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Nigel Maidment, Ph.D.

Email Address:
nmaidmen@ucla.edu

Work Address:
Laboratory
MRL Building
Los Angeles, CA 90095
UNITED STATES

Office
MRL Building, Room 2770
675 Charles Young Drive So.
Los Angeles, CA 90095
UNITED STATES

Lab Number:
(310) 206 7890
Office Phone Number:
(310) 206-7767



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Department / Division Affiliations
Professor, Psychiatry and Biobehavioral Sciences, Hatos Center for Neuropharmacology
Member, ACCESS Program, Access Neuroscience Home Area, Brain Research Institute, Center for Neurodegenerative Disease Studies, Neuroscience IDP

Bio:

Professor Maidment received B.Sc., M.Sc. and Ph.D. degrees from the Universities of Reading, Southampton and Nottingham, U.K. His doctorate work was on in vivo voltammetry and microdialysis studies of the action of antipsychotic drugs on dopamine transmission in the laboratory of Prof. Charles Marsden. He received post-doctoral training at Stanford University in the laboratory of Prof. Jack Barchas where he developed microdialysis-radioimmunoassy procedures for studying neuropeptide transmission in the limbic system, joining the UCLA faculty in 1990.

Publications:

Fitzmaurice Arthur G, Rhodes Shannon L, Lulla Aaron, Murphy Niall P, Lam Hoa A, O'Donnell Kelley C, Barnhill Lisa, Casida John E, Cockburn Myles, Sagasti Alvaro, Stahl Mark C, Maidment Nigel T, Ritz Beate, Bronstein Jeff M Aldehyde dehydrogenase inhibition as a pathogenic mechanism in Parkinson disease. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(2): 636-41.
Ostlund Sean B, Kosheleff Alisa, Maidment Nigel T, Murphy Niall P Decreased consumption of sweet fluids in mu opioid receptor knockout mice: a microstructural analysis of licking behavior. Psychopharmacology. 2013; 229(1): 105-13.
Chen Audrey, Ng Fanny, Lebestky Tim, Grygoruk Anna, Djapri Christine, Lawal Hakeem O, Zaveri Harshul A, Mehanzel Filmon, Najibi Rod, Seidman Gabriel, Murphy Niall P, Kelly Rachel L, Ackerson Larry C, Maidment Nigel T, Jackson F Rob, Krantz David E Dispensable, redundant, complementary, and cooperative roles of dopamine, octopamine, and serotonin in Drosophila melanogaster. Genetics. 2013; 193(1): 159-76.
Tolosa Vanessa M, Wassum Kate M, Maidment Nigel T, Monbouquette Harold G Electrochemically deposited iridium oxide reference electrode integrated with an electroenzymatic glutamate sensor on a multi-electrode array microprobe. Biosensors & bioelectronics. 2013; 42(8): 256-60.
Blouin Ashley M, Fried Itzhak, Wilson Charles L, Staba Richard J, Behnke Eric J, Lam Hoa A, Maidment Nigel T, Karlsson Karl Æ, Lapierre Jennifer L, Siegel Jerome M Human hypocretin and melanin-concentrating hormone levels are linked to emotion and social interaction. Nature communications. 2013; 4(1): 1547.
Leblanc Kimberly H, Maidment Nigel T, Ostlund Sean B Impact of repeated intravenous cocaine administration on incentive motivation depends on mode of drug delivery. Addiction biology. 2013; 229(1): .
Wassum Kate M, Ostlund Sean B, Loewinger Gabriel C, Maidment Nigel T Phasic mesolimbic dopamine release tracks reward seeking during expression of pavlovian-to-instrumental transfer. Biological psychiatry. 2013; 73(8): 747-55.
LeBlanc Kimberly H, Maidment Nigel T, Ostlund Sean B Repeated cocaine exposure facilitates the expression of incentive motivation and induces habitual control in rats. PloS one. 2013; 8(4): e61355.
