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Jerome Siegel, Ph.D.

Email Address:
jsiegel@ucla.edu

Work Address:
Office
Bldg 7, GLAHS Sepulveda
Los Angeles, CA 91343
UNITED STATES

Laboratory
Bldg 7, GLAHS Sepulveda
Los Angeles, CA 91343
UNITED STATES

Work Phone Number:
818-891-7711 x7581
818-891-8612


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Department / Division Affiliations
Chief, Neurobiology Research
Professor, Psychiatry and Biobehavioral Sciences
Professor in Residence, Semel Institute (NPI)
Member, Neuroscience Graduate Program, Brain Research Institute

Bio:

Sleep, Motor control Our primary interest is in understanding the evolution, function and disorders of REM sleep. We are analyzing the brainstem-forebrain interactions responsible for the control of muscle tone in waking and across the sleep cycle. This is of importance in understanding REM sleep behavior disorder, cataplexy and sleep apnea. We are studying the phylogeny of sleep by investigating the physiology and neurochemistry of sleep in reptiles, marine mammals and other species. We are particularly interested in the role of monoamines in the control of arousal and movement. A major focus of the laboratory is on narcolepsy, its anatomy, pathophysiology and treatment. We have identified the cause of human narcolepsy, a loss of hypocretin cells. We are investigating ways of identifying, controlling and reversing the symptoms of narcolepsy in narcoleptic animals and in humans.
Publications:

See: http://www.npi.ucla.edu/sleepresearch . ; .
Siegel, J.M. A tribute to Nathaniel Kleitman.. Arch. Ital. Biol. 2001; 139: 3-10.
Eiland, M.M., Lyamin, O.I. and Siegel, J.M. State related discharge of neruons in the brainstem of freely moving box turtles, Terapene Carolina major.. Arch. Ital. Biol. 2001; 139: 23-36.
Siegel, J. M. Brainstem mechanisms generating REM sleep.. Principles and Practice of Sleep Medicine 2000; Third Edition: 112-133.
Siegel, J. M. Brainstem mechanisms generating REM sleep.. Principles and Practice of Sleep Medicine 2000; Third Edition: 112-133.
Siegel, J.M. Narcolepsy.. Scientific American 2000; 282: 76-81.
Siegel, J.M. Phylogenetic data bearing on the REM sleep-learning connection.. The Behavioral and Brain Sciences 2000; 23: 1007.
Lyamin, O.I., Manger,P.R. Mukhametov, L.M., Siegel, J.M.and Shpak, O.V. Rest and activity states in a gray whale.. J. Sleep Res. 2000; 9: 261-267.
Rechtschaffen, A. and Siegel, J.M. Sleep and Dreaming.. Principles of Neuroscience. 2000; Fourth Edition: 936-947.
John, J Wu, MF Siegel, JM Systemic administration of hypocretin-1 reduces cataplexy and normalizes sleep and waking durations in narcoleptic dogs.. Sleep research online [electronic resource] : SRO. . 2000; 3(1): 23-8.
Wu, MF Gulyani, SA Yau, E Mignot, E Phan, B Siegel, JM Locus coeruleus neurons: cessation of activity during cataplexy.. Neuroscience. . 1999; 91(4): 1389-99.
Siegel, J.M. Narcolepsy: A key role for hypocretins (orexins).. Cell 1999; 98: 409-412.
Lai. Y.Y., Shalita, T., Hajnik, T., Wu, J.-P., Kuo, J.-S., Chia, L.-G., and Siegel, J.M. Neurotoxic Nmethyl-D-Aspartate lesion of the ventral midbrain and mesopontine junction alters sleep-wake organization.. Neuroscience 1999; 90: 469-483.
Siegel, JM Manger, PR Nienhuis, R Fahringer, HM Shalita, T Pettigrew, JD Sleep in the platypus.. Neuroscience. . 1999; 91(1): 391-400.
Siegel, J.M. Sleep.. Encarta Encyclopedia 1999; 2000: 0000.
Siegel, J.M. Sleep.. Encarta Encyclopedia 1999; 2000: 0000.
