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Gerry Weinmaster, Ph.D.

Work Email Address:
gweinmaster@mednet.ucla.edu

Work Address:
Laboratory
354-06 BSRB
Los Angeles, CA 90095
UNITED STATES

Office
390A BSRB
Los Angeles, CA 90095
UNITED STATES

Work Phone Number:
(310) 206-8400
(310) 206-9446



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Department / Division Affiliations
Professor, Biological Chemistry
Member, ACCESS Program: Dept. of Biological Chemistry, Brain Research Institute, JCCC Cancer and Stem Cell Biology Program Area

Research Interest:

Notch Signaling in Mammalian Cells

<p>The Weinmaster laboratory is defining the mechanisms of ligand-induced Notch signaling. The Notch pathway is a cell-to-cell communication system used by multi-cellular organisms to ensure the correct cell types form at a precise time and location in the body. Remarkably, this system is used over and over again during the formation of almost every cell type. Given the extensive requirement for Notch, it is not surprising that defects in this signaling pathway are associated with a number of inherited human disorders and cancer. The potential use of Notch agonists and antagonists as therapeutic agents underscores the importance of defining the molecular basis of Notch signaling. Dr. Weinmasterís lab has contributed to the understanding of Notch signaling through the cloning of multiple Notch receptors and ligands that are cell surface proteins that promote direct cell-cell interactions. Notch ligands activate signaling through a remarkable mechanism that involves proteolytic release of the Notch intracellular domain (NICD) that moves to the nucleus and activates Notch target gene expression. Notch activation must be tightly controlled because inappropriate signaling causes developmental defects and cancer. In the absence of activating ligand, Notch is folded into a protease-resistant conformation that structural studies suggest masks or protects the proteolytic cleavage site. Ligand binding alone is not sufficient to activate Notch, and subsequent endocytosis by the ligand cell is necessary for ligands to activate signaling. Based on these findings, a pulling force model has been proposed in which following ligand binding to Notch ligand endocytosis generates a pulling force to unfold Notch and allow activating proteolysis for downstream signaling. Consistent with this model, the Weinmaster lab has imaged the transfer of the Notch extracellular domain from the Notch cell to the ligand cell, and accumulation of the NICD in the nucleus of the Notch cell. Using optical tweezers, the group has recently obtained biophysical evidence that ligand cells do indeed generate mechanical force when bound to Notch. Importantly, the same endocytic components required for ligand cells to activate Notch signaling are also required for mechanical force, providing compelling support for the pulling force model. Mammalian cell culture assays and mutant mice along with imaging, cell biology, genetic, biochemical and biophysical approaches are being used to characterize Notch signaling. Current areas of research in the laboratory include (i) characterizing the proteolytic cleavage events required for Notch signaling, (ii) identifying components of the endocytic machinery and cytoskeleton required for ligand cells to activate Notch, (iii) developing methods to determine whether mechanical force can pull Notch apart and activate signaling, (iv) characterizing requirements for Notch endocytosis and the cytoskeleton in signaling, and (v) clarifying the role Notch furin processing plays in regulating signaling.</p>

Bio:

Geraldine (Gerry) Weinmaster is a molecular, developmental and cell biologist who has served on the UCLA School of Medicine faculty since joining the Biological Chemistry Department in 1992 as an assistant professor and advancing to a full professor in 2002. Dr. Weinmaster obtained her Ph.D. at the University of British Columbia working with Tony Pawson on oncogenic tyrosine kinases. In collaboration with Michael Smith, who won the 1993 Nobel prize in Chemistry for the use of oligonucleotides in the development of site-directed mutagenesis, they were the first to show that tyrosine phosphorylation is required for both tyrosine kinase and oncogenic activities. She continued her training as a post-doctoral fellow in Tony Hunterís group at the Salk Institute, and later with Greg Lemke where she cloned the mammalian homolog of Drosophila Notch. Her studies also identified the closely related Notch2 providing the first evidence for a family of Notch genes, of which there are now four known members. In her own laboratory at UCLA she cloned the first vertebrate Notch ligand, Jagged1 that is mutated in the inherited developmental syndrome Alagille. Her group has developed an extensive battery of reagents to study mechanisms of ligand-induced Notch signaling using cell culture and mouse mutants. She has received the March of Dimes Basil O'Conner Starter Award, STOP Cancer Research Career Development Award, NIH/NINDS Javits Neuroscience Investigator Award and the UCLA College of Letters and Science Deanís Recognition Award for her studies on Notch signaling in mammalian cells.

