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Rajesh Kumar, Ph.D.

Email Address:
rkumar@mednet.ucla.edu

Department Address:
Departments of Anesthesiology and Radiological Sciences
56-132 CHS
10833 Le Conte Av
University of California at Los Angeles
Los Angeles, CA 90095
UNITED STATES

Office Phone Number:
310-206-1679
310-206-6133



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Department / Division Affiliations
Assistant Professor In-Residence, Brain Research Institute, Neuroscience IDP

Research Interest:

Evaluation of neural tissue integrity, resulting from breathing or cardiovascular effects, in brain areas of patients with obstructive sleep apnea (OSA) and heart failure (HF), which helps us to understand the brain processes by which autonomic, memory, and mood regulations are affected in these conditions

I have doctoral degree in Radiology, with expertise in various magnetic resonance imaging (MRI) and spectroscopy procedures. My current research involves the evaluation of neural tissue integrity, resulting from breathing or cardiovascular effects, in brain areas of patients with obstructive sleep apnea (OSA) and heart failure (HF), which helps us to understand the brain processes by which autonomic, memory, and mood regulations are affected in these conditions. I have used magnetic resonance spectroscopy (MRS) and various MRI procedures, including high-resolution T1-weighted imaging, T2-relaxometry, magnetization transfer imaging, diffusional kurtosis imaging, diffusion tensor imaging, arterial spin labeling, and functional magnetic resonance imaging to assist in the localization of abnormal brain regions and assess neural activity in patients with OSA and HF. I demonstrated that HF patients show brain injury in autonomic, mood, and cognitive regulatory areas, differentiated different types of white matter injury (axonal or myelin injury), and showed that HF subjects even show more neural damage than OSA patients, particularly in brain areas that serve memory functions and which, if damaged, can contribute to depression. I seek to determine the onset of the neural damage in HF and OSA, the specific cardiovascular or breathing effects that the damage could exert, and the extent of progression as the syndrome continues. These findings could lead to preventative measures before the severe consequences, such as hypertension, stroke, and daytime hypersomnia in OSA patients, and autonomic, mood, and cognitive deficits including memory issues in HF patients. The potential value is both the early identification of problems, which leads to earlier treatment, and a greater understanding of the causes of HF and OSA.

Publications:

