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Guoping Fan, Ph.D.

Work Email Address:
gfan@mednet.ucla.edu

Work Address:
Office
695 Charles Young Drive South
UCLA
Los Angeles, CA 90095
UNITED STATES

Laboratory
695 Charles Young Drive South
UCLA
Los Angeles, CA 90095
UNITED STATES

Room 6357C, Gonda Building
Campus - 708822
CA
UNITED STATES

Work Phone Number:
(310) 267-0438 Lab
(310) 267-0439 Office


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Department / Division Affiliations
Associate Professor, Human Genetics
Member, ACCESS Program: Dept. of Human Genetics, Brain Research Institute, Neuroscience Graduate Program, JCCC Cancer Cell Biology Program Area, JCCC Gene Regulation Program Area
ACCESS Affinity - Stem Cell Biology

Bio:

Guoping Fan is a molecular geneticist and neuroscientist who joined UCLA Department of Human Genetics as an Assistant Professor in 2001. Dr. Fan earned his B.S. in Biochemistry at Nanjing University, China and Ph.D. in Neuroscience at Case Western Reserve University. He was a postdoctoral fellow at the Whitehead Institute for Biomedical Institute/MIT, where he studies the role of DNA methylation and neurotrophins in neural development. His current research focuses on the actions of DNA methylation and chromatin-remodeling in regulating neural gene expression, neuronal function, and stem cell differentiation.

Publications:

Shen, Y., Matsuno, Y., Fouse, S., Rao, N., Root, S., Xu, R.H., Pellegrini, Riggs, A., Fan, G. X-inactivation in female human embryonic stem cells is in a non-random pattern and prone to epigenetic alterations. . Proc. Natl. Acad. Sci. USA 2008; 105(12): 4709-4714.
Fouse, S., Shen, Y., Pellegrini, M., Cole, S., Meissner, A., Van Neste, L., Jaenisch, R., Fan, G. Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation.. Cell Stem Cell 2008; 2(2): 160-169.
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Golshani, P., Hutnick, L., Schweizer, F., Fan, G. Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation. Thalamus and Related System . 2007; Published online in March 2007: .
Feng, J., Fouse, S., Fan, G. Epigenetic regulation of neural gene expression and neuronal function. Pediatric Research. 2007; 61 (5 Pt 2): 58R-63R.
Shen Y, Chow J, Wang Z, FanG Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells. . Human Molecular Genetics. 2006; 15(17): 2623-2635.
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He F, Ge W, Zhu W, Becker-Catania S, Martinowich K, Wu H, Coskun V, Fan G, deVellis J, Sun Y A positive autoregulation loop of JAK-STAT signaling is part of the clock mechanism regulating astrogliogenesis.. Nature Neuroscience 2005; 8: 616-625.
Lyckman AW, Fan G, Rios M, Jaenisch R, Sur M Normal eye-specific patterning of retinal inputs to murine subcortical visual nuclei in the absence of brain-derived neurotrophic factor.. Visual neuroscience. . 2005; 22(1): 27-36.
Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L, Hattori D, Ge W, Shen Y, Wu H, ten Hoeve J, Shuai K, Sun YE DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling.. Development (Cambridge, England) . 2005; 132(15): 3345-56.
Fan G, Hutnick L Methyl-CpG binding proteins in the nervous system.. Cell research. . 2005; 15(4): 255-61.
Feng J, Chang H, Li E, Fan G Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res. 2005; 79: 734-746 (Cover art).
Chi MM, Fan G, Fox EA Increased short-term food satiation and sensitivity to cholecystokinin in neurotrophin-4 knock-in mice.. American journal of physiology. Regulatory, integrative and comparative physiology. . 2004; 287(5): R1044-53.
Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, Sun YE DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation.. Science. . 2003; 302(5646): 890-3.
Ge W, Martinowich K, Wu X, He F, Miyamoto A, Fan G, Weinmaster G, Sun YE Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation.. Journal of neuroscience research. . 2002; 69(6): 848-60.
Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms.. Cell. . 2001; 104(3): 365-76.
Fan G, Beard C, Chen RZ, Csankovszki G, Sun Y, Siniaia M, Biniszkiewicz D, Bates B, Lee PP, Kuhn R, Trumpp A, Poon C, Wilson CB, Jaenisch R DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2001; 21(3): 788-97.
Fan G, Copray S, Wong E, Yan Q, Jones K, Walro J, Jaenisch R, Kucera J Formation of the cranial proprioceptive system requires multiple neurotrophins.. Developmental Dynamics 2000; 218: 359-370.
Endres M, Fan G (equal contribution), Hirt L, Fujji M, Liu X, Jaenisch R, Moskowitz MA Ischemic brain damage after selectively modifying BDNF or NT-4 expression in vivo.. J. Cereb.Blood Flow. Metab. 2000; 20: 139-144.
Fan G, Egles C, Sun Y, Minichiello L, Renger JJ, Klein R, Liu G, Jaenisch R Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities.. Nature neuroscience. . 2000; 3(4): 350-7.
Fan G, Xiao L, Cheng L, Wang X, Sun B, Hu G Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice.. FEBS letters. . 2000; 467(1): 7-11.
Fan G, Jaenisch R, Kucera J A role for p75 receptor in NT3 functioning during the development of limb proprioception.. Neuroscience 1999; 90: 259-268.
Bates B, Rios M, Trumpp A, Chen C, Fan G, Bishop JM, Jaenisch R Neurotrophin-3 is required for proper cerebellar development.. Nature neuroscience. . 1999; 2(2): 115-7.