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Riccardo Olcese, Ph.D.

Email Address:
rolcese@ucla.edu

Work Address:
Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES

Office
CHS
100 Jules Stein Plaza
Division of Molecular Medicine, Dept. of Anesthesiology
Los Angeles, CA 90095
UNITED STATES

Fax Number:
310-206-1947
Lab Number:
310-206-2685
Office Phone Number:
310-206-2214



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Department / Division Affiliations
Professor, Physiology
Associate Professor, Anesthesiology
Member, ACCESS Program: Dept. of Molecular, Cell & Integrative Physiology, Molecular Medicine, Access Biochemistry, Biophysics, Structural Biology Home Area, Access Molecular, Cellular and Integrative Physiology Home Area, Access Neuroscience Home Area, Brain Research Institute, Neuroscience IDP
Faculty, Cardiovascular Research Laboratory, Molecular, Cellular, and Integrative Physiology IDP

Publications:

Mahajan A, Shiferaw Y, Sato D, Baher A, Olcese R, Xie LH, Yang MJ, Chen PS, Restrepo JG, Karma A, Garfinkel A, Qu Z, Weiss JN. 2008 A rabbit ventricular action potential model replicating cardiac dynamics at rapid heart rates. Biophys J 2008; 94(2): 392-410.
Mahajan A, Sato D, Shiferaw Y, Baher A, Xie LH, Peralta R, Olcese R, Garfinkel A, Qu Z, Weiss JN. Modifying L-type calcium current kinetics: consequences for cardiac excitation and arrhythmia dynamics. Biophys J. 2008; 94(2): 411-23. .
Yusifov T, Savalli N, Gandhi CS, Ottolia M, Olcese R. The RCK2 domain of the human BKCa channel is a calcium sensor. Proc Natl Acad Sci U S A 2008; 105(1): 376-81.
Olcese Riccardo And yet it moves: conformational States of the Ca2+ channel pore. J Gen Physiol. 2007; 129(6)((6)): 457-9..
Gudzenko V, Shiferaw Y, Savalli N, Vyas R, Weiss JN, Olcese R. Influence of channel subunit composition on L-type Ca2+ current kinetics and cardiac wave stability. Am J Physiol Heart Circ Physiol 2007; 293(3): H1805-15.
Savalli N, Kondratiev A, de Quintana SB, Toro L, Olcese R. Modes of operation of the BKCa channel beta2 subunit. J Gen Physiol 2007; 130((1)): 117-31.
Savalli N, Kondratiev A, Toro L, Olcese R. Voltage-dependent conformational changes in human Ca(2+)- and voltage-activated K(+) channel, revealed by voltage-clamp fluorometry. Proc Natl Acad Sci U S A. 2006; 103(33): 12619-24.
Chen ZW, Chang CS, Leil TA, Olcese R, Olsen RW. GABAA receptor-associated protein regulates GABAA receptor cell-surface number in Xenopus laevis oocytes. Mol Pharmacol 2005; 68(1): 152-9..
Haug T., Olcese, R., Ciani S, Toro L., Stefani, E. Regulation of inward K flow by a negative residue in the outer vestibule of the MaxiK channel pore Part I. Journal of General Physiology 2004; 124(2): 185-97.
Haug T, Ciani S, Toro L., Stefani, Olcese, R. Regulation of inward K flow by a negative residue in the outer vestibule of the MaxiK channel pore Part II. Journal of General Physiology 2004; 124(2): 173-184.
Chang CS., Olcese, R., and R. Olsen A single M1 residue in the beta2 subunit alters channel gating of GAGAA receptor in anesthetic modulation and direct activation. Journal of Biological Chemistry 2003; 278(44): 42821.
Latorre R.,Olcese R.,Basso C.,Gonzalez C., Munoz F.,Cosmelli D. and Osvaldo Alvarez. Molecular coupling between voltage sensor and pore opening in the Arabidopis inward rectifier K+ channel KAT1. Journal of General Physiology 2003; 122(4): 459-469.
Helguera G., Olcese, R., Song M., Toro L. and Stefani E. Tissue-specific regulation of K+ and Ca2+ channel protein expression. Biochimica et Biophysica Acta 2002; 1569(1-3): 59-66.
Olcese, R., Sigg D., Bezanilla F., Stefani E A conducting state with properties of a slow inactivated state in Shaker K+ channel mutant. Journal of General Physiology 2001; 117: 149-163.
Platano, D. Qin N., Birnbaumer L., Stefani, E. and Olcese, R. Alpha-2-delta subunit interferes with prepulse facilitation in L-type Ca2+ channels. Biophysical Journal 2000; 78: 2959-2972.
Noceti, F., Olcese, R., Qin, N., Birnbaumer, L., and Stefani, E. Effect of Bay K 8644(-) and the b2a subunit on Ca2+ dependent inactivation in a1C Ca2+ channels: A model. 1998; 111(3): 463-475.
Roux, M., Olcese, R., Toro, L., Bezanilla, F. and Stefani, E. Fast inactivation in Shaker K+ channels: properties of ionic and gating currents. 1998; 111: 625-638.
Qin N, Olcese, R., Stefani, E., and Birnbaumer L. Modulation of human neuronal a1E calcium channel by a2d ?subunit. 1998; 274: C1324-1331.
Birnbaumer. L., Qin N., Olcese, R., Tareilus E., Platano, D., Costantin J. and Stefani, E. Structures and functions of calcium channel b subunits. J. of Bioenergy and Biomembrane 1998; 30(4): 357-375.
