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Edwin Cooper, Ph.D., Sc.D.

Email Address:
cooper@mednet.ucla.edu
Email Address:
cooper@ucla.edu

Mailing Address:
Department of Neurobiology
CAMPUS - 176318
Laboratory of Comparative Neuroimmunology
Department of Neurobiology
David Geffen School of Medicine at UCLA
Los Angeles, CA 90095
UNITED STATES

Work Address:
Office
CHS
Los Angeles, CA 90095
UNITED STATES

Work Phone Number:
(310)825-9567
310-825-9567



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Department / Division Affiliations
Distinguished Professor, Neurobiology
Member, Basic/Translational Research, Jonsson Comprehensive Cancer Center, Brain Research Institute

Publications:

Cooper E.L. Hrzenjak, T.M. and Grdisa, T. Alternative sources of fibrinolytic, anticoagulative, antimicrobial and anticancer molecules. Int. J. Immunopathol. and Pharacol ; 237-244.
Salvioli S, Sikora E, Cooper EL, Franceschi C. Curcumin in Cell Death Processes: A Challenge for CAM of Age-Related Pathologies. Evid Based Complement Alternat MEd ; 4(2): 181-190.
Prakash M, Balamurugan M, Parthasarathi K, Gunasekaran G, Cooper EL, Ranganathan LS. Anti-ulceral and anti-oxidative properties of "earthworm paste" of Lampito mauritii (Kinberg) on Rattus Norvegicus. Eur Rev Med Pharmacol Sci 2007; 11(1): 9-15.
Balamurugan M, Parthasarathi K, Cooper EL, Ranganthan LS. Earthworm paste (Lampito mauritii, Kinberg) alters inflammatory, oxidative, haematological and serum biochemical indices of inflamed rat. Eur Rev Med Pharmacol Sci 2007; 11(2): 77-90.
Cooper EL. Is There Room for Paradox in CAM?. Evid Based Complement Alternat Med 2007; 4(2): 135-7.
Cooper El. On the Road to an Impact Factor for eCAM. Evid Based Complement Alternat Med 2007; 4(1): 1-2.
Salzet M, Tasiemski A, Cooper E. Innate immunity in Lophotrochozoans: The Annelids. Current Pharmaceutical Design 2006; 12: 3043-3050.
Cooper EL. Regional Strength in CAM. Evid Based Complement Alternat Med 2006; 3(3): 291-2.
Cooper EL. Stem Cells and CAM. Evid Based Complement Alternat Med 2006; 3(2): 167-9.
Cooper EL, Kvell K, EngelmanN P, Nemeth P. Still waiting for the toll?. Immunol Lett 2006; 104(1-2): 18-28.
Cooper EL. eCAM: On To Year 4. Evid Based Complement Alternat Med 2006; 3(4): 395-6.
Engelmann, P., Cooper, E.L. and Nemeth, P. Anticipating innate immunity without a Toll. Mol. Immunol. Molecular Immunology 2005; 931-342.
Lugli E, Troiano L, Ferraresi R, Roat E, Prada N, Nasi M, Pinti M, Cooper EL. Characterization of cells with different mitochondrial membrane potential during apoptosis. Cytometry 2005; 68: 28-35.
Ferraresi R, Troiano L, Roat E, Lugli E, Nemes E, Nasi M, Pinti M, Fernandez MI, Cooper EL, Cossarizza A. Essential Requirement of reduced glutathione (GSH) for the anti-oxidant effect of the flavonoid quercetin. Free Radic Res 2005; 39: 1249-1258.
Cossarizza A, Pinti M, Troiano L, Cooper EL. Flow cytometry as a tool for analyzing invertebrate cells. Invertebrate Survival Journal 2005; 2: 32-40.
Cunha da Silva JRM, Cooper EL, Sinhorini IL, Borges JCS, Jensch-Junior BE, Porto-Neto LR, Hernandez-Blazquez FJ, Vellutini BC, Pressinotti LN, Costa-Pinto FA. Microscopial study of experimental wound healing in Notenia coriiceps (Cabecuda) at 0 degree C. Cell Tissue Res 2005; 321: 401-410.
