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Aldons Lusis, Ph.D.

Work Email Address:

Mailing Address:
10833 Le Conte Avenue
CAMPUS - 167917, BH-307 CHS
Los Angeles, CA 90095

Work Address:
MRL 3-730
Los Angeles, CA 90095

Los Angeles, CA 90095

Fax Number:
Work Phone Number:
(310) 825-1359

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Department / Division Affiliations
Professor, Department of Medicine, Human Genetics, Microbiology, Immunology & Molecular Genetics
Vice Chair, Human Genetics
Member, ACCESS Program: Dept. of Microbiology, Immunology, & Molecular Genetics, Access Genetics and Genomics Home Area, Access Molecular Pharmacology: Therapeutics, Diagnostics, and Biology of Disease Home Area, Access Molecular, Cellular and Integrative Physiology Home Area, Brain Research Institute, CTSI, Center for Duchenne Muscular Dystrophy, JCCC Cancer and Stem Cell Biology Program Area, Pharmacology Home Area, Research Education, Training, and Career Development Program (CTSI-ED)
Faculty, Cardiology, BWF-IT-MD, Center for Metabolic Disease Prevention

Research Interest:

The analysis of complex genetic diseases

Atherosclerosis, a disease of the large arteries that is the major cause of heart disease and stroke, has a very complex etiology. Although cholesterol levels, diabetes, blood pressure, and a number of other risk factors have been associated with the disease, its primary causes and mechanistic details remain poorly understood. Our lab is using genetic approaches to clarify the molecular and cellular interactions involved in the disease. Through mapping and positional cloning in both human subjects and mouse animal models, we hope to identify new genes and pathways contributing to atherosclerosis. Such gene mapping approaches have revolutionized our understanding of Mendelian diseases, but their application to complex diseases such as atherosclerosis has thus far been disappointing. However, we are optimistic that new resources, particularly the sequences of the human and mouse genomes, and new tools, such as global analysis of transcript levels, will greatly enhance our ability to identify novel genes using positional cloning. We are also using transgenic and gene targeting technologies to examine in detail the interactions contributing to the initiation and progression of the disease. Our research is divided into two general areas, one concerning A?metabolic syndromeA? and the other inflammation and oxidation. A?Metabolic syndromeA? consists of a cluster of metabolic disturbances with insulin resistance as a central feature, and it is strongly associated with coronary heart disease. We have focused on one form of the disease, termed A?familial combined hyperlipidemiaA?, characterized by elevated triglyceride and cholesterol levels. For these studies, we are collaborating with Dr. Tjerk deBruin and his group in the Netherlands, who have collected numerous families with multiple affected individuals. Although we have identified and characterized some genes that modify the familial combined hyperlipidemic phenotype, we have as yet been unable to identify the major genes involved. Some preliminary evidence suggests that the disease may be very heterogeneous, complicating positional cloning approaches. Using mapping strategies in the mouse, we have identified and studied some genes that result in hypertriglyceridemia or insulin resistance, including apolipoprotein AII, thioredoxin inhibitory protein, and 5-lipoxygenase. We are now testing the relevance of these genes in human metabolic syndrome. In studies with mouse models, we have recently made some important finding regarding the role of inflammation and oxidation in atherosclerosis. One very exciting result was the demonstration that genetic differences in atherosclerosis susceptibility in mice are due in part to genetic variation in inflammatory responses of endothelial cells to oxidized lipids. We are now attempting to identify the underlying genes and test whether similar differences occur in human populations. Another important achievement was the identification of 5-lipoxygenase as an important determinant of atherosclerosis susceptibility in mice. Preliminary work suggests that variations of the enzyme may be an important determinant of the disease in humans as well.


Marquart Tyler J, Wu Judy, Lusis Aldons J, Baldán Ángel Anti-miR-33 therapy does not alter the progression of atherosclerosis in low-density lipoprotein receptor-deficient mice. Arteriosclerosis, thrombosis, and vascular biology. 2013; 33(3): 455-8.
Mahendran Yuvaraj, Vangipurapu Jagadish, Cederberg Henna, Stancáková Alena, Pihlajamäki Jussi, Soininen Pasi, Kangas Antti J, Paananen Jussi, Civelek Mete, Saleem Niyas K, Pajukanta Päivi, Lusis Aldons J, Bonnycastle Lori L, Morken Mario A, Collins Francis S, Mohlke Karen L, Boehnke Michael, Ala-Korpela Mika, Kuusisto Johanna, Laakso Markku Association of ketone body levels with hyperglycemia and type 2 diabetes in 9,398 Finnish men. Diabetes. 2013; 19(5): .
Parks Brian W, Nam Elizabeth, Org Elin, Kostem Emrah, Norheim Frode, Hui Simon T, Pan Calvin, Civelek Mete, Rau Christoph D, Bennett Brian J, Mehrabian Margarete, Ursell Luke K, He Aiqing, Castellani Lawrence W, Zinker Bradley, Kirby Mark, Drake Thomas A, Drevon Christian A, Knight Rob, Gargalovic Peter, Kirchgessner Todd, Eskin Eleazar, Lusis Aldons J Genetic control of obesity and gut microbiota composition in response to high-fat, high-sucrose diet in mice. Cell metabolism. 2013; 17(1): 141-52.
Civelek Mete, Hagopian Raffi, Pan Calvin, Che Nam, Yang Wen-Pin, Kayne Paul S, Saleem Niyas K, Cederberg Henna, Kuusisto Johanna, Gargalovic Peter S, Kirchgessner Todd G, Laakso Markku, Lusis Aldons J Genetic regulation of human adipose microRNA expression and its consequences for metabolic traits. Human molecular genetics. 2013; 19(5): .