Publications:

Miyamoto A and Weinmaster G. Notch Signal Transduction: Molecular and Cellular Mechanisms. In Larry R. Squire, Editor-in-Chief, Encyclopedia of Neuroscience, Academic Press, Oxford 2008; .
Nichols JT and Weinmaster, G. Proteolytic activation of Notch signaling: Roles for ligand endocytosis and mechanotransduction. In Handbook of Cell Signaling, Second Edition, Ed. Bradshaw RA and Dennis EA 2008; .
D'Souza B, Miyamoto A and Weinmaster G. The many facets of Notch ligands. Oncogene 2008; .
Nichols J, Miyamoto A, Olsen S, D???Souza B, Yao C, and Weinmaster G. DSL-ligand endocytosis physically dissociates Notch1 heterodimers prior to activating proteolysis. . Journal of Cell Biology 2007; 176(4): 445-458.
Nichols JT, Miyamoto A, Weinmaster G. Notch signaling--constantly on the move. . Traffic 2007; 8: 959-69.
Weinmaster G. and Kopan R. A garden of Notch-ly delights. 2006; 133: 3277-82.
Miyamoto A, Lau R, Hein PW, Shipley JM, Weinmaster G. Microfibrillar proteins MAGP-1 and MAGP-2 induce Notch1 extracellular domain dissociation and receptor activation. . JBC 2006; 281(15): 10089-97.
Ladi, E., Nichols, J. T., Ge, W., Miyamoto, A., Yao, C., Yang, L-T, Boulter, J., Sun, Y. E., Kintner, C., Weinmaster, G. The divergent DSL ligand Dll3 does not activate Notch signaling but cell-autonomously attenuates signaling induced by other DSL ligands. Jounal of Cell Biology 2005; 170: 983-992.
Irvin DK, Dhaka A, Hicks C, Weinmaster G, Kornblum HI Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures. Developmental neuroscience. . 2003; 25(2-4): 162-72.
Weinmaster G, Kintner C Modulation of notch signaling during somitogenesis. Annual review of cell and developmental biology. . 2003; 19: 367-95.
Patten, B. A., Peyrin, J. M. Weinmaster, G. and Corfas, G. Sequential signaling through Notch1 and erbB receptors mediate radial glia differentiation. J. Neuroscience 2003; 23(14): 6132-6140.
Haritunians, T., Boulter, J., Hicks, C., Buhrman, J., diSibio, G., Shawber, C., Weinmaster, G., Nofziger, D., and Schanen, N. C. (). CADASIL Notch3 mutant proteins localize to the cell surface and bind ligand. . Circulation Res. 2002; 90(5): 506-8..
Hicks, C., Ladi, E., Lindsell, C., Hsieh, J.-D., Hayward, S.D, Collazo, A., and Weinmaster, G. (2002). J. Neurosc. Res. 68 (6): 655-667. A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling. 2002; .
Ge W, Martinowich K, Wu X, He F, Miyamoto A, Fan G, Weinmaster G, Sun YE. Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation. J Neurosci Res 2002; 69(6): 848-60.
McCright, B., X. Gao, L. Shen, J. Lozier, Y. Lan, M. Maguire, D. Herzlinger, G. Weinmaster, R. Jiang and T. Gridley. Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development 2001; 128: 491-502.
JimEnez E, Vicente A, SacedUn R, MuOoz JJ, Weinmaster G, Zapata AG, and Varas A Distinct Mechanisms Contribute to Generate and Change the CD4:CD8 Cell Ratio During Thymus Development: A Role for the Notch Ligand, Jagged1. 2001; 166: 5898-5908.
Irvin DK, Zurcher SD, Nguyen T, Weinmaster G., and Kornblum HI. Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development. . J Comp Neurol 2001; 436: 167-181.
Bush, G., diSibio, G., Miyamoto, A., Denault, J-B., Leduc, R., and Weinmaster, G. Ligand-induced signaling in the absence of furin processing of Notch1. . Developmental Biology 2001; 229(2): 494-502.
Yamamoto N, Yamamoto Si S, Inagaki F, Kawaichi M, Fukamizu A, Kishi N, Matsuno K, Nakamura K, Weinmaster G, Okano H, Nakafuku M. Role of Deltex-1 as a transcriptional regulator downstream of the notch receptor. 2001; 276 (48) : 45031-45040.