Engelmann P, Palinkas L, Cooper EL, Nemeth P. Monoclonal antibodies identify four distinct annelid leukocyte markers. Dev Comp Immunol 2005; 29: 599-614.
Cooper E.L, Torres AP, Castel AR. Comparative Immunology of the Integument. Skin Immune System 2004; 9-24.
Cooper EL, P??rez A, Castell A. Comparative Immunology of the Integument. skin immune system: cutaneous immunology and clinical immunodermatology 3rd edition 2004; 19-54.
Cooper EL, Yamaguchi N Complementary and alternative approaches to biomedicine. Advances in experimental medicine and biology 2004; 546: .
Wiesner L, Hahn ME, Karchner SI, Cooper EL, Kauschke E Does an aryl hydrocarbon receptor (AHR)-like molecule exist in earthworms? Some implications for immunity. Pedobiologia 2004; 47: 646-50.
Cooper EL, Roch P Earthworm immunity: a model of immune competence. Pedobiologia 2004; 47: 676-88.
Engelmann, P., Molnar, L., Palinkas, L., Cooper, E.L. and Nemeth, P. Earthworm leukocyte populations specifically harbor lysosomal enzymes that may respond to bacterial challenge. Cell and Tissue Research 2004; 316: 391-401.
Engelmann, P., Kiss, J., Csongei, V., Cooper, E.L. and Nemeth, P. Earthworm leukocytes kill HeLa, HEp-2, PC-12 and PA317 cells in vitro. J Biochem Biophys Methods 2004; 61: 215-227.
Cooper, E. L., Ru, B. and Weng, N. Earthworms: sources of antimicrobial and anticancer molecules. Adv Exp Med Biol - Complementary and Alternative Approaches to Biomedicine 2004; 359-390.
Cooper E.L. Effector mechanisms of natural immunity: an invertebrate perspective. Chow D, Bertok L, editors. Neuroimmune biology 2004; 5(Natural Immunity): 103-122.
Blanco, G.A. and Cooper, E.L. Environmental Pollutants, Immune Systems, Geographic Information Systems (GIS). J. Toxicol. and Environ. Health B. Crit 2004; 465-80.
Field SG, Kurtz J, Cooper EL, Michiels NK Evaluation of an innate immune reaction to parasites in earthworms. J Invert Pathol 2004; 86: 45-49.
Vojdani A, Bazargan M, Vojdani E, Samadi J, Nourian AA, Eghbalieh N, Cooper EL. Heat shock protein and gliadin peptide promote development of peptidase antibodies in children with autism and patients with autoimmune disease. Clin Diag Lab Immunol 2004; 11: 515-524.
Vojdani, A. and Cooper, E.L. Identification of diseases that may be targets for complementary and alternative medicine (CAM). Adv. Exp. Med. Biol 2004; 546: 75-104.
Vojdani, A., O'Bryan, T., Green, J.A., McCandless, J., Woeller, K.N., Vojdani, E., Nourian, A.A., and Cooper, E.L. Immune response to dietary proteins, gliadin and cerebellar petpides in children with autism. Nutr Neurosci 2004; 7: 151-161.
Rosas, C., Coooper, E.L., Pascual, C., Brito, R., Belabert, R., Moreno, T., MIranda, G. and Sanchez, A. Indicators of physiological and immunological status of Litopenaeus setiferus wild population (Crustacea, Penaeidae). Marine Biology 2004; 145: 401-413.
Silva JRMC, Sinhorini IL, Jensch-Jr BE, Porto-Neto LR, Hernandez-Blazquez FJ, Vellutini BC, Pressinotti LN, Pinto FAC, Cooper EL, Borges JCS. Kinetics of induced wound repair at O degree C in the Antarctic fish (Cabecuda) Notothenia coriiceps. Polar Biol 2004; 27: 458-465.
