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Guoping Fan, Ph.D.

Work Email Address:

Work Address:
695 Charles Young Drive South
Los Angeles, CA 90095

Room 6357C, Gonda Building
Campus - 708822

695 Charles Young Drive South
Los Angeles, CA 90095

Lab Number:
(310) 267-0438
Office Phone Number:
(310) 267-0439

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Department / Division Affiliations
Professor, Human Genetics
Member, ACCESS Program: Dept. of Human Genetics, Access Bioinformatics Home Area, Access Genetics and Genomics Home Area, Access Neuroscience Home Area, Brain Research Institute, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, JCCC Gene Regulation Program Area, Neuroscience IDP
Faculty, Molecular Biology IDP


Guoping Fan is a Professor in the Department of Human Genetics, David Geffen School of Medicine at UCLA. He has been a faculty member at UCLA since 2001. Pior to that, he was a postdoctoral fellow at the Whitehead Institute for Biomedical Institute/MIT, where he studies the role of DNA methylation and neurotrophins in neural development. Dr. Fan earned his B.S. in Biochemistry at Nanjing University, China and Ph.D. in Neuroscience at Case Western Reserve University. His current research focuses on the actions of DNA methylation and chromatin-remodeling in regulating neural gene expression, neuronal function, and stem cell differentiation and reprogramming.