Davis Richard C, van Nas Atila, Bennett Brian, Orozco Luz, Pan Calvin, Rau Christoph D, Eskin Eleazar, Lusis Aldons J Genome-wide association mapping of blood cell traits in mice. Mammalian genome : official journal of the International Mammalian Genome Society. 2013; 24(3-4): 105-18.
Weissglas-Volkov Daphna, Aguilar-Salinas Carlos A, Nikkola Elina, Deere Kerry A, Cruz-Bautista Ivette, Arellano-Campos Olimpia, Muñoz-Hernandez Linda Liliana, Gomez-Munguia Lizeth, Ordoñez-Sánchez Maria Luisa, Reddy Prasad M V Linga, Lusis Aldons J, Matikainen Niina, Taskinen Marja-Riitta, Riba Laura, Cantor Rita M, Sinsheimer Janet S, Tusie-Luna Teresa, Pajukanta Päivi Genomic study in Mexicans identifies a new locus for triglycerides and refines European lipid loci. Journal of medical genetics. 2013; 50(5): 298-308.
Shih Diana M, Shaposhnik Zory, Meng Yonghong, Rosales Melenie, Wang Xuping, Wu Judy, Ratiner Boris, Zadini Filiberto, Zadini Georgio, Lusis Aldons J Hyodeoxycholic acid improves HDL function and inhibits atherosclerotic lesion formation in LDLR-knockout mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2013; 54(7): .
Erbilgin Ayca, Civelek Mete, Romanoski Casey E, Pan Calvin, Hagopian Raffi, Berliner Judith A, Lusis Aldons J Identification of CAD candidate genes in GWAS loci and their expression in vascular cells. Journal of lipid research. 2013; 54(7): 1894-905.
Koeth Robert A, Wang Zeneng, Levison Bruce S, Buffa Jennifer A, Org Elin, Sheehy Brendan T, Britt Earl B, Fu Xiaoming, Wu Yuping, Li Lin, Smith Jonathan D, Didonato Joseph A, Chen Jun, Li Hongzhe, Wu Gary D, Lewis James D, Warrier Manya, Brown J Mark, Krauss Ronald M, Tang W H Wilson, Bushman Frederic D, Lusis Aldons J, Hazen Stanley L Intestinal microbiota metabolism of l-carnitine, a nutrient in red meat, promotes atherosclerosis. Nature medicine. 2013; 19(5): 576-85.
Lagarrigue Sandrine, Hormozdiari Farhad, Martin Lisa J, Lecerf Frédéric, Hasin Yehudit, Rau Christoph, Hagopian Raffi, Xiao Yu, Yan Jun, Drake Thomas A, Ghazalpour Anatole, Eskin Eleazar, Lusis Aldons J Limited RNA editing in exons of mouse liver and adipose. Genetics. 2013; 193(4): 1107-15.
Rau Christoph D, Wisniewski Nicholas, Orozco Luz D, Bennett Brian, Weiss James, Lusis Aldons J Maximal information component analysis: a novel non-linear network analysis method. Frontiers in genetics. 2013; 4(1): 28.
Martin Lisa J, Lau Edward, Singh Harpreet, Vergnes Laurent, Tarling Elizabeth J, Mehrabian Margarete, Mungrue Imran, Xiao Sheila, Shih Diana, Castellani Lawrence, Ping Peipei, Reue Karen, Stefani Enrico, Drake Thomas A, Bostrom Kristina, Lusis Aldons J Response to Pomozi et al's Research Commentary. Circulation research. 2013; 112(11): e152-3.
van Nas Atila, Pan Calvin, Ingram-Drake Leslie A, Ghazalpour Anatole, Drake Thomas A, Sobel Eric M, Papp Jeanette C, Lusis Aldons J The systems genetics resource: a web application to mine global data for complex disease traits. Frontiers in genetics. 2013; 4(11): 84.
Bennett Brian J, de Aguiar Vallim Thomas Q, Wang Zeneng, Shih Diana M, Meng Yonghong, Gregory Jill, Allayee Hooman, Lee Richard, Graham Mark, Crooke Rosanne, Edwards Peter A, Hazen Stanley L, Lusis Aldons J Trimethylamine-N-oxide, a metabolite associated with atherosclerosis, exhibits complex genetic and dietary regulation. Cell metabolism. 2013; 17(1): 49-60.
Halperin Daniel S, Pan Calvin, Lusis Aldons J, Tontonoz Peter Vestigial-like 3 is an inhibitor of adipocyte differentiation. Journal of lipid research. 2013; 54(2): 473-81.
Weiss James N, Karma Alain, MacLellan W Robb, Deng Mario, Rau Christoph D, Rees Colin M, Wang Jessica, Wisniewski Nicholas, Eskin Eleazar, Horvath Steve, Qu Zhilin, Wang Yibin, Lusis Aldons J "Good enough solutions" and the genetics of complex diseases. Circulation research. 2012; 111(4): 493-504.
Langfelder Peter, Castellani Lawrence W, Zhou Zhiqiang, Paul Eric, Davis Richard, Schadt Eric E, Lusis Aldons J, Horvath Steve, Mehrabian Margarete A systems genetic analysis of high density lipoprotein metabolism and network preservation across mouse models. Biochimica et biophysica acta. 2012; 1821(3): 435-47.