Laurent Vincent, Leung Beatrice, Maidment Nigel, Balleine Bernard W ?- and ?-opioid-related processes in the accumbens core and shell differentially mediate the influence of reward-guided and stimulus-guided decisions on choice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012; 32(5): 1875-83.
Ostlund Sean B, Maidment Nigel T Dopamine receptor blockade attenuates the general incentive motivational effects of noncontingently delivered rewards and reward-paired cues without affecting their ability to bias action selection. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2012; 37(2): 508-19.
LeBlanc Kimberly H, Ostlund Sean B, Maidment Nigel T Pavlovian-to-instrumental transfer in cocaine seeking rats. Behavioral neuroscience. 2012; 126(5): 681-9.
Wassum Kate M, Ostlund Sean B, Maidment Nigel T Phasic mesolimbic dopamine signaling precedes and predicts performance of a self-initiated action sequence task. Biological psychiatry. 2012; 71(10): 846-54.
Ostlund Sean B, Kosheleff Alisa R, Maidment Nigel T Relative response cost determines the sensitivity of instrumental reward seeking to dopamine receptor blockade. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2012; 37(12): 2653-60.
Wassum Kate M, Tolosa Vanessa M, Tseng Tina C, Balleine Bernard W, Monbouquette Harold G, Maidment Nigel T Transient extracellular glutamate events in the basolateral amygdala track reward-seeking actions. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2012; 32(8): 2734-46.
Lam Hoa, Maga Matthew, Pradhan Amynah, Evans Christopher J, Maidment Nigel T, Hales Tim G, Walwyn Wendy Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking ?-arrestin 2. Molecular pain. 2011; 7(17): 24.
Wassum Kate M, Ostlund Sean B, Balleine Bernard W, Maidment Nigel T Differential dependence of Pavlovian incentive motivation and instrumental incentive learning processes on dopamine signaling. Learning & memory (Cold Spring Harbor, N.Y.). 2011; 18(7): 475-83.
Lam Hoa A, Wu Nanping, Cely Ingrid, Kelly Rachel L, Hean Sindalana, Richter Franziska, Magen Iddo, Cepeda Carlos, Ackerson Larry C, Walwyn Wendy, Masliah Eliezer, Chesselet Marie-Françoise, Levine Michael S, Maidment Nigel T Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human ?-synuclein. Journal of neuroscience research. 2011; 89(7): 1091-102.
Ostlund Sean B, Wassum Kate M, Murphy Niall P, Balleine Bernard W, Maidment Nigel T Extracellular dopamine levels in striatal subregions track shifts in motivation and response cost during instrumental conditioning. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(1): 200-7.
Wassum Kate M, Cely Ingrid C, Balleine Bernard W, Maidment Nigel T Micro-opioid receptor activation in the basolateral amygdala mediates the learning of increases but not decreases in the incentive value of a food reward. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(5): 1591-9.
Remage-Healey Luke, Dong Stephanie, Maidment Nigel T, Schlinger Barney A Presynaptic control of rapid estrogen fluctuations in the songbird auditory forebrain. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(27): 10034-8.
Wu Ming-Fung, Nienhuis Robert, Maidment Nigel, Lam Hoa A, Siegel Jerome M Role of the hypocretin (orexin) receptor 2 (Hcrt-r2) in the regulation of hypocretin level and cataplexy. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2011; 31(17): 6305-10.
Ostlund Sean B, Maidment Nigel T, Balleine Bernard W Alcohol-Paired Contextual Cues Produce an Immediate and Selective Loss of Goal-directed Action in Rats. Frontiers in integrative neuroscience. 2010; 4(1): .
Fei Hao, Chow Dawnis M, Chen Audrey, Romero-Calderón Rafael, Ong Wei S, Ackerson Larry C, Maidment Nigel T, Simpson Julie H, Frye Mark A, Krantz David E Mutation of the Drosophila vesicular GABA transporter disrupts visual figure detection. The Journal of experimental biology. 2010; 213(Pt 10): 1717-30.
