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Igor Spigelman, Ph.D.

Email Address:
igor@ucla.edu

Work Address:
Laboratory
CHS
Los Angeles, CA 90095
UNITED STATES

Office
CHS
Los Angeles, CA 90095
UNITED STATES

Lab Number:
310-825-6509
Office Phone Number:
310-825-1955
310-825-3190



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Department / Division Affiliations
Professor, Dentistry (Oral Biology & Medicine)
Member, ACCESS Program: Dept. of Oral Biology, Access Molecular Pharmacology: Therapeutics, Diagnostics, and Biology of Disease Home Area, Access Molecular, Cellular and Integrative Physiology Home Area, Access Neuroscience Home Area, Brain Research Institute, Interdepartmental Undergraduate Program, Neuroengineering Training Program, Neuroscience IDP, Pharmacology Home Area
Faculty, Biomedical Engineering IDP

Research Interest:

Neuropharmacology

Dr. Spigelman is a neuropharmacologist conducting research on the mechanisms and relief of chronic pain, alcohol abuse, seizures and other neurodegenerative conditions such as stroke and brain trauma. His laboratory utilizes various multidisciplinary approaches to identify molecular targets for therapy of neuropathic pain. This includes studies on the alterations of voltage- and ligand-gated ion channels after peripheral nerve injuries, followed by the development of novel pharmaceuticals and non-viral gene delivery methodologies targeting the hyperexcitable sensory neurons which are involved in the transmission and processing of pain signals. The current focus of alcohol research is the GABA(A) receptor complex, which has been demonstrated to undergo profound molecular, functional and location-specific alterations in response to acute and chronic alcohol consumption.

Publications:

Ruangsri Supanigar, Lin Audrey, Mulpuri Yatendra, Lee Kyung, Spigelman Igor, Nishimura Ichiro RELATIONSHIP OF AXONAL VOLTAGE-GATED SODIUM CHANNEL 1.8 (NaV1.8) mRNA ACCUMULATION TO SCIATIC NERVE INJURY-INDUCED PAINFUL NEUROPATHY IN RATS. The Journal of biological chemistry. 2011; .
Shen Yi, Lindemeyer A Kerstin, Spigelman Igor, Sieghart Werner, Olsen Richard W, Liang Jing Plasticity of GABAA receptors after ethanol pre-exposure in cultured hippocampal neurons. Molecular pharmacology. 2011; 79(3): 432-42.
Suryanarayanan Asha, Liang Jing, Meyer Edward M, Lindemeyer A Kerstin, Chandra Dev, Homanics Gregg E, Sieghart Werner, Olsen Richard W, Spigelman Igor Subunit Compensation and Plasticity of Synaptic GABA(A) Receptors Induced by Ethanol in ?4 Subunit Knockout Mice. Frontiers in neuroscience. 2011; 5(3): 110.
Liang Jing, Suryanarayanan Asha, Chandra Dev, Homanics Gregg E, Olsen Richard W, Spigelman Igor Functional consequences of GABAA receptor alpha 4 subunit deletion on synaptic and extrasynaptic currents in mouse dentate granule cells. Alcoholism, clinical and experimental research. 2008; 32(1): 19-26.
Liang Jing, Suryanarayanan Asha, Abriam Alana, Snyder Bradley, Olsen Richard W, Spigelman Igor Mechanisms of reversible GABAA receptor plasticity after ethanol intoxication. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2007; 27(45): 12367-77.
Thakor Devang, Spigelman Igor, Tabata Yasuhiko, Nishimura Ichiro Subcutaneous peripheral injection of cationized gelatin/DNA polyplexes as a platform for non-viral gene transfer to sensory neurons. Molecular therapy : the journal of the American Society of Gene Therapy. 2007; 15(12): 2124-31.
Liang, J., Zhang, N., Cagetti, E. Houser, C.R., Olsen, R.W. and Spigelman, I. Chronic intermittent ethanol treatment-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors. Journal of Neuroscience 2006; 26: 1749-1758.
Liang Jing, Zhang Nianhui, Cagetti Elisabetta, Houser Carolyn R, Olsen Richard W, Spigelman Igor Chronic intermittent ethanol-induced switch of ethanol actions from extrasynaptic to synaptic hippocampal GABAA receptors. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2006; 26(6): 1749-58.
Chandra, D., Jia, F., Liang, J., Peng, Z., Suryanarayanan, A., Werner, D.F., Spigelman, I., Houser, C.R., Olsen, R.W., Harrison, N.L. and Homanics, G.E. GABA(A) receptor alpha4 subunits mediate extrasynaptic inhibition in thalamus and dentate gyrus and the action of gaboxadol. Proceedings of the National Academy of Sciences USA 2006; 103: 15230-15235.
Spigelman, I. Physiologic mechanisms of inhibition and status epilepticus. In: Status Epilepticus, Mechanisms and Management, C.G. Wasterlain and D.M. Treiman editors, MIT Press, Cambridge, 2006; Chapter 21: 281-293.
Mitrirattanakul Somsak, Ramakul Navapoln, Guerrero Andre V, Matsuka Yoshizo, Ono Takeshi, Iwase Hirotate, Mackie Ken, Faull Kym F, Spigelman Igor Site-specific increases in peripheral cannabinoid receptors and their endogenous ligands in a model of neuropathic pain. Pain. 2006; 126(1-3): 102-14.
Olsen, R.W., Liang, J., Cagetti, E., and Spigelman, I. Plasticity of GABAA receptors in brains of rats treated with chronic intermittent ethanol . Neurochemical Research 2005; 30: 1579-1588.
Matsuka Y. and Spigelman, I. Hyperosmolar solutions selectively block action potentials in rat myelinated sensory fibers: implications for diabetic neuropathy. Journal of Neurophysiology 2004; 91: 48-56.
Matsuka, Y Neubert, JK Maidment, NT Spigelman, I Concurrent release of ATP and substance P within guinea pig trigeminal ganglia in vivo. Brain research. . 2001; 915(2): 248-55.
Spigelman, I., Gold, M.S., Light A.R. Electrophysiological Methods in Pain Research. Methods in Pain Research 2001; Chapter 8: 147-168.
Spigelman, I., Neubert, J.K., Matsuka, Y., Maidment, N.T. Extracellular Sampling. Methods in Pain Research 2001; Chapter 7: 133-146.
Neubert, JK Maidment, NT Matsuka, Y Adelson, DW Kruger, L Spigelman, I Inflammation-induced changes in primary afferent-evoked release of substance P within trigeminal ganglia in vivo. Brain research. . 2000; 871(2): 181-91.
Spigelman, I Yan, XX Obenaus, A Lee, EY Wasterlain, CG Ribak, CE Dentate granule cells form novel basal dendrites in a rat model of temporal lobe epilepsy. Neuroscience. . 1998; 86(1): 109-20.
Spigelman, I Obenaus, A Mazarati, A Wasterlain, CG Intravenously administered cell-permeant calcium buffer decreases evoked synaptic potentials in rat dentate gyrus in vivo. Brain research. . 1998; 810(1-2): 269-73.
Spigelman, I Tymianski, M Wallace, CM Carlen, PL Velumian, AA Modulation of hippocampal synaptic transmission by low concentrations of cell-permeant Ca2+ chelators: effects of Ca2+ affinity, chelator structure and binding kinetics. Neuroscience. . 1996; 75(2): 559-72.