Site Search



Karen Gylys, Ph.D.

Email Address:
kgylys@sonnet.ucla.edu

Work Address:
Office
Factor Building
Los Angeles, CA 90095
UNITED STATES

Work Phone Number:
310 794-5472
310-206-3840



Login to the Faculty Database

Department / Division Affiliations
Associate Professor, School of Nursing
Member, Neuroscience IDP, Brain Research Institute

Bio:

Karen Hoppens Gylys is a neuroscientist who joined the faculty of the School of Nursing and the Brain Research Institute in 1998. Dr. Gylys earned a B.S. degree in Nursing and a M.S. degree in Human Development at the University of Texas, Dallas. She received her Ph.D. in Neuroscience, with a major in neuropharmacology, at UCLA in 1993, and did postdoctoral work on molecular mechanisms of opioid tolereance in the NPI. Since joining the faculty of the School of Nursing, she has taught pharmacology and research in the School of Nursing and is actively involved in the BRI. Her laboratory research is focused on understanding the dysfunction and loss of synapses that occurs in Alzheimer's disease, which is thought to underlie the earliest cognitive impairments.

Publications:

Gylys, Karen H., Fein, Jeffrey A, Yang, F, and Cole, Gregory M. Enrichment of pre- and post-synaptic markers by size-based gating analysis of synaptosome preparations from rat and human cortex.. Cytometry Part A ; 60: 90-96.
Ringman JM, Younkin SG, Pratico D, Seltzer W, Cole GM, Geshwind DH, Rodriguez-Agudelo Y, Schaffer B, Fein J, Sokolow S, Rosario ER, Gylys KH, Varpetian A, Medina LD, Cummings JL. Biochemical markers in persons with preclinical familial Alzheimer disease. Neurology 2008; 71(1): 85-92.
Fein JA, Sokolow S, Miller CA, Vinters HV, Yang F, Cole GM , Gylys KH Co-localization of amyloid beta and tau pathology in Alzheimer?s disease synaptosomes. The American Journal of Pathology. 2008; 172(6): 1682-1691.
Gylys Karen H., Fein Jeffrey A., Yang Fusheng, Miller Carol A., Cole Gregory M. Increased Cholesterol in Amyloid beta-positive Nerve terminals from Alzheimers Disease Cortex. Neurobiology of Aging 2007; 28: 8-17.
Gylys, KH, Fein JA, Tan AM, Cole GM Apolipoprotein E enhances uptake of soluble but not aggregated amyloid-beta into synaptic terminals.. J. Neurochem. 2003; 84: 1442-1451.
Cole, G.M. and Gylys, K.H. Detection and analysis of synaptosis. Neuromethods, Vol. 37: Apoptosis techniques and Protocols, 2nd Ed., (LeBlanc A.C., ed.) Humana Press, Inc., Totowa NJP. 2002; .
Gylys, Karen H., Fein, Jeffrey A and Cole, Gregory M. Flow cytometric analysis of a crude synaptosomal fraction (P-2) from rat brain. Journal of Neurosci Res. Journal of Neurosci Res 2000; 61(8): 186-192.
Gylys, KH Fein, JA Yang, F Wiley, DJ Miller, CA Cole, GM Synaptic changes in Alzheimer's disease: increased amyloid-beta and gliosis in surviving terminals is accompanied by decreased PSD-95 fluorescence.. The American Journal of Pathology. . 2004; 165(5): 1809-17.