Rosas, C., Cooper, E.L., Pascual, C., Brito, R., Gelabert. R., Morena, T., Miranda, G. and S??nchez, A. La condici??n reproductiva del camar??n blanco Litopenaeus setiferus (Crustacea; Penaeidae): Evidencias de deterioro ambiental en el Sur del Golfo de M??xico. Diagn??stico ambiental del Golfo de M??xico, Secretaria de Medio Ambiente y Rcursos, Instituto Nacional de Ecolog??a 2004; 2: 789-822.
Kasahara S, Cooper EL. Nervous, endocrine, immune systems as a target for complementary and alternative medicine. Complementary and Alternative Approaches to Biomedicine 2004; 405-426.
Komiyama K, Okaue M, Miki Y, Ohkubo M, Moro I, Cooper EL Non-specific cellular function of Eisenia fetida regulated by polycyclic aromatic hydrocarbons. Pedobiologia 2004; 47: 717-23.
Pascual, C., Sanchez, A., Garcia, T., Moreno, T., Cooper E.L. and Rosas, C. Reproductive conditio of an adult male population of the white shrimp Litopenaeus setiferus. J. Crust. Biol 2004; In press.: .
Cooper, E.L. What happened in Kanazawa? The birth of eCAM. Complementary and Alternative Approaches to Biomedicine 2004; .
Vojdani A., Vojdani E. and Cooper E.L. Antibodies to myelin basic protein, myelin oligodendrocytes, peptides, alpha-beta-crystallin, lymphocyte activation and cytokine production in patients with multiple sclerosis. J. Internal Med 2003; 254: 363-374.
Cooper EL. Comparative Immunology. Integr Comp Biol 2003; 43: 278-280.
Cooper, E.L. Comparative immunology of the animal kingdom. The New Panorama of Animal Evolution, Proceedings XVIII International Congress of Zoology 2003; 117-125.
Cooper, E.L. Comparative immunology. Current Pharmaceutical Design 2003; 9: 119-31.
Salzet, M., Tasiemski, A., Lefebvre, Ch. And Cooper, E. L. Comparison of molecular neuroimmune processes between leeches and human. The New Panorama of Animal Evolution, Proceedings XVIII International Congress of Zoology 2003; 147-157.
Parrinello, N., Cammarata, M., Arizza, V., Vazzana, M., and Cooper, E. L. How do cells of the invertebrate immune systems kill other cells?. The New Panorama of Animal Evolution, Proceedings XVIII International Congress of Zoology 2003; 167-175.
Vojdani A, Pangborn JB, Vojdani E, Cooper EL Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism. International journal of immunopathology and pharmacology. . 2003; 16(3): 189-99.
Vojdani A., Pangborn J.B., Vojdani E. and Cooper E.L. Infections, toxic chemicals and dietary peptides binding to lymphocyte receptors and tissue enzymes are major instigators of autoimmunity in autism. Int. J. Immunopathol. Pharmacol 2003; 16: 189-200.
Tettamanti G, Grimaldi A, Ferrarese R, Palazzi M, Perletti G, Valvassori R, Cooper EL, Lanzavecchia G, de Eguileor M. Leech responses to tissue transplantation. Tissue & Cell 2003; 35: 199-212.
de Eguileor M, Tettamanti G, Grimaldi A, Congiu T, Ferrarese R, Perletti G, Valvassori R, Cooper EL, Lanzavecchia G Leeches: immune response, angiogenesis and biomedical applications. Curr Pharm Des 2003; 2: 133-47.
Koenig S, Wagner F, Kauschke E, Peter-Katalinic J, Cooper EL, Eue I Mass spectrometric analyses of CL39, CL41 and H1,H2, H3 confirm identity with fetidin and lysenin produced by earthworm leukocytes. Dev Comp Immunol 2003; 27: 513-20.
Cooper, E.L. Neuroimmunology of autism: a multifaceted hypothesis. Int. J. Immunopathol. Pharmacol 2003; 16: 289-92.
de Eguileor, M., Grimaldi, A., Tettamanti, G., Valvassori, R. and Cooper, E. L. State of the art for the immune system in leeches. The New Panorama of Animal Evolution, Proceedings XVIII International Congress of Zoology 2003; 139-145.
