feldman Jack L Active expiration induced by excitation of ventral medulla in adult anesthetized rats. J. Neurosci. 2011; 31(8): 2895-905.
Feldman Jack L Chapter 14--looking forward to breathing. Prog. Brain. Res. 2011; 188(8): 213-8.
Morgado-Valle Consuelo, Baca Serapio M, Feldman Jack L Glycinergic pacemaker neurons in preBötzinger complex of neonatal mouse. J. Neurosci. 2010; 30(10): 3634-9.
Tan Wenbin, Pagliardini Silvia, Yang Paul, Janczewski Wiktor A, Feldman Jack L Projections of preBötzinger complex neurons in adult rats. J. Comp. Neurol. 2010; 518(10): 1862-78.
Saywell Shane A, Babiec Walter E, Neverova Natalia V, Feldman Jack L Protein kinase G-dependent mechanisms modulate hypoglossal motoneuronal excitability and long-term facilitation. J. Physiol. 2010; 588(Pt 22): 4431-9.
Schwab David J, Bruinsma Robijn F, Feldman Jack L, Levine Alex J Rhythmogenic neuronal networks, emergent leaders, and k-cores. Phys. Rev. E. 2010; 82(5 Pt 1): 051911.
Del Negro Christopher A, Hayes John A, Pace Ryland W, Brush Benjamin R, Teruyama Ryoichi, Feldman Jack L Synaptically activated burst-generating conductances may underlie a group-pacemaker mechanism for respiratory rhythm generation in mammals. Prog. Brain. Res. 2010; 187(10): 111-36.
Del Negro CA, KK, Hayes JA, Feldman JL Asymmetric control of inspiratory and expiratory phases by excitability in the respiratory network of neonatal mice in vitro. J. Physiol. 2009; 587(Pt 6): 1217-31.
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Shao Xuesi M, Feldman Jack L Central cholinergic regulation of respiration: nicotinic receptors. Acta pharmacologica Sinica. 2009; 30(6): 761-70.
Feldman JL, Kam KK, Janczewski WA Practice makes perfect, even for breathing. Nature Neuroscience. 2009; 12(8): 961-3.
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Shao XM, Tan W, Xiu J, Puskar N, Fonck C, Lester HA, Feldman JL Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm. J Neurosci 2008; 28(2): 519-28.
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Shao Xuesi M, Tan Wenbin, Xiu Joanne, Puskar Nyssa, Fonck Carlos, Lester Henry A, Feldman Jack L Alpha4* nicotinic receptors in preBotzinger complex mediate cholinergic/nicotinic modulation of respiratory rhythm. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2008; 28(2): 519-28.
Feldman, JL, McCrimmon DR Neural Control of Breathing. Fundamental Neuroscience, 3rd Edition 2008; .
Tan W, Janczewski WA, Yang Pl, Shao XM, Callaway EM, Feldman JL Silencing preBötzinger complex somatostatin-expressing neurons induces persistent apnea in awake rat. Nature Neuroscience. 2008; 11(5): 538-40.
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Morgado-Valle Consuelo, Beltran-Parrazal Luis, DiFranco Marino, Vergara Julio L, Feldman Jack L Somatic Ca2+ transients do not contribute to inspiratory drive in preBötzinger Complex neurons. The Journal of physiology. 2008; 586(Pt 18): 4531-40.
McKay LC, Feldman JL Unilateral ablation of pre-Botzinger complex disrupts breathing during sleep but not wakefulness. American Journal of Respiratory and Critical Care Medicine. 2008; 178(1): 89-95.
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Shao XM, Feldman JL. Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC. J Neurosci Methods 2007; 160(2): 256-63.
Shao Xuesi M, Feldman Jack L Efficient measurement of endogenous neurotransmitters in small localized regions of central nervous systems in vitro with HPLC. Journal of neuroscience methods. 2007; 160(2): 256-63.
Neverova NV, Saywell SA, Nashold LJ, Mitchell GS, Feldman JL. Episodic stimulation of alpha 1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability. J Neurosci 2007; 27(16): 4435-42.
Neverova Natalia V, Saywell Shane A, Nashold Lisa J, Mitchell Gordon S, Feldman Jack L Episodic stimulation of alpha1-adrenoreceptors induces protein kinase C-dependent persistent changes in motoneuronal excitability. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007; 27(16): 4435-42.
Pace RW, Mackay DD, Feldman JL, Del Negro CA Inspiratory bursts in the preBotzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice. J Physiol 2007; 582(Pt 1): 113-25.
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Pace Ryland W, Mackay Devin D, Feldman Jack L, Del Negro Christopher A Inspiratory bursts in the preBötzinger complex depend on a calcium-activated non-specific cation current linked to glutamate receptors in neonatal mice. The Journal of physiology. 2007; 582(Pt 1): 113-25.
Shao XM, Feldman JL. Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials. J Neurosci Methods 2007; 159(1): 108-15.
Shao Xuesi M, Feldman Jack L Micro-agar salt bridge in patch-clamp electrode holder stabilizes electrode potentials. Journal of neuroscience methods. 2007; 159(1): 108-15.
