Mailing Address:
10945 Le Conte Avenue 2338-C2 Peter V. Ueberroth Building Los Angeles, CA 90095 UNITED STATES
Fax Number:
(310) 825-1919
Work Phone Number:
(310) 478-3711
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Dr. Labus���s research focuses on mapping the neural networks underlying stress neurobiology with specific emphasis on models of visceral and functional pain and brain-body interactions. Specifically, she is examining altered central and autonomic nervous system processes in functional pain disorders, stress neurobiology, and the statistical methodology applied to interpret the complex data yielded by psychophysiological assessments such as fMRI, PET, acoustic startle response, and heart-rate variability. Dr. Labus recently received a K08 award from the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) to delineate the neural networks involved in visceral pain and GI function using network analysis. Her research has shown activation of inhibitory cortico-limbic circuitry is associated with more effective descending pain inhibition. In collaboration with the Center for Neurobiology of Stress (formerly named the Center of Neurovisceral Sciences and Women���s Health), her research investigates sex-specific differences in the effective connectivity of emotional-arousal circuitry. Her work also involves imaging genetics and she is currently examining group differences in the neural networks associated with variants of the function polymorphism in the promoter region of the serotonin transporter gene (5-HTTLPR) and the effects of acute lowering of 5-HT levels on engagement of a central arousal network involved in central pain amplification.
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