760 Westwood Plaza
Los Angeles, CA 90024
760 Westwood Plaza
Los Angeles, CA 90024
Office Phone Number:
Psychiatry and Biobehavioral Sciences,
Hatos Center for Neuropharmacology
ACCESS Program: Dept. of Molecular, Cell & Integrative Physiology,
Access Molecular, Cellular and Integrative Physiology Home Area,
Access Neuroscience Home Area,
Brain Research Institute,
Molecular, Cellular, and Integrative Physiology IDP
Dr. Tracy Xie is a professor at the Department of Psychiatry and Biobehavioral Sciences. She earned her doctorate degree in medicine and physiology at Peking University, China. She received postdoctoral training in electrophysiology and molecular biology at National Institute of Health (NIH) and Duke University in North Carolina, where she studied regulation of hippocampal synaptic plasticity by endogenous neuropeptides. Since joining UCLA faculty in 1995, Dr. Xie has been studying cellular mechanisms of neural and synaptic plasticity, and implications of such mechanisms in drug dependence and memory loss related to aging and Alzheimer's disease. Her research is funded by grants from National Institute of Aging (NIA), National Institute on Drug abuse (NIDA), and Alzheimer's Association.
Wu Zhongqi-Phyllis, Washburn Lorraine, Bilousova Tina V, Boudzinskaia Maia, Escande-Beillard Nathalie, Querubin Jyes, Dang Hoa, Xie Cui-Wei, Tian Jide, Kaufman Daniel L Enhanced neuronal expression of major histocompatibility complex class
I leads to aberrations in neurodevelopment and neurorepair.
Journal of neuroimmunology
Li Huiyuan, Monien Bernhard H, Lomakin Aleksey, Zemel Reeve, Fradinger Erica A, Tan Miao, Spring Sean M, Urbanc Brigita, Xie Cui-Wei, Benedek George B, Bitan Gal Mechanistic Investigation of the Inhibition of Abeta42 Assembly and Neurotoxicity by Abeta42 C-Terminal Fragments.
Zeng Yan, Zhao Danyun, Xie Cui-Wei Neurotrophins Enhance CaMKII Activity and Rescue Amyloid-beta-Induced Deficits in Hippocampal Synaptic Plasticity.
Journal of Alzheimer's Disease
Tan Miao, Walwyn Wendy M, Evans Christopher J, Xie Cui-Wei p38 MAPK and beta-arrestin 2 mediate functional interactions between
endogenous micro-opioid and alpha2A-adrenergic receptors in neurons.
The Journal of biological chemistry
Fradinger Erica A, Monien Bernhard H, Urbanc Brigita, Lomakin Aleksey, Tan Miao, Li Huiyuan, Spring Sean M, Condron Margaret M, Cruz Luis, Xie Cui-Wei, Benedek George B, Bitan Gal C-terminal peptides coassemble into Abeta42 oligomers and protect
neurons against Abeta42-induced neurotoxicity.
Proceedings of the National Academy of Sciences of the United States of America
Walwyn, W. M. Wei, W. Xie, C. W. Chiu, K. Kieffer, B. L. Evans, C. J. Maidment, N. T. Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons.
Zhao Danyun, Watson Joseph B, Xie Cui-Wei Amyloid beta prevents activation of calcium/calmodulin-dependent
protein kinase II and AMPA receptor phosphorylation during hippocampal
Journal of neurophysiology
Xie Cui-Wei Calcium-regulated signaling pathways: role in amyloid beta-induced
Israely Inbal, Costa Rui M, Xie Cui Wei, Silva Alcino J, Kosik Kenneth S, Liu Xin Deletion of the neuron-specific protein delta-catenin leads to severe
cognitive and synaptic dysfunction.
Current biology : CB
Walwyn, W. M. Keith, D. E., Jr. Wei, W. Tan, A. M. Xie, C. W. Evans, C. J. Kieffer, B. L. Maidment, N. T. Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice.
Chen Qi-Sheng, Wei Wei-Zheng, Shimahara Takeshi, Xie Cui-Wei Alzheimer amyloid beta-peptide inhibits the late phase of long-term
potentiation through calcineurin-dependent mechanisms in the
hippocampal dentate gyrus.
Neurobiology of learning and memory
Xie, C. W. Sayah, D. Chen, Q. S. Wei, W. Z. Smith, D. Liu, X. Deficient long-term memory and long-lasting long-term potentiation in mice with a targeted deletion of neurotrophin-4 gene.
Proc Natl Acad Sci U S A
Chen, Q. S. Kagan, B. L. Hirakura, Y. Xie, C. W. Impairment of hippocampal long-term potentiation by Alzheimer amyloid beta-peptides.
J Neurosci Res