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Xin Liu, M.D., Ph.D.

Work Email Address:
xliu@mednet.ucla.edu

Work Address:
1P-217 CHS
CAMPUS - 173216
CA
UNITED STATES

Work Phone Number:
(310) 794-5880



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Department / Division Affiliations
Director, Embryonic Stem Cells
Associate Professor, Molecular & Medical Pharmacology
Assistant Professor, Pathology and Laboratory Medicine
Member, ACCESS Program: Dept. of Cellular & Molecular Pathology, Brain Research Institute, JCCC Cancer and Stem Cell Biology Program Area, Molecular Biology Institute, Neuroengineering Training Program
Faculty, Cellular and Molecular Pathology PhD Program

Publications:

Kosik KS, Donahue CP, Israely I, Liu X, Ochiishi T Delta-catenin at the synaptic-adherens junction. Trends in cell biology. 2005; 15(3): 172-8.
Yue Q, Groszer M, Gil JS, Berk AJ, Messing A, Wu H, Liu X PTEN deletion in Bergmann glia leads to premature differentiation and affects laminar organization. Development (Cambridge, England) . 2005; 132(14): 3281-91.
Israely I, Costa RM, Xie CW, Silva AJ, Kosik K and Liu X The neuronal specific protein Delta-Catenin is essential for cognitive function. . Current Biology 2004; 14 (18): 1657-1663.
Colwell CS, Michel S, Itri J, Rodriguez W, Tam J, Lelievre V, Hu Z, Liu X, Waschek JA Disrupted circadian rhythms in VIP- and PHI-deficient mice. American journal of physiology. Regulatory, integrative and comparative physiology. . 2003; 285(5): R939-49.
Wang S, Gao J, Lei Q, Rozengurt N, Pritchard C, Jiao J, Thomas GV, Li G, Roy-Burman P, Nelson PS, Liu X, Wu H Prostate-specific deletion of the murine Pten tumor suppressor gene leads to metastatic prostate cancer. Cancer cell. . 2003; 4(3): 209-21.
Smith DJ, Leil TA, Liu X Neurotrophin-4 is required for tolerance to morphine in the mouse. Neuroscience letters. . 2003; 340(2): 103-6.
Tan M, Groszer M, Tan AM, Pandya A, Liu X, Xie CW Phosphoinositide 3-kinase cascade facilitates mu-opioid desensitization in sensory neurons by altering G-protein-effector interactions. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2003; 23(32): 10292-301.
Li G, Robinson GW, Lesche R, Martinez-Diaz H, Jiang Z, Rozengurt N, Wagner KU, Wu DC, Lane TF, Liu X, Hennighausen L, Wu H Conditional loss of PTEN leads to precocious development and neoplasia in the mammary gland. Development (Cambridge, England) . 2002; 129(17): 4159-70.
Lesche R, Groszer M, Gao J, Wang Y, Messing A, Liu X and Wu H Cre/loxp-Mediated Inactivation of The Murine Pten Tumor Suppressor Gene. Genesis 2002; 32: 148-149.
Stiles B, Gilman V, Khanzenzon N, Lesche R, Li A, Qiao R, Liu X, Wu H Essential role of AKT-1/protein kinase B alpha in PTEN-controlled tumorigenesis. Molecular and cellular biology. . 2002; 22(11): 3842-51.
Groszer M, Erickson R, Scripture-Adams DD, Lesche R, Trumpp A, Zack JA, Kornblum HI, Liu X, Wu H Negative regulation of neural stem/progenitor cell proliferation by the Pten tumor suppressor gene in vivo. Science. . 2001; 294(5549): 2186-9.
Xie CW, Sayah D, Chen QS, Wei Wz, Smith D and Liu X Deficient long-term memory and long-term potentiation with a targeted null mutation in neurotrophin-4 gene. Proc. Natl. Acad. Sci. USA 2000; 97: 8116-8121.
Endres M, Fan GP, Hirt L, Fujii M, Liu X, Jaenisch R, Moskowitz MA Ischemic brain damage in mice after selectively modifying BDNF or NT4 gene expression. Journal of Cerebral Blood Flow and Metabolism 2000; 20(1): 139-144.
Liu X, Jaenisch R Severe peripheral sensory neuron loss and modest motor neuron reduction in mice with combined deficiency of brain-derived neurotrophic factor, neurotrophin 3 and neurotrophin 4/5. Developmental dynamics : an official publication of the American Association of Anatomists. . 2000; 218(1): 94-101.
Wu H, Lee SH, Gao J, Liu X, Iruela-Arispe ML Inactivation of erythropoietin leads to defects in cardiac morphogenesis. Development (Cambridge, England) . 1999; 126(16): 3597-605.
