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Cui-Wei (Tracy) Xie, M.D., Ph.D.

Email Address:
cxie@mednet.ucla.edu

Work Address:
Laboratory
NPI 78-144
UCLA
760 Westwood Plaza
Box 77
Los Angeles, CA 90024
UNITED STATES

Office
NPI 78-168
UCLA
760 Westwood Plaza
Box 77
Los Angeles, CA 90024
UNITED STATES

Fax Number:
310-206-2946
Lab Number:
310-206-2946
Office Phone Number:
310-206-0083



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Department / Division Affiliations
Professor, Psychiatry and Biobehavioral Sciences, Hatos Center for Neuropharmacology
Member, ACCESS Program: Dept. of Molecular, Cell & Integrative Physiology, ACCESS Program, Access Molecular, Cellular and Integrative Physiology Home Area, Access Neuroscience Home Area, Brain Research Institute, Neuroscience IDP
Faculty, Molecular, Cellular, and Integrative Physiology IDP

Bio:

Dr. Tracy Xie is a professor at the Department of Psychiatry and Biobehavioral Sciences. She earned her doctorate degree in medicine and physiology at Peking University, China. She received postdoctoral training in electrophysiology and molecular biology at National Institute of Health (NIH) and Duke University in North Carolina, where she studied regulation of hippocampal synaptic plasticity by endogenous neuropeptides. Since joining UCLA faculty in 1995, Dr. Xie has been studying cellular mechanisms of neural and synaptic plasticity, and implications of such mechanisms in drug dependence and memory loss related to aging and Alzheimer's disease. Her research is funded by grants from National Institute of Aging (NIA), National Institute on Drug abuse (NIDA), and Alzheimer's Association.

Publications:

Mittal Nitish, Tan Miao, Egbuta Onyemachi, Desai Nina, Crawford Cynthia, Xie Cui-Wei, Evans Christopher, Walwyn Wendy Evidence that Behavioral Phenotypes of Morphine in ?-arr2-/- Mice Are Due to the Unmasking of JNK Signaling. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2012; 37(8): 1953-62.
Wu Zhongqi-Phyllis, Washburn Lorraine, Bilousova Tina V, Boudzinskaia Maia, Escande-Beillard Nathalie, Querubin Jyes, Dang Hoa, Xie Cui-Wei, Tian Jide, Kaufman Daniel L Enhanced neuronal expression of major histocompatibility complex class I leads to aberrations in neurodevelopment and neurorepair. Journal of neuroimmunology. 2011; 232(1-2): 8-16.
Li Huiyuan, Monien Bernhard H, Lomakin Aleksey, Zemel Reeve, Fradinger Erica A, Tan Miao, Spring Sean M, Urbanc Brigita, Xie Cui-Wei, Benedek George B, Bitan Gal Mechanistic Investigation of the Inhibition of Abeta42 Assembly and Neurotoxicity by Abeta42 C-Terminal Fragments. Biochemistry. 2010; 49(30): 6358-64.
Zeng Yan, Zhao Danyun, Xie Cui-Wei Neurotrophins Enhance CaMKII Activity and Rescue Amyloid-beta-Induced Deficits in Hippocampal Synaptic Plasticity. Journal of Alzheimer's Disease . 2010; 21(3): 823-31.
Tan Miao, Walwyn Wendy M, Evans Christopher J, Xie Cui-Wei p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons. The Journal of biological chemistry. 2009; 284(10): 6270-81.
Fradinger Erica A, Monien Bernhard H, Urbanc Brigita, Lomakin Aleksey, Tan Miao, Li Huiyuan, Spring Sean M, Condron Margaret M, Cruz Luis, Xie Cui-Wei, Benedek George B, Bitan Gal C-terminal peptides coassemble into Abeta42 oligomers and protect neurons against Abeta42-induced neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105(37): 14175-80.
Guo Guang, Tong Yuying, Xie Cui-Wei, Lange Leslie A Dopamine transporter, gender, and number of sexual partners among young adults. European journal of human genetics : EJHG. 2007; 15(3): 279-87.
Walwyn, W. M. Wei, W. Xie, C. W. Chiu, K. Kieffer, B. L. Evans, C. J. Maidment, N. T. Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons. Neuroscience. 2006; 142(2): 493-503.
Zhao Danyun, Watson Joseph B, Xie Cui-Wei Amyloid beta prevents activation of calcium/calmodulin-dependent protein kinase II and AMPA receptor phosphorylation during hippocampal long-term potentiation. Journal of neurophysiology. 2004; 92(5): 2853-8.
Xie Cui-Wei Calcium-regulated signaling pathways: role in amyloid beta-induced synaptic dysfunction. Neuromolecular medicine. 2004; 6(1): 53-64.
Israely Inbal, Costa Rui M, Xie Cui Wei, Silva Alcino J, Kosik Kenneth S, Liu Xin Deletion of the neuron-specific protein delta-catenin leads to severe cognitive and synaptic dysfunction. Current biology : CB. 2004; 14(18): 1657-63.
Walwyn, W. M. Keith, D. E., Jr. Wei, W. Tan, A. M. Xie, C. W. Evans, C. J. Kieffer, B. L. Maidment, N. T. Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice. Neuroscience. 2004; 123(1): 111-21.
Tan Miao, Groszer Matthias, Tan Aiko M, Pandya Amy, Liu Xin, Xie Cui-Wei Phosphoinositide 3-kinase cascade facilitates mu-opioid desensitization in sensory neurons by altering G-protein-effector interactions. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003; 23(32): 10292-301.
Chen Qi-Sheng, Wei Wei-Zheng, Shimahara Takeshi, Xie Cui-Wei Alzheimer amyloid beta-peptide inhibits the late phase of long-term potentiation through calcineurin-dependent mechanisms in the hippocampal dentate gyrus. Neurobiology of learning and memory. 2002; 77(3): 354-71.
Xie, C. W. Sayah, D. Chen, Q. S. Wei, W. Z. Smith, D. Liu, X. Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene. Proc Natl Acad Sci U S A. 2000; 97(14): 8116-21.
Chen, Q. S. Kagan, B. L. Hirakura, Y. Xie, C. W. Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides. J Neurosci Res. 2000; 60(1): 65-72.