Richardson Heidi L, Macey Paul M, Kumar Rajesh, Valladares Edwin M, Woo Mary A, Harper Ronald M Neural and physiological responses to a cold pressor challenge in healthy adolescents. Journal of neuroscience research. 2013; 91(12): 1618-27.
Macey Paul M, Kumar Rajesh, Woo Mary A, Yan-Go Frisca L, Harper Ronald M Heart rate responses to autonomic challenges in obstructive sleep apnea. PloS one. 2013; 8(10): e76631.
Yadav Santosh K, Kumar Rajesh, Macey Paul M, Richardson Heidi L, Wang Danny J J, Woo Mary A, Harper Ronald M Regional cerebral blood flow alterations in obstructive sleep apnea. Neuroscience letters. 2013; 555(12): 159-64.
Harper Ronald M, Kumar Rajesh, Ogren Jennifer A, Macey Paul M Sleep-disordered breathing: effects on brain structure and function. Respiratory physiology & neurobiology. 2013; 188(3): 383-91.
Kumar Rajesh, Harper Ronald M Response. Journal of magnetic resonance imaging : JMRI. 2013; 38(2): 506-7.
Kumar Rajesh, Chavez Alexa S, Macey Paul M, Woo Mary A, Harper Ronald M Brain axial and radial diffusivity changes with age and gender in healthy adults. Brain research. 2013; 1512(2): 22-36.
Pan Alan, Kumar Rajesh, Macey Paul M, Fonarow Gregg C, Harper Ronald M, Woo Mary A Visual assessment of brain magnetic resonance imaging detects injury to cognitive regulatory sites in patients with heart failure. Journal of cardiac failure. 2013; 19(2): 94-100.
Ogren Jennifer A, Macey Paul M, Kumar Rajesh, Fonarow Gregg C, Hamilton Michele A, Harper Ronald M, Woo Mary A Impaired cerebellar and limbic responses to the valsalva maneuver in heart failure. Cerebellum (London, England). 2012; 11(4): 931-8.
Macey Paul M, Kumar Rajesh, Yan-Go Frisca L, Woo Mary A, Harper Ronald M Sex differences in white matter alterations accompanying obstructive sleep apnea. Sleep. 2012; 35(12): 1603-13.
Kumar Rajesh, Chavez Alexa S, Macey Paul M, Woo Mary A, Yan-Go Frisca L, Harper Ronald M Altered global and regional brain mean diffusivity in patients with obstructive sleep apnea. Journal of neuroscience research. 2012; 90(10): 2043-52.
Harper Ronald M, Kumar Rajesh, Macey Paul M, Ogren Jennifer A, Richardson Heidi L Functional neuroanatomy and sleep-disordered breathing: implications for autonomic regulation. Anatomical record (Hoboken, N.J. : 2007). 2012; 295(9): 1385-95.
Macey Paul M, Moiyadi Ammar S, Kumar Rajesh, Woo Mary A, Harper Ronald M Decreased cortical thickness in central hypoventilation syndrome. Cerebral cortex (New York, N.Y. : 1991). 2012; 22(8): 1728-37.
Kumar Rajesh, Woo Marlyn S, Macey Paul M, Woo Mary A, Harper Ronald M Progressive gray matter changes in patients with congenital central hypoventilation syndrome. Pediatric research. 2012; 71(6): 701-6.
Macey Paul M, Wu Paula, Kumar Rajesh, Ogren Jennifer A, Richardson Heidi L, Woo Mary A, Harper Ronald M Differential responses of the insular cortex gyri to autonomic challenges. Autonomic neuroscience : basic & clinical. 2012; 168(1-2): 72-81.
Kumar Rajesh, Nguyen Haidang D, Macey Paul M, Woo Mary A, Harper Ronald M Regional brain axial and radial diffusivity changes during development. Journal of neuroscience research. 2012; 90(2): 346-55.
Kumar Rajesh, Woo Mary A, Macey Paul M, Fonarow Gregg C, Hamilton Michele A, Harper Ronald M Brain axonal and myelin evaluation in heart failure. Journal of the neurological sciences. 2011; 307(1-2): 106-13.