Siegel, J.M. The evolution of REM sleep.. In Handbook of Behavioral State Control 1999; first edition: pp 87-100.
Kohyama, J., Lai, Y.Y. and Siegel, J.M. Conduction velocity of the reticulospinal system mediating muscle tone suppression.. J. Neurophysiol. 1998; 80: 1839-1851.
Lai, Y.Y. and Siegel, J.M. Muscle atonia and REM sleep.. Rapid eye movement sleep 1998; first edition: 69-90.
Nitz, D. and Siegel, J.M. GABA release in the locus coeruleus as a function of sleep/wake state.. Neuroscience 1997; 78: 795-801.
Siegel, J.M. Sleep in monotremes; implications for the evolution of REM sleep.. Sleep and sleep disorders: from molecule to behavior 1997; First edition: 113-128.
Siegel, J.M. and Harper, R.H. Sleep.. Human Physiology 1996; 1: 1183-1197.
Siegel, J.M. and Harper, R.H. Sleep.. Human Physiology 1996; 1: 1183-1197.
Nishino, S., Tafti, M., Reid, M., Shelton, J., Siegel, J.M., Dement, W.C., and Mignot, E. Muscle atonia is triggered by cholinergic stimulation of the basal forebrain: Implications for the pathophysiology of narcolepsy.. J. Neuroscience 1995; 15: 4806-4814.
Siegel, JM Phylogeny and the function of REM sleep.. Behavioural brain research. . 1995; 69(1-2): 29-34.
Siegel, J. M. Brainstem mechanisms generating REM sleep.. Principles and Practice of Sleep Medicine 1994; Third Edition: 125-144.
Siegel, J.M., and Lai, Y.Y. Brainstem systems mediating the control of muscle tone.. Environment and Physiology 1994; First Edition: 62-78.
Carskadon, M.A., Rechtschaffen, A., Richardson, G., Roth, T., Siegel, J.M.v (Editor).. Encyclopedia of Sleep and Dreaming 1993; 703 pages.
Kodama, T., and Siegel, J.M. Brainstem acetylcholine release and REM sleep.. Sleep Wakefulness 1993; First edition: 51-56.
Wu, M.F, Jenden, D.J., Fairchild, D.M. and Siegel, J.M. Cholinergic mechanisms in startle and prepulse inhibition:Effect of the false cholinergic precursor N-aminodeanol.. Behavioral Neurosci. 1993; 107: 306-316.
Siegel, J.M. Function of REM sleep.. Encyclopedia of Sleep and Dreaming 1993; First Edition: 507-510.
Siegel, J.M. Medulla.. Encyclopedia of Sleep and Dreaming 1993; 358-359.
Siegel, J.M. Pons.. Encyclopedia of Sleep and Dreaming 1993; First edition: 461-462.
Siegel, J.M. REM sleep Mechanisms.. Encyclopedia of Sleep and Dreaming 1993; First Edition: 510-513.
Kodama, T., Lai, Y.Y. and Siegel, J.M. Enhancement of acetylcholine release during REM sleep in the caudo-medial medulla measured by in vivo microdialysis.. Brain Res. 1992; 580: 348-350.
McGinty, D. J. and Siegel, J. M. Neuronal unit recording in unrestrained animals: Role in structure-function analysis of sleep-waking mechanisms.. Progress in Physiological Psychology 1992; 15: 85-140.
Siegel, J.M. Brain Mechanisms of Sleep and Wakefulness.. Basics of Sleep Behavior 1991; .
Lai, Y.Y. and Siegel, J.M. Ponto-medullary glutamate receptors mediating locomotion and muscle tone suppression.. J. Neurosci. 1991; 11: 2931-2937.
Shouse, M. N., King, A., Langer, J., Wellesley, K., Vreeken, T., King, K., Siegel, J., Szymusiak, R. Basic mechanisms underlying seizure prone and seizure resistant sleep states.. Kindling 1990; 4: 313-327.
Siegel, J. M. Mechanisms of sleep control.. J. Clin Neurophysiol. 1990; 7: 49-65.