Lu Xiao-Hong, Fleming Sheila M, Meurers Bernhard, Ackerson Larry C, Mortazavi Farzad, Lo Victor, Hernandez Daniela, Sulzer David, Jackson George R, Maidment Nigel T, Chesselet Marie-Francoise, Yang X William Bacterial artificial chromosome transgenic mice expressing a truncated mutant parkin exhibit age-dependent hypokinetic motor deficits, dopaminergic neuron degeneration, and accumulation of proteinase K-resistant alpha-synuclein. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009; 29(7): 1962-76.
Romero-Calderón Rafael, Uhlenbrock Guido, Borycz Jolanta, Simon Anne F, Grygoruk Anna, Yee Susan K, Shyer Amy, Ackerson Larry C, Maidment Nigel T, Meinertzhagen Ian A, Hovemann Bernhard T, Krantz David E A glial variant of the vesicular monoamine transporter is required to store histamine in the Drosophila visual system. PLoS genetics. 2008; 4(11): e1000245.
Simon Jeff M, Daniels Jeff M, Romero-Calderòn Jeff M, Grygoruk Jeff M, Chang Jeff M, Najibi Jeff M, Shamouelian Jeff M, Salazar Jeff M, Solomon Jeff M, Ackerson Jeff M, Maidment Jeff M, Diantonio Jeff M, Krantz Jeff M Drosophila Vesicular Monoamine Transporter Mutants can adapt to Reduced or Eliminated Vesicular Stores of Dopamine and Serotonin. Genetics. 2008; 283(50): .
Remage-Healey Luke, Maidment Nigel T, Schlinger Barney A Forebrain steroid levels fluctuate rapidly during social interactions. Nature neuroscience. 2008; 11(11): 1327-34.
Wassum Kate M, Tolosa Vanessa M, Wang Jianjun, Walker Eric, Monbouquette Harold G, Maidment Nigel T Silicon Wafer-Based Platinum Microelectrode Array Biosensor for Near Real-Time Measurement of Glutamate in Vivo. Sensors (Basel, Switzerland). 2008; 8(8): 5023-5036.
Chou Arthur P, Maidment Nigel, Klintenberg Rebecka, Casida John E, Li Sharon, Fitzmaurice Arthur G, Fernagut Pierre-Olivier, Mortazavi Farzad, Chesselet Marie-Francoise, Bronstein Jeff M Ziram causes dopaminergic cell damage by inhibiting E1 ligase of the proteasome. The Journal of biological chemistry. 2008; 283(50): 34696-703.
Sang Tzu-Kang, Chang Hui-Yun, Lawless George M, Ratnaparkhi Anuradha, Mee Lisa, Ackerson Larry C, Maidment Nigel T, Krantz David E, Jackson George R A Drosophila model of mutant human parkin-induced toxicity demonstrates selective loss of dopaminergic neurons and dependence on cellular dopamine. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007; 27(5): 981-92.
Kliem Michele A, Maidment Nigel T, Ackerson Larry C, Chen Sugong, Smith Yoland, Wichmann Thomas Activation of nigral and pallidal dopamine D1-like receptors modulates basal ganglia outflow in monkeys. Journal of neurophysiology. 2007; 98(3): 1489-500.
Shoblock, J. R. Maidment, N. T. Enkephalin release promotes homeostatic increases in constitutively active mu opioid receptors during morphine withdrawal. Neuroscience. 2007; 149(3): 642-9.
Walker Eric, Wang Jianjun, Hamdi Naser, Monbouquette Harold G, Maidment Nigel T Selective detection of extracellular glutamate in brain tissue using microelectrode arrays coated with over-oxidized polypyrrole. The Analyst. 2007; 132(11): 1107-11.
Phillips Janice M, Lam Hoa A, Ackerson Larry C, Maidment Nigel T Blockade of mGluR glutamate receptors in the subthalamic nucleus ameliorates motor asymmetry in an animal model of Parkinson's disease. The European journal of neuroscience. 2006; 23(1): 151-60.
Shoblock James R, Maidment Nigel T Constitutively active micro opioid receptors mediate the enhanced conditioned aversive effect of naloxone in morphine-dependent mice. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2006; 31(1): 171-7.