Kumar Rajesh, Nguyen Haidang D, Ogren Jennifer A, Macey Paul M, Thompson Paul M, Fonarow Gregg C, Hamilton Michele A, Harper Ronald M, Woo Mary A Global and regional putamen volume loss in patients with heart failure. European journal of heart failure. 2011; 13(6): 651-5.
Kumar R, Macey P M, Woo M A, Harper R M Selectively diminished corpus callosum fibers in congenital central hypoventilation syndrome. Neuroscience. 2011; 178(6): 261-9.
Kumar Rajesh, Delshad Sean, Macey Paul M, Woo Mary A, Harper Ronald M Development of T2-relaxation values in regional brain sites during adolescence. Magnetic resonance imaging. 2011; 29(2): 185-93.
Kumar Rajesh, Macey Paul M, Woo Mary A, Harper Ronald M Rostral brain axonal injury in congenital central hypoventilation syndrome. Journal of neuroscience research. 2010; 88(10): 2146-54.
Singhal Aparna, Nagarajan Rajakumar, Hinkin Charles H, Kumar Rajesh, Sayre James, Elderkin-Thompson Virginia, Huda Amir, Gupta Rakesh K, Han Steven-Huy, Thomas M Albert Two-dimensional MR spectroscopy of minimal hepatic encephalopathy and neuropsychological correlates in vivo. Journal of magnetic resonance imaging : JMRI. 2010; 32(1): 35-43.
Ogren J A, Macey P M, Kumar R, Woo M A, Harper R M Central autonomic regulation in congenital central hypoventilation syndrome. Neuroscience. 2010; 167(4): 1249-56.
Macey Paul M, Kumar Rajesh, Ogren Jennifer A, Woo Mary A, Harper Ronald M Images in sleep medicine. Altered cerebral blood flow in a patient with congenital central hypoventilation syndrome. Sleep medicine. 2010; 11(6): 589-90.
Macey Paul M, Woo Mary A, Kumar Rajesh, Cross Rebecca L, Harper Ronald M Relationship between obstructive sleep apnea severity and sleep, depression and anxiety symptoms in newly-diagnosed patients. PloS one. 2010; 5(4): e10211.
Kumar Rajesh, Nguyen Haidang D, Macey Paul M, Woo Mary A, Harper Ronald M Dilated basilar arteries in patients with congenital central hypoventilation syndrome. Neuroscience letters. 2009; 467(2): 139-43.
Singhal Aparna, Nagarajan Rajakumar, Kumar Rajesh, Huda Amir, Gupta Rakesh K, Thomas M Albert Magnetic resonance T2-relaxometry and 2D L-correlated spectroscopy in patients with minimal hepatic encephalopathy. Journal of magnetic resonance imaging : JMRI. 2009; 30(5): 1034-41.
Kumar R, Ahdout R, Macey P M, Woo M A, Avedissian C, Thompson P M, Harper R M Reduced caudate nuclei volumes in patients with congenital central hypoventilation syndrome. Neuroscience. 2009; 163(4): 1373-9.
Macey Paul M, Richard Christopher A, Kumar Rajesh, Woo Mary A, Ogren Jennifer A, Avedissian Christina, Thompson Paul M, Harper Ronald M Hippocampal volume reduction in congenital central hypoventilation syndrome. PloS one. 2009; 4(7): e6436.
Kumar Rajesh, Lee Kwanoo, Macey Paul M, Woo Mary A, Harper Ronald M Mammillary body and fornix injury in congenital central hypoventilation syndrome. Pediatric research. 2009; 66(4): 429-34.
Woo Mary A, Kumar Rajesh, Macey Paul M, Fonarow Gregg C, Harper Ronald M Brain injury in autonomic, emotional, and cognitive regulatory areas in patients with heart failure. Journal of cardiac failure. 2009; 15(3): 214-23.
Kumar Rajesh, Woo Mary A, Birrer Bramley V X, Macey Paul M, Fonarow Gregg C, Hamilton Michele A, Harper Ronald M Mammillary bodies and fornix fibers are injured in heart failure. Neurobiology of disease. 2009; 33(2): 236-42.
Kumar Rajesh, Macey Paul M, Cross Rebecca L, Woo Mary A, Yan-Go Frisca L, Harper Ronald M Neural alterations associated with anxiety symptoms in obstructive sleep apnea syndrome. Depression and anxiety. 2009; 26(5): 480-91.