Feng Jian, Zhou Yu, Campbell Susan L, Le Thuc, Li En, Sweatt J David, Silva Alcino J, Fan Guoping Dnmt1 and Dnmt3a maintain DNA methylation and regulate synaptic function in adult forebrain neurons. Nature neuroscience. 2010; 13(4): 423-30.
Zhong Jin, Chan Albert, Morad Leeron, Kornblum Harley I, Fan Guoping, Carmichael S Thomas Hydrogel Matrix to Support Stem Cell Survival After Brain Transplantation in Stroke. Neurorehabilitation and neural repair. 2010; 285(27): .
Hutnick Leah K, Huang Xinhua, Loo Tao-Chuan, Ma Zhicheng, Fan Guoping Repression of retrotransposal elements in mouse embryonic stem cells is primarily mediated by a DNA methylation-independent mechanism. The Journal of biological chemistry. 2010; 285(27): 21082-91.
Tamar Dvash, Neta Lavon, Guoping Fan Variations of X Chromosome Inactivation Occur in Early Passages of Female Human Embryonic Stem Cells. PLOS ONE 2010; 5(6): e11330.
Fan Zhipeng, Yamaza Takayoshi, Lee Janice S, Yu Jinhua, Wang Songlin, Fan Guoping, Shi Songtao, Wang Cun-Yu BCOR regulates mesenchymal stem cell function by epigenetic mechanisms. Nature cell biology. 2009; 11(8): 1002-9.
Hutnick Leah K, Golshani Peyman, Namihira Masakasu, Xue Zhigang, Matynia Anna, Yang X William, Silva Alcino J, Schweizer Felix E, Fan Guoping DNA hypomethylation restricted to the murine forebrain induces cortical degeneration and impairs postnatal neuronal maturation. Human molecular genetics. 2009; 18(15): 2875-88.
Mason Mike J, Fan Guoping, Plath Kathrin, Zhou Qing, Horvath Steve Signed weighted gene co-expression network analysis of transcriptional regulation in murine embryonic stem cells. BMC genomics. 2009; 10(8): 327.
Feng Jian, Fan Guoping The role of DNA methylation in the central nervous system and neuropsychiatric disorders. International review of neurobiology. 2009; 89(1): 67-84.
Fouse, S., Shen, Y., Pellegrini, M., Cole, S., Meissner, A., Van Neste, L., Jaenisch, R., Fan, G. Promoter CpG methylation contributes to ES cell gene regulation in parallel with Oct4/Nanog, PcG complex, and histone H3 K4/K27 trimethylation. Cell Stem Cell 2008; 2(2): 160-169.
Shen, Y., Matsuno, Y., Fouse, S., Rao, N., Root, S., Xu, R.H., Pellegrini, Riggs, A., Fan, G. X-inactivation in female human embryonic stem cells is in a non-random pattern and prone to epigenetic alterations. . Proc. Natl. Acad. Sci. USA 2008; 105(12): 4709-4714.
Golshani, P., Hutnick, L., Schweizer, F., Fan, G. Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation. Thalamus and Related System . 2007; Published online in March 2007: .
Feng, J., Fouse, S., Fan, G. Epigenetic regulation of neural gene expression and neuronal function. Pediatric Research. 2007; 61 (5 Pt 2): 58R-63R.
Shen Y, Chow J, Wang Z, FanG Abnormal CpG island methylation occurs during in vitro differentiation of human embryonic stem cells. . Human Molecular Genetics. 2006; 15(17): 2623-2635.
He F, Ge W, Zhu W, Becker-Catania S, Martinowich K, Wu H, Coskun V, Fan G, deVellis J, Sun Y A positive autoregulation loop of JAK-STAT signaling is part of the clock mechanism regulating astrogliogenesis. Nature Neuroscience 2005; 8: 616-625.
Fan G, Martinowich K, Chin MH, He F, Fouse SD, Hutnick L, Hattori D, Ge W, Shen Y, Wu H, ten Hoeve J, Shuai K, Sun YE DNA methylation controls the timing of astrogliogenesis through regulation of JAK-STAT signaling. Development (Cambridge, England) . 2005; 132(15): 3345-56.
Feng J, Chang H, Li E, Fan G Dynamic expression of de novo DNA methyltransferases Dnmt3a and Dnmt3b in the central nervous system. J Neurosci Res. 2005; 79: 734-746 (Cover art).
Fan G, Hutnick L Methyl-CpG binding proteins in the nervous system. Cell research. . 2005; 15(4): 255-61.
Lyckman AW, Fan G, Rios M, Jaenisch R, Sur M Normal eye-specific patterning of retinal inputs to murine subcortical visual nuclei in the absence of brain-derived neurotrophic factor. Visual neuroscience. . 2005; 22(1): 27-36.
Chi MM, Fan G, Fox EA Increased short-term food satiation and sensitivity to cholecystokinin in neurotrophin-4 knock-in mice. American journal of physiology. Regulatory, integrative and comparative physiology. . 2004; 287(5): R1044-53.
Martinowich K, Hattori D, Wu H, Fouse S, He F, Hu Y, Fan G, Sun YE DNA methylation-related chromatin remodeling in activity-dependent BDNF gene regulation. Science. . 2003; 302(5646): 890-3.