Zeitzer Jamie M, Morales-Villagran Alberto, Maidment Nigel T, Behnke Eric J, Ackerson Larry C, Lopez-Rodriguez Faustino, Fried Itzhak, Engel Jerome, Wilson Charles L Extracellular adenosine in the human brain during sleep and sleep deprivation: an in vivo microdialysis study. Sleep. 2006; 29(4): 455-61.
Walwyn, W. M. Matsuka, Y. Arai, D. Bloom, D. C. Lam, H. Tran, C. Spigelman, I. Maidment, N. T. HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy. Exp Neurol. 2006; 198(1): 260-70.
Walwyn, W. M. Wei, W. Xie, C. W. Chiu, K. Kieffer, B. L. Evans, C. J. Maidment, N. T. Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons. Neuroscience. 2006; 142(2): 493-503.
Chang, H. Y. Grygoruk, A. Brooks, E. S. Ackerson, L. C. Maidment, N. T. Bainton, R. J. Krantz, D. E. Overexpression of the Drosophila vesicular monoamine transporter increases motor activity and courtship but decreases the behavioral response to cocaine. Mol Psychiatry. 2006; 11(1): 99-113.
Skoubis, P. D. Lam, H. A. Shoblock, J. Narayanan, S. Maidment, N. T. Endogenous enkephalins, not endorphins, modulate basal hedonic state in mice. Eur J Neurosci. 2005; 21(5): 1379-84.
Galvan Adriana, Villalba Rosa M, West Sara M, Maidment Nigel T, Ackerson Larry C, Smith Yoland, Wichmann Thomas GABAergic modulation of the activity of globus pallidus neurons in primates: in vivo analysis of the functions of GABA receptors and GABA transporters. Journal of neurophysiology. 2005; 94(2): 990-1000.
Walwyn Wendy, Maidment Nigel T, Sanders Matthew, Evans Christopher J, Kieffer Brigitte L, Hales Tim G Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons. Molecular pharmacology. 2005; 68(6): 1688-98.
Shoblock James R, Wichmann Jürgen, Maidment Nigel T The effect of a systemically active ORL-1 agonist, Ro 64-6198, on the acquisition, expression, extinction, and reinstatement of morphine conditioned place preference. Neuropharmacology. 2005; 49(4): 439-46.
John Joshi, Wu Ming-Fung, Maidment Nigel T, Lam Hoa A, Boehmer Lisa N, Patton Melanie, Siegel Jerome M Developmental changes in CSF hypocretin-1 (orexin-A) levels in normal and genetically narcoleptic Doberman pinschers. The Journal of physiology. 2004; 560(Pt 2): 587-92.
Narayanan, S. Lam, H. Christian, L. Levine, M. S. Grandy, D. Rubinstein, M. Maidment, N. T. Endogenous opioids mediate basal hedonic tone independent of dopamine D-1 or D-2 receptor activation. Neuroscience. 2004; 124(1): 241-6.
Walwyn, W. M. Keith, D. E., Jr. Wei, W. Tan, A. M. Xie, C. W. Evans, C. J. Kieffer, B. L. Maidment, N. T. Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice. Neuroscience. 2004; 123(1): 111-21.
West Andrew B, Maidment Nigel T Genetics of parkin-linked disease. Human genetics. 2004; 114(4): 327-36.
West Andrew B, Kapatos Gregory, O'Farrell Casey, Gonzalez-de-Chavez Fanny, Chiu Kelvin, Farrer Matthew J, Maidment Nigel T N-myc regulates parkin expression. The Journal of biological chemistry. 2004; 279(28): 28896-902.
Murphy, N. P. Tan, A. M. Lam, H. A. Maidment, N. T. Nociceptin/orphanin FQ modulation of rat midbrain dopamine neurons in primary culture. Neuroscience. 2004; 127(4): 929-40.
Skoubis, P. D. Maidment, N. T. Blockade of ventral pallidal opioid receptors induces a conditioned place aversion and attenuates acquisition of cocaine place preference in the rat. Neuroscience. 2003; 119(1): 241-9.