Siegel, J. M. Brainstem mechanisms generating REM sleep.. Principles and Practice of Sleep Medicine 1989; 104-121.
Siegel, J. M. Brainstem mechanisms generating REM sleep.. Principles and Practice of Sleep Medicine 1989; 104-121.
Wu, M.F., Mallick, B.N. and Siegel J.M. Lateral geniculate spikes, muscle atonia and startle response elicited by auditory stimuli as a function of stimulus parameters and arousal state.. Brain Res. 1989; 499: 7-17.
Lai, Y. Y., Siegel, J. M. and Wilson, W. J. Effect of blood pressure manipulations on medial medulla-induced muscle atonia.. Am. J. Physiol. 1987; 252: H1249-H1257.
Siegel, J. M., Tomaszewski, K. S. and Nienhuis, R. Behavioral states in the chronic medullary and mid-pontine cat.. Electroenceph. clin Neurophysiol. 1986; 63: 274-288.
Siegel, JM Fahringer, H Tomaszewski, KS Kaitin, K Kilduff, T Dement, WC Heart rate and blood pressure changes associated with cataplexy in canine narcolepsy.. Sleep. . 1986; 9(1 Pt 2): 216-21.
Siegel, J. M. and McGinty, D. J. Location of the systems generating REM sleep: lateral vs. medial pons. Commentary.. Behav. Brain Sci. 1986; 9: 420-421.
Siegel, J. M. Pontomedullary interactions in the generation of REM sleep.. Brain Mechanisms of Sleep 1985; 157-174.
Siegel, J. M. A behavioral approach to the analysis of reticular formation unit activity.. Behavioral Approaches to Brain Research 1983; 94-116.
Siegel, J. M. Brainstem mechanisms in REM sleep control.. Sleep Functions and Mechanisms in Animals and Man: An Evolutionary Perspective. 1983; 217-231.
Siegel, J. M. Reticular activity and arousal. Commentary.. Behav. Brain Sci. 1983; 6: 741-743.
McGinty, D. J. and Siegel, J. M. Sleep states.. Handbook of Behavioral Neurobiology: Motivation 1983; 105-181.
Siegel, J. M. Behavioral functions of the reticular formation.. Brain Res. Rev. 1979; 1: 69-105.
Breedlove, SM McGinty, DJ Siegel, JM Operant conditioning of pontine gigantocellular units.. Brain research bulletin. . 1979; 4(5): 663-7.
Siegel, J. M. Reticular formation activity and REM sleep.. The Functions of Sleep 1979; 37-71.
Siegel, J. M. and McGinty, D. J. Pontine reticular formation neurons and motor activity.. Science 1978; 199: 207-208.
McGinty, D. J. and Siegel, J. M. Neuronal activity patterns during rapid-eye- movement sleep:relation to waking patterns.. Neurobiology of Sleep and Memory 1977; 135-158.
Siegel, J. M. and McGinty, D. J. Brainstem neurons without spontaneous unit discharge.. Science 1976; 193: 240-242.
Kiyashchenko, LI Mileykovskiy, BY Lai, YY Siegel, JM Increased and decreased muscle tone with orexin (hypocretin) microinjections in the locus coeruleus and pontine inhibitory area.. Journal of neurophysiology. . 2001; 85(5): 2008-16.
Mileykovskiy, BY Kiyashchenko, LI Kodama, T Lai, YY Siegel, JM Activation of pontine and medullary motor inhibitory regions reduces discharge in neurons located in the locus coeruleus and the anatomical equivalent of the midbrain locomotor region.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2000; 20(22): 8551-8.
Hajnik, T Lai, YY Siegel, JM Atonia-related regions in the rodent pons and medulla.. Journal of neurophysiology. . 2000; 84(4): 1942-8.
Thannickal, TC Moore, RY Nienhuis, R Ramanathan, L Gulyani, S Aldrich, M Cornford, M Siegel, JM Reduced number of hypocretin neurons in human narcolepsy.. Neuron. . 2000; 27(3): 469-74.
