West LA VA Bldg 114
West Los Angeles, CA 90073
West LA VA, Bldg 500, Rm 3257
11301 Wilshire Blvd
West Los Angeles, CA 90073
Work Phone Number:
West LA Veterans Hospital
Brain Research Institute
My current interests center on the basic mechanisms of the acquired epilepsies: how does epilepsy come about, how does it affect brain development, what is the mechanism of seizure-induced neuronal death, and how do maladaptive changes in receptor trafficking cause the uncontrolled seizures of status epilepticus. And, most importantly, how can we prevent those phenomena and improve the life of people who suffer from that disease?
University of Liege (Belgium), M.D., 1961
Free University of Brussels, L.Sc., Molecular Biology, 1969
Cornell University Medical College: Neurology residency, research fellowship in Jerry Posner's lab
Instructor, Department of Neurology, Cornell University Medical College, New York, NY,1969-70
Assistant Professor of Neurology, Cornell University Medical College, New York, NY, 1970-75.
Associate Professor of Neurology, Cornell University Medical College, New York, NY, 1975-76.
Associate Professor of Neurology, UCLA School of Medicine, Los Angeles, CA 1976-79.
Vice-Chair, Department of Neurology, UCLA School of Medicine, 1976-present.
Professor of Neurology, UCLA School of Medicine, 1979-present.
Chief, Neurology Section, VA Medical Center, Sepulveda, CA 1976-79.
Chief, Neurology Service, VA Medical Center, Sepulveda, CA 1979-98.
Chair, Department of Neurology, VA Greater Los Angeles Healthcare System, 1998-present
HONORS AND AWARDS
M.D. with Distinction.
L.Sc. in Molecular Biology Summa Cum Laude.
Research Career Development Award, NIH, 1973-1976.
Elected "Outstanding Faculty Member" (best clinical teacher) by the UCLA-SFVMP Interns & Residents Assoc. 1976-77.
Grass Traveling Fellow, 1983.
William Evans Fellow, Auckland Medical School, 1984.
Visiting Professor, University of Otago, 1984.
American Epilepsy Society-Milken Family Foundation Award for Basic Research in Epilepsy, 1992.
Distinguished Lecturer in Neuroscience, LSU Center of Excellence, 1996.
"Golden Hammer" teaching award, UCLA dpt of Neurology, 1996.
"Ambassador for Epilepsy" award, International League Against Epilepsy, 2003.
Distinguished Professor of Neurology, Geffen School of Medicine at UCLA, 2005.
Pierre Gloor Award, American Clinical Neurophysiology Society, 2006.
Seo DW, Lopez-Meraz ML, Allen S, Wasterlain CG, Niquet J. Contribution of a mitochondrial pathway to excitotoxic neuronal necrosis. http://www.ncbi.nlm.nih.gov/pubmed/19235896?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum>
J Neurosci Res. 2009 PMID: 19235896
Wasterlain CG, Chen JW. Mechanistic and pharmacologic aspects of status
epilepticus and its treatment with new antiepileptic drugs.
Chen JWY, Wasterlain CG, Status Epilepticus, Lancet Neurology 5:246-256, 2006. PMID: 16488380
Wasterlain CG, Liu H, Naylor DE, Thompson KW, Suchomelova L, Niquet J, Mazarati AM, Baldwin RA. Molecular basis of self-sustaining seizures and pharmacoresistance during status epilepticus: The receptor trafficking hypothesis revisited. Epilepsia. 50(s12):16-18, 2009. PMID: 19941513
Lopez-Meraz ML, Wasterlain CG, Rocha LL, Allen S, Niquet J. Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage. Neurobiol Dis. 2009 Oct 29. [Epub ahead of print] PMID: 19879360.
Chen JWY, Wasterlain CG, Status Epilepticus.
Claude G. Wasterlain and David M. Treiman (Editors) Status Epilepticus: Mechanisms and Management.
Naylor DE, Liu H, Wasterlain C. Trafficking of GABAA receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus.
Seo Dae-Won, Lopez-Meraz Maria-Leonor, Allen Suni, Wasterlain Claude Guy, Niquet Jerome Contribution of a mitochondrial pathway to excitotoxic neuronal
Journal of neuroscience research
Wasterlain Claude G, Chen James W Y Mechanistic and pharmacologic aspects of status epilepticus and its
treatment with new antiepileptic drugs.
2008; 49 Suppl 9(9):
Niquet Jerome, Auvin Stéphane, Archie Mark, Seo Dae-Won, Allen Suni, Sankar Raman, Wasterlain Claude G Status epilepticus triggers caspase-3 activation and necrosis in the
immature rat brain.
Sankar, R Shin, D Mazarati, AM Liu, H Katsumori, H Lezama, R Wasterlain, CG Epileptogenesis after status epilepticus reflects age- and model-dependent plasticity.
Annals of neurology.