Martin Lisa J, Lau Edward, Singh Harpreet, Vergnes Laurent, Tarling Elizabeth J, Mehrabian Margarete, Mungrue Imran, Xiao Sheila, Shih Diana, Castellani Lawrence, Ping Peipei, Reue Karen, Stefani Enrico, Drake Thomas A, Bostrom Kristina, Lusis Aldons J ABCC6 localizes to the mitochondria-associated membrane. Circulation research. 2012; 111(5): 516-20.
Kim Juyong Brian, Deluna Andres, Mungrue Imran N, Vu Christine, Pouldar Delila, Civelek Mete, Orozco Luz, Wu Judy, Wang Xuping, Charugundla Sarada, Castellani Lawrence W, Rusek Marta, Jakubowski Hieronim, Jakobowski Hieronim, Lusis Aldons J Effect of 9p21.3 coronary artery disease locus neighboring genes on atherosclerosis in mice. Circulation. 2012; 126(15): 1896-906.
Johansen Christopher T, Wang Jian, McIntyre Adam D, Martins Rebecca A, Ban Matthew R, Lanktree Matthew B, Huff Murray W, Péterfy Miklós, Mehrabian Margarete, Lusis Aldons J, Kathiresan Sekar, Anand Sonia S, Yusuf Salim, Lee Ann-Hwee, Glimcher Laurie H, Cao Henian, Hegele Robert A Excess of rare variants in non-genome-wide association study candidate genes in patients with hypertriglyceridemia. Circulation. Cardiovascular genetics. 2012; 5(1): 66-72.
Smolock Elaine M, Ilyushkina Irina A, Ghazalpour Anatole, Gerloff Janice, Murashev Arkady N, Lusis Aldons J, Korshunov Vyacheslav A Genetic locus on mouse chromosome 7 controls elevated heart rate. Physiological genomics. 2012; 44(13): 689-98.
Lusis Aldons J Genetics of atherosclerosis. Trends in genetics : TIG. 2012; 28(6): 267-75.
Bennett Brian J, Orozco Luz, Kostem Emrah, Erbilgin Ayca, Dallinga Marchien, Neuhaus Isaac, Guan Bo, Wang Xuping, Eskin Eleazar, Lusis Aldons J High-resolution association mapping of atherosclerosis loci in mice. Arteriosclerosis, thrombosis, and vascular biology. 2012; 32(8): 1790-8.
Ghazalpour Anatole, Rau Christoph D, Farber Charles R, Bennett Brian J, Orozco Luz D, van Nas Atila, Pan Calvin, Allayee Hooman, Beaven Simon W, Civelek Mete, Davis Richard C, Drake Thomas A, Friedman Rick A, Furlotte Nick, Hui Simon T, Jentsch J David, Kostem Emrah, Kang Hyun Min, Kang Eun Yong, Joo Jong Wha, Korshunov Vyacheslav A, Laughlin Rick E, Martin Lisa J, Ohmen Jeffrey D, Parks Brian W, Pellegrini Matteo, Reue Karen, Smith Desmond J, Tetradis Sotirios, Wang Jessica, Wang Yibin, Weiss James N, Kirchgessner Todd, Gargalovic Peter S, Eskin Eleazar, Lusis Aldons J, LeBoeuf Renée C Hybrid mouse diversity panel: a panel of inbred mouse strains suitable for analysis of complex genetic traits. Mammalian genome : official journal of the International Mammalian Genome Society. 2012; 23(9-10): 680-92.
Stancáková Alena, Civelek Mete, Saleem Niyas K, Soininen Pasi, Kangas Antti J, Cederberg Henna, Paananen Jussi, Pihlajamäki Jussi, Bonnycastle Lori L, Morken Mario A, Boehnke Michael, Pajukanta Päivi, Lusis Aldons J, Collins Francis S, Kuusisto Johanna, Ala-Korpela Mika, Laakso Markku Hyperglycemia and a common variant of GCKR are associated with the levels of eight amino acids in 9,369 Finnish men. Diabetes. 2012; 61(7): 1895-902.
Furlotte Nicholas A, Kang Eun Yong, Van Nas Atila, Farber Charles R, Lusis Aldons J, Eskin Eleazar Increasing association mapping power and resolution in mouse genetic studies through the use of meta-analysis for structured populations. Genetics. 2012; 191(3): 959-67.
Hong Cynthia, Bradley Michele N, Rong Xin, Wang Xuping, Wagner Alan, Grijalva Victor, Castellani Lawrence W, Salazar Jon, Realegeno Susan, Boyadjian Rima, Fogelman Alan M, Van Lenten Brian J, Reddy Srinivasa T, Lusis Aldons J, Tangirala Rajendra K, Tontonoz Peter LXRα is uniquely required for maximal reverse cholesterol transport and atheroprotection in ApoE-deficient mice. Journal of lipid research. 2012; 53(6): 1126-33.
Lusis Aldons J Life after GWAS: functional genomics in vascular biology. Arteriosclerosis, thrombosis, and vascular biology. 2012; 32(2): 169.
Lee Sangderk, Springstead James R, Parks Brian W, Romanoski Casey E, Palvolgyi Roland, Ho Tiffany, Nguyen Phuc, Lusis Aldons J, Berliner Judith A Metalloproteinase processing of HBEGF is a proximal event in the response of human aortic endothelial cells to oxidized phospholipids. Arteriosclerosis, thrombosis, and vascular biology. 2012; 32(5): 1246-54.
Lee Sangderk, Birukov Konstantin G, Romanoski Casey E, Springstead James R, Lusis Aldons J, Berliner Judith A Role of phospholipid oxidation products in atherosclerosis. Circulation research. 2012; 111(6): 778-99.