Morgado-Valle C, Feldman JL NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptors. J Physiol 2007; 582(Pt 1): 359-68.
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Morgado-Valle C, Feldman JL NMDA receptors in preBotzinger complex neurons can drive respiratory rhythm independent of AMPA receptors. The Journal of physiology. 2007; 582(Pt 1): 359-68.
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Pace RW, Mackay DD, Feldman JL, Del Negro CA. Role of persistent sodium current in mouse preBotzinger Complex neurons and respiratory rhythm generation. J Physiol 2007; 580(Pt 2): 485-96.
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Pace Ryland W, Mackay Devin D, Feldman Jack L, Del Negro Christopher A Role of persistent sodium current in mouse preBötzinger Complex neurons and respiratory rhythm generation. The Journal of physiology. 2007; 580(Pt. 2): 485-96.
Janczewski WA, Feldman JL Distinct rhythm generators for inspiration and expiration in the juvenile rat. J. Physiol. 2006; 570: 407-420.
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Janczewski WA, Feldman JL. Distinct rhythm generators for inspiration and expiration in the juvenile rat. J Physiol 2006; 570(Pt 2): 407-20.
Janczewski Wiktor A, Feldman Jack L Distinct rhythm generators for inspiration and expiration in the juvenile rat. The Journal of physiology. 2006; 570(Pt 2): 407-20.
Feldman JL, Del Negro CA Looking for inspiration: new perspectives on respiratory rhythm. Nature Reviews Neuroscience 2006; 7(3): 232-42.
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Feldman Jack L, Del Negro Christopher A Looking for inspiration: new perspectives on respiratory rhythm. Nature reviews. Neuroscience. 2006; 7(3): 232-42.
Janczewski WA, Feldman JL. Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on "respiratory-related rhythmic activity in the rostral medulla of newborn rats". J Neurophysiol 2006; 96(1): 1-2.
Janczewski Wiktor A, Feldman Jack L Novel data supporting the two respiratory rhythm oscillator hypothesis. Focus on "respiration-related rhythmic activity in the rostral medulla of newborn rats". Journal of neurophysiology. 2006; 96(1): 1-2.
Feldman JL, Janczewski WA. Point: Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBotC is the primary site of respiratroy rhythm generation in the mammal. J Appl Physiol 2006; 100(6): 2096-7.
Feldman Jack L, Janczewski Wiktor A Point:Counterpoint: The parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal. Counterpoint: the preBötC is the primary site of respiratory rhythm generation in the mammal. Journal of applied physiology (Bethesda, Md. : 1985). 2006; 100(6): 2096-7; discussion 2097-8, 2103-8.
Feldman JL, Janczewski WA. The Last Word: Point: Counterpoint authors respond to commentaries on "the parafacial respiratory group (pFRG)/ pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal". J Appl Physiol 2006; 101(2): 689.
Feldman Jack L, Janczewski Wiktor A The Last Word: Point:Counterpoint authors respond to commentaries on "the parafacial respiratory group (pFRG)/pre-Botzinger complex (preBotC) is the primary site of respiratory rhythm generation in the mammal". Journal of applied physiology (Bethesda, Md. : 1985). 2006; 101(2): 689.
Shao XM, Feldman JL. Cholinergic neurotransmission in the preBotzinger Complex modulates excitability of inspiratory neurons and regulates respiratory rhythm. Neuroscience 2005; 130(4): 1069-81.
Feldman JL, Neverova NV, Saywell SA. Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades. Respir Physiol Neurobiol 2005; 147(2-3): 131-43.
Feldman Jack L, Neverova Natalia V, Saywell Shane A Modulation of hypoglossal motoneuron excitability by intracellular signal transduction cascades. Respiratory physiology & neurobiology. 2005; 147(2-3): 131-43.
McKay LC, Janczewski WA, Feldman JL Sleep-disordered breathing after targeted ablation of preBotzinger complex neurons. Nature Neuroscience. 2005; 8(9): 1142-1144.
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McKay LC, Janczewski WA, Feldman JL Sleep-disordered breathing after targeted ablation of preBötzinger complex neurons. Nature Neuroscience. 2005; 8(9): 1142-4.
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Del Negro CA, Morgado-Valle C, Hayes JA, Mackay DD, Pace RW, Crowder EA, Feldman JL. Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation. J Neurosci 2005; 25(2): 446-53.
Del Negro CA, Morgado-Valle C, Hayes JA, Mackay DD, Pace RW, Crowder EA, Feldman JL Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation. J. Neurosci. 2005; 25(2): 446-53.
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Del Negro Christopher A, Morgado-Valle Consuelo, Hayes John A, Mackay Devin D, Pace Ryland W, Crowder Erin A, Feldman Jack L Sodium and calcium current-mediated pacemaker neurons and respiratory rhythm generation. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005; 25(2): 446-53.
Mellen Nicholas M, Roham Maryam, Feldman Jack L Afferent modulation of neonatal rat respiratory rhythm in vitro: cellular and synaptic mechanisms. The Journal of physiology. 2004; 556(Pt 3): 859-74.