Cooper, E.L., Beschin, A. and Bilej, M. A new model for analyzing antimicrobial peptides with biomedical applications. 2002; .
Bilej, M., Kauschke, E., Komiyama, K., Roch, R., Kohlerova, P., Silerova, M., Cooper, E.L., De Baetselier, P., Tuckova, L. and Beschin, A. An overview of cytolytic factors in Eisenia foetida coelomic fluid. A new model for analyzing antimicrobial peptides with biomedical applications 2002; 177-184.
Engelmann, P., Cooper, E.L. and Nemeth, P. Comparative analysis of earthworm immune system using cell surface and intracellular markers. A new model for analyzing antimicrobial peptides with biomedical applications 2002; 53-60.
Vazzana M, Cammarata M, Cooper EL, Parrinello N Confinement stress in sea bass (Dicentrarchus labrax) depresses peritoneal leukocyte cytotoxicity. Aquaculture 2002; 210: 231-43.
Hamed, S.S., Kauschke, E. and Cooper, E.L. Cytochemical properties of earthworm coelomocytes enriched by percol. A new model for analyzing antimicrobial peptides with biomedical applications 2002; 29-37.
Cooper, E.L., Kauschke, E. and Cossarizza, A. Digging for innate immunity since Darwin and Metchnikoff. Bioessays 2002; 24: 319-333.
Kasahara, S., Wago, H. and Cooper, E.L. Dissociation of innate and adaptive immunity by UVB irradiation. Int. J. Immunopath Pharmacol 2002; 15: 1-12.
Kauschke, E., Lange, S., Wagner, F., Mohrig, W. and Cooper, E.L. Earthworm humoral immune system: interaction of hemolysins with lipid membranes requires sphingolipids. A new model for analyzing antimicrobial peptides with biomedical applications 2002; 62-72.
Engelmann P, Pal J, Berki T, Cooper EL, Nemeth P. Earthworm leukocytes react with different mammalian antigen-specific monoclonal antibodies. Zoology 2002; 105(3): 257-65.
Engelmann P, Pal J, Berki T, Cooper EL, Nemeth P. Earthworm leukocytes react with different mammalian antigen-specific monoclonal antibodies. Zoology (Jena) 2002; 105(3): 257-65.
Komiyama, K., Kauschke, E. and Cooper E. L. Evidence for a perforin-like cell-mediated cytolysis by earthworm coelomocytes. A new model for analyzing antimicrobial peptides with biomedical applications 2002; 82-92.
de Eguileor, M, Tettamanti, G., Grimaldi, A. Ferrarese, R. Perletti, G., Valvassori, R., Cooper, E.L. Lanzavecchia, G. Leech immune responses: contributions and biomedical applications. A new model for analyzing antimicrobial peptides with biomedical applications 2002; 93-102.
Cooper, EL. The earthworm: a new model with biomedical applications. A new model for analyzing antimicrobiol peptides with biomedical applications 2002; 3-28.
Nasi M., Pinti, M., Troiano, L. Moretti, L. Cooper, E.L. and Cossarizza, A. The evolution of cell killing: when a target cell became "invited" to choose how to die. A new model for analyzing antimicrobial peptides with biomedical applications 2002; 82-92.
Cooper, E.L., Kauschke, E. and Cossarizza, A. Annelid humoral immunity: cell lysis in earthworms. Phylogenic Perspectives on the Vertebrate Immune System 2001; .
G. Beck, M. Sugumaran and E.L. Cooper Annelid humoral immunity: cell lysis in earthworms. Advancdes in Experimental Medicine and Biology 2001; 484: 169-184.
Kauschke E, Komiyama K, Moro I, Eue I, Konig S, Cooper EL Evidence for perforin-like activity associated with earthworm leukocytes. Zoology 2001; 32: 13-24.
Cooper EL. Immune Response: Evolution. Encyclopedia of Sciences 2001; .
Cooper EL, Parrinello N Immunodefense in Tunicates: cells and molecules. The Biology of Ascidians 2001; 383-94.
Parrinello, N., Cammarata, M., Vazzana, M. and Arizza, V. Immunological Activity of Ascidian Hemocytes. The Biology of Ascidians 2001; .
