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Claude Wasterlain, M.D., L.Sc.D.

Work Email Address:
wasterla@ucla.edu

Work Address:
Laboratory
West LA VA Bldg 114
West Los Angeles, CA 90073
UNITED STATES

Office
West LA VA, Bldg 500, Rm 3257
11301 Wilshire Blvd
West Los Angeles, CA 90073
UNITED STATES

Fax Number:
310-268-4611
Work Phone Number:
310-268-3595



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Department / Division Affiliations
Distinguished Professor, Neurology
Hospital Affiliations:
Neurology, West LA Veterans Hospital
Department / Division Affiliations
Member, Brain Research Institute

Research Interest:

Basic mechanisms of epilepsy

My current interests center on the basic mechanisms of the acquired epilepsies: how does epilepsy come about, how does it affect brain development, what is the mechanism of seizure-induced neuronal death, and how do maladaptive changes in receptor trafficking cause the uncontrolled seizures of status epilepticus. And, most importantly, how can we prevent those phenomena and improve the life of people who suffer from that disease?

Bio:

EDUCATION University of Liege (Belgium), M.D., 1961 Free University of Brussels, L.Sc., Molecular Biology, 1969 Cornell University Medical College: Neurology residency, research fellowship in Jerry Posner's lab POSITIONS Instructor, Department of Neurology, Cornell University Medical College, New York, NY,1969-70 Assistant Professor of Neurology, Cornell University Medical College, New York, NY, 1970-75. Associate Professor of Neurology, Cornell University Medical College, New York, NY, 1975-76. Associate Professor of Neurology, UCLA School of Medicine, Los Angeles, CA 1976-79. Vice-Chair, Department of Neurology, UCLA School of Medicine, 1976-present. Professor of Neurology, UCLA School of Medicine, 1979-present. Chief, Neurology Section, VA Medical Center, Sepulveda, CA 1976-79. Chief, Neurology Service, VA Medical Center, Sepulveda, CA 1979-98. Chair, Department of Neurology, VA Greater Los Angeles Healthcare System, 1998-present HONORS AND AWARDS M.D. with Distinction. L.Sc. in Molecular Biology Summa Cum Laude. Research Career Development Award, NIH, 1973-1976. Elected "Outstanding Faculty Member" (best clinical teacher) by the UCLA-SFVMP Interns & Residents Assoc. 1976-77. Grass Traveling Fellow, 1983. William Evans Fellow, Auckland Medical School, 1984. Visiting Professor, University of Otago, 1984. American Epilepsy Society-Milken Family Foundation Award for Basic Research in Epilepsy, 1992. Distinguished Lecturer in Neuroscience, LSU Center of Excellence, 1996. "Golden Hammer" teaching award, UCLA dpt of Neurology, 1996. "Ambassador for Epilepsy" award, International League Against Epilepsy, 2003. Distinguished Professor of Neurology, Geffen School of Medicine at UCLA, 2005. Pierre Gloor Award, American Clinical Neurophysiology Society, 2006. Seo DW, Lopez-Meraz ML, Allen S, Wasterlain CG, Niquet J. Contribution of a mitochondrial pathway to excitotoxic neuronal necrosis. http://www.ncbi.nlm.nih.gov/pubmed/19235896?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum> J Neurosci Res. 2009 PMID: 19235896 Wasterlain CG, Chen JW. Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs. Chen JWY, Wasterlain CG, Status Epilepticus, Lancet Neurology 5:246-256, 2006. PMID: 16488380 Wasterlain CG, Liu H, Naylor DE, Thompson KW, Suchomelova L, Niquet J, Mazarati AM, Baldwin RA. Molecular basis of self-sustaining seizures and pharmacoresistance during status epilepticus: The receptor trafficking hypothesis revisited. Epilepsia. 50(s12):16-18, 2009. PMID: 19941513 Lopez-Meraz ML, Wasterlain CG, Rocha LL, Allen S, Niquet J. Vulnerability of postnatal hippocampal neurons to seizures varies regionally with their maturational stage. Neurobiol Dis. 2009 Oct 29. [Epub ahead of print] PMID: 19879360.

Publications:

Chen JWY, Wasterlain CG, Status Epilepticus. Lancet Neurology 2006; 5: 246-256.
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Claude G. Wasterlain and David M. Treiman (Editors) Status Epilepticus: Mechanisms and Management. 2006; .
Naylor DE, Liu H, Wasterlain C. Trafficking of GABAA receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J Neurosci 2005; 25: 7724-7733.
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Seo Dae-Won, Lopez-Meraz Maria-Leonor, Allen Suni, Wasterlain Claude Guy, Niquet Jerome Contribution of a mitochondrial pathway to excitotoxic neuronal necrosis. Journal of neuroscience research. 2009; 87(9): 2087-94.
Wasterlain Claude G, Chen James W Y Mechanistic and pharmacologic aspects of status epilepticus and its treatment with new antiepileptic drugs. Epilepsia. 2008; 49 Suppl 9(9): 63-73.
Niquet Jerome, Auvin Stéphane, Archie Mark, Seo Dae-Won, Allen Suni, Sankar Raman, Wasterlain Claude G Status epilepticus triggers caspase-3 activation and necrosis in the immature rat brain. Epilepsia. 2007; 48(6): 1203-6.
Niquet, J Baldwin, RA Allen, SG Fujikawa, DG Wasterlain, CG Hypoxic neuronal necrosis: protein synthesis-independent activation of a cell death program. Proceedings of the National Academy of Sciences of the United States of America. . 2003; 100(5): 2825-30.
Sankar, R Shin, D Mazarati, AM Liu, H Katsumori, H Lezama, R Wasterlain, CG Epileptogenesis after status epilepticus reflects age- and model-dependent plasticity. Annals of neurology. . 2000; 48(4): 580-9.
Mazarati, AM Hohmann, JG Bacon, A Liu, H Sankar, R Steiner, RA Wynick, D Wasterlain, CG Modulation of hippocampal excitability and seizures by galanin. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2000; 20(16): 6276-81.
Liu, H Cao, Y Basbaum, AI Mazarati, AM Sankar, R Wasterlain, CG Resistance to excitotoxin-induced seizures and neuronal death in mice lacking the preprotachykinin A gene. Proceedings of the National Academy of Sciences of the United States of America. . 1999; 96(21): 12096-101.
Liu, H Mazarati, AM Katsumori, H Sankar, R Wasterlain, CG Substance P is expressed in hippocampal principal neurons during status epilepticus and plays a critical role in the maintenance of status epilepticus. Proceedings of the National Academy of Sciences of the United States of America. . 1999; 96(9): 5286-91.
Mazarati, AM Liu, H Soomets, U Sankar, R Shin, D Katsumori, H Langel, U Wasterlain, CG Galanin modulation of seizures and seizure modulation of hippocampal galanin in animal models of status epilepticus. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1998; 18(23): 10070-7.
Sankar, R Shin, DH Liu, H Mazarati, A Pereira de Vasconcelos, A Wasterlain, CG Patterns of status epilepticus-induced neuronal injury during development and long-term consequences. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1998; 18(20): 8382-93.