Site Search



Hong Wu, M.D., Ph.D.

Work Email Address:
hwu@mednet.ucla.edu

Department Address:
Department of Molecular and Medical Pharmacology
UCLA School of Medicine
650 Charles E .Young Drive South
Los Angeles, CA 90095
UNITED STATES

Office Address:
Office
650 Charles E. Young Drive South
CHS 33-131E
Los Angeles, CA 90095
UNITED STATES

Work Phone Number:
(310) 825-5160



Login to the Faculty Database

Department / Division Affiliations
Co-Leader, Pilot and Collaborative Translational Clinical Studies Program
Associate Director, JCCC Genitourinary Oncology Program Area
Professor, Molecular & Medical Pharmacology
Member, ACCESS Program: Dept. of Molecular & Medical Pharmacology, DOE Funded Faculty, Brain Research Institute, CTSI, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, JCCC Signal Transduction and Therapeutics Program Area, Pharmacology Home Area

Publications:

Donahue, T., Tran, L., Wu, H., Toste, P., Wu, N., Wong, J., Li, X., Dawson, D., Wu, X., and Malkhassian, D Endoscopically Acquired Pancreatic Cyst Fluid MicroRNA 21 and 221 are associated with Invasive Cancer . American Journal of Gastroenterology 2013; .
Download
Smith Kathleen B, Tran Linh M, Tam Brenna M, Shurell Elizabeth M, Li Yunfeng, Braas Daniel, Tap William D, Christofk Heather R, Dry Sarah M, Eilber Fritz C, Wu Hong Novel dedifferentiated liposarcoma xenograft models reveal PTEN down-regulation as a malignant signature and response to PI3K pathway inhibition. The American journal of pathology. 2013; 182(4): 1400-11.
Ruscetti, Marcus and Wu, Hong PTEN and Prostate Cancer. In D.J. Tindall's Book "Prostate Cancer: Biochemistry, Molecular Biology, and Genetics, Protein Reviews" 2013; (Chapter 4): 87-137.
Download
Mulholland, David, and Wu, Hong Stem Cell Cells and Prostate Cancer . In Scott Cramer's Book "Stem Cells and Prostate Cancer" 2013; (Chapter 6): 77-90.
Download
Schlacher Katharina, Wu Hong, Jasin Maria A Distinct Replication Fork Protection Pathway Connects Fanconi Anemia Tumor Suppressors to RAD51-BRCA1/2. Cancer cell. 2012; 22(1): 106-16.
Hill Reginald, Li Yunfeng, Tran Linh M, Dry Sarah, Hargan Calvopina Joseph, Garcia Alejandro J, Kim Christine, Wang Ying, Donahue Timothy R, Herschman Harvey R, Wu Hong Cell Intrinsic Role of Cox-2 in Pancreatic Cancer Development. Molecular cancer therapeutics. 2012; .
Tran Linh M, Chang Chun-Ju, Plaisier Seema, Wu Shumin, Dang Julie, Mischel Paul S, Liao James C, Graeber Thomas G, Wu Hong Determining PTEN functional status by network component deduced transcription factor activities. PloS one. 2012; 7(2): e31053.
Graham Nicholas A, Tahmasian Martik, Kohli Bitika, Komisopoulou Evangelia, Zhu Maggie, Vivanco Igor, Teitell Michael A, Wu Hong, Ribas Antoni, Lo Roger S, Mellinghoff Ingo K, Mischel Paul S, Graeber Thomas G Glucose deprivation activates a metabolic and signaling amplification loop leading to cell death. Molecular systems biology. 2012; 8(1): 589.
Jiao Jing, Hindoyan Antreas, Wang Shunyou, Tran Linh M, Goldstein Andrew S, Lawson Devon, Chen Donghui, Li Yunfeng, Guo Changyong, Zhang Baohui, Fazli Ladan, Gleave Martin, Witte Owen N, Garraway Isla P, Wu Hong Identification of CD166 as a surface marker for enriching prostate stem/progenitor and cancer initiating cells. PloS one. 2012; 7(8): e42564.
Donahue Timothy R, Tran Linh M, Hill Reginald, Li Yunfeng, Kovochich Anne, Calvopina Joseph H, Patel Sanjeet G, Wu Nanping, Hindoyan Antreas, Farrell James J, Li Xinmin, Dawson David W, Wu Hong Integrative survival-based molecular profiling of human pancreatic cancer. Clinical cancer research : an official journal of the American Association for Cancer Research. 2012; 18(5): 1352-63.
Hübner Anette, Mulholland David J, Standen Claire L, Karasarides Maria, Cavanagh-Kyros Julie, Barrett Tamera, Chi Hongbo, Greiner Dale L, Tournier Cathy, Sawyers Charles L, Flavell Richard A, Wu Hong, Davis Roger J JNK and PTEN cooperatively control the development of invasive adenocarcinoma of the prostate. Proceedings of the National Academy of Sciences of the United States of America. 2012; 109(30): 12046-51.
Di Vizio Dolores, Morello Matteo, Dudley Andrew C, Schow Peter W, Adam Rosalyn M, Morley Samantha, Mulholland David, Rotinen Mirja, Hager Martin H, Insabato Luigi, Moses Marsha A, Demichelis Francesca, Lisanti Michael P, Wu Hong, Klagsbrun Michael, Bhowmick Neil A, Rubin Mark A, D'Souza-Schorey Crislyn, Freeman Michael R Large oncosomes in human prostate cancer tissues and in the circulation of mice with metastatic disease. The American journal of pathology. 2012; 181(5): 1573-84.
Braas Daniel, Ahler Ethan, Tam Brenna, Nathanson David, Riedinger Mirielle, Benz Matthias R, Smith Kathleen B, Eilber Fritz C, Witte Owen N, Tap William D, Wu Hong, Christofk Heather R Metabolomics Strategy Reveals Subpopulation of Liposarcomas Sensitive to Gemcitabine Treatment. Cancer discovery. 2012; 2(12): 1109-1117.