Calabrese Gina, Bennett Brian J, Orozco Luz, Kang Hyun M, Eskin Eleazar, Dombret Carlos, De Backer Olivier, Lusis Aldons J, Farber Charles R Systems genetic analysis of osteoblast-lineage cells. PLoS genetics. 2012; 8(12): e1003150.
Davis Richard C, van Nas Atila, Castellani Lawrence W, Zhao Yi, Zhou Zhiqiang, Wen Pingzi, Yu Suzanne, Qi Hongxiu, Rosales Melenie, Schadt Eric E, Broman Karl W, Péterfy Miklós, Lusis Aldons J Systems genetics of susceptibility to obesity-induced diabetes in mice. Physiological genomics. 2012; 44(1): 1-13.
MacLellan W Robb, Wang Yibin, Lusis Aldons J Systems-based approaches to cardiovascular disease. Nature reviews. Cardiology. 2012; 9(3): 172-84.
Arnold Arthur P, Lusis Aldons J Understanding the sexome: measuring and reporting sex differences in gene systems. Endocrinology. 2012; 153(6): 2551-5.
Orozco Luz D, Bennett Brian J, Farber Charles R, Ghazalpour Anatole, Pan Calvin, Che Nam, Wen Pingzi, Qi Hong Xiu, Mutukulu Adonisa, Siemers Nathan, Neuhaus Isaac, Yordanova Roumyana, Gargalovic Peter, Pellegrini Matteo, Kirchgessner Todd, Lusis Aldons J Unraveling inflammatory responses using systems genetics and gene-environment interactions in macrophages. Cell. 2012; 151(3): 658-70.
Ishikawa Kazunobu, Navab Mohamad, Lusis Aldons J Vasculitis, Atherosclerosis, and Altered HDL Composition in Heme-Oxygenase-1-Knockout Mice. International journal of hypertension. 2012; 2012(3): 948203.
Mungrue Imran N, Zhao Peng, Yao Yucheng, Meng Haijin, Rau Christoph, Havel Jocelyn V, Gorgels Theo G M F, Bergen Arthur A B, MacLellan W Robb, Drake Thomas A, Boström Kristina I, Lusis Aldons J Abcc6 deficiency causes increased infarct size and apoptosis in a mouse cardiac ischemia-reperfusion model. Arteriosclerosis, thrombosis, and vascular biology. 2011; 31(12): 2806-12.
Terra Jill K, France Bryan, Cote Christopher K, Jenkins Amy, Bozue Joel A, Welkos Susan L, Bhargava Ragini, Ho Chi-Lee, Mehrabian Margarete, Pan Calvin, Lusis Aldons J, Davis Richard C, LeVine Steven M, Bradley Kenneth A Allelic variation on murine chromosome 11 modifies host inflammatory responses and resistance to Bacillus anthracis. PLoS pathogens. 2011; 7(12): e1002469.
Ghazalpour Anatole, Bennett Brian, Petyuk Vladislav A, Orozco Luz, Hagopian Raffi, Mungrue Imran N, Farber Charles R, Sinsheimer Janet, Kang Hyun M, Furlotte Nicholas, Park Christopher C, Wen Ping-Zi, Brewer Heather, Weitz Karl, Camp David G, Pan Calvin, Yordanova Roumyana, Neuhaus Isaac, Tilford Charles, Siemers Nathan, Gargalovic Peter, Eskin Eleazar, Kirchgessner Todd, Smith Desmond J, Smith Richard D, Lusis Aldons J Comparative analysis of proteome and transcriptome variation in mouse. PLoS genetics. 2011; 7(6): e1001393.
Civelek Mete, Lusis Aldons J Conducting the metabolic syndrome orchestra. Nature genetics. 2011; 43(6): 506-8.
Park Christopher C, Gale Greg D, de Jong Simone, Ghazalpour Anatole, Bennett Brian J, Farber Charles R, Langfelder Peter, Lin Andy, Khan Arshad H, Eskin Eleazar, Horvath Steve, Lusis Aldons J, Ophoff Roel A, Smith Desmond J Gene networks associated with conditional fear in mice identified using a systems genetics approach. BMC systems biology. 2011; 5(4): 43.
Wang Zeneng, Klipfell Elizabeth, Bennett Brian J, Koeth Robert, Levison Bruce S, Dugar Brandon, Feldstein Ariel E, Britt Earl B, Fu Xiaoming, Chung Yoon-Mi, Wu Yuping, Schauer Phil, Smith Jonathan D, Allayee Hooman, Tang W H Wilson, DiDonato Joseph A, Lusis Aldons J, Hazen Stanley L Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 2011; 472(7341): 57-63.
Besler Christian, Heinrich Kathrin, Rohrer Lucia, Doerries Carola, Riwanto Meliana, Shih Diana M, Chroni Angeliki, Yonekawa Keiko, Stein Sokrates, Schaefer Nicola, Mueller Maja, Akhmedov Alexander, Daniil Georgios, Manes Costantina, Templin Christian, Wyss Christophe, Maier Willibald, Tanner Felix C, Matter Christian M, Corti Roberto, Furlong Clement, Lusis Aldons J, von Eckardstein Arnold, Fogelman Alan M, Lüscher Thomas F, Landmesser Ulf Mechanisms underlying adverse effects of HDL on eNOS-activating pathways in patients with coronary artery disease. The Journal of clinical investigation. 2011; 121(7): 2693-708.