Ge W, Martinowich K, Wu X, He F, Miyamoto A, Fan G, Weinmaster G, Sun YE Notch signaling promotes astrogliogenesis via direct CSL-mediated glial gene activation. Journal of neuroscience research. . 2002; 69(6): 848-60.
Fan G, Beard C, Chen RZ, Csankovszki G, Sun Y, Siniaia M, Biniszkiewicz D, Bates B, Lee PP, Kuhn R, Trumpp A, Poon C, Wilson CB, Jaenisch R DNA hypomethylation perturbs the function and survival of CNS neurons in postnatal animals. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2001; 21(3): 788-97.
Sun Y, Nadal-Vicens M, Misono S, Lin MZ, Zubiaga A, Hua X, Fan G, Greenberg ME Neurogenin promotes neurogenesis and inhibits glial differentiation by independent mechanisms. Cell. . 2001; 104(3): 365-76.
Fan G, Copray S, Wong E, Yan Q, Jones K, Walro J, Jaenisch R, Kucera J Formation of the cranial proprioceptive system requires multiple neurotrophins. Developmental Dynamics 2000; 218: 359-370.
Endres M, Fan G (equal contribution), Hirt L, Fujji M, Liu X, Jaenisch R, Moskowitz MA Ischemic brain damage after selectively modifying BDNF or NT-4 expression in vivo. J. Cereb.Blood Flow. Metab 2000; 20: 139-144.
Fan G, Egles C, Sun Y, Minichiello L, Renger JJ, Klein R, Liu G, Jaenisch R Knocking the NT4 gene into the BDNF locus rescues BDNF deficient mice and reveals distinct NT4 and BDNF activities. Nature neuroscience. . 2000; 3(4): 350-7.
Fan G, Xiao L, Cheng L, Wang X, Sun B, Hu G Targeted disruption of NDST-1 gene leads to pulmonary hypoplasia and neonatal respiratory distress in mice. FEBS letters. . 2000; 467(1): 7-11.
Fan G, Jaenisch R, Kucera J A role for p75 receptor in NT3 functioning during the development of limb proprioception. Neuroscience 1999; 90: 259-268.
Bates B, Rios M, Trumpp A, Chen C, Fan G, Bishop JM, Jaenisch R Neurotrophin-3 is required for proper cerebellar development. Nature neuroscience. . 1999; 2(2): 115-7.
Cushman Jesse D, Maldonado Jose, Kwon Eunice E, Garcia A Denise, Fan Guoping, Imura Tetsuya, Sofroniew Michael V, Fanselow Michael S Juvenile neurogenesis makes essential contributions to adult brain structure and plays a sex-dependent role in fear memories. Frontiers in behavioral neuroscience. 2012; 6(21): 3.
Moore Lisa D, Le Thuc, Fan Guoping DNA methylation and its basic function. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2013; 38(1): 23-38.
Hu Ganlu, Huang Kevin, Yu Juehua, Gopalakrishna-Pillai Sailesh, Kong Jun, Xu He, Liu Zhenshan, Zhang Kunshan, Xu Jun, Luo Yuping, Li Siguang, Sun Yi E, Iverson Linda E, Xue Zhigang, Fan Guoping Identification of miRNA signatures during the differentiation of hESCs into retinal pigment epithelial cells. PloS one. 2012; 7(7): e37224.
Li Ji, Jiang Ting-Xin, Hughes Michael W, Wu Ping, Yu Juehua, Widelitz Randall B, Fan Guoping, Chuong Cheng-Ming Progressive alopecia reveals decreasing stem cell activation probability during aging of mice with epidermal deletion of DNA methyltransferase 1. The Journal of investigative dermatology. 2012; 132(12): 2681-90.
Xue Zhigang, Huang Kevin, Cai Chaochao, Cai Lingbo, Jiang Chun-yan, Feng Yun, Liu Zhenshan, Zeng Qiao, Cheng Liming, Sun Yi E, Liu Jia-yin, Horvath Steve, Fan Guoping Genetic programs in human and mouse early embryos revealed by single-cell RNA sequencing. Nature. 2013; 500(7464): 593-7.
Wu Zhourui, Huang Kevin, Yu Juehua, Le Thuc, Namihira Masakasu, Liu Yupeng, Zhang Jun, Xue Zhigang, Cheng Liming, Fan Guoping Dnmt3a regulates both proliferation and differentiation of mouse neural stem cells. Journal of neuroscience research. 2012; 90(10): 1883-91.
Vincent John J, Huang Yun, Chen Pao-Yang, Feng Suhua, Calvopiña Joseph H, Nee Kevin, Lee Serena A, Le Thuc, Yoon Alexander J, Faull Kym, Fan Guoping, Rao Anjana, Jacobsen Steven E, Pellegrini Matteo, Clark Amander T Stage-specific roles for tet1 and tet2 in DNA demethylation in primordial germ cells. Cell stem cell. 2013; 12(4): 470-8.
Biswas Anuradha, Liu Ying, Liu Tianfei, Fan Guoping, Tang Yi Polyethylene glycol-based protein nanocapsules for functional delivery of a differentiation transcription factor. Biomaterials. 2012; 33(21): 5459-67.
Chen Yinyin, Huang Kevin, Nakatsu Martin N, Xue Zhigang, Deng Sophie X, Fan Guoping Identification of novel molecular markers through transcriptomic analysis in human fetal and adult corneal endothelial cells. Human molecular genetics. 2013; 22(7): 1271-9.