Pope Whitney B, Prins Robert M, Albert Thomas M, Nagarajan Rajakumar, Yen Katharine E, Bittinger Mark A, Salamon Noriko, Chou Arthur P, Yong William H, Soto Horacio, Wilson Neil, Driggers Edward, Jang Hyun G, Su Shinsan M, Schenkein David P, Lai Albert, Cloughesy Timothy F, Kornblum Harley I, Wu Hong, Fantin Valeria R, Liau Linda M Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy. Journal of neuro-oncology. 2012; 107(1): 197-205.
Mulholland David J, Kobayashi Naoko, Ruscetti Marcus, Zhi Allen, Tran Linh M, Huang Jiaoti, Gleave Martin, Wu Hong Pten loss and RAS/MAPK activation cooperate to promote EMT and metastasis initiated from prostate cancer stem/progenitor cells. Cancer research. 2012; 72(7): 1878-89.
Kim Tae Hyong, Song Jieun, Alcantara Llaguno Sheila R, Murnan Eric, Liyanarachchi Sandya, Palanichamy Kamalakannan, Yi Ji-Yeun, Viapiano Mariano Sebastian, Nakano Ichiro, Yoon Sung Ok, Wu Hong, Parada Luis F, Kwon Chang-Hyuk Suppression of peroxiredoxin 4 in glioblastoma cells increases apoptosis and reduces tumor growth. PloS one. 2012; 7(8): e42818.
Palaskas Nicolaos, Larson Steven M, Schultz Nikolaus, Komisopoulou Evangelia, Wong Justin, Rohle Dan, Campos Carl, Yannuzzi Nicolas, Osborne Joseph R, Linkov Irina, Kastenhuber Edward R, Taschereau Richard, Plaisier Seema B, Tran Chris, Heguy Adriana, Wu Hong, Sander Chris, Phelps Michael E, Brennan Cameron, Port Elisa, Huse Jason T, Graeber Thomas G, Mellinghoff Ingo K 18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers. Cancer research. 2011; 71(15): 5164-74.
McCabe Katelyn E, Liu Bin, Marks James D, Tomlinson James S, Wu Hong, Wu Anna M An Engineered Cysteine-Modified Diabody for Imaging Activated Leukocyte Cell Adhesion Molecule (ALCAM)-Positive Tumors. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2011; 111(6): .
Tsutsui Hideaki, Valamehr Bahram, Hindoyan Antreas, Qiao Rong, Ding Xianting, Guo Shuling, Witte Owen N, Liu Xin, Ho Chih-Ming, Wu Hong An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells. Nature communications. 2011; 2(1): 167.
Mulholland David J, Tran Linh M, Li Yunfeng, Cai Houjian, Morim Ashkan, Wang Shunyou, Plaisier Seema, Garraway Isla P, Huang Jiaoti, Graeber Thomas G, Wu Hong Cell Autonomous Role of PTEN in Regulating Castration-Resistant Prostate Cancer Growth. Cancer cell. 2011; 19(6): 792-804.
Valamehr Bahram, Tsutsui Hideaki, Ho Chih-Ming, Wu Hong Developing defined culture systems for human pluripotent stem cells. Regenerative medicine. 2011; 6(5): 623-34.
Santiskulvong Chintda, Konecny Gottfried E, Fekete Mirela, Chen Kuang-Yui Michael, Karam Amer, Mulholland David, Eng Carol, Wu Hong, Song Min, Dorigo Oliver Dual targeting of phosphoinositide 3-kinase and mammalian target of rapamycin using NVP-BEZ235 as a novel therapeutic approach in human ovarian carcinoma. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011; 17(8): 2373-84.
Tap William D, Eilber Fritz C, Ginther Charles, Dry Sarah M, Reese Nicholas, Barzan-Smith Kate, Chen Hsiao-Wang, Wu Hong, Eilber Frederick R, Slamon Dennis J, Anderson Lee Evaluation of well-differentiated/de-differentiated liposarcomas by high-resolution oligonucleotide array-based comparative genomic hybridization. Genes, chromosomes & cancer. 2011; 50(2): 95-112.
Lindgren Anne G, Natsuhara Kyle, Tian E, Vincent John J, Li Xinmin, Jiao Jing, Wu Hong, Banerjee Utpal, Clark Amander T Loss of Pten causes tumor initiation following differentiation of murine pluripotent stem cells due to failed repression of Nanog. PloS one. 2011; 6(1): e16478.
Le Belle Janel E, Orozco Nicolas M, Paucar Andres A, Saxe Jonathan P, Mottahedeh Jack, Pyle April D, Wu Hong, Kornblum Harley I Proliferative neural stem cells have high endogenous ROS levels that regulate self-renewal and neurogenesis in a PI3K/Akt-dependant manner. Cell stem cell. 2011; 8(1): 59-71.
Guo Wei, Schubbert Suzanne, Chen James Y, Valamehr Bahram, Mosessian Sherly, Shi Hubing, Dang Nhi H, Garcia Consuelo, Theodoro Mariana F, Varella-Garcia Marileila, Wu Hong Suppression of leukemia development caused by PTEN loss. Proceedings of the National Academy of Sciences of the United States of America. 2011; 108(4): 1409-14.
Sun Jing, Masterman-Smith Michael D, Graham Nicholas A, Jiao Jing, Mottahedeh Jack, Laks Dan R, Ohashi Minori, DeJesus Jason, Kamei Ken-ichiro, Lee Ki-Bum, Wang Hao, Yu Zeta T F, Lu Yi-Tsung, Hou Shuang, Li Keyu, Liu Max, Zhang Nangang, Wang Shutao, Angenieux Brigitte, Panosyan Eduard, Samuels Eric R, Park Jun, Williams Dirk, Konkankit Vera, Nathanson David, van Dam R Michael, Phelps Michael E, Wu Hong, Liau Linda M, Mischel Paul S, Lazareff Jorge A, Kornblum Harley I, Yong William H, Graeber Thomas G, Tseng Hsian-Rong A microfluidic platform for systems pathology: multiparameter single-cell signaling measurements of clinical brain tumor specimens. Cancer research. 2010; 70(15): 6128-38.