Walker L, Carlson A, Tan-Pertel HT, Weinmaster G, Gasson J The notch receptor and its ligands are selectively expressed during hematopoietic development in the mouse. Stem cells (Dayton, Ohio) . 2001; 19(6): 543-52.
Villa, N., Walker, L., Lindsell, C.E., Gasson, J., Iruela-Arispe, M. L., and Weinmaster, G. Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Mech. Dev 2001; 108: 161-164..
Hicks C., Johnston S. H., diSibio G., Collazo A., Vogt T. F., & Weinmaster G. Fringe differentially modulates Jagged1 and Delta1 signaling through Notch1 and Notch2 receptors in mammalian cells. . Nature Cell Biology 2000; 2: 515-520.
Jensen J, Heller RS, Pedersen EE, Funder-Nielsen T, Lindsell C, Weinmaster G, Madsen OD, and erup P Independent development of pancreatic a- and b-cells from neurogenin3 expressing precursors: A role for the Notch pathway in repression of premature differentiation. Diabetes 2000; 49: 163-176.
Uyttendaele H, Closson V, Wu G, Roux F, Weinmaster G & Kitajewski J Notch4 and Jagged1 induce microvessel differentiation of rat brain endothelial cells. Microvascular Res 2000; 60 (2): 91-103.
Berezovska O, Jack C, McLean P, Aster JC, Hicks C, Xia W, Wolfe MS, Taylor Kimberly W, Weinmaster G, Selkoe D & Hyman BT Two transmembrane aspartate mutationin presenilin impair Notch1 proteolysis and nuclear translocation with relative preservation of Notch signaling. J. Neurochem 2000; 75(2): 583-593.
Nofziger D, Miyamoto A, Lyons KM, and Weinmaster G Notch signaling imposes two distinct blocks in the diffentiation of C2C12 myoblasts. Development 1999; 126: 1689-1702..
Lanford PJ, Lan Y, Jiang R, Lindsell C, Weinmaster G, Gridley T, and Kelley MW Regulation of hair cell development in the mammalian cochlea by the Notch ligand Jagged2. Nature Genetics 1999; 21 (3): 289-292.
Walker L, Lynch M, Silverman S, Fraser J, Boulter J, Weinmaster G, Gasson JC The Notch/Jagged pathway inhibits proliferation of human hematopoietic progenitors in vitro. Stem cells (Dayton, Ohio) . 1999; 17(3): 162-71.
Weinmaster G Notch Signaling: Direct or what?. Curr. Opin Genetics and Development 1998; 8: 436-442...
Hsieh J, J-D Nofziger D, Weinmaster G, and Hayward D EBV Immortalization: Notch2 interacts with CBF1. J. Virology 1997; 71 (3): 1616-1625.
Lan Y, Jiang R, Shawber C, Weinmaster G, Gridley T The Jagged2 gene maps to chromosome 12 and is a candidate for the lgl and sm mutations. Mammalian genome : official journal of the International Mammalian Genome Society. . 1997; 8(11): 875-6.
Weinmaster G The ins and outs of notch signaling. Molecular and cellular neurosciences. . 1997; 9(2): 91-102.
Lindsell CE, Boulter J, diSibio G, Gossler A, Weinmaster G Expression patterns of Jagged, Delta1, Notch1, Notch2, and Notch3 genes identify ligand-receptor pairs that may function in neural development. Molecular and cellular neurosciences. . 1996; 8(1): 14-27.
Shawber CJ, Boulter J, Lindsell CE, and Weinmaster G Jagged2: A Serrate-related gene expressed during rat embryogenesis. Developmental Biology 1996; 180: 370-376.
Shawber C, Nofziger D, Lindsell C, Hsieh J, J-D Bogler O, Hayward D, and Weinmaster G Notch signaling inhibits muscle cell differentiation through a CBF1-independent pathway. Development 1996; 122: 3775-3784.
Feinstein DL, Weinmaster GA and Milner RJ Isolation of cDNA clones encoding rat glial fibrillary acidic protein: Expression in astrocytes and in Schwann cells. J. Neurosci. Res 1992; 31: 110-124.