Sun H, Lesche R, Li Dm, Liliental J, Zhang H, Gao J, Gavriola N, Mueller B, Liu X, and Wu H PTEN Modulates Cell Cycle Progression and Cell Survival by Regulating Phosphatidylinositol 3,4,5,-Triphophate and Akt/Protein Kinase B Signaling Pathway. PNAS 1999; 96: 6199-6204.
Liu X, Wu H, Loring J, Hormuzdi S, Disteche CM, Bornstein P, Jaenisch R Trisomy eight in ES cells is a common potential problem in gene targeting and interferes with germ line transmission. Developmental dynamics : an official publication of the American Association of Anatomists. . 1997; 209(1): 85-91.
Liu X, Wu H, Byrne M, Krane S, Jaenisch R Type III collagen is crucial for collagen I fibrillogenesis and for normal cardiovascular development. Proceedings of the National Academy of Sciences of the United States of America. . 1997; 94(5): 1852-6.
Byrne M, Eeckhout Y, Henriet P, Lemaitre V, Jeffrey JJ, Witter J, Liu X, Wu H, Jaenisch R and Krane SM Different collagenase gene products have different roles in degradation of type I collagen. J. Biol. Chem. 1996; 271: 28509-28515.
Liu X, Wu H, Byrne M, Jeffrey J, Krane S, Jaenisch R A targeted mutation at the known collagenase cleavage site in mouse type I collagen impairs tissue remodeling. The Journal of cell biology. . 1995; 130(1): 227-37.
Wu H, Liu X, Jaenisch R and Lodish H Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor. Cell 1995; 83: 59-67.
Liu X, Enfors P, Wu H and Jaenisch R Sensory but not motor neuron deficits in mice lacking NT4 and BDNF. Nature 1995; 375: 238-241.
Wu H, Liu X and Jaenisch R Double Replacement: A Strategy for Efficient Introduction of Subtle Mutations into Col1a1 gene by Homologous Recombination in ES Cells. Proc. Natl. Acad. Sci. USA 1994; 91: 2819-2823.
Andrikopoulos K, Liu X, Keene DR, Jaenisch R, Ramirez F Targeted mutation in the col5a2 gene reveals a regulatory role for type V collagen during matrix assembly. Nature genetics. . 1995; 9(1): 31-6.
Liu X, Zwiebel LJ, Hinton D, Benzer S, Hall JC, Rosbash M The period gene encodes a predominantly nuclear protein in adult Drosophila. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 1992; 12(7): 2735-44.
Zwieble L, Hardin P, Liu X, Hall J and Rosbash M A post-transcriptional mechanism contributes to circadian cycling of per-b-galactosidase fusion protein. Proc. Natl. Acad. Sci. USA 1991; 88: 3882-3886.
Liu X, Yu QA, Huang ZS, Zwiebel LJ, Hall JC, Rosbash M The strength and periodicity of D. melanogaster circadian rhythms are differentially affected by alterations in period gene expression. Neuron. . 1991; 6(5): 753-66.
Liu X, Lorenz L, Yu Q, Hall J and Rosbash M Spatial and temporal expression of the period gene in Drosophila melanogaster. Genes Dev. 1988; 2: 228-238.
Goebbels, S., Oltrogge, J., Kemper, R., Heilmann, I., Wichert, S., Bormuth, I., Wolfer, S., Liu, X., Lappe-Siefke, C., Rossner, M., Groszer, M., Suter, U., Frahm, J., Boretius, S., and Nave, K. Elevated phosphatidylinositol 3,4,5 trisphosphate in glia triggers cell autonomous membrane wrapping and myelination. J. Neuroscience 2010; 30(26): 8953-64.
Hideaki Tsutsui*, Bahram Valamehr*, Antreas Hindoyan, Rong Qiao, Xianting Ding, Shuling Guo, Owen N. Witte, Xin Liu, Chih-Ming Ho & Hong Wu. An optimized small molecule inhibitor cocktail supports long-term maintenance of human embryonic stem cells. Nat Commun 2011; 2:167: 1-8.
He, XP., Bulter, L., Liu, X., and McNamara, JO. The tyrosine receptor kinase B ligand, neurotrophin-4, is not required for either epileptogenesis or tyrosine receptor kinase B activation in the kindling model. Neuroscience 2006; 141(1): 515-520.
Li, G., Hu, Y., Huo, Y., Liu, M., Freeman, D., Gao, J., Liu, X., Wu, DC., and Wu, H. PTEN deletion leads to up-regulation of a secreted growth factor pleiotrophin. . J Biol Chem. 2006; 281(16): 10663-8.
Arikkath, J., Israely, I., Tao, Y., Mei, L., Liu, X., and Reigardt, L Erbin controls dendritic morphogenesis by regulating localization of -catenin. J. Neuroscience 2008; 28(28): 7047-7056.