Saywell, SA Feldman, JL Dynamic interactions of excitatory and inhibitory inputs in hypoglossal motoneurones: respiratory phasing and modulation by PKA. The Journal of physiology. . 2004; 554(Pt 3): 879-89.
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McKay Leanne C, Janczewski Wiktor A, Feldman Jack L Episodic hypoxia evokes long-term facilitation of genioglossus muscle activity in neonatal rats. The Journal of physiology. 2004; 557(Pt 1): 13-8.
Feldman JL, Janczewski WA. Slip of the tongue. Am J Respir Crit Care Med 2004; 170(6): 581-2.
Feldman Jack L, Janczewski Wiktor A Slip of the tongue. American journal of respiratory and critical care medicine. 2004; 170(6): 581-2.
Bocchiaro CM, Feldman JL Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons. PNAS. 2004; 101(12): 4292-5.
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Bocchiaro Christopher M, Feldman Jack L Synaptic activity-independent persistent plasticity in endogenously active mammalian motoneurons. Proceedings of the National Academy of Sciences of the United States of America. 2004; 101(12): 4292-5.
Feldman JL, Mitchell GS, Nattie EE Breathing: rhythmicity, plasticity, chemosensitivity. Annual Review of Neuroscience. 2003; 26: 239-66.
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Bocchiaro CM, Saywell SA, Feldman JL Dynamic modulation of inspiratory drive currents by protein kinase A and protein phosphatases in functionally active motoneurons. J. Neurosci. 2003; 23(4): 1099-103.
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Shao XM, Ge Q, Feldman JL Modulation of AMPA receptors by cAMP-dependent protein kinase in preBotzinger complex inspiratory neurons regulates respiratory rhythm in the rat. J Physiol 2003; 545(Pt 2): 543-53.
Mellen NM, Janczewski WA, Bocchiaro CM, Feldman, JL Opioid-induced quantal slowing reveals dual networks for respiratory rhythm generation. Neuron. 2003; 37(5): 821-6.
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Parkis, MA Feldman, JL Robinson, DM Funk, GD Oscillations in endogenous inputs to neurons affect excitability and signal processing. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2003; 23(22): 8152-8.
Mellen, NM Milsom, WK Feldman, JL Hypothermia and recovery from respiratory arrest in a neonatal rat in vitro brain stem preparation. American journal of physiology. Regulatory, integrative and comparative physiology. . 2002; 282(2): R484-91.
Chamberlin, NL Bocchiaro, CM Greene, RW Feldman, JL Nicotinic excitation of rat hypoglossal motoneurons. Neuroscience. . 2002; 115(3): 861-70.
Janczewski WA, Onimaru H, Homma I, Feldman JL Opioid-resistant respiratory pathway from the preinspiratory neurones to abdominal muscles: in vivo and in vitro study in the newborn rat. J. Physiol. 2002; 545(Pt 3): 1017-26.
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Alheid, GF Gray, PA Jiang, MC Feldman, JL McCrimmon, DR Parvalbumin in respiratory neurons of the ventrolateral medulla of the adult rat. Journal of neurocytology. . 2002; 31(8-9): 693-717.
Shao XM, Feldman JL Pharmacology of nicotinic receptors in preBotzinger complex that mediate modulation of respiratory pattern. J Neurophysiol 2002; 88(4): 1851-8.
Del Negro CA, Morgado-Valle C, Feldman JL Respiratory rhythm: an emergent network property?. Neuron. 2002; 34(5): 821-30.
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Gray PA, Janczewski WA, Mellen N, McCrimmon DR, Feldman JL Normal breathing requires preBotzinger Complex neurokinin-1 receptor expressing neurons. Nature Neuroscience 2001; 4(9): 927-930.
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Mellen, NM Feldman, JL Phasic vagal sensory feedback transforms respiratory neuron activity in vitro. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2001; 21(18): 7363-71.
Lai J, Shao XM, Pan RW, Dy E, Huang CH, Feldman JL RT-PCR reveals muscarinic acetylcholine receptor mRNA in the pre-Botzinger complex. Am J Physiol Lung Cell Mol Physiol 2001; 281(6): L1420-4.
Rekling JC, Funk GD, Bayliss DA, Dong XW, Feldman JL Synaptic control of motoneuronal excitability. Physiological Reviews . 2000; 80(2): 767-852.
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Gray PA, Rekling JC, Bocchiaro CM, Feldman JL Modulation of respiratory frequency by peptidergic input to rhythmogenic neurons in the preBotzinger complex. Science. 1999; 286: 1566-1568.
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Rekling JC, Feldman JL PreBötzinger Complex and pacemaker neurons: hypothesized site and kernel for respiratory rhythm generation. Annual Review of Physiology. 1998; 60: 385-405.
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Smith JC, Ellenberger HH, Ballanyi K, Richter DW, Feldman JL PreBötzinger Complex: A brain region that may generate respiratory rhythm in mammals. Science 1991; 254: 726-729.
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