Weinmaster G, Roberts V and Lemke G Notch 2: a second mammalian Notch gene. Development 1992; 116: 931-941.
Lemke G, Kuhn R, Monuki ES, Weinmaster G Expression and activity of the transcription factor SCIP during glial differentiation and myelination. Annals of the New York Academy of Sciences. . 1991; 633: 189-95.
Monuki ES, Kuhn R, Weinmaster G, Trapp BD and Lemke G Novel expression and activity of the POU transcription factor SCIP. Science 1990; 249: 1300-1303.
Lemke G, Weinmaster G and Monuki ES The myelination cascade. Cellular and Molecular Biology of Myelination 1990; 533-541.
Lemke G, Kuhn R, Monuki ES, Weinmaster G Transcriptional controls underlying Schwann cell differentiation and myelination. Annals of the New York Academy of Sciences. . 1990; 605: 248-53.
Weinmaster GA, Middlemas DA, and Hunter T A major site of tyrosine phosphorylation within the SH2 domain of FSV P130gag-fps is not required for protein-tyrosine kinase activity or transforming potential. J. Virol 1988; 62: 2016-2025.
Weinmaster GA, Misra V, McGuire R, Babiuk LA, and DeClerq E Bovid Herpesvirus Type I-Induced Thymidine Kinase. Virology 1982; 118: 191-201.
Weinmaster G, Pawson T Localization and characterization of phosphorylation sites of the Fujinami avian sarcoma virus and PRCII virus transforming proteins. Journal of cellular biochemistry. . 1982; 20(4): 337-48.
Musse Abdiwahab A, Meloty-Kapella Laurence, Weinmaster Gerry Notch ligand endocytosis: Mechanistic basis of signaling activity. Seminars in cell & developmental biology. 2012; .
Weinmaster Gerry, Fischer Janice A Notch ligand ubiquitylation: what is it good for?. Developmental cell. 2011; 21(1): 134-44.
Hofmann Jennifer J, Zovein Ann C, Koh Huilin, Radtke Freddy, Weinmaster Gerry, Iruela-Arispe M Luisa Jagged1 in the portal vein mesenchyme regulates intrahepatic bile duct development: insights into Alagille syndrome. Development (Cambridge, England). 2010; 137(23): 4061-72.
D'Souza Brendan, Meloty-Kapella Laurence, Weinmaster Gerry Canonical and non-canonical Notch ligands. Current topics in developmental biology. 2010; 92(4): 73-129.
Kim Woo-Kyun, Meliton Vicente, Tetradis Sotirios, Weinmaster Gerry, Hahn Theodore J, Carlson Marc, Nelson Stanley F, Parhami Farhad Osteogenic oxysterol, 20(S)-hydroxycholesterol, induces notch target gene expression in bone marrow stromal cells. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2010; 25(4): 782-95.
Bozkulak Esra Cagavi, Weinmaster Gerry Selective use of ADAM10 and ADAM17 in activation of Notch1 signaling. Molecular and cellular biology. 2009; 29(21): 5679-95.
Nehring LC, Miyamoto A, Hein PW, Weinmaster G, Shipley JM The extracellular matrix protein MAGP-2 interacts with Jagged1 and induces its shedding from the cell surface. The Journal of biological chemistry. . 2005; 280(21): 20349-55.
Yang LT, Nichols JT, Yao C, Manilay JO, Robey EA, Weinmaster G Fringe glycosyltransferases differentially modulate Notch1 proteolysis induced by Delta1 and Jagged1. Molecular biology of the cell. . 2005; 16(2): 927-42.
Patten BA, Peyrin JM, Weinmaster G, Corfas G Sequential signaling through Notch1 and erbB receptors mediates radial glia differentiation. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2003; 23(14): 6132-40.
Oakley F, Mann J, Ruddell RG, Pickford J, Weinmaster G, Mann DA Basal expression of IkappaBalpha is controlled by the mammalian transcriptional repressor RBP-J (CBF1) and its activator Notch1. The Journal of biological chemistry. . 2003; 278(27): 24359-70.