Lutfy Kabirullah, Eitan Shoshana, Bryant Camron D, Yang Yu C, Saliminejad Nazli, Walwyn Wendy, Kieffer Brigitte L, Takeshima Hiroshi, Carroll F Ivy, Maidment Nigel T, Evans Christopher J Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2003; 23(32): 10331-7.
Rocha, L. Maidment, N. T. Opioid peptide release in the rat hippocampus after kainic acid-induced status epilepticus. Hippocampus. 2003; 13(4): 472-80.
Goldberg Matthew S, Fleming Sheila M, Palacino James J, Cepeda Carlos, Lam Hoa A, Bhatnagar Anushree, Meloni Edward G, Wu Nanping, Ackerson Larry C, Klapstein Gloria J, Gajendiran Mahadevan, Roth Bryan L, Chesselet Marie-Francoise, Maidment Nigel T, Levine Michael S, Shen Jie Parkin-deficient mice exhibit nigrostriatal deficits but not loss of dopaminergic neurons. The Journal of biological chemistry. 2003; 278(44): 43628-35.
Lopez-Rodriguez, F. Wilson, C. L. Maidment, N. T. Poland, R. E. Engel, J. Total sleep deprivation increases extracellular serotonin in the rat hippocampus. Neuroscience. 2003; 121(2): 523-30.
Murphy Niall P, Lam Hoa A, Chen Zhenping, Pintar John E, Maidment Nigel T Heroin-induced locomotion and mesolimbic dopamine release is unchanged in mice lacking the ORL.1 receptor gene. Brain research. 2002; 953(1-2): 276-80.
Wu, M. F. John, J. Maidment, N. Lam, H. A. Siegel, J. M. Hypocretin release in normal and narcoleptic dogs after food and sleep deprivation, eating, and movement. Am J Physiol Regul Integr Comp Physiol. 2002; 283(5): R1079-86.
Neubert John K, Matsuka Yoshizo, Maidment Nigel T, Spigelman Igor Microdialysis in trigeminal ganglia. Brain research. Brain research protocols. 2002; 10(2): 102-8.
Lutfy Kabirullah, Khaliq Imran, Carroll F Ivy, Maidment Nigel T Orphanin FQ/nociceptin blocks cocaine-induced behavioral sensitization in rats. Psychopharmacology. 2002; 164(2): 168-76.
Maidment Nigel T, Chen Yiling, Tan Aiko M, Murphy Niall P, Leslie Frances M Rat ventral midbrain dopamine neurons express the orphanin FQ/nociceptin receptor ORL-1. Neuroreport. 2002; 13(9): 1137-40.
Kiyashchenko Lyudmila I, Mileykovskiy Boris Y, Maidment Nigel, Lam Hoa A, Wu Ming-Fung, John Joshi, Peever John, Siegel Jerome M Release of hypocretin (orexin) during waking and sleep states. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2002; 22(13): 5282-6.
Lutfy Kabirullah, Maidment Nigel T Sensitization does not develop to cocaine-induced potentiation of the antinociceptive effect of morphine. Brain research bulletin. 2002; 58(1): 7-12.
Narayanan Shridhar, Lutfy Kabirullah, Maidment Nigel Sensitization to cocaine after a single intra-cerebral injection of orphanin FQ/nociceptin. Behavioural brain research. 2002; 131(1-2): 97-103.
Narayanan, S. Lutfy, K. Maidment, N. Sensitization to cocaine after a single intra-cerebral injection of orphanin FQ/nociceptin. Behav Brain Res. 2002; 131(1-2): 97-103.
Zeitzer, J. M. Maidment, N. T. Behnke, E. J. Ackerson, L. C. Fried, I. Engel, J., Jr. Wilson, C. L. Ultradian sleep-cycle variation of serotonin in the human lateral ventricle. Neurology. 2002; 59(8): 1272-4.
Murphy, N. P. Lam, H. A. Maidment, N. T. A comparison of morphine-induced locomotor activity and mesolimbic dopamine release in C57BL6, 129Sv and DBA2 mice. J Neurochem. 2001; 79(3): 626-35.