Lukacs Rita U, Memarzadeh Sanaz, Wu Hong, Witte Owen N Bmi-1 is a crucial regulator of prostate stem cell self-renewal and malignant transformation. Cell stem cell. 2010; 7(6): 682-93.
Lillehoj Peter B, Tsutsui Hideaki, Valamehr Bahram, Wu Hong, Ho Chih-Ming Continuous sorting of heterogeneous-sized embryoid bodies. Lab on a chip. 2010; 10(13): 1678-82.
Tsutsui Hideaki, Yu Edmond, Marquina Sabrina, Valamehr Bahram, Wong Ieong, Wu Hong, Ho Chih-Ming Efficient dielectrophoretic patterning of embryonic stem cells in energy landscapes defined by hydrogel geometries. Annals of biomedical engineering. 2010; 38(12): 3777-88.
Hill Reginald, Calvopina Joseph Hargan, Kim Christine, Wang Ying, Dawson David W, Donahue Timothy R, Dry Sarah, Wu Hong PTEN loss accelerates KrasG12D-induced pancreatic cancer development. Cancer research. 2010; 70(18): 7114-24.
He Lina, Hou Xiaogang, Kanel Gary, Zeng Ni, Galicia Vivian, Wang Ying, Yang Jian, Wu Hong, Birnbaum Morris J, Stiles Bangyan L The critical role of AKT2 in hepatic steatosis induced by PTEN loss. The American journal of pathology. 2010; 176(5): 2302-8.
Conway Anne E, Lindgren Anne, Galic Zoran, Pyle April D, Wu Hong, Zack Jerome A, Pelligrini Matteo, Teitell Michael A, Clark Amander T A self-renewal program controls the expansion of genetically unstable cancer stem cells in pluripotent stem cell-derived tumors. Stem cells (Dayton, Ohio). 2009; 27(1): 18-28.
Mosessian Sherly, Avliyakulov Nuraly K, Mulholland David J, Boontheung Pinmanee, Loo Joseph A, Wu Hong Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex. The Journal of biological chemistry. 2009; 284(44): 30159-66.
Ruan,R., Ren, S., Li, J., Li, G., Kim, R., Gao, J., Wu, H., Wang Y. Inducible and Cardiac Specific PTEN Inactivation Protects Ischemia/Reperfusion Injury. Journal of Molecular and Cellular Cardiology 2009; 46(2): 193-200.
Mulholland David J, Xin Li, Morim Ashkan, Lawson Devon, Witte Owen, Wu Hong Lin-Sca-1+CD49fhigh stem/progenitors are tumor-initiating cells in the Pten-null prostate cancer model. Cancer research. 2009; 69(22): 8555-62.
Gregorian Caroline, Nakashima Jonathan, Dry Sarah M, Nghiemphu P Leia, Smith Kate Barzan, Ao Yan, Dang Julie, Lawson Gregory, Mellinghoff Ingo K, Mischel Paul S, Phelps Michael, Parada Luis F, Liu Xin, Sofroniew Michael V, Eilber Fritz C, Wu Hong PTEN dosage is essential for neurofibroma development and malignant transformation. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(46): 19479-84.
Haga, K., Tomioka, A., Liao, C., Kimura, T., Matsumoto, H., Ohno, I., Hermann, K., Logg, C., Tanaka, M., Hirao, Y., Wu, H., Kruse, C., Roy-Burman, P., and Kasahara N. PTEN knockout prostate cancer as a model for experimental immunotherapy. The Journal of Urology 2009; 181: 354-362.
Hill Reginald, Wu Hong PTEN, stem cells, and cancer stem cells. The Journal of biological chemistry. 2009; 284(18): 11755-9.
Gregorian Caroline, Nakashima Jonathan, Le Belle Janel, Ohab John, Kim Rachel, Liu Annie, Smith Kate Barzan, Groszer Matthias, Garcia A Denise, Sofroniew Michael V, Carmichael S Thomas, Kornblum Harley I, Liu Xin, Wu Hong Pten deletion in adult neural stem/progenitor cells enhances constitutive neurogenesis. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009; 29(6): 1874-86.
Couto Suzana S, Cao Mei, Duarte Paulo C, Banach-Petrosky Whitney, Wang Shunyou, Romanienko Peter, Wu Hong, Cardiff Robert D, Abate-Shen Cory, Cunha Gerald R Simultaneous haploinsufficiency of Pten and Trp53 tumor suppressor genes accelerates tumorigenesis in a mouse model of prostate cancer. Differentiation; research in biological diversity. 2009; 77(1): 103-11.
Guertin David A, Stevens Deanna M, Saitoh Maki, Kinkel Stephanie, Crosby Katherine, Sheen Joon-Ho, Mullholland David J, Magnuson Mark A, Wu Hong, Sabatini David M mTOR complex 2 is required for the development of prostate cancer induced by Pten loss in mice. Cancer cell. 2009; 15(2): 148-59.
Majumder Pradip K, Grisanzio Chiara, O'Connell Fionnuala, Barry Marc, Brito Joseph M, Xu Qing, Guney Isil, Berger Raanan, Herman Paula, Bikoff Rachel, Fedele Giuseppe, Baek Won-Ki, Wang Shunyou, Ellwood-Yen Katharine, Wu Hong, Sawyers Charles L, Signoretti Sabina, Hahn William C, Loda Massimo, Sellers William R A prostatic intraepithelial neoplasia-dependent p27 Kip1 checkpoint induces senescence and inhibits cell proliferation and cancer progression. Cancer cell. 2008; 14(2): 146-55.