Farber Charles R, Bennett Brian J, Orozco Luz, Zou Wei, Lira Ana, Kostem Emrah, Kang Hyun Min, Furlotte Nicholas, Berberyan Ani, Ghazalpour Anatole, Suwanwela Jaijam, Drake Thomas A, Eskin Eleazar, Wang Q Tian, Teitelbaum Steven L, Lusis Aldons J Mouse genome-wide association and systems genetics identify Asxl2 as a regulator of bone mineral density and osteoclastogenesis. PLoS genetics. 2011; 7(4): e1002038.
Barajas Berenice, Che Nam, Yin Fen, Rowshanrad Amir, Orozco Luz D, Gong Ke Wei, Wang Xuping, Castellani Lawrence W, Reue Karen, Lusis Aldons J, Araujo Jesus A NF-E2-related factor 2 promotes atherosclerosis by effects on plasma lipoproteins and cholesterol transport that overshadow antioxidant protection. Arteriosclerosis, thrombosis, and vascular biology. 2011; 31(1): 58-66.
Romanoski Casey E, Che Nam, Yin Fen, Mai Nguyen, Pouldar Delila, Civelek Mete, Pan Calvin, Lee Sangderk, Vakili Ladan, Yang Wen-Pin, Kayne Paul, Mungrue Imran N, Araujo Jesus A, Berliner Judith A, Lusis Aldons J Network for activation of human endothelial cells by oxidized phospholipids: a critical role of heme oxygenase 1. Circulation research. 2011; 109(5): e27-41.
Kim Juyong Brian, Xia Yu-Rong, Romanoski Casey E, Lee Sangderk, Meng YongHong, Shi Yi-Shou, Bourquard Noam, Gong Ke Wei, Port Zachary, Grijalva Victor, Reddy Srinivasa T, Berliner Judith A, Lusis Aldons J, Shih Diana M Paraoxonase-2 modulates stress response of endothelial cells to oxidized phospholipids and a bacterial quorum-sensing molecule. Arteriosclerosis, thrombosis, and vascular biology. 2011; 31(11): 2624-33.
Suwanwela Jaijam, Farber Charles R, Haung Bau-Lin, Song Buer, Pan Calvin, Lyons Karen M, Lusis Aldons J Systems genetics analysis of mouse chondrocyte differentiation. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2011; 26(4): 747-60.
Bennett Brian J, Farber Charles R, Orozco Luz, Kang Hyun Min, Ghazalpour Anatole, Siemers Nathan, Neubauer Michael, Neuhaus Isaac, Yordanova Roumyana, Guan Bo, Truong Amy, Yang Wen-pin, He Aiqing, Kayne Paul, Gargalovic Peter, Kirchgessner Todd, Pan Calvin, Castellani Lawrence W, Kostem Emrah, Furlotte Nicholas, Drake Thomas A, Eskin Eleazar, Lusis Aldons J A high-resolution association mapping panel for the dissection of complex traits in mice. Genome research. 2010; 20(2): 281-90.
Hsu Yi-Hsiang, Zillikens M Carola, Wilson Scott G, Farber Charles R, Demissie Serkalem, Soranzo Nicole, Bianchi Estelle N, Grundberg Elin, Liang Liming, Richards J Brent, Estrada Karol, Zhou Yanhua, van Nas Atila, Moffatt Miriam F, Zhai Guangju, Hofman Albert, van Meurs Joyce B, Pols Huibert A P, Price Roger I, Nilsson Olle, Pastinen Tomi, Cupples L Adrienne, Lusis Aldons J, Schadt Eric E, Ferrari Serge, Uitterlinden André G, Rivadeneira Fernando, Spector Timothy D, Karasik David, Kiel Douglas P An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits. PLoS genetics. 2010; 6(6): e1000977.
Shaposhnik Zory, Wang Xuping, Lusis Aldons J Arterial colony stimulating factor-1 influences atherosclerotic lesions by regulating monocyte migration and apoptosis. Journal of lipid research. 2010; 51(7): 1962-70.
Lusis Aldons J, Weiss James N Cardiovascular networks: systems-based approaches to cardiovascular disease. Circulation. 2010; 121(1): 157-70.
Weinstein Michael M, Yin Liya, Tu Yiping, Wang Xuping, Wu Xiaohui, Castellani Lawrence W, Walzem Rosemary L, Lusis Aldons J, Fong Loren G, Beigneux Anne P, Young Stephen G Chylomicronemia elicits atherosclerosis in mice--brief report. Arteriosclerosis, thrombosis, and vascular biology. 2010; 30(1): 20-3.
Davis Richard C, Castellani Lawrence W, Hosseini Maryam, Ben-Zeev Osnat, Mao Hui Z, Weinstein Michael M, Jung Dae Young, Jun John Y, Kim Jason K, Lusis Aldons J, Péterfy Miklós Early hepatic insulin resistance precedes the onset of diabetes in obese C57BLKS-db/db mice. Diabetes. 2010; 59(7): 1616-25.
van Nas Atila, Ingram-Drake Leslie, Sinsheimer Janet S, Wang Susanna S, Schadt Eric E, Drake Thomas, Lusis Aldons J Expression quantitative trait loci: replication, tissue- and sex-specificity in mice. Genetics. 2010; 185(3): 1059-68.
Yang Xia, Peterson Larry, Thieringer Rolf, Deignan Joshua L, Wang Xuping, Zhu Jun, Wang Susanna, Zhong Hua, Stepaniants Serguei, Beaulaurier John, Wang I-Ming, Rosa Ray, Cumiskey Anne-Marie, Luo Jane Ming-Juan, Luo Qi, Shah Kashmira, Xiao Jianying, Nickle David, Plump Andrew, Schadt Eric E, Lusis Aldons J, Lum Pek Yee Identification and validation of genes affecting aortic lesions in mice. The Journal of clinical investigation. 2010; 120(7): 2414-22.