Matsuka, Y. Neubert, J. K. Maidment, N. T. Spigelman, I. Concurrent release of ATP and substance P within guinea pig trigeminal ganglia in vivo. Brain Res. 2001; 915(2): 248-55.
Fried, I. Wilson, C. L. Morrow, J. W. Cameron, K. A. Behnke, E. D. Ackerson, L. C. Maidment, N. T. Increased dopamine release in the human amygdala during performance of cognitive tasks. Nat Neurosci. 2001; 4(2): 201-6.
Skoubis, P. D. Matthes, H. W. Walwyn, W. M. Kieffer, B. L. Maidment, N. T. Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice. Neuroscience. 2001; 106(4): 757-63.
Lutfy, K. Do, T. Maidment, N. T. Orphanin FQ/nociceptin attenuates motor stimulation and changes in nucleus accumbens extracellular dopamine induced by cocaine in rats. Psychopharmacology (Berl). 2001; 154(1): 1-7.
Lutfy, K. Hossain, S. M. Khaliq, I. Maidment, N. T. Orphanin FQ/nociceptin attenuates the development of morphine tolerance in rats. Br J Pharmacol. 2001; 134(3): 529-34.
Lutfy, K. Maidment, N. T. Blockade of mu-opioid receptors reveals the hyperalgesic effect of orphanin FQ/nociceptin in the rat hot plate test. Br J Pharmacol. 2000; 131(8): 1684-8.
Neubert, J. K. Maidment, N. T. Matsuka, Y. Adelson, D. W. Kruger, L. Spigelman, I. Inflammation-induced changes in primary afferent-evoked release of substance P within trigeminal ganglia in vivo. Brain Res. 2000; 871(2): 181-91.
Fried, I. Wilson, C. L. Maidment, N. T. Engel, J., Jr. Behnke, E. Fields, T. A. MacDonald, K. A. Morrow, J. W. Ackerson, L. Cerebral microdialysis combined with single-neuron and electroencephalographic recording in neurosurgical patients. Technical note. J Neurosurg. 1999; 91(4): 697-705.
Walwyn, W. M. Ta-Haung, J. Ackerson, L. Maidment, N. T. Edgerton, V. R. Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping. Pharmacol Biochem Behav. 1999; 63(4): 581-8.
Rocha, L. Ondarza-Rovira, R. Maidment, N. T. Gabapentin modifies extracellular opioid peptide content in amygdala: a microdialysis study. Epilepsy Res. 1999; 35(1): 13-20.
Park, S. P. Lopez-Rodriguez, F. Wilson, C. L. Maidment, N. Matsumoto, Y. Engel, J., Jr. In vivo microdialysis measures of extracellular serotonin in the rat hippocampus during sleep-wakefulness. Brain Res. 1999; 833(2): 291-6.
Rocha, L. Cano, A. Cruz, C. Omana-Zapata, I. Villalobos, R. Maidment, N. T. Opioid peptide systems following a subconvulsant dose of pentylenetetrazol in rats. Epilepsy Res. 1999; 37(2): 141-50.
Narayanan, S. Maidment, N. T. Orphanin FQ and behavioral sensitization to cocaine. Pharmacol Biochem Behav. 1999; 63(2): 271-7.
Murphy, N. P. Lee, Y. Maidment, N. T. Orphanin FQ/nociceptin blocks acquisition of morphine place preference. Brain Res. 1999; 832(1-2): 168-70.
Murphy, N. P. Maidment, N. T. Orphanin FQ/nociceptin modulation of mesolimbic dopamine transmission determined by microdialysis. J Neurochem. 1999; 73(1): 179-86.
Lutfy, K. Sharza, S. A. Maidment, N. T. Tolerance develops to the inhibitory effect of orphanin FQ on morphine-induced antinociception in the rat. Neuroreport. 1999; 10(1): 103-6.
King, B. H. Cromwell, H. C. Lee, H. T. Behrstock, S. P. Schmanke, T. Maidment, N. T. Dopaminergic and glutamatergic interactions in the expression of self-injurious behavior. Dev Neurosci. 1998; 20(2-3): 180-7.