Qin, N., Platano, D., Olcese, R., Constantin J.L., Stefani, E., and Birnbaumer, L. Unique regulatory properties of type 2a Ca2+ channel b ?subunit due to palmitoylation. 1998; 95: 4690-4695.
Stefani, E., Ottolia, M., Noceti, F., Olcese, R., Wallner, M., and Latorre, R. Calcium independent and voltage-controlled gating in a Ca2+-sensitive K+ channel (hslo). Proceedings of National Academy of Science USA. 1997; 94: 5427-5431.
Olcese, R., Neely, A.,Qin, N., Wei, X., Birnbaumer, L., and Stefani, E. Coupling between charge movement and pore opening in type-E Ca2+ channel. Journal of Physiology 1997; 497: 675-686.
Qin, N., Platano, D., Olcese, R., Stefani, E., and Birnbaumer, L. Direct interaction of Gbg with a novel C-terminal Gbg binding domain of a1 is responsible for inhibition of presynaptic Ca2+ channels by G-protein-coupled receptors. Proceedings of National Academy of Science USA 1997; 94: 8866-8871.
Nobile, M., Olcese, R., Toro, L., and Stefani, E. Fast inactivation of Shaker K+ channels is highly temperature dependent. Experimental Brain Research 1997; 114 (1):: 138-142.
Zhou, J., Olcese, R., Qin, N., Birnbaumer, L. and Stefani, E. Feedback inhibition of calcium channels by calcium depends on a short sequence of carboxy terminus that does not include the calcium binding function of a motif with similarity to calcium binding domains. 1997; 94: 2301-2305.
Olcese, R., Noceti, F., Baldelli, P., Qin, N., Birnbaumer, L. and Stefani, E. beta subunit modulation of the coupling between charge movement and pore opening in calcium channels. From ion channels to cell to cell conversation 1997; 91-104.
Tareilus, E. Roux, M., Qin, N., Olcese, R., Zhou, J., Stefani, E. and Birnbaumer, L. A Xenopus Oocytes b subunit: evidence for a role in Assembly/expression of voltage-gated calcium channels that is separated from a role as a regulatory subunit. Proceedings of National Academy of Science USA 1996; 94: 1703-170.
Qin, N., Olcese, R., Zhou, J., Cabello, O.A., Birnbaumer, L. and Stefani E. Identification of a second region of the b subunit involved in the regulation of calcium channel inactivation. American Journal of Physiology 1996; 271: C1539-C1545.
Wei, X., Neely, A., Olcese, R., Stefani, E., and Birnbaumer, L. Increase in Ca2+ channel expression by deletions at the amino terminus of the cardiac a1 subunit. Receptors and channels. 1996; 4 (4):: 205-215.
Neely, A., Olcese, R., Wei, X., Baldelli, P., Birnbaumer, L. and Stefani E. Dual activation kinetic in cloned calcium channel and its modulation by the b subunit. American Journal of Physiology 1995; 268: C732-C740.
Neely, A., Olcese, R., Wei, X., Birnbaumer, L. and Stefani E. Calcium-dependent inactivation of cardiac calcium channels expressed in Xenopus oocytes. Biophysical J 1994; 66 (6): 1895-1903.
Wei, X., Neely, A., Lacerda, A.E., Olcese, R., Stefani, E., and Birnbaumer, L. Modification of Ca2+ channel activity by deletions at the carboxyl terminus of the cardiac a1 subunit. J. Biol. Chem 1994; 239 (3):: 1635-40.
Schneider, T., Wei, X., Olcese, R., Costantin J.L., Neely, A., Palade, P., Perez-Reyes, E.; Pan, S., Qin, N., Zhou, J., Crawford, G.D., Smith, R.G., Appel, S.H., Stefani, E., and Birnbaumer, L. Molecular analysis and functional expression of the human type E neuronal Ca2+ channel a1 subunit. Receptors and Channels 1994; 2: 255-270.
Neely, A., Wei, X., Olcese, R., Birnbaumer, L., and Stefani E. Potentiation by the b subunit of the ratio of the ionic current to charge movement in the cardiac calcium channel. Science 1993; 262: 575-578.
Eghbali, M Olcese, R Zarei, MM Toro, L Stefani, E External pore collapse as an inactivation mechanism for Kv4.3 K+ channels. The Journal of membrane biology. . 2002; 188(1): 73-86.
Qin, N Olcese, R Bransby, M Lin, T Birnbaumer, L Ca2+-induced inhibition of the cardiac Ca2+ channel depends on calmodulin. Proceedings of the National Academy of Sciences of the United States of America. . 1999; 96(5): 2435-8.
Olcese, R Latorre, R Toro, L Bezanilla, F Stefani, E Correlation between charge movement and ionic current during slow inactivation in Shaker K+ channels. The Journal of general physiology. . 1997; 110(5): 579-89.
Olcese, R Qin, N Schneider, T Neely, A Wei, X Stefani, E Birnbaumer, L The amino terminus of a calcium channel beta subunit sets rates of channel inactivation independently of the subunit's effect on activation. Neuron. . 1994; 13(6): 1433-8.
Olcese, R Usai, C Maestrone, E Nobile, M The general anesthetic propofol inhibits transmembrane calcium current in chick sensory neurons. Anesthesia and analgesia. . 1994; 78(5): 955-60.