Tarling Elizabeth J, Bojanic Dragana D, Tangirala Rajendra K, Wang Xuping, Lovgren-Sandblom Anita, Lusis Aldons J, Bjorkhem Ingemar, Edwards Peter A Impaired development of atherosclerosis in Abcg1-/- Apoe-/- mice: identification of specific oxysterols that both accumulate in Abcg1-/- Apoe-/- tissues and induce apoptosis. Arteriosclerosis, thrombosis, and vascular biology. 2010; 30(6): 1174-80.
Yao Yucheng, Bennett Brian J, Wang Xuping, Rosenfeld Michael E, Giachelli Cecilia, Lusis Aldons J, Boström Kristina I Inhibition of bone morphogenetic proteins protects against atherosclerosis and vascular calcification. Circulation research. 2010; 107(4): 485-94.
Gargalovic Peter S, Erbilgin Aya, Kohannim Omid, Pagnon Joanne, Wang Xuping, Castellani Lawrence, LeBoeuf Renee, Peterson Martha L, Spear Brett T, Lusis Aldons J Quantitative trait locus mapping and identification of Zhx2 as a novel regulator of plasma lipid metabolism. Circulation. Cardiovascular genetics. 2010; 3(1): 60-7.
Romanoski Casey E, Lee Sangderk, Kim Michelle J, Ingram-Drake Leslie, Plaisier Christopher L, Yordanova Roumyana, Tilford Charles, Guan Bo, He Aiqing, Gargalovic Peter S, Kirchgessner Todd G, Berliner Judith A, Lusis Aldons J Systems genetics analysis of gene-by-environment interactions in human cells. American journal of human genetics. 2010; 86(3): 399-410.
Priceman Saul J, Sung James L, Shaposhnik Zory, Burton Jeremy B, Torres-Collado Antoni X, Moughon Diana L, Johnson Mai, Lusis Aldons J, Cohen Donald A, Iruela-Arispe M Luisa, Wu Lily Targeting distinct tumor-infiltrating myeloid cells by inhibiting CSF-1 receptor: combating tumor evasion of antiangiogenic therapy. Blood. 2010; 115(7): 1461-71.
Shih Diana M, Xia Yu-Rong, Yu Janet M, Lusis Aldons J Temporal and tissue-specific patterns of Pon3 expression in mouse: in situ hybridization analysis. Advances in experimental medicine and biology. 2010; 660(7): 73-87.
Woo Jennifer M P, Lin Zhuofeng, Navab Mohamad, Van Dyck Casey, Trejo-Lopez Yvette, Woo Krystal M T, Li Hongyun, Castellani Lawrence W, Wang Xuping, Iikuni Noriko, Rullo Ornella J, Wu Hui, La Cava Antonio, Fogelman Alan M, Lusis Aldons J, Tsao Betty P Treatment with apolipoprotein A-1 mimetic peptide reduces lupus-like manifestations in a murine lupus model of accelerated atherosclerosis. Arthritis research & therapy. 2010; 12(3): R93.
Wu Sulin, Mar-Heyming Rebecca, Dugum Eric Z, Kolaitis Nicholas A, Qi Hongxiu, Pajukanta Pivi, Castellani Lawrence W, Lusis Aldons J, Drake Thomas A Upstream transcription factor 1 influences plasma lipid and metabolic traits in mice. Human molecular genetics. 2010; 19(4): 597-608.
Stoltz David A, Ozer Egon A, Recker Thomas J, Estin Miriam, Yang Xia, Shih Diana M, Lusis Aldons J, Zabner Joseph A common mutation in paraoxonase-2 results in impaired lactonase activity. The Journal of biological chemistry. 2009; 284(51): 35564-71.
Wu Sulin, Lusis Aldons J, Drake Thomas A A systems-based framework for understanding complex metabolic and cardiovascular disorders. Journal of lipid research. 2009; 50 Suppl(3): S358-63.
Farber Charles R, van Nas Atila, Ghazalpour Anatole, Aten Jason E, Doss Sudheer, Sos Brandon, Schadt Eric E, Ingram-Drake Leslie, Davis Richard C, Horvath Steve, Smith Desmond J, Drake Thomas A, Lusis Aldons J An integrative genetics approach to identify candidate genes regulating BMD: combining linkage, gene expression, and association. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2009; 24(1): 105-16.
Mungrue Imran N, Pagnon Joanne, Kohannim Omid, Gargalovic Peter S, Lusis Aldons J CHAC1/MGC4504 is a novel proapoptotic component of the unfolded protein response, downstream of the ATF4-ATF3-CHOP cascade. Journal of immunology (Baltimore, Md. : 1950). 2009; 182(1): 466-76.
Orozco Luz D, Cokus Shawn J, Ghazalpour Anatole, Ingram-Drake Leslie, Wang Susanna, van Nas Atila, Che Nam, Araujo Jesus A, Pellegrini Matteo, Lusis Aldons J Copy number variation influences gene expression and metabolic traits in mice. Human molecular genetics. 2009; 18(21): 4118-29.
