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J. David Jentsch, Ph.D.

Email Address:
jentsch@psych.ucla.edu

Work Address:
Office
Franz Hall
Los Angeles, CA 90095
UNITED STATES

Work Phone Number:
310-825-8258



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Department / Division Affiliations
Professor, Psychology, Psychiatry and Biobehavioral Sciences

Research Interest:

Neuropsychopharmacology

Genetic and neurochemical determinants of cognitive and executive functions; mechanisms of action of psychotherapeutic drugs; novel strategies for modulating cognitive deficits in schizophrenia, addiction and AD/HD; animal models for psychiatric disorders

Publications:

Seu, Jentsch Effect of acute and repeated treatment with desipramine or methylphenidate on serial reversal learning in rats.. Neuropharmacology. 2009; .
Jasinska, Service, Choi, Deyoung, Grujic, Kong, Jorgensen, Bailey, Breidenthal, Fairbanks, Woods, Jentsch, Freimer Identification of Brain Transcriptional Variation Reproduced in Peripheral Blood: an Approach for Mapping Brain Expression Traits.. Human molecular genetics. 2009; .
Groman Stephanie M, James Alex S, Jentsch J David Poor response inhibition: at the nexus between substance abuse and attention deficit/hyperactivity disorder.. Neuroscience and biobehavioral reviews. 2009; 33(5): 690-8.
Jentsch J David, Aarde Shawn M, Seu Emanuele Effects of atomoxetine and methylphenidate on performance of a lateralized reaction time task in rats.. Psychopharmacology. 2009; 202(1-3): 497-504.
Seu Emanuele, Lang Andrew, Rivera Ronald J, Jentsch J David Inhibition of the norepinephrine transporter improves behavioral flexibility in rats and monkeys.. Psychopharmacology. 2009; 202(1-3): 505-19.
Bilder J David, Sabb J David, Cannon J David, London J David, Jentsch J David, Parker J David, Poldrack J David, Evans J David, Freimer J David Phenomics: The systematic study of phenotypes on a genome-wide scale.. Neuroscience. 2009; 33(5): .
Jentsch J David, Sanchez Diana, Elsworth John D, Roth Robert H Clonidine and guanfacine attenuate phencyclidine-induced dopamine overflow in rat prefrontal cortex: mediating influence of the alpha-2A adrenoceptor subtype.. Brain research. 2008; 1246(1-3): 41-6.
Kalechstein Ari D, Jentsch J David, Kantak Kathleen M Stimulant-associated cognitive abnormalities: mechanisms and impact on reward-related behavior and addiction.. Drug and alcohol dependence. 2008; 97(3): 276-80.
Elsworth John D, Jentsch J David, Morrow Bret A, Redmond D Eugene, Roth Robert H Clozapine normalizes prefrontal cortex dopamine transmission in monkeys subchronically exposed to phencyclidine.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2008; 33(3): 491-6.
James Alex S, Groman Stephanie M, Seu Emanuele, Jorgensen Matthew, Fairbanks Lynn A, Jentsch J David Dimensions of impulsivity are associated with poor spatial working memory performance in monkeys.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007; 27(52): 14358-64.
Olausson Peter, Jentsch J David, Krueger Dilja D, Tronson Natalie C, Nairn Angus C, Taylor Jane R Orbitofrontal cortex and cognitive-motivational impairments in psychostimulant addiction: evidence from experiments in the non-human primate.. Annals of the New York Academy of Sciences. 2007; 1121(52): 610-38.
Li Weidong, Zhou Yu, Jentsch J David, Brown Robert A M, Tian Xiaoli, Ehninger Dan, Hennah William, Peltonen Leena, Lönnqvist Jouko, Huttunen Matti O, Kaprio Jaakko, Trachtenberg Joshua T, Silva Alcino J, Cannon Tyrone D Specific developmental disruption of disrupted-in-schizophrenia-1 function results in schizophrenia-related phenotypes in mice.. Proceedings of the National Academy of Sciences of the United States of America. 2007; 104(46): 18280-5.
Olausson Peter, Jentsch J David, Tronson Natalie, Neve Rachel L, Nestler Eric J, Taylor Jane R DeltaFosB in the nucleus accumbens regulates food-reinforced instrumental behavior and motivation.. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006; 26(36): 9196-204.
Moore Holly, Jentsch J David, Ghajarnia Mehdi, Geyer Mark A, Grace Anthony A A neurobehavioral systems analysis of adult rats exposed to methylazoxymethanol acetate on E17: implications for the neuropathology of schizophrenia.. Biological psychiatry. 2006; 60(3): 253-64.
Aarde Shawn M, Jentsch J David Haploinsufficiency of the arginine-vasopressin gene is associated with poor spatial working memory performance in rats.. Hormones and behavior. 2006; 49(4): 501-8.
Li Weidong, Cui Yijun, Kushner Steven A, Brown Robert A M, Jentsch J David, Frankland Paul W, Cannon Tyrone D, Silva Alcino J The HMG-CoA reductase inhibitor lovastatin reverses the learning and attention deficits in a mouse model of neurofibromatosis type 1.. Current biology : CB. 2005; 15(21): 1961-7.
Lue Yanhe, Jentsch J David, Wang Christina, Rao P Nagesh, Hikim Amiya P Sinha, Salameh Wael, Swerdloff Ronald S XXY mice exhibit gonadal and behavioral phenotypes similar to Klinefelter syndrome.. Endocrinology. 2005; 146(9): 4148-54.
Marrs William, Kuperman Julie, Avedian Tahlin, Roth Robert H, Jentsch J David Alpha-2 adrenoceptor activation inhibits phencyclidine-induced deficits of spatial working memory in rats.. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology. 2005; 30(8): 1500-10.
Jentsch J David Impaired visuospatial divided attention in the spontaneously hypertensive rat.. Behavioural brain research. 2005; 157(2): 323-30.
Arguello P Alexander, Jentsch J David Cannabinoid CB1 receptor-mediated impairment of visuospatial attention in the rat.. Psychopharmacology. 2004; 177(1-2): 141-50.
Jentsch J David, Anzivino Luigi A A low dose of the alpha2 agonist clonidine ameliorates the visual attention and spatial working memory deficits produced by phencyclidine administration to rats.. Psychopharmacology. 2004; 175(1): 76-83.