Olive, M. F. Maidment, N. T. Opioid regulation of pallidal enkephalin release: bimodal effects of locally administered mu and delta opioid agonists in freely moving rats. J Pharmacol Exp Ther. 1998; 285(3): 1310-6.
Olive, M. F. Maidment, N. T. Repeated heroin administration increases extracellular opioid peptide-like immunoreactivity in the globus pallidus/ventral pallidum of freely moving rats. Psychopharmacology (Berl). 1998; 139(3): 251-4.
Rocha, L. L. Evans, C. J. Maidment, N. T. Amygdala kindling modifies extracellular opioid peptide content in rat hippocampus measured by microdialysis. J Neurochem. 1997; 68(2): 616-24.
Bergasa, N. V. Mohajer, B. Maisonneuve, I. M. Ho, A. Maidment, N. T. Olive, F. Gunduz, M. Kreek, M. J. Basal total opioid peptide release in the striatum of rats with cholestasis from bile duct resection: a study by the use of in vivo microdialysis. Life Sci. 1997; 61(12): 1169-75.
Maidment, N. T. Villafranca, N. P. Persistence of the releasable pool of CCK in the rat nucleus accumbens and caudate-putamen following lesions of the midbrain. Brain Res. 1997; 747(2): 290-6.
Olive, M. F. Anton, B. Micevych, P. Evans, C. J. Maidment, N. T. Presynaptic versus postsynaptic localization of mu and delta opioid receptors in dorsal and ventral striatopallidal pathways. J Neurosci. 1997; 17(19): 7471-9.
Wilson, C. L. Maidment, N. T. Shomer, M. H. Behnke, E. J. Ackerson, L. Fried, I. Engel, J., Jr. Comparison of seizure related amino acid release in human epileptic hippocampus versus a chronic, kainate rat model of hippocampal epilepsy. Epilepsy Res. 1996; 26(1): 245-54.
Maidment, N. T. Tan, A. M. Bloom, D. C. Anton, B. Feldman, L. T. Stevens, J. G. Expression of the lacZ reporter gene in the rat basal forebrain, hippocampus, and nigrostriatal pathway using a nonreplicating herpes simplex vector. Exp Neurol. 1996; 139(1): 107-14.
Murphy, N. P. Ly, H. T. Maidment, N. T. Intracerebroventricular orphanin FQ/nociceptin suppresses dopamine release in the nucleus accumbens of anaesthetized rats. Neuroscience. 1996; 75(1): 1-4.
Cromwell, H. C. Witte, E. A. Crawford, C. A. Ly, H. T. Maidment, N. T. King, B. H. Pemoline produces ipsilateral turning behavior in unilateral 6-OHDA-lesioned rats. Prog Neuropsychopharmacol Biol Psychiatry. 1996; 20(3): 503-14.
Rocha, L. Briones, M. Ackermann, R. F. Anton, B. Maidment, N. T. Evans, C. J. Engel, J., Jr. Pentylenetetrazol-induced kindling: early involvement of excitatory and inhibitory systems. Epilepsy Res. 1996; 26(1): 105-113.
Olive, M. F. Bertolucci, M. Evans, C. J. Maidment, N. T. Microdialysis reveals a morphine-induced increase in pallidal opioid peptide release. Neuroreport. 1995; 6(8): 1093-6.
Bloom, D. C. Lokensgard, J. R. Maidment, N. T. Feldman, L. T. Stevens, J. G. Long-term expression of genes in vivo using non-replicating HSV vectors. Gene Ther. 1994; 1 Suppl 1: S36-8.
Rocha, L. Maidment, N. T. Evans, C. J. Ackermann, R. F. Engel, J., Jr. Microdialysis reveals changes in extracellular opioid peptide levels in the amygdala induced by amygdaloid kindling stimulation. Exp Neurol. 1994; 126(2): 277-83.