Kumar Rajesh, Macey Paul M, Woo Mary A, Alger Jeffry R, Harper Ronald M Diffusion tensor imaging demonstrates brainstem and cerebellar abnormalities in congenital central hypoventilation syndrome. Pediatric research. 2008; 64(3): 275-80.
Cross Rebecca L, Kumar Rajesh, Macey Paul M, Doering Lynn V, Alger Jeffry R, Yan-Go Frisca L, Harper Ronald M Neural alterations and depressive symptoms in obstructive sleep apnea patients. Sleep. 2008; 31(8): 1103-9.
Macey Paul M, Kumar Rajesh, Woo Mary A, Valladares Edwin M, Yan-Go Frisca L, Harper Ronald M Brain structural changes in obstructive sleep apnea. Sleep. 2008; 31(7): 967-77.
Woo Mary A, Macey Paul M, Keens Peter T, Kumar Rajesh, Fonarow Gregg C, Hamilton Michele A, Harper Ronald M Aberrant central nervous system responses to the Valsalva maneuver in heart failure. Congestive heart failure (Greenwich, Conn.). 2008; 13(1): 29-35.
Serber Stacy L, Kumar Rajesh, Woo Mary A, Macey Paul M, Fonarow Gregg C, Harper Ronald M Cognitive test performance and brain pathology. Nursing research. 2008; 57(2): 75-83.
Kumar Rajesh, Birrer Bramley V X, Macey Paul M, Woo Mary A, Gupta Rakesh K, Yan-Go Frisca L, Harper Ronald M Reduced mammillary body volume in patients with obstructive sleep apnea. Neuroscience letters. 2008; 438(3): 330-4.
Kumar Rajesh, Gupta Rakesh K, Elderkin-Thompson Virginia, Huda Amir, Sayre James, Kirsch Claudia, Guze Barry, Han Steve, Thomas M Albert Voxel-based diffusion tensor magnetic resonance imaging evaluation of low-grade hepatic encephalopathy. Journal of magnetic resonance imaging : JMRI. 2008; 27(5): 1061-8.
Kumar Rajesh, Macey Paul M, Woo Mary A, Alger Jeffry R, Harper Ronald M Elevated mean diffusivity in widespread brain regions in congenital central hypoventilation syndrome. Journal of magnetic resonance imaging : JMRI. 2006; 24(6): 1252-8.
Woo Mary A, Macey Paul M, Keens Peter T, Kumar Rajesh, Fonarow Gregg C, Hamilton Michele A, Harper Ronald M Functional abnormalities in brain areas that mediate autonomic nervous system control in advanced heart failure. Journal of cardiac failure. 2005; 11(6): 437-46.
Kumar Rajesh, Macey Paul M, Woo Mary A, Alger Jeffry R, Keens Thomas G, Harper Ronald M Neuroanatomic deficits in congenital central hypoventilation syndrome. The Journal of comparative neurology. 2005; 487(4): 361-71.
Agarwal Atul, Raghav Sanjay, Husain Mazhar, Kumar Rajesh, Gupta Rakesh K Epilepsy with focal cerebral calcification: role of magnetization transfer MR imaging. Neurology India. 2004; 52(2): 197-9.
Chawla S, Kumar S, Garg M, Kumar R, Roy R, Gupta R K Metabolite pattern of Cysticercus cellulosae metacestode from different predilection sites of swine using proton magnetic resonance spectroscopy. Parasite (Paris, France). 2004; 11(2): 161-7.
Macey Paul M, Macey Katherine E, Kumar Rajesh, Harper Ronald M A method for removal of global effects from fMRI time series. NeuroImage. 2004; 22(1): 360-6.
Garg Monika, Gupta Rakesh K, Husain Mazhar, Chawla Sanjeev, Chawla Jayant, Kumar Rajesh, Rao Sajja B, Misra Mithlesh K, Prasad Kashi N Brain abscesses: etiologic categorization with in vivo proton MR spectroscopy. Radiology. 2004; 230(2): 519-27.
Chawla Sanjeev, Gupta Rakesh K, Husain Nuzhat, Garg Monika, Kumar Rajesh, Kumar Sunil Prediction of viability of porcine neurocysticercosis with proton magnetic resonance spectroscopy: correlation with histopathology. Life sciences. 2004; 74(9): 1081-92.