Burton Jeremy B, Johnson Mai, Sato Makoto, Koh Sok Boon S, Mulholland David J, Stout David, Chatziioannou Arion F, Phelps Michael E, Wu Hong, Wu Lily Adenovirus-mediated gene expression imaging to directly detect sentinel lymph node metastasis of prostate cancer. Nature medicine. 2008; 14(8): 882-8.
Degtyarev, M., De Mazière, A., Orr, C., Lin, J., Tien, J., Prior, W., Lee, B., van Dijk, S., Gray, D., Wu, H., Davis, D., Stern, H., Murray, L., Hoeflich, K., Klumperman, J., Friedman, L. and Lin, K. Akt Inhibition Promotes Autophagy And Sensitizes PTEN-Null Tumors To Late-Stage Autophagy Inhibition. Journal of Cell Biology 2008; 186: 101-106.
Yao Denggao, Alexander Claire L, Quinn Jean A, Chan Weng-Chyn, Wu Hong, Greenhalgh David A Fos cooperation with PTEN loss elicits keratoacanthoma not carcinoma, owing to p53/p21 WAF-induced differentiation triggered by GSK3beta inactivation and reduced AKT activity. Journal of cell science. 2008; 121(Pt 10): 1758-69.
Mulholland, D.J., Jiao, J. and Wu, H. Hormone refractory prostate cancer: lesions leaned from the PTEN prostate cancer model. Adv Exp Med Biol 2008; 617: 87-95.
Valamehr Bahram, Jonas Steven J, Polleux Julien, Qiao Rong, Guo Shuling, Gschweng Eric H, Stiles Bangyan, Kam Korey, Luo Tzy-Jiun M, Witte Owen N, Liu Xin, Dunn Bruce, Wu Hong Hydrophobic surfaces for enhanced differentiation of embryonic stem cell-derived embryoid bodies. Proceedings of the National Academy of Sciences of the United States of America. 2008; 105(38): 14459-64.
Guo Wei, Lasky Joseph L, Chang Chun-Ju, Mosessian Sherly, Lewis Xiaoman, Xiao Yun, Yeh Jennifer E, Chen James Y, Iruela-Arispe M Luisa, Varella-Garcia Marileila, Wu Hong Multi-genetic events collaboratively contribute to Pten-null leukaemia stem-cell formation. Nature. 2008; 453(7194): 529-33.
Chang Chun-Ju, Mulholland David J, Valamehr Bahram, Mosessian Sherly, Sellers William R, Wu Hong PTEN nuclear localization is regulated by oxidative stress and mediates p53-dependent tumor suppression. Molecular and cellular biology. 2008; 28(10): 3281-9.
Kwon Chang-Hyuk, Zhao Dawen, Chen Jian, Alcantara Sheila, Li Yanjiao, Burns Dennis K, Mason Ralph P, Lee Eva Y-H P, Wu Hong, Parada Luis F Pten haploinsufficiency accelerates formation of high-grade astrocytomas. Cancer research. 2008; 68(9): 3286-94.
Iwanaga, K., Yang, Y., Raso, M., Ma, L., Hanna, A., Thilaganathan N., Moghaddam, S., Evans, C., Li, H., Cai, W., Sato, M., Minna, H., Wu, H., Creighton, C., Demayo, F., Wistuba, I. and Kurie, J. Pten inactivation accelerates oncogenic K-ras-initiated tumorigenesis in a mouse model of lung cancer. Cancer Research 2008; 68: 1119-1127.
Vivanco, I., Rohle, D., Versele, M., Palaskas, N., Evans, M., Hsueh, T., Brennan, C., Mulholland, D., Rajasekaran, S., Wolle, D., Rajasekaran, R., Dikic, I., Wu, H., Perera, T. and Mellinghoff, I.K. Regulation of Epidermal Growth Factor Receptor Signaling by the PTEN Tumor Suppressor. 2008; Submitted: .
Tahk S., Liu, B., Chenishof, V., Wong, K., Wu, H. and Shuai, K. Control of specificity and magnitude of NF-kB and STAT1-mediated gene activation through PIASy and PIAS1 co-operation. Proceddings of the National Academy of Sciences, USA. 2007; 104(28): 11643-11648.
Memarzadeh, S., Xin, L., Mulholland, D., Mansukhani,A., Wu, H., Teitell,M., and Witte, O. Enhanced Paracrine FGF10 Expression Promotes Formation of Multifocal Prostate Adenocarcinoma and an Increase in Epithelial Androgen Receptor. Cancer Cell. 2007; 12(6): 572-585.
Shen, W. H., Balajee, A.S., Wang, J., Wu, H., Eng, C., Pandolfi, PP, and Yin, Y. Essential Role for Nuclear PTEN in Maintaining Chromosomal Integrity. Cell 2007; (128): 157-170.
Vivanco, I., Palaskas, N., Tran, C., Finn, S.P., Getz, G., Kennedy, N.G., Jiao, J., Rose, J., Xie, W., Loda, M., Golub, T., Mellinghoff, I., Davis, R., Wu, H. and Sawyers, C.L Identification of the JNK Signaling Pathway as a Functional Target of the Tumor Suppressor PTEN. Cancer Cell 2007; (11): 555-569.
He, X., Zhang, J., Grindley, J.C., Tian, Q., Sato, T., Tao, W.A., Dirisina, R., Porter-Westpfahl, K.S., Hembree, M., Johnson, T., Wiedemann, L., Barrett, T., Hood, L., Wu, H. and Li, L. Inactivation of PTEN leads to enhanced activation of intestinal stem cells and biasing on lineage fate determination. Nature Genetics 2007; (39): 189-198.