Anton, R. Kordower, J. H. Maidment, N. T. Manaster, J. S. Kane, D. J. Rabizadeh, S. Schueller, S. B. Yang, J. Rabizadeh, S. Edwards, R. H. et al., Neural-targeted gene therapy for rodent and primate hemiparkinsonism. Exp Neurol. 1994; 127(2): 207-18.
Sulzer, D. Maidment, N. T. Rayport, S. Amphetamine and other weak bases act to promote reverse transport of dopamine in ventral midbrain neurons. J Neurochem. 1993; 60(2): 527-35.
Lo, E. H. Steinberg, G. K. Panahian, N. Maidment, N. T. Newcomb, R. Profiles of extracellular amino acid changes in focal cerebral ischaemia: effects of mild hypothermia. Neurol Res. 1993; 15(4): 281-7.
Sulzer, D. Pothos, E. Sung, H. M. Maidment, N. T. Hoebel, B. G. Rayport, S. Weak base model of amphetamine action. Ann N Y Acad Sci. 1992; 654: 525-8.
Maidment, N. T. Siddall, B. J. Rudolph, V. R. Erdelyi, E. Evans, C. J. Dual determination of extracellular cholecystokinin and neurotensin fragments in rat forebrain: microdialysis combined with a sequential multiple antigen radioimmunoassay. Neuroscience. 1991; 45(1): 81-93.
Maidment, N. T. Siddall, B. Rudolph, V. D. Evans, C. J. Postmortem changes in rat brain extracellular opioid peptides revealed by microdialysis. J Neurochem. 1991; 56(6): 1980-4.
Maidment, N. T. Brumbaugh, D. R. Rudolph, V. D. Erdelyi, E. Evans, C. J. Microdialysis of extracellular endogenous opioid peptides from rat brain in vivo. Neuroscience. 1989; 33(3): 549-57.
Gonzalez-Mora, J. L. Maidment, N. T. Guadalupe, T. Mas, M. Post-mortem dopamine dynamics assessed by voltammetry and microdialysis. Brain Res Bull. 1989; 23(4-5): 323-7.
Yeomans, J. S. Maidment, N. T. Bunney, B. S. Excitability properties of medial forebrain bundle axons of A9 and A10 dopamine cells. Brain Res. 1988; 450(1-2): 86-93.
Maidment, N. T. Marsden, C. A. Acute administration of clozapine, thioridazine and metoclopramide increases extracellular DOPAC and decreases extracellular 5-HIAA, measured in the nucleus accumbens and striatum of the rat using in vivo voltammetry. Neuropharmacology. 1987; 26(2-3): 187-93.
Maidment, N. T. Marsden, C. A. Repeated atypical neuroleptic administration: effects on central dopamine metabolism monitored by in vivo voltammetry. Eur J Pharmacol. 1987; 136(2): 141-9.
Marsden, C. A. Martin, K. F. Routledge, C. Brazell, M. P. Maidment, N. T. Application of intracerebral dialysis and in vivo voltammetry to pharmacological and physiological studies of amine neurotransmitters. Ann N Y Acad Sci. 1986; 473: 106-25.
Maidment, N. T. Marsden, C. A. In vivo voltammetric and behavioural evidence for somatodendritic autoreceptor control of mesolimbic dopamine neurones. Brain Res. 1985; 338(2): 317-25.
Sharp, T. Maidment, N. T. Brazell, M. P. Zetterstrom, T. Ungerstedt, U. Bennett, G. W. Marsden, C. A. Changes in monoamine metabolites measured by simultaneous in vivo differential pulse voltammetry and intracerebral dialysis. Neuroscience. 1984; 12(4): 1213-21.
Crespi, F. Sharp, T. Maidment, N. T. Marsden, C. A. Differential pulse voltammetry: simultaneous in vivo measurement of ascorbic acid, catechols and 5-hydroxyindoles in the rat striatum. Brain Res. 1984; 322(1): 135-8.
Crespi, F. Sharp, T. Maidment, N. Marsden, C. Differential pulse voltammetry in vivo--evidence that uric acid contributes to the indole oxidation peak. Neurosci Lett. 1983; 43(2-3): 203-7.