Lai, YY Clements, JR Wu, XY Shalita, T Wu, JP Kuo, JS Siegel, JM Brainstem projections to the ventromedial medulla in cat: retrograde transport horseradish peroxidase and immunohistochemical studies.. The Journal of comparative neurology. . 1999; 408(3): 419-36.
Siegel, JM Nienhuis, R Gulyani, S Ouyang, S Wu, MF Mignot, E Switzer, RC McMurry, G Cornford, M Neuronal degeneration in canine narcolepsy.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1999; 19(1): 248-57.
Kohyama, J Lai, YY Siegel, JM Inactivation of the pons blocks medullary-induced muscle tone suppression in the decerebrate cat.. Sleep. . 1998; 21(7): 695-9.
Siegel, JM Manger, PR Nienhuis, R Fahringer, HM Pettigrew, JD Monotremes and the evolution of rapid eye movement sleep.. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. . 1998; 353(1372): 1147-57.
Reid, MS Nishino, S Tafti, M Siegel, JM Dement, WC Mignot, E Neuropharmacological characterization of basal forebrain cholinergic stimulated cataplexy in narcoleptic canines.. Experimental neurology. . 1998; 151(1): 89-104.
Kodama, T Lai, YY Siegel, JM Enhanced glutamate release during REM sleep in the rostromedial medulla as measured by in vivo microdialysis.. Brain research. . 1998; 780(1): 178-81.
Nitz, D Siegel, J GABA release in the dorsal raphe nucleus: role in the control of REM sleep.. The American journal of physiology. . 1997; 273(1 Pt 2): R451-5.
Lai, YY Siegel, JM Brainstem-mediated locomotion and myoclonic jerks. I. Neural substrates.. Brain research. . 1997; 745(1-2): 257-64.
Lai, YY Siegel, JM Brainstem-mediated locomotion and myoclonic jerks. II Pharmacological effects.. Brain research. . 1997; 745(1-2): 265-70.
Nitz, D Siegel, JM GABA release in posterior hypothalamus across sleep-wake cycle.. The American journal of physiology. . 1996; 271(6 Pt 2): R1707-12.
Reid, MS Tafti, M Nishino, S Sampathkumaran, R Siegel, JM Mignot, E Local administration of dopaminergic drugs into the ventral tegmental area modulates cataplexy in the narcoleptic canine.. Brain research. . 1996; 733(1): 83-100.
Siegel, JM Manger, PR Nienhuis, R Fahringer, HM Pettigrew, JD The echidna Tachyglossus aculeatus combines REM and non-REM aspects in a single sleep state: implications for the evolution of sleep.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1996; 16(10): 3500-6.
Nitz, D Andersen, A Fahringer, H Nienhuis, R Mignot, E Siegel, J Altered distribution of cholinergic cells in the narcoleptic dog.. Neuroreport. . 1995; 6(11): 1521-4.
Reid, MS Tafti, M Nishino, S Siegel, JM Dement, WC Mignot, E Cholinergic regulation of cataplexy in canine narcolepsy in the pontine reticular formation is mediated by M2 muscarinic receptors.. Sleep. . 1994; 17(5): 424-35.
Reid, MS Tafti, M Geary, JN Nishino, S Siegel, JM Dement, WC Mignot, E Cholinergic mechanisms in canine narcolepsy--I. Modulation of cataplexy via local drug administration into the pontine reticular formation.. Neuroscience. . 1994; 59(3): 511-22.
Reid, MS Siegel, JM Dement, WC Mignot, E Cholinergic mechanisms in canine narcolepsy--II. Acetylcholine release in the pontine reticular formation is enhanced during cataplexy.. Neuroscience. . 1994; 59(3): 523-30.
Lai, YY Clements, JR Siegel, JM Glutamatergic and cholinergic projections to the pontine inhibitory area identified with horseradish peroxidase retrograde transport and immunohistochemistry.. The Journal of comparative neurology. . 1993; 336(3): 321-30.
Mignot, E Nishino, S Sharp, LH Arrigoni, J Siegel, JM Reid, MS Edgar, DM Ciaranello, RD Dement, WC Heterozygosity at the canarc-1 locus can confer susceptibility for narcolepsy: induction of cataplexy in heterozygous asymptomatic dogs after administration of a combination of drugs acting on monoaminergic and cholinergic systems.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1993; 13(3): 1057-64.