Beck G, Sugumaran M, and Cooper, E.L. Phylogenic Perspectives on the Vertebrate Immune System. Advance in Experimental Medicine and Biology 2001; 484: .
Kasahara S, Fugo H, Cooper EL, Wago H Preliminary evidence of modulating Th1 cytokine after allergen challenge. Int J Immunopath Pharmacol 2001; 14: 63-69.
Cooper, E.L. and Bosch, T.C.G. Evolution of the immune system. Exp. Clin. Immunogenetics 2000; 17: 77-82.
Kauschke, E., Eue, I., Lange, S., Mohrig, W. and Cooper, E.L. Immune proteins in earthworms. Recent. Res.Devel. Comparative Biochem. Physiol 2000; 1: 105-122.
Lange S, Kauschke E, Mohrig W, Cooper EL Biochemical characteristics of Eiseniapore, a pore-forming protein in the coelomic fluid of earthworms. Eur J Biochem 1999; 262: 547-56.
Cooper, E. L., Kauschke, E., Cossarizza, A. and Franceschi, C. Cell adhesion and the immune system: A case study using earthworms. Microscopy Res Tech 1999; 44: 237-253.
de Eguileor, M., Tettamanti, G., Grimaldi, A., Boselli, A., Scari, G., Valvassori, R., Cooper, E.L., and Lanzavecchia, G. Histopathological changes after induced injuries in leeches. J Invertebr Pathol 1999; 74: 14-28.
de Eguileor M, Tettamanti G, Grimaldi A, Boselli A, Scari G, Valvassori R, Cooper EL, Lanzavecchia G Histopathological changes after induced injury in leeches. J Invertebr Pathol 1999; 74: 14-28.
Cooper, E.L. Immune Response: Phylogeny. Encyclopedia of Life Sciences (Article 519) Macmillan Reference Limited, Grove's Dictionaries Inc 1999; .
Raftos, D.A., Stillman, D.L. and Cooper E.L. Chemotactic responses of tunicate (Urochordata, Ascidiacea) menocytes in vitro. J Invertebr Patho 1998; 72: 44-49.
Eue, I., Kauschke, E., Mohrig, W. and Cooper, E.L. Isolation and characterization of earthworm hemolysins and agglutinins. Dev. Comp. Immunol 1998; 22: 13-25.
Grether GF, Kasahara S, Kolluru GR, Cooper EL Sex-specific effects of carotenoid intake on the immunological response to allografts in guppies (Poecilia reticulata). Proceedings. Biological sciences / The Royal Society. . 2004; 271(1534): 45-9.
Cabrera PV, Blanco G, Ernst G, Alvarez E, Cooper EL, Hajos S Coelomocyte locomotion in the sipunculan Themiste petricola induced by exogenous and endogenous chemoattractants: role of a CD44-like antigen--HA interaction. Journal of invertebrate pathology. . 2002; 79(2): 111-9.
Kasahara S, Aizawa K, Okamiya M, Kazuno N, Mutoh S, Fugo H, Cooper EL, Wago H UVB irradiation suppresses cytokine production and innate cellular immune functions in mice. Cytokine. . 2001; 14(2): 104-11.
de Eguileor M, Grimaldi A, Tettamanti G, Valvassori R, Cooper EL, Lanzavecchia G Lipopolysaccharide-dependent induction of leech leukocytes that cross-react with vertebrate cellular differentiation markers. Tissue & cell. . 2000; 32(5): 437-45.
de Eguileor M, Grimaldi A, Tettamanti G, Valvassori R, Cooper EL, Lanzavecchia G Different types of response to foreign antigens by leech leukocytes. Tissue & cell. . 2000; 32(1): 40-8.
Cikutovic MA, Fitzpatrick LC, Goven AJ, Venables BJ, Giggleman MA, Cooper EL Wound healing in earthworms Lumbricus terrestris: a cellular-based biomarker for assessing sublethal chemical toxicity. Bulletin of environmental contamination and toxicology. 1999; 62(4): 508-14.