Macey Paul M, Alger Jeffry R, Kumar Rajesh, Macey Katherine E, Woo Mary A, Harper Ronald M Global BOLD MRI changes to ventilatory challenges in congenital central hypoventilation syndrome. Respiratory physiology & neurobiology. 2003; 139(1): 41-50.
Prasad Narayan, Gulati Sanjeev, Gupta Rakesh Kumar, Kumar Rajesh, Sharma Kumudini, Sharma Raj Kumar Is reversible posterior leukoencephalopathy with severe hypertension completely reversible in all patients?. Pediatric nephrology (Berlin, Germany). 2003; 18(11): 1161-6.
Kumar Rajesh, Gupta Rakesh K, Rao Sajja B, Chawla Sanjeev, Husain Mazhar, Rathore Ram K S Magnetization transfer and T2 quantitation in normal appearing cortical gray matter and white matter adjacent to focal abnormality in patients with traumatic brain injury. Magnetic resonance imaging. 2003; 21(8): 893-9.
Pradhan S, Kumar R, Gupta R K Intermittent symptoms in neurocysticercosis: could they be epileptic?. Acta neurologica Scandinavica. 2003; 107(4): 260-6.
Kumar Rajesh, Gupta Rakesh K, Husain Mazhar, Vatsal Davender K, Chawla Sanjeev, Rathore Ram Kishore S, Pradhan Sunil Magnetization transfer MR imaging in patients with posttraumatic epilepsy. AJNR. American journal of neuroradiology. 2003; 24(2): 218-24.
Gupta Rakesh K, Kumar Rajesh, Chawla Sanjeev, Pradhan Sunil Demonstration of scolex within calcified cysticercus cyst: its possible role in the pathogenesis of perilesional edema. Epilepsia. 2002; 43(12): 1502-8.
Chawla S, Gupta R K, Kumar R, Garg M, Pradhan S, Pal L, Husain N, Gupta A, Rathore R K S Demonstration of scolex in calcified cysticercus lesion using gradient echo with or without corrected phase imaging and its clinical implications. Clinical radiology. 2002; 57(9): 826-34.
Garg Monika, Chawla Sanjeev, Prasad Kashi N, Roy Raja, Sikora Sadiq S, Kumar Rajesh, Husain Mazhar, Khetrapal C L, Gupta Rakesh K Differentiation of hydatid cyst from cysticercus cyst by proton MR spectroscopy. NMR in biomedicine. 2002; 15(5): 320-6.
Garg Monika, Gupta Rakesh K, Prasad Kashi N, Sikora Sadiq S, Pal Lily, Chawla Sanjeev, Kumar Rajesh, Husain Mazhar, Saxena Sudhir, Husain Nuzhat, Roy Raja Fertility assessment of hydatid cyst by proton MR spectroscopy. The Journal of surgical research. 2002; 106(1): 196-201.
Malik G K, Pandey M, Kumar R, Chawla S, Rathi B, Gupta R K MR imaging and in vivo proton spectroscopy of the brain in neonates with hypoxic ischemic encephalopathy. European journal of radiology. 2002; 43(1): 6-13.
Gupta Rakesh K, Husain Mazhar, Vatsal Devendra K, Kumar Rajesh, Chawla Sanjeev, Husain Nuzhat Comparative evaluation of magnetization transfer MR imaging and in-vivo proton MR spectroscopy in brain tuberculomas. Magnetic resonance imaging. 2002; 20(5): 375-81.
Kumar R, Gupta R K, Rathore R K S, Rao S B, Chawla S, Pradhan S Multiparametric quantitation of the perilesional region in patients with healed or healing solitary cysticercus granuloma. NeuroImage. 2002; 15(4): 1015-20.
Gupta R K, Rao S B, Jain R, Pal L, Kumar R, Venkatesh S K, Rathore R K Differentiation of calcification from chronic hemorrhage with corrected gradient echo phase imaging. Journal of computer assisted tomography. 2001; 25(5): 698-704.
Gupta R K, Vatsal D K, Husain N, Chawla S, Prasad K N, Roy R, Kumar R, Jha D, Husain M Differentiation of tuberculous from pyogenic brain abscesses with in vivo proton MR spectroscopy and magnetization transfer MR imaging. AJNR. American journal of neuroradiology. 2001; 22(8): 1503-9.