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Brain Tumor Translational Resource
Pathology and Laboratory Medicine,
Brain Research Institute,
JCCC Signal Transduction and Therapeutics Program Area
The overarching goal of our lab is to improve the delivery and quality of neuropathology diagnoses ultimately enhancing the ability of patients and clinicians to make better decisions on therapy in a timely fashion. The main thrust of the lab is studying biomarkers in surgical and autopsy brain tumor tissues to predict response to therapy. In close co-operation with others in the UCLA brain tumor program, we hope to translate these findings into individualized treatment profiles for each brain tumor patient by amalgamating biomarker results with the standard histopathologic diagnoses in pathology reports. A secondary area of interest is the development of software that will improve the ease of tracking pathology specimens. As neuropathology laboratories move a substantial volume of materials inside and outside of the medical center for special studies and consultations, good tracking systems are important for timely delivery of materials for processing and to prevent loss of vital clinical specimens. In addition, I provide pathology support to the Alzheimer Disease Center and the SPOTRIAS (Stroke) Center research programs.
Dr. Yong obtained a bachelors degree in molecular biology at UC Berkeley and a masters degree in biology (cellular and molecular) at San Francisco State University. For the masters degree, he studied the AIDS retrovirus while in the laboratory of Professor Jay Levy at UCSF. He attended medical school at UCLA where he completed his Honors thesis research with Professor Harry Vinters and graduated as a Deans Scholar. He trained in Pathology and Laboratory Medicine at Massachusetts General Hospital, Harvard Medical School, where he worked in the molecular neuro-oncology laboratory of Dr. David Louis. For his work there, Dr. Yong was awarded the American Association of Neuropathologists Lucien J. Rubinstein Award in Neuro-oncology. He completed his neuropathology fellowship at UCLA. Subsequently, he was the Director of Neuropathology at Cedars-Sinai Medical Center for eight years before returning to the UCLA Medical Center. He is currently Director of the UCLA Brain Tumor Translational Resource and of the UCLA Neuropathology Fellowship Program. Along with Drs. R. Mehta, H. Vinters and others, he is a recent co-awardeee of the Moore Award from the American Association of Neuropathologists.
Dr. Yong is Professor of Pathology and Laboratory Medicine and serves on the editorial boards of the Journal of Neuro-oncology and the Journal of Chinese Clinical Medicine. He teaches UCLA medical and dental students as well as residents and fellows in pathology, neuropathology, neurosurgery, and neurology. As an attending neuropathologist at the UCLA Medical Center, his clinical expertise includes brain and pituitary tumors as well as neuromuscular pathology. He works closely with UCLA Neurosurgery and Neuro-oncology physicians in determining diagnoses and molecular testing of brain tumor samples. He also consults in neuropathology for the West Los Angeles Veterans Administration Hospital, Northridge Hospital, Kaiser-Permanente Southern California, and the National Neurologic AIDS Bank. He runs the Brain Tumor Translational Resource (BTTR)- a brain tumor biorepository dedicated to a cure for brain cancers. The focus of this resource is to develop the tools and logistics to power a broad range of brain tumor research labs in the UCLA Neuro-oncology program. He has an interest in biospecimen research to improve the usability of tissue specimens for biomarker assays and individualized molecular profiling for patients. The lab also focuses on ways to speed the delivery of specimen derivatives to researchers. His laboratory has an interest in pathology informatics including software and RFID technology. It also evaluates and develops approaches for storing biospecimens at room temperature. He is a co-investigator and neuropathologist in research programs on brain tumors, AIDS, stroke, and dementia.
Buchbinder David, Danielpour Moise, Yong William H, Salamon Noriko, Lasky Joseph Treatment of atypical central neurocytoma in a child with high dose
chemotherapy and autologous stem cell rescue.
Journal of neuro-oncology
Butte Pramod V, Fang Qiyin, Jo Javier A, Yong William H, Pikul Brian K, Black Keith L, Marcu Laura Intraoperative delineation of primary brain tumors using time-resolved
Journal of biomedical optics
Mehta Rupal I, Mehta Rashi I, Fishbein Michael C, Solis Orestes E, Jahan Reza, Salamon Noriko, Vinters Harry V, Yong William H Intravascular polymer material after coil embolization of a giant
Mehta Rupal I, Cutler Aaron R, Lasky Joseph L, Yong William H, Lerner Jason T, Hirota Brandon K, Salamon Noriko, Mathern Gary W, Vinters Harry V "Primary" leptomeningeal medulloblastoma.
Khanlou Négar, Mathern Gary W, Mitchell Wendy G, Salamon Noriko, Pope Whitney B, Yong William H, Vinters Harry V Cortical dysplasia with prominent Rosenthal fiber formation in a case
of intractable pediatric epilepsy.
Lerner Jason T, Salamon Noriko, Hauptman Jason S, Velasco Tonicarlo R, Hemb Marta, Wu Joyce Y, Sankar Raman, Donald Shields W, Engel Jerome, Fried Itzhak, Cepeda Carlos, Andre Veronique M, Levine Michael S, Miyata Hajime, Yong William H, Vinters Harry V, Mathern Gary W Assessment and surgical outcomes for mild type I and severe type II
cortical dysplasia: a critical review and the UCLA experience.
Sarkar Rajashree, Yong William H, Lazareff Jorge A A case report of intraventricular gliofibroma.
Guo Deliang, Prins Robert M, Dang Julie, Kuga Daisuke, Iwanami Akio, Soto Horacio, Lin Kelly Y, Huang Tiffany T, Akhavan David, Hock M Benjamin, Zhu Shaojun, Kofman Ava A, Bensinger Steve J, Yong William H, Vinters Harry V, Horvath Steve, Watson Andrew D, Kuhn John G, Robins H Ian, Mehta Minesh P, Wen Patrick Y, DeAngelis Lisa M, Prados Michael D, Mellinghoff Ingo K, Cloughesy Timothy F, Mischel Paul S EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant
pathway sensitizes glioblastomas to antilipogenic therapy.
