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Bennett Novitch, M.M.Sc., Ph.D.

Email Address:
bnovitch@ucla.edu
Work Email Address:
bnovitch@ucla.edu

Laboratory Address:
Laboratory
610 Charles E Young Dr. East
Department of Neurobiology
Broad Center for Regenerative Medicine and Stem Cell Research
Los Angeles, CA 90095
UNITED STATES

Mailing Address:
Broad Center for Regenerative Medicine and Stem Cell Research
Department of Neurobiology
David Geffen School of Medicine at UCLA
610 Charles E Young Dr. East
Los Angeles, CA 90095
UNITED STATES

Office Address:
Office
Terasaki Life Sciences Building
Room 3024

UNITED STATES

Work Phone Number:
310-794-9339



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Department / Division Affiliations
Assistant Professor, Neuroscience IDP, Neurobiology
Member, ACCESS Program: Dept. of Neurobiology, Access Cell and Developmental Biology Home Area, Access Gene Regulation Home Area, Access Neuroscience Home Area, Brain Research Institute, Eli & Edythe Broad Center of Regenerative Medicine & Stem Cell Research, JCCC Cancer and Stem Cell Biology Program Area, Neuroscience IDP
Faculty, Molecular Biology IDP

Publications:

Niewiadomski Pawel, Kong Jennifer H, Ahrends Robert, Ma Yan, Humke Eric W, Khan Sohini, Teruel Mary N, Novitch Bennett G, Rohatgi Rajat Gli protein activity is controlled by multisite phosphorylation in vertebrate hedgehog signaling. Cell reports. 2014; 6(1): 168-81.
Xu Ben, Hrycaj Steven M, McIntyre Daniel C, Baker Nicholas C, Takeuchi Jun K, Jeannotte Lucie, Gaber Zachary B, Novitch Bennett G, Wellik Deneen M Hox5 interacts with Plzf to restrict Shh expression in the developing forelimb. Proceedings of the National Academy of Sciences of the United States of America. 2013; 110(48): 19438-43.
Kong Jennifer H, Butler Samantha J, Novitch Bennett G My brain told me to do it. Developmental cell. 2013; 25(5): 436-8.
Gaber Zachary B, Butler Samantha J, Novitch Bennett G PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors. PLoS biology. 2013; 11(10): e1001676.
Jacob John, Kong Jennifer, Moore Steven, Milton Christopher, Sasai Noriaki, Gonzalez-Quevedo Rosa, Terriente Javier, Imayoshi Itaru, Kageyama Ryoichiro, Kageyama Ryoichoro, Wilkinson David G, Novitch Bennett G, Briscoe James Retinoid acid specifies neuronal identity through graded expression of Ascl1. Current biology : CB. 2013; 23(5): 412-8.
Wang Yuan, Kim Edward, Wang Xiaojing, Novitch Bennett G, Yoshikawa Kazuaki, Chang Long-Sheng, Zhu Yuan ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. Cell. 2012; 150(4): 816-30.
Rousso David L, Pearson Caroline Alayne, Gaber Zachary B, Miquelajauregui Amaya, Li Shanru, Portera-Cailliau Carlos, Morrisey Edward E, Novitch Bennett G Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS. Neuron. 2012; 74(2): 314-30.
Umbach Joy A, Adams Katrina L, Gundersen Cameron B, Novitch Bennett G Functional neuromuscular junctions formed by embryonic stem cell-derived motor neurons. PloS one. 2012; 7(5): e36049.
Roy Agnes, Francius Cedric, Rousso David L, Seuntjens Eve, Debruyn Joke, Luxenhofer Georg, Huber Andrea B, Huylebroeck Danny, Novitch Bennett G, Clotman Frederic Onecut transcription factors act upstream of Isl1 to regulate spinal motoneuron diversification. Development (Cambridge, England). 2012; 139(17): 3109-19.
Kang Peng, Lee Hyun Kyoung, Glasgow Stacey M, Finley Meggie, Donti Tataka, Gaber Zachary B, Graham Brett H, Foster Aaron E, Novitch Bennett G, Gronostajski Richard M, Deneen Benjamin Sox9 and NFIA coordinate a transcriptional regulatory cascade during the initiation of gliogenesis. Neuron. 2012; 74(1): 79-94.
Gaber Zachary B, Novitch Bennett G All the embryo's a stage, and Olig2 in its time plays many parts. Neuron. 2011; 69(5): 833-5.
Huettl Rosa-Eva, Soellner Heidi, Bianchi Elisa, Novitch Bennett G, Huber Andrea B Npn-1 contributes to axon-axon interactions that differentially control sensory and motor innervation of the limb. PLoS biology. 2011; 9(2): e1001020.
Skaggs Kaia, Martin Donna M, Novitch Bennett G Regulation of spinal interneuron development by the Olig-related protein Bhlhb5 and Notch signaling. Development (Cambridge, England). 2011; 138(15): 3199-211.