Berquin, I.M., Min, Y., Wu, R., Wu, J., Perry, D., Cline, J.M., Thomas, M.J., Thornburg, T., Kulik. G., Smith, A., Edward, I.J., D?Agostino, R., Zhang, H., Wu, H., Kang, J.X., Chen, Y.Q. Modulation of Prostate Cancer Genetic Risk by Omega-3 and Omega-6 Fatty Acids. Journal of Clinical Investigation. 2007; 117(7): 1866-1875.
Jiao, J., Wang, S., Qiao, R., Vivanco, I., Watson, P., Sawyers, C. and Wu, H. Murine Cell Lines Derived from Pten Null Prostate Cancer Demonstrate the Critical Role of PTEN in Hormone Refractory Prostate Cancer Development. Cancer Research 2007; (67): 6083-6091.
Tsai PT, Ohab JJ, Kertesz N, Groszer M, Matter C, Gao J, Liu X, Wu H, Carmichael ST A critical role of erythropoietin receptor in neurogenesis and post-stroke recovery. J Neurosci. 2006; 26(4): 1269-74.
Horvath, S. Zhang, B. Carlson, M. Lu, K. V. Zhu, S. Felciano, R. M. Laurance, M. F. Zhao, W. Qi, S. Chen, Z. Lee, Y. Scheck, A. C. Liau, L. M. Wu, H. Geschwind, D. H. Febbo, P. G. Kornblum, H. I. Cloughesy, T. F. Nelson, S. F. Mischel, P. S. Analysis of oncogenic signaling networks in glioblastoma identifies ASPM as a molecular target. Proc Natl Acad Sci U S A. 2006; 103(46): 17402-7.
Guo, W. Lasky, J. L., 3rd Wu, H. Cancer stem cells. Pediatr Res. 2006; 59(4 Pt 2): 59R-64R.
Stiles, B., Kurlawalla-Martinez, C., Guo, W., Tian, J. Wang, Y., and Wu, H. Deletion of Pten in insulin producing pancreatic ?-cells leads to increased ?-cell mass and rescues STZ-induced diabetes. Molecular Cell Biology 2006; (26): 2772-2781.
Huang, W. Chang, H. Y. Fei, T. Wu, H. Chen, Y. G. GSK3beta mediates suppression of cyclin D2 expression by tumor suppressor PTEN. Oncogene. 2006; .
Freeman, D. Lesche, R. Kertesz, N. Wang, S. Li, G. Gao, J. Groszer, M. Martinez-Diaz, H. Rozengurt, N. Thomas, G. Liu, X. Wu, H. Genetic background controls tumor development in PTEN-deficient mice. Cancer Res. 2006; 66(13): 6492-6.
Khodavirdi, A. C. Song, Z. Yang, S. Zhong, C. Wang, S. Wu, H. Pritchard, C. Nelson, P. S. Roy-Burman, P. Increased expression of osteopontin contributes to the progression of prostate cancer. Cancer Res. 2006; 66(2): 883-8.
Xu, X. Kobayashi, S. Qiao, W. Li, C. Xiao, C. Radaeva, S. Stiles, B. Wang, R. H. Ohara, N. Yoshino, T. LeRoith, D. Torbenson, M. S. Gores, G. J. Wu, H. Gao, B. Deng, C. X. Induction of intrahepatic cholangiocellular carcinoma by liver-specific disruption of Smad4 and Pten in mice. J Clin Invest. 2006; 116(7): 1843-52.
Lei, Q. Jiao, J. Xin, L. Chang, C. J. Wang, S. Gao, J. Gleave, M. E. Witte, O. N. Liu, X. Wu, H. NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss. Cancer Cell. 2006; 9(5): 367-78.
Mulholland, D. J. Dedhar, S. Wu, H. Nelson, C. C. PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. Oncogene. 2006; 25(3): 329-37.
Li, G. Hu, Y. Huo, Y. Liu, M. Freeman, D. Gao, J. Liu, X. Wu, D. Wu, H. PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin. J Biol Chem. 2006; .
Yao, D. Alexander, C. L. Quinn, J. A. Porter, M. J. Wu, H. Greenhalgh, D. A. PTEN loss promotes rasHa-mediated papillomatogenesis via dual up-regulation of AKT activity and cell cycle deregulation but malignant conversion proceeds via PTEN-associated pathways. Cancer Res. 2006; 66(3): 1302-12.
Zhang, J. Grindley, J. C. Yin, T. Jayasinghe, S. He, X. C. Ross, J. T. Haug, J. S. Rupp, D. Porter-Westpfahl, K. S. Wiedemann, L. M. Wu, H. Li, L. PTEN maintains haematopoietic stem cells and acts in lineage choice and leukaemia prevention. Nature. 2006; 441(7092): 518-22.
Groszer M, Erickson R, Scripture-Adams DD, Dougherty JD, Le Belle J, Zack JA, Geschwind DH, Liu X, Kornblum HI, Wu H PTEN negatively regulates neural stem cell self-renewal by modulating G0-G1 cell cycle entry. Proc Natl Acad Sci U S A. 2006; 103(1): 111-6.
Yoo, L. I. Liu, D. W. Le Vu, S. Bronson, R. T. Wu, H. Yuan, J. Pten deficiency activates distinct downstream signaling pathways in a tissue-specific manner. Cancer Res. 2006; 66(4): 1929-39.
Wang S, Garcia AJ, Wu M, Lawson DA, Witte ON, Wu H Pten deletion leads to the expansion of a prostatic stem/progenitor cell subpopulation and tumor initiation. Proc Natl Acad Sci U S A. 2006; 103(5): 1480-5.
Yilmaz, O. H. Valdez, R. Theisen, B. K. Guo, W. Ferguson, D. O. Wu, H. Morrison, S. J. Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells. Nature. 2006; 441(7092): 475-82.