Chojnacki A, Shimazaki T, Gregg C, Weinmaster G, Weiss S Glycoprotein 130 signaling regulates Notch1 expression and activation in the self-renewal of mammalian forebrain neural stem cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2003; 23(5): 1730-41.
Hicks C, Ladi E, Lindsell C, Hsieh JJ, Hayward SD, Collazo A, Weinmaster G A secreted Delta1-Fc fusion protein functions both as an activator and inhibitor of Notch1 signaling. Journal of neuroscience research. . 2002; 68(6): 655-67.
Kubu CJ, Orimoto K, Morrison SJ, Weinmaster G, Anderson DJ, Verdi JM Developmental changes in Notch1 and numb expression mediated by local cell-cell interactions underlie progressively increasing delta sensitivity in neural crest stem cells. Developmental biology. . 2002; 244(1): 199-214.
Haritunians T, Boulter J, Hicks C, Buhrman J, DiSibio G, Shawber C, Weinmaster G, Nofziger D, Schanen C CADASIL Notch3 mutant proteins localize to the cell surface and bind ligand. Circulation research. . 2002; 90(5): 506-8.
Yamamoto S, Nagao M, Sugimori M, Kosako H, Nakatomi H, Yamamoto N, Takebayashi H, Nabeshima Y, Kitamura T, Weinmaster G, Nakamura K, Nakafuku M Transcription factor expression and Notch-dependent regulation of neural progenitors in the adult rat spinal cord. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2001; 21(24): 9814-23.
Villa N, Walker L, Lindsell CE, Gasson J, Iruela-Arispe ML, Weinmaster G Vascular expression of Notch pathway receptors and ligands is restricted to arterial vessels. Mechanisms of development. . 2001; 108(1-2): 161-4.
Irvin DK, Zurcher SD, Nguyen T, Weinmaster G, Kornblum HI Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development. The Journal of comparative neurology. . 2001; 436(2): 167-81.
Imai T, Tokunaga A, Yoshida T, Hashimoto M, Mikoshiba K, Weinmaster G, Nakafuku M, Okano H The neural RNA-binding protein Musashi1 translationally regulates mammalian numb gene expression by interacting with its mRNA. Molecular and cellular biology. . 2001; 21(12): 3888-900.
Zhang J, Chen H, Weinmaster G, Hayward SD Epstein-Barr virus BamHi-a rightward transcript-encoded RPMS protein interacts with the CBF1-associated corepressor CIR to negatively regulate the activity of EBNA2 and NotchIC. Journal of virology. . 2001; 75(6): 2946-56.
McCright B, Gao X, Shen L, Lozier J, Lan Y, Maguire M, Herzlinger D, Weinmaster G, Jiang R, Gridley T Defects in development of the kidney, heart and eye vasculature in mice homozygous for a hypomorphic Notch2 mutation. Development (Cambridge, England) . 2001; 128(4): 491-502.
Bush G, diSibio G, Miyamoto A, Denault JB, Leduc R, Weinmaster G Ligand-induced signaling in the absence of furin processing of Notch1. Developmental biology. . 2001; 229(2): 494-502.
Tan-Pertel HT, Walker L, Browning D, Miyamoto A, Weinmaster G, Gasson JC Notch signaling enhances survival and alters differentiation of 32D myeloblasts. Journal of immunology (Baltimore, Md. : 1950) . 2000; 165(8): 4428-36.
Hicks C, Johnston SH, diSibio G, Collazo A, Vogt TF, Weinmaster G Fringe differentially modulates Jagged1 and Delta1 signalling through Notch1 and Notch2. Nature cell biology. . 2000; 2(8): 515-20.
Weinmaster G Notch signal transduction: a real rip and more. Current opinion in genetics & development. . 2000; 10(4): 363-9.
Morrison SJ, Perez SE, Qiao Z, Verdi JM, Hicks C, Weinmaster G, Anderson DJ Transient Notch activation initiates an irreversible switch from neurogenesis to gliogenesis by neural crest stem cells. Cell. . 2000; 101(5): 499-510.
Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Molecular and cellular biology. . 2000; 20(7): 2400-10.
Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Molecular and cellular biology. . 2000; 20(7): 2400-10.
Redmond L, Oh SR, Hicks C, Weinmaster G, Ghosh A Nuclear Notch1 signaling and the regulation of dendritic development. Nature neuroscience. . 2000; 3(1): 30-40.
Louis AA, Van Eyken P, Haber BA, Hicks C, Weinmaster G, Taub R, Rand EB Hepatic jagged1 expression studies. Hepatology (Baltimore, Md.) . 1999; 30(5): 1269-75.
Xue Y, Gao X, Lindsell CE, Norton CR, Chang B, Hicks C, Gendron-Maguire M, Rand EB, Weinmaster G, Gridley T Embryonic lethality and vascular defects in mice lacking the Notch ligand Jagged1. Human molecular genetics. . 1999; 8(5): 723-30.
Wang S, Sdrulla AD, diSibio G, Bush G, Nofziger D, Hicks C, Weinmaster G, Barres BA Notch receptor activation inhibits oligodendrocyte differentiation. Neuron. . 1998; 21(1): 63-75.
Jiang R, Lan Y, Chapman HD, Shawber C, Norton CR, Serreze DV, Weinmaster G, Gridley T Defects in limb, craniofacial, and thymic development in Jagged2 mutant mice. Genes & development. . 1998; 12(7): 1046-57.
Weinmaster G Reprolysins and astacins...alive, alive-o. Science. . 1998; 279(5349): 336-7.
Zhong W, Jiang MM, Weinmaster G, Jan LY, Jan YN Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis. Development (Cambridge, England) . 1997; 124(10): 1887-97.
Robey E, Chang D, Itano A, Cado D, Alexander H, Lans D, Weinmaster G, Salmon P An activated form of Notch influences the choice between CD4 and CD8 T cell lineages. Cell. . 1996; 87(3): 483-92.
Lindsell CE, Shawber CJ, Boulter J, Weinmaster G Jagged: a mammalian ligand that activates Notch1. Cell. . 1995; 80(6): 909-17.
Swiatek PJ, Lindsell CE, del Amo FF, Weinmaster G, Gridley T Notch1 is essential for postimplantation development in mice. Genes & development. . 1994; 8(6): 707-19.
Weinmaster, G Roberts, VJ Lemke, G A homolog of Drosophila Notch expressed during mammalian development. Development (Cambridge, England) . 1991; 113(1): 199-205.
Weinmaster G, Lemke G Cell-specific cyclic AMP-mediated induction of the PDGF receptor. The EMBO journal. . 1990; 9(3): 915-20.
Monuki ES, Weinmaster G, Kuhn R, Lemke G SCIP: a glial POU domain gene regulated by cyclic AMP. Neuron. . 1989; 3(6): 783-93.
Weinmaster GA, Hunter T Investigation of the role of P130gag-fps in transformation: generation and use of a temperature-sensitive mutant P130gag-fps. Journal of virology. . 1988; 62(10): 3849-54.
Auersperg N, Pawson T, Worth A, Weinmaster G Modifications of tumor histology by point mutations in the v-fps oncogene: possible role of extracellular matrix. Cancer research. . 1987; 47(23): 6341-8.
Weinmaster G, Pawson T Protein kinase activity of FSV (Fujinami sarcoma virus) P130gag-fps shows a strict specificity for tyrosine residues. The Journal of biological chemistry. . 1986; 261(1): 328-33.
Weinmaster G, Zoller MJ, Pawson T A lysine in the ATP-binding site of P130gag-fps is essential for protein-tyrosine kinase activity. The EMBO journal. . 1986; 5(1): 69-76.
Weinmaster G, Zoller MJ, Smith M, Hinze E, Pawson T Mutagenesis of Fujinami sarcoma virus: evidence that tyrosine phosphorylation of P130gag-fps modulates its biological activity. Cell. . 1984; 37(2): 559-68.
Weinmaster G, Hinze E, Pawson T Mapping of multiple phosphorylation sites within the structural and catalytic domains of the Fujinami avian sarcoma virus transforming protein. Journal of virology. . 1983; 46(1): 29-41.