Baghdoyan, HA Spotts, JL Snyder, SG Simultaneous pontine and basal forebrain microinjections of carbachol suppress REM sleep.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1993; 13(1): 229-42.
Siegel, JM Nienhuis, R Fahringer, HM Chiu, C Dement, WC Mignot, E Lufkin, R Activity of medial mesopontine units during cataplexy and sleep-waking states in the narcoleptic dog.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1992; 12(5): 1640-6.
Lai, YY Siegel, JM Corticotropin-releasing factor mediated muscle atonia in pons and medulla.. Brain research. . 1992; 575(1): 63-8.
Shouse, MN Siegel, JM Pontine regulation of REM sleep components in cats: integrity of the pedunculopontine tegmentum (PPT) is important for phasic events but unnecessary for atonia during REM sleep.. Brain research. . 1992; 571(1): 50-63.
Mallick, BN Fahringer, HM Wu, MF Siegel, JM REM sleep deprivation reduces auditory evoked inhibition of dorsolateral pontine neurons.. Brain research. . 1991; 552(2): 333-7.
Siegel, JM Nienhuis, R Fahringer, HM Paul, R Shiromani, P Dement, WC Mignot, E Chiu, C Neuronal activity in narcolepsy: identification of cataplexy-related cells in the medial medulla.. Science. . 1991; 252(5010): 1315-8.
Wu, MF Siegel, JM Facilitation of the acoustic startle reflex by ponto-geniculo-occipital waves: effects of PCPA.. Brain research. . 1990; 532(1-2): 237-41.
Wu, MF Siegel, JM Shouse, MN Schenkel, E Lesions producing REM sleep without atonia disinhibit the acoustic startle reflex without affecting prepulse inhibition.. Brain research. . 1990; 528(2): 330-4.
Lai, YY Siegel, JM Muscle tone suppression and stepping produced by stimulation of midbrain and rostral pontine reticular formation.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1990; 10(8): 2727-34.
Shiromani, PJ Lai, YY Siegel, JM Descending projections from the dorsolateral pontine tegmentum to the paramedian reticular nucleus of the caudal medulla in the cat.. Brain research. . 1990; 517(1-2): 224-8.
Mallick, BN Siegel, JM Fahringer, H Changes in pontine unit activity with REM sleep deprivation.. Brain research. . 1990; 515(1-2): 94-8.
Lai, YY Siegel, JM Cardiovascular and muscle tone changes produced by microinjection of cholinergic and glutamatergic agonists in dorsolateral pons and medial medulla.. Brain research. . 1990; 514(1): 27-36.
Shouse, MN Siegel, JM Wu, MF Szymusiak, R Morrison, AR Mechanisms of seizure suppression during rapid-eye-movement (REM) sleep in cats.. Brain research. . 1989; 505(2): 271-82.
Suzuki, SS Siegel, JM Wu, MF Role of pontomedullary reticular formation neurons in horizontal head movements: an ibotenic acid lesion study in the cat.. Brain research. . 1989; 484(1-2): 78-93.
Schenkel, E Siegel, JM REM sleep without atonia after lesions of the medial medulla.. Neuroscience letters. . 1989; 98(2): 159-65.
Schenkel, E Siegel, JM REM sleep without atonia after lesions of the medial medulla.. Neuroscience letters. . 1989; 98(2): 159-65.
Schenkel, E Siegel, JM REM sleep without atonia after lesions of the medial medulla.. Neuroscience letters. . 1989; 98(2): 159-65.
Schenkel, E Siegel, JM REM sleep without atonia after lesions of the medial medulla.. Neuroscience letters. . 1989; 98(2): 159-65.
Nienhuis, R Siegel, JM Analysis of head movement and position using hall effect devices.. Physiology & behavior. . 1989; 45(1): 199-203.