Wang Susanna S, Martin Lisa J, Schadt Eric E, Meng Haijin, Wang Xuping, Zhao Wei, Ingram-Drake Leslie, Nebohacova Martina, Mehrabian Margarete, Drake Thomas A, Lusis Aldons J Disruption of the aortic elastic lamina and medial calcification share genetic determinants in mice. Circulation. Cardiovascular genetics. 2009; 2(6): 573-82.
van Nas Atila, Guhathakurta Debraj, Wang Susanna S, Yehya Nadir, Horvath Steve, Zhang Bin, Ingram-Drake Leslie, Chaudhuri Gautam, Schadt Eric E, Drake Thomas A, Arnold Arthur P, Lusis Aldons J Elucidating the role of gonadal hormones in sexually dimorphic gene coexpression networks. Endocrinology. 2009; 150(3): 1235-49.
Farber Charles R, Lusis Aldons J Future of osteoporosis genetics: enhancing genome-wide association studies. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 2009; 24(12): 1937-42.
Farber Charles R, Aten Jason E, Farber Emily A, de Vera Vincent, Gularte Rodrigo, Islas-Trejo Alma, Wen Pengzi, Horvath Steve, Lucero Michael, Lusis Aldons J, Medrano Juan F Genetic dissection of a major mouse obesity QTL (Carfhg2): integration of gene expression and causality modeling. Physiological genomics. 2009; 37(3): 294-302.
Bennett Brian J, Wang Susanna S, Wang Xuping, Wu Xiaohui, Lusis Aldons J Genetic regulation of atherosclerotic plaque size and morphology in the innominate artery of hyperlipidemic mice. Arteriosclerosis, thrombosis, and vascular biology. 2009; 29(3): 348-55.
White Cory H, Ohmen Jeffrey D, Sheth Sonal, Zebboudj Amina F, McHugh Richard K, Hoffman Larry F, Lusis Aldons J, Davis Richard C, Friedman Rick A Genome-wide screening for genetic loci associated with noise-induced hearing loss. Mammalian genome : official journal of the International Mammalian Genome Society. 2009; 20(4): 207-13.
Bhasin Kum Kum S, van Nas Atila, Martin Lisa J, Davis Richard C, Devaskar Sherin U, Lusis Aldons J Maternal low-protein diet or hypercholesterolemia reduces circulating essential amino acids and leads to intrauterine growth restriction. Diabetes. 2009; 58(3): 559-66.
Arnold Arthur P, van Nas Atila, Lusis Aldons J Systems biology asks new questions about sex differences. Trends in endocrinology and metabolism: TEM. 2009; 20(10): 471-6.
Shih Diana M, Lusis Aldons J The roles of PON1 and PON2 in cardiovascular disease and innate immunity. Current opinion in lipidology. 2009; 20(4): 288-92.
Shaposhnik Zory, Wang Xuping, Trias Joaquim, Fraser Heather, Lusis Aldons J The synergistic inhibition of atherogenesis in apoE-/- mice between pravastatin and the sPLA2 inhibitor varespladib (A-002). Journal of lipid research. 2009; 50(4): 623-9.
Yang Xia, Deignan Joshua L, Qi Hongxiu, Zhu Jun, Qian Su, Zhong Judy, Torosyan Gevork, Majid Sana, Falkard Brie, Kleinhanz Robert R, Karlsson Jenny, Castellani Lawrence W, Mumick Sheena, Wang Kai, Xie Tao, Coon Michael, Zhang Chunsheng, Estrada-Smith Daria, Farber Charles R, Wang Susanna S, van Nas Atila, Ghazalpour Anatole, Zhang Bin, Macneil Douglas J, Lamb John R, Dipple Katrina M, Reitman Marc L, Mehrabian Margarete, Lum Pek Y, Schadt Eric E, Lusis Aldons J, Drake Thomas A Validation of candidate causal genes for obesity that affect shared metabolic pathways and networks. Nature genetics. 2009; 41(4): 415-23.
Lusis Aldons J, Pajukanta Päivi A treasure trove for lipoprotein biology. Nature genetics. 2008; 40(2): 129-30.
Oskolkova Olga V, Afonyushkin Taras, Leitner Alexander, von Schlieffen Elena, Gargalovic Peter S, Lusis Aldons J, Binder Bernd R, Bochkov Valery N ATF4-dependent transcription is a key mechanism in VEGF up-regulation by oxidized phospholipids: critical role of oxidized sn-2 residues in activation of unfolded protein response. Blood. 2008; 112(2): 330-9.
Araujo Jesus A, Barajas Berenice, Kleinman Michael, Wang Xuping, Bennett Brian J, Gong Ke Wei, Navab Mohamad, Harkema Jack, Sioutas Constantinos, Lusis Aldons J, Nel Andre E Ambient particulate pollutants in the ultrafine range promote early atherosclerosis and systemic oxidative stress. Circulation research. 2008; 102(5): 589-96.
Castellani Lawrence W, Nguyen Cara N, Charugundla Sarada, Weinstein Michael M, Doan Chau X, Blaner William S, Wongsiriroj Nuttaporn, Lusis Aldons J Apolipoprotein AII is a regulator of very low density lipoprotein metabolism and insulin resistance. The Journal of biological chemistry. 2008; 283(17): 11633-44.
Mar-Heyming Rebecca, Miyazaki Makoto, Weissglas-Volkov Daphna, Kolaitis Nicholas A, Sadaat Narimaan, Plaisier Christopher, Pajukanta Päivi, Cantor Rita M, de Bruin Tjerk W A, Ntambi James M, Lusis Aldons J Association of stearoyl-CoA desaturase 1 activity with familial combined hyperlipidemia. Arteriosclerosis, thrombosis, and vascular biology. 2008; 28(6): 1193-9.