Wu, H. Khodavirdi, A Roy-Burman, P. Capturing signal anomalies of human prostate cancer into mouse models. Prostate cancer: basic mechanisms and therapeutic approaches 2005; in press.
Shi, Y. Sharma, A. Wu, H. Lichtenstein, A. Gera, J. Cyclin D1 and c-myc internal ribosome entry site (IRES)-dependent translation is regulated by AKT activity and enhanced by rapamycin through a p38 MAPK- and ERK-dependent pathway. J Biol Chem. 2005; 280(12): 10964-73.
Berquin, I. M. Min, Y. Wu, R. Wu, H. Chen, Y. Q. Expression signature of the mouse prostate. J Biol Chem. 2005; 280(43): 36442-51.
Kurlawalla-Martinez C, Stiles B, Wang Y, Devaskar SU, Kahn BB, Wu H Insulin hypersensitivity and resistance to streptozotocin-induced diabetes in mice lacking PTEN in adipose tissue. Molecular and cellular biology. . 2005; 25(6): 2498-510.
Download
Nakano I, Paucar AA, Bajpai R, Dougherty JD, Zewail A, Kelly TK, Kim KJ, Ou J, Groszer M, Imura T, Freije WA, Nelson SF, Sofroniew MV, Wu H, Liu X, Terskikh AV, Geschwind DH, Kornblum HI Maternal embryonic leucine zipper kinase (MELK) regulates multipotent neural progenitor proliferation. J Cell Biol. 2005; 170(3): 413-27.
Lasky JL, Wu H Notch signaling, brain development, and human disease. Pediatric research. . 2005; 57(5 Pt 2): 104R-109R.
Download
Liu B, Yang R, Wong KA, Getman C, Stein N, Cheng G, Wu H, and Shuai K PIAS1 Participates in the Negative Regulation of NF-kB Signaling. Mol. Cell Biol 2005; 25: 1113-23.
Download
Sanchez, T. Thangada, S. Wu, M. T. Kontos, C. D. Wu, D. Wu, H. Hla, T. PTEN as an effector in the signaling of antimigratory G protein-coupled receptor. Proc Natl Acad Sci U S A. 2005; 102(12): 4312-7.
Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization. Development (Cambridge, England) . 2005; 132(14): 3281-91.
Download
Stanger BZ, Stiles B, Lauwers GY, Bardeesy N, Mendoza M, Wang Y, Greenwood A, Cheng KH, McLaughlin M, Brown D, Depinho RA, Wu H, Melton DA, Dor Y Pten constrains centroacinar cell expansion and malignant transformation in the pancreas. Cancer cell. . 2005; 8(3): 185-95.
Tsao H, Goel V, Wu H, Yang G, Haluska FG Genetic interaction between NRAS and BRAF mutations and PTEN/MMAC1 inactivation in melanoma. The Journal of investigative dermatology. . 2004; 122(2): 337-41.
Roy-Burman P, Wu H, Powell WC, Hagenkord J, Cohen MB Genetically defined mouse models that mimic natural aspects of human prostate cancer development. Endocrine-related cancer. . 2004; 11(2): 225-54.
Stiles B, Wang Y, Stahl A, Bassilian S, Lee WP, Kim YJ, Sherwin R, Devaskar S, Lesche R, Magnuson MA, Wu H Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity [corrected]. Proc Natl Acad Sci U S A. 2004; 101(7): 2082-7.
Sundaresan G, Paulmurugan R, Berger F, Stiles B, Nagayama Y, Wu H, Gambhir SS MicroPET imaging of Cre-loxP-mediated conditional activation of a herpes simplex virus type 1 thymidine kinase reporter gene. Gene therapy. . 2004; 11(7): 609-18.
Liu B, Mink S, Wong KA, Stein N, Getman C, Dempsey PW, Wu H, Shuai K PIAS1 selectively inhibits interferon-inducible genes and is important in innate immunity. Nat Immunol. 2004; 5(9): 891-8.
Chang CJ, Freeman DJ, Wu H PTEN regulates Mdm2 expression through the P1 promoter. The Journal of biological chemistry. . 2004; 279(28): 29841-8.
Stiles B, Groszer M, Wang S, Jiao J, Wu H PTENless means more. Dev Biol. 2004; 273(2): 175-84.
Wong KA, Kim R, Christofk H, Gao J, Lawson G, Wu H Protein inhibitor of activated STAT Y (PIASy) and a splice variant lacking exon 6 enhance sumoylation but are not essential for embryogenesis and adult life. Mol Cell Biol. 2004; 24(12): 5577-86.
Lim, M. A. Yang, L. Zheng, Y. Wu, H. Dong, L. Q. Liu, F. Roles of PDK-1 and PKN in regulating cell migration and cortical actin formation of PTEN-knockout cells. Oncogene. 2004; 23(58): 9348-58.
Johnson JD, Han Z, Otani K, Ye H, Zhang Y, Wu H, Horikawa Y, Misler S, Bell GI, Polonsky KS RyR2 and calpain-10 delineate a novel apoptosis pathway in pancreatic islets. J Biol Chem. 2004; 279(23): 24794-802.
Kertesz N, Wu J, Chen TH, Sucov HM, Wu H The role of erythropoietin in regulating angiogenesis. Dev Biol. 2004; 276(1): 101-10.
Tsai, P. T. Lee, R. A. Wu, H. BMP4 acts upstream of FGF in modulating thymic stroma and regulating thymopoiesis. Blood. 2003; 102(12): 3947-53.
Freeman DJ, Li AG, Wei G, Li HH, Kertesz N, Lesche R, Whale AD, Martinez-Diaz H, Rozengurt N, Cardiff RD, Liu X, Wu H PTEN tumor suppressor regulates p53 protein levels and activity through phosphatase-dependent and -independent mechanisms. Cancer Cell. 2003; 3(2): 117-30.
Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer cell. . 2003; 4(3): 209-21.