Laks Dan R, Masterman-Smith Michael, Visnyei Koppany, Angenieux Brigitte, Orozco Nicholas M, Foran Ian, Yong William H, Vinters Harry V, Liau Linda M, Lazareff Jorge A, Mischel Paul S, Cloughesy Timothy F, Horvath Steve, Kornblum Harley I Neurosphere formation is an independent predictor of clinical outcome
in malignant glioma.
Stem cells (Dayton, Ohio)
Brown Paul D, Krishnan Sunil, Sarkaria Jann N, Wu Wenting, Jaeckle Kurt A, Uhm Joon H, Geoffroy Francois J, Arusell Robert, Kitange Gaspar, Jenkins Robert B, Kugler John W, Morton Roscoe F, Rowland Kendrith M, Mischel Paul, Yong William H, Scheithauer Bernd W, Schiff David, Giannini Caterina, Buckner Jan C, Buckner Jan C Phase I/II trial of erlotinib and temozolomide with radiation therapy
in the treatment of newly diagnosed glioblastoma multiforme: North
Central Cancer Treatment Group Study N0177.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology
Lai Albert, Filka Emese, McGibbon Bruce, Nghiemphu Phioanh Leia, Graham Carrie, Yong William H, Mischel Paul, Liau Linda M, Bergsneider Marvin, Pope Whitney, Selch Michael, Cloughesy Tim Phase II pilot study of bevacizumab in combination with temozolomide
and regional radiation therapy for up-front treatment of patients with
newly diagnosed glioblastoma multiforme: interim analysis of safety
International journal of radiation oncology, biology, physics
Jahan Reza, Stewart Daphne, Vinters Harry V, Yong William, Vinuela Fernando, Vandeberg Pete, Marder Victor J Middle cerebral artery occlusion in the rabbit using selective
angiography: application for assessment of thrombolysis.
Stroke; a journal of cerebral circulation
Yoshimoto Koji, Dang Julie, Zhu Shaojun, Nathanson David, Huang Tiffany, Dumont Rebecca, Seligson David B, Yong William H, Xiong Zhenggang, Rao Nagesh, Winther Henrik, Chakravarti Arnab, Bigner Darell D, Mellinghoff Ingo K, Horvath Steve, Cavenee Webster K, Cloughesy Timothy F, Mischel Paul S Development of a real-time RT-PCR assay for detecting EGFRvIII in
Clinical cancer research : an official journal of the American Association for Cancer Research
Lelievre Vincent, Seksenyan Akop, Nobuta Hiroko, Yong William H, Chhith Seririthanar, Niewiadomski Pawel, Cohen Joseph R, Dong Hongmei, Flores Avegail, Liau Linda M, Kornblum Harley I, Scott Matthew P, Waschek James A Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant
Wang Jingjing, Yong William H, Sun Yinghua, Vernier P Thomas, Koeffler H Phillip, Gundersen Martin A, Marcu Laura Receptor-targeted quantum dots: fluorescent probes for brain tumor
Journal of biomedical optics
Lim Stephen, Shahinian Hrayr, Maya Menahem M, Yong William, Heaney Anthony P Temozolomide: a novel treatment for pituitary carcinoma.
The lancet oncology
Butte Pramod V, Pikul Brian K, Hever Aviv, Yong William H, Black Keith L, Marcu Laura Diagnosis of meningioma by time-resolved fluorescence spectroscopy.
Journal of biomedical optics
Scoles Daniel R, Yong William H, Qin Yun, Wawrowsky Kolja, Pulst Stefan Matthias Schwannomin inhibits tumorigenesis through direct interaction with the
eukaryotic initiation factor subunit c (eIF3c).
Human molecular genetics
Yong William H, Butte Pramod V, Pikul Brian K, Jo Javier A, Fang Qiyin, Papaioannou Thanassis, Black Keith, Marcu Laura Distinction of brain tissue, low grade and high grade glioma with
time-resolved fluorescence spectroscopy.
Frontiers in bioscience : a journal and virtual library
Marcu Laura, Jo Javier A, Butte Pramod V, Yong William H, Pikul Brian K, Black Keith L, Thompson Reid C Fluorescence lifetime spectroscopy of glioblastoma multiforme.
Photochemistry and photobiology
Yu John S, Liu Gentao, Ying Han, Yong William H, Black Keith L, Wheeler Christopher J Vaccination with tumor lysate-pulsed dendritic cells elicits
antigen-specific, cytotoxic T-cells in patients with malignant glioma.
Ehtesham Moneeb, Kabos Peter, Yong William H, Schievink Wouter I, Black Keith L, Yu John S Development of an intracranial ependymoma at the site of a
pre-existing cavernous malformation.
80-2; discussion 83.
Schievink Wouter I, Thompson Reid C, Yong William H A syndrome of spontaneous cerebral and cervical artery dissections
with angiolipomatosis. Report of two cases.
Journal of neurosurgery
Ben-Shlomo Anat, Miklovsky Irina, Ren Song-Guang, Yong William H, Heaney Anthony P, Culler Michael D, Melmed Shlomo Leukemia inhibitory factor regulates prolactin secretion in
prolactinoma and lactotroph cells.
The Journal of clinical endocrinology and metabolism
Heaney Anthony P, Fernando Manory, Yong William H, Melmed Shlomo Functional PPAR-gamma receptor is a novel therapeutic target for
ACTH-secreting pituitary adenomas.