Park Christopher C, Ahn Sangtae, Bloom Joshua S, Lin Andy, Wang Richard T, Wu Tongtong, Sekar Aswin, Khan Arshad H, Farr Christine J, Lusis Aldons J, Leahy Richard M, Lange Kenneth, Smith Desmond J Fine mapping of regulatory loci for mammalian gene expression using radiation hybrids. Nature genetics. 2008; 40(4): 421-9.
McLin Jessica Pilar, Thompson Leslie Michels, Lusis Aldons J, Davis Richard C, Steward Oswald Genes on distal chromosome 18 determine vulnerability to excitotoxic neurodegeneration following status epilepticus, but not striatal neurodegeneration induced by quinolinic acid. Neurobiology of disease. 2008; 29(3): 391-9.
Ghazalpour Anatole, Doss Sudheer, Kang Hyun, Farber Charles, Wen Ping-Zi, Brozell Alec, Castellanos Ruth, Eskin Eleazar, Smith Desmond J, Drake Thomas A, Lusis Aldons J High-resolution mapping of gene expression using association in an outbred mouse stock. PLoS genetics. 2008; 4(8): e1000149.
Farber Charles R, Lusis Aldons J Integrating global gene expression analysis and genetics. Advances in genetics. 2008; 60(2): 571-601.
Schadt Eric E, Molony Cliona, Chudin Eugene, Hao Ke, Yang Xia, Lum Pek Y, Kasarskis Andrew, Zhang Bin, Wang Susanna, Suver Christine, Zhu Jun, Millstein Joshua, Sieberts Solveig, Lamb John, GuhaThakurta Debraj, Derry Jonathan, Storey John D, Avila-Campillo Iliana, Kruger Mark J, Johnson Jason M, Rohl Carol A, van Nas Atila, Mehrabian Margarete, Drake Thomas A, Lusis Aldons J, Smith Ryan C, Guengerich F Peter, Strom Stephen C, Schuetz Erin, Rushmore Thomas H, Ulrich Roger Mapping the genetic architecture of gene expression in human liver. PLoS biology. 2008; 6(5): e107.
Lusis Aldons J, Attie Alan D, Reue Karen Metabolic syndrome: from epidemiology to systems biology. Nature reviews. Genetics. 2008; 9(11): 819-30.
Allayee Hooman, Baylin Ana, Hartiala Jaana, Wijesuriya Hemani, Mehrabian Margarete, Lusis Aldons J, Campos Hannia Nutrigenetic association of the 5-lipoxygenase gene with myocardial infarction. The American journal of clinical nutrition. 2008; 88(4): 934-40.
Bhattacharyya Tamali, Nicholls Stephen J, Topol Eric J, Zhang Renliang, Yang Xia, Schmitt David, Fu Xiaoming, Shao Mingyuan, Brennan Danielle M, Ellis Stephen G, Brennan Marie-Luise, Allayee Hooman, Lusis Aldons J, Hazen Stanley L Relationship of paraoxonase 1 (PON1) gene polymorphisms and functional activity with systemic oxidative stress and cardiovascular risk. JAMA : the journal of the American Medical Association. 2008; 299(11): 1265-76.
Chen Junqin, Hui Simon T, Couto Francesca M, Mungrue Imran N, Davis Dawn B, Attie Alan D, Lusis Aldons J, Davis Roger A, Shalev Anath Thioredoxin-interacting protein deficiency induces Akt/Bcl-xL signaling and pancreatic beta-cell mass and protects against diabetes. FASEB journal : official publication of the Federation of American Societies for Experimental Biology. 2008; 22(10): 3581-94.
Chen Junqin, Saxena Geetu, Mungrue Imran N, Lusis Aldons J, Shalev Anath Thioredoxin-interacting protein: a critical link between glucose toxicity and beta-cell apoptosis. Diabetes. 2008; 57(4): 938-44.
Aten Jason E, Fuller Tova F, Lusis Aldons J, Horvath Steve Using genetic markers to orient the edges in quantitative trait networks: the NEO software. BMC systems biology. 2008; 2(17): 34.
Chen Yanqing, Zhu Jun, Lum Pek Yee, Yang Xia, Pinto Shirly, MacNeil Douglas J, Zhang Chunsheng, Lamb John, Edwards Stephen, Sieberts Solveig K, Leonardson Amy, Castellini Lawrence W, Wang Susanna, Champy Marie-France, Zhang Bin, Emilsson Valur, Doss Sudheer, Ghazalpour Anatole, Horvath Steve, Drake Thomas A, Lusis Aldons J, Schadt Eric E Variations in DNA elucidate molecular networks that cause disease. Nature. 2008; 452(7186): 429-35.
Martin Lisa Joy, Chen Haiyan, Liao Xiaoyan, Allayee Hooman, Shih Diana Mouhan, Lee Grace Sangeun, Hovland David Norman, Robbins Wendie Anne, Carnes Kay, Hess Rex Allen, Lusis Aldons Jake, Collins Michael David FK506, a calcineurin inhibitor, prevents cadmium-induced testicular toxicity in mice. Toxicological sciences : an official journal of the Society of Toxicology. 2007; 100(2): 474-85.
Wang Susanna S, Shi Weibin, Wang Xuping, Velky Leandra, Greenlee Sarah, Wang Min T, Drake Thomas A, Lusis Aldons J Mapping, genetic isolation, and characterization of genetic loci that determine resistance to atherosclerosis in C3H mice. Arteriosclerosis, thrombosis, and vascular biology. 2007; 27(12): 2671-6.
Péterfy Miklós, Davis Richard C, Lusis Aldons J Metabolic syndrome as a modifier of atherosclerosis in murine models. Current drug targets. 2007; 8(11): 1215-20.