Siegel, JM Tomaszewski, KS Fahringer, H Cave, G Kilduff, T Dement, WC Heart rate and blood pressure changes during sleep-waking cycles and cataplexy in narcoleptic dogs.. The American journal of physiology. . 1989; 256(1 Pt 2): H111-9.
Lai, YY Siegel, JM Medullary regions mediating atonia.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1988; 8(12): 4790-6.
Siegel, JM Rogawski, MA A function for REM sleep: regulation of noradrenergic receptor sensitivity.. Brain research. . 1988; 472(3): 213-33.
Wu, MF Suzuki, SS Siegel, JM Anatomical distribution and response patterns of reticular neurons active in relation to acoustic startle.. Brain research. . 1988; 457(2): 399-406.
Shiromani, PJ Siegel, JM Tomaszewski, KS McGinty, DJ Alterations in blood pressure and REM sleep after pontine carbachol microinfusion.. Experimental neurology. . 1986; 91(2): 285-92.
Suzuki, SS Siegel, JM Reticular formation neurons related to tongue movement in the behaving cat.. Experimental neurology. . 1985; 89(3): 689-97.
Siegel, JM Nienhuis, R Tomaszewski, KS REM sleep signs rostral to chronic transections at the pontomedullary junction.. Neuroscience letters. . 1984; 45(3): 241-6.
Siegel, JM Tomaszewski, KS Behavioral organization of reticular formation: studies in the unrestrained cat. I. Cells related to axial, limb, eye, and other movements.. Journal of neurophysiology. . 1983; 50(3): 696-716.
Siegel, JM Tomaszewski, KS Wheeler, RL Behavioral organization of reticular formation: studies in the unrestrained cat. II. Cells related to facial movements.. Journal of neurophysiology. . 1983; 50(3): 717-23.
Siegel, JM Nienhuis, R Tomaszewski, KS Rostral brainstem contributes to medullary inhibition of muscle tone.. Brain research. . 1983; 268(2): 344-8.
Siegel, JM Nienhuis, R Wheeler, RL McGinty, DJ Harper, RM Discharge pattern of reticular formation unit pairs in waking and REM sleep.. Experimental neurology. . 1981; 74(3): 875-91.
Siegel, JM Wheeler, RL Breedlove, SM McGinty, DJ Brain stem units related to movements of the pinna.. Brain research. . 1980; 202(1): 183-8.
Siegel, JM Wheeler, RL McGinty, DJ Activity of medullary reticular formation neurons in the unrestrained cat during waking and sleep.. Brain research. . 1979; 179(1): 49-60.
Siegel, JM Behavioral relations of medullary reticular formation cells.. Experimental neurology. . 1979; 65(3): 691-8.
Siegel, JM Sterman, MB Ross, S Automatic detection and operant reinforcement of slow potential shifts.. Physiology & behavior. . 1979; 23(2): 411-3.
Siegel, JM Breedlove, SM McGinty, DJ Photographic analysis of relation between unit activity and movement.. Journal of neuroscience methods. . 1979; 1(2): 159-64.
Bowersox, SS Siegel, JM Sterman, MB Effects of restraint on electroencephalographic variables and monomethylhydrazine-induced seizures in the cat.. Experimental neurology. . 1978; 61(1): 154-64.
Siegel, JM McGinty, DJ Breedlove, SM Sleep and waking activity of pontine gigantocellular field neurons.. Experimental neurology. . 1977; 56(3): 553-73.
Siegel, JM McGinty, DJ Pontine reticular formation neurons: relationship of discharge to motor activity.. Science. . 1977; 196(4290): 678-80.
Siegel, JM REM sleep predicts subsequent food intake.. Physiology & behavior. . 1975; 15(5): 399-403.
Siegel, JM A stereotaxic map of the bony tentorium of the cat.. Physiology & behavior. . 1974; 13(5): 715-7.
Siegel, JM Coleman, PD Riesen, AH Pattern evoked response deficiency in pattern deprived cats.. Electroencephalography and clinical neurophysiology. . 1973; 35(6): 569-73.
Zeigler, HP Green, HL Siegel, J Food and water intake and weight regulation in the pigeon.. Physiology & behavior. . 1972; 8(1): 127-34.