Anzelon AN, Wu H, Rickert RC Pten inactivation alters peripheral B lymphocyte fate and reconstitutes CD19 function. Nat Immunol. 2003; 4(3): 287-94.
Kertesz, N. Samson, J. Debacker, C. Wu, H. Labastie, M. C. Cloning and characterization of human and mouse SNRK sucrose non-fermenting protein (SNF-1)-related kinases. Gene. 2002; 294(1-2): 13-24.
Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development. 2002; 129(17): 4159-70.
Lesche R, Groszer M, Gao J, Wang Y, Messing A, Liu X, and Wu H Cre/loxp-Mediated Inactivation of The Murine Pten Tumor Suppressor Gene. Genesis. 2002; 32: 148-149.
Download
Jegalian A and Wu H Differential Regulation of SOCS Gene Expression and Distinct Roles of SOCS family Members in Erythropoietin Receptor Signal Transduction. J. Cyto.Research . 2002; 22: 3842-3851.
Download
Osawa M, Yamaguchi T, Nakamura Y, Kaneko S, Onodera M, Sawada K, Jegalian A, Wu H, Nakauchi H, Iwama A Erythroid expansion mediated by the Gfi-1B zinc finger protein: role in normal hematopoiesis. Blood. . 2002; 100(8): 2769-77.
Download
Jegalian, A., Acurio, A., Dranoff, G., Wu, H. Erythropoietin receptor haploinsufficiency and in vivo interplay with granulocyte-macrophage colony-stimulating factor and interleukine 3. Blood . 2002; 99: 2603-2605.
Download
Wong K, Tsai P, Jegalian A, Kertesz N, Lee R and Wu H Erythropoietin. In Encyclopedia of Hormones and Related Cell Regulators; 2002; .
Stiles B, Gilman V, Khanzenzon N, Lesche R, Li A, Qiao R, Liu X, Wu H Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis. Mol Cell Biol. 2002; 22(11): 3842-51.
Jegalian, AG Wu, H Regulation of Socs gene expression by the proto-oncoprotein GFI-1B: two routes for STAT5 target gene induction by erythropoietin. The Journal of biological chemistry. . 2002; 277(3): 2345-52.
Download
Makita, T. Hernandez-Hoyos, G. Chen, T. H. Wu, H. Rothenberg, E. V. Sucov, H. M. A developmental transition in definitive erythropoiesis: erythropoietin expression is sequentially regulated by retinoic acid receptors and HNF4. Genes Dev. 2001; 15(7): 889-901.
Dubey P, Wu H, Reiter RE, Witte ON Alternative pathways to prostate carcinoma activate prostate stem cell antigen expression. Cancer Res. 2001; 61(8): 3256-61.
Neshat MS, Mellinghoff IK, Tran C, Stiles B, Thomas G, Petersen R, Frost P, Gibbons JJ, Wu H, Sawyers CL Enhanced sensitivity of PTEN-deficient tumors to inhibition of FRAP/mTOR. Proc Natl Acad Sci U S A. 2001; 98(18): 10314-9.
Lee R, Kertesz N, Joseph SB, Jegalian A, Wu H Erythropoietin (Epo) and EpoR expression and 2 waves of erythropoiesis. Blood. 2001; 98(5): 1408-15.
Hisakawa H, Sugiyama D, Nishijima I, Xu MJ, Wu H, Nakao K, Watanabe S, Katsuki M, Asano S, Arai K, Nakahata T, Tsuji K Human granulocyte-macrophage colony-stimulating factor (hGM-CSF) stimulates primitive and definitive erythropoiesis in mouse embryos expressing hGM-CSF receptors but not erythropoietin receptors. Blood. 2001; 98(13): 3618-25.
Groszer, M. Erickson, R. Scripture-Adams, D. D. Lesche, R. Trumpp, A. Zack, J. A. Kornblum, H. I. Liu, X. Wu, H. Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science. 2001; 294(5549): 2186-9.
Mamillapalli R, Gavrilova N, Mihaylova VT, Tsvetkov LM, Wu H, Zhang H, Sun H PTEN regulates the ubiquitin-dependent degradation of the CDK inhibitor p27(KIP1) through the ubiquitin E3 ligase SCF(SKP2). Curr Biol. 2001; 11(4): 263-7.
Satterthwaite, A. B. Willis, F. Kanchanastit, P. Fruman, D. Cantley, L. C. Helgason, C. D. Humphries, R. K. Lowell, C. A. Simon, M. Leitges, M. Tarakhovsky, A. Tedder, T. F. Lesche, R. Wu, H. Witte, O. N. A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A. 2000; 97(12): 6687-92.
Liliental J, Moon SY, Lesche R, Mamillapalli R, Li D, Zheng Y, Sun H, Wu H Genetic deletion of the Pten tumor suppressor gene promotes cell motility by activation of Rac1 and Cdc42 GTPases. Curr Biol. 2000; 10(7): 401-4.
Ghaffari, S. Wu, H. Gerlach, M. Han, Y. Lodish, H. F. Daley, G. Q. BCR-ABL and v-SRC tyrosine kinase oncoproteins support normal erythroid development in erythropoietin receptor-deficient progenitor cells. Proc Natl Acad Sci U S A. 1999; 96(23): 13186-90.
Wu H, Lee SH, Gao J, Liu X, Iruela-Arispe ML Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development (Cambridge, England) . 1999; 126(16): 3597-605.
Download
Sun H, Lesche R, Li DM, Liliental J, Zhang H, Gao J, Gavrilova N, Mueller B, Liu X, Wu H PTEN modulates cell cycle progression and cell survival by regulating phosphatidylinositol 3,4,5,-trisphosphate and Akt/protein kinase B signaling pathway. Proc Natl Acad Sci U S A. 1999; 96(11): 6199-204.
Neubauer H, Cumano A, Muller M, Wu H, Huffstadt U, Pfeffer K Jak2 deficiency defines an essential developmental checkpoint in definitive hematopoiesis. Cell. 1998; 93(3): 397-409.
Constantinescu, S. N. Wu, H. Liu, X. Beyer, W. Fallon, A. Lodish, H. F. The anemic Friend virus gp55 envelope protein induces erythroid differentiation in fetal liver colony-forming units-erythroid. Blood. 1998; 91(4): 1163-72.
Wu H, Klingmuller U, Acurio A, Hsiao JG and Lodish HF Functional Interaction of Erythropoietin and Stem Cell Factor Receptors is Essential for Erythroid Colony Formation. Proc. Natl. Acad. Sci. USA. . 1997; 94: 1806-1810.
Download
Wu, H. Klingmuller, U. Acurio, A. Hsiao, J. G. Lodish, H. F. Functional interaction of erythropoietin and stem cell factor receptors is essential for erythroid colony formation. Proc Natl Acad Sci U S A. 1997; 94(5): 1806-10.
Klingmuller K, Wu H, Hsiao J, Duckworth B, Toker A, Cantley LC and Lodish HF Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc. Natl. Acad. Sci. USA . 1997; 94: 3016-3021.
Download
Klingmuller U, Wu H, Hsiao JG, Toker A, Duckworth BC, Cantley LC, Lodish HF Identification of a novel pathway important for proliferation and differentiation of primary erythroid progenitors. Proc Natl Acad Sci U S A. 1997; 94(7): 3016-21.
Liu X, Wu H, Loring J, Hormuzdi S, Disteche CM, Bornstein P, Jaenisch R Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Developmental dynamics : an official publication of the American Association of Anatomists. . 1997; 209(1): 85-91.
Download
Liu X, Wu H, Byrne M, Krane S, Jaenisch R Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proc Natl Acad Sci U S A. 1997; 94(5): 1852-6.
Watowich SS, Wu H, Socolovsky M, Klingmuller U, Constantinescu SN, Lodish HF Cytokine receptor signal transduction and the control of hematopoietic cell development. Annu Rev Cell Dev Biol. 1996; 12: 91-128.
Krane SM, Byrne M, Henrie P, Lemaitre V, Jeffrey JJ, Witter J, Liu X, Wu H, Jaenisch R and Eeckhout Y Different collagenase gene products have different roles in remodeling of type I collagen-containing extracellular matrices. J. Biol. Chem. . 1996; 271: 28509-28515.
Download
Wu H and Lodish H The erythropoietin receptor: dimerization and intracellular signal transduction. Journal of Experimental hematology 1996; 4: 229-235.
Iruela ML, Vernon RB, Wu H, Jeanisch R and Sage H Type I collagen is required for the association of SPARC with the extracellular matrix in Mov-13 mice: implications for fibroblast function. Developmental Dynamics . 1996; 207: 171-183.
Liu X, Wu H, Byrne M, Jeffrey J, Krane S, Jaenisch R A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. The Journal of cell biology. . 1995; 130(1): 227-37.
Download
Wu H, Liu X, Jaenisch R and Lodish H Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell. 1995; 83: 59-67.
Wu, H. Klingmuller, U. Besmer, P. Lodish, H. F. Interaction of the erythropoietin and stem-cell-factor receptors. Nature. 1995; 377(6546): 242-6.
Lodish HF, Hilton DJ, Klingmuller U, Watowich SS, Wu H The erythropoietin receptor: biogenesis, dimerization, and intracellular signal transduction. Cold Spring Harb Symp Quant Biol. 1995; 60: 93-104.
Liu X, Enfors P, Wu H and Jaenisch R nsory neuron deficit, but show no motor neuron loss.Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature. 1995; 375: 238-241.
Download
Wu, H. Liu, X. Jaenisch, R. Double replacement: strategy for efficient introduction of subtle mutations into the murine Col1a-1 gene by homologous recombination in embryonic stem cells. Proc Natl Acad Sci U S A. 1994; 91(7): 2819-23.
Dzamba, B. J. Wu, H. Jaenisch, R. Peters, D. M. Fibronectin binding site in type I collagen regulates fibronectin fibril formation. J Cell Biol. 1993; 121(5): 1165-72.
Hasty K, Wu H, Byrne M, Goldring M, Jaenisch R, Krane S and Mainardi C Susceptibility of type I collagen containing mutated alpha1(I) chains to cleavage by human neutrophil collagenase. Matrix. 1993; 13: 181-186.
Wu, H. Fassler, R. Schnieke, A. Barker, D. Lee, K. H. Chapman, V. Francke, U. Jaenisch, R. An X-linked human collagen transgene escapes X inactivation in a subset of cells. Development. 1992; 116(3): 687-95.
Barker DD, Wu H, Hartung S, Breindl M, Jaenisch R Retrovirus-induced insertional mutagenesis: mechanism of collagen mutation in Mov13 mice. Molecular and cellular biology. . 1991; 11(10): 5154-63.
Download
Wu, H. Byrne, M. H. Stacey, A. Goldring, M. B. Birkhead, J. R. Jaenisch, R. Krane, S. M. Generation of collagenase-resistant collagen by site-directed mutagenesis of murine pro alpha 1(I) collagen gene. Proc Natl Acad Sci U S A. 1990; 87(15): 5888-92.
Wu H, Bateman JF, Schnieke A, Sharpe A, Barker D, Mascara T, Eyre D, Bruns R, Krimpenfort P, Berns A Human-mouse interspecies collagen I heterotrimer is functional during embryonic development of Mov13 mutant mouse embryos. Molecular and cellular biology. . 1990; 10(4): 1452-60.
Download
Silverman, D. H. Wu, H. Karnovsky, M. L. Muramyl peptides and serotonin interact at specific binding sites on macrophages and enhance superoxide release. Biochem Biophys Res Commun. 1985; 131(3): 1160-7.