Ribes Vanessa, Balaskas Nikolaos, Sasai Noriaki, Cruz Catarina, Dessaud Eric, Cayuso Jordi, Tozer Samuel, Yang Lin Lin, Novitch Ben, Marti Elisa, Briscoe James Distinct Sonic Hedgehog signaling dynamics specify floor plate and ventral neuronal progenitors in the vertebrate neural tube. Genes & development. 2010; 24(11): 1186-200.
Dessaud Eric, Ribes Vanessa, Balaskas Nikolaos, Yang Lin Lin, Pierani Alessandra, Kicheva Anna, Novitch Bennett G, Briscoe James, Sasai Noriaki Dynamic assignment and maintenance of positional identity in the ventral neural tube by the morphogen sonic hedgehog. PLoS biology. 2010; 8(6): e1000382.
Palmesino Elena, Rousso David L, Kao Tzu-Jen, Klar Avihu, Laufer Ed, Uemura Osamu, Okamoto Hitoshi, Novitch Bennett G, Kania Artur Foxp1 and lhx1 coordinate motor neuron migration with axon trajectory choice by gating Reelin signalling. PLoS biology. 2010; 8(8): e1000446.
Karumbayaram Saravanan, Novitch Bennett G, Patterson Michaela, Umbach Joy A, Richter Laura, Lindgren Anne, Conway Anne E, Clark Amander T, Goldman Steve A, Plath Kathrin, Wiedau-Pazos Martina, Kornblum Harley I, Lowry William E Directed differentiation of human-induced pluripotent stem cells generates active motor neurons. Stem cells (Dayton, Ohio). 2009; 27(4): 806-11.
Novitch Bennett G, Butler Samantha J Reducing the mystery of neuronal differentiation. Cell. 2009; 138(6): 1062-4.
Vue Tou Yia, Bluske Krista, Alishahi Amin, Yang Lin Lin, Koyano-Nakagawa Naoko, Novitch Bennett, Nakagawa Yasushi Sonic hedgehog signaling controls thalamic progenitor identity and nuclei specification in mice. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009; 29(14): 4484-97.
Rousso David L, Gaber Zachary B, Wellik Deneen, Morrisey Edward E, Novitch Bennett G Coordinated actions of the forkhead protein Foxp1 and Hox proteins in the columnar organization of spinal motor neurons. Neuron. 2008; 59(2): 226-40.
Briscoe James, Novitch Bennett G Regulatory pathways linking progenitor patterning, cell fates and neurogenesis in the ventral neural tube. Philosophical transactions of the Royal Society of London. Series B, Biological sciences. 2008; 363(1489): 57-70.
Dessaud Eric, Yang Lin Lin, Hill Katy, Cox Barny, Ulloa Fausto, Ribeiro Ana, Mynett Anita, Novitch Bennett G, Briscoe James Interpretation of the sonic hedgehog morphogen gradient by a temporal adaptation mechanism. Nature. 2007; 450(7170): 717-20.
Mukouyama Yoh-suke, Deneen Benjamin, Lukaszewicz Agn├Ęs, Novitch Bennett G, Wichterle Hynek, Jessell Thomas M, Anderson David J Olig2+ neuroepithelial motoneuron progenitors are not multipotent stem cells in vivo. Proceedings of the National Academy of Sciences of the United States of America. 2006; 103(5): 1551-6.
Marshall Christine A G, Novitch Bennett G, Goldman James E Olig2 directs astrocyte and oligodendrocyte formation in postnatal subventricular zone cells. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2005; 25(32): 7289-98.
Novitch Bennett G, Wichterle Hynek, Jessell Thomas M, Sockanathan Shanthini A requirement for retinoic acid-mediated transcriptional activation in ventral neural patterning and motor neuron specification. Neuron. 2003; 40(1): 81-95.
Qu Jian, Li Xiaofan, Novitch Bennet G, Zheng Ye, Kohn Matthew, Xie Jian-Ming, Kozinn Spencer, Bronson Roderick, Beg Amer A, Minden Audrey PAK4 kinase is essential for embryonic viability and for proper neuronal development. Molecular and cellular biology. 2003; 23(20): 7122-33.
Bylund Magdalena, Andersson Elisabeth, Novitch Bennett G, Muhr Jonas Vertebrate neurogenesis is counteracted by Sox1-3 activity. Nature neuroscience. 2003; 6(11): 1162-8.
Novitch B G, Chen A I, Jessell T M Coordinate regulation of motor neuron subtype identity and pan-neuronal properties by the bHLH repressor Olig2. Neuron. 2001; 31(5): 773-89.
Novitch B G, Spicer D B, Kim P S, Cheung W L, Lassar A B pRb is required for MEF2-dependent gene expression as well as cell-cycle arrest during skeletal muscle differentiation. Current biology : CB. 1999; 9(9): 449-59.
Sellers W R, Novitch B G, Miyake S, Heith A, Otterson G A, Kaye F J, Lassar A B, Kaelin W G Stable binding to E2F is not required for the retinoblastoma protein to activate transcription, promote differentiation, and suppress tumor cell growth. Genes & development. 1998; 12(1): 95-106.
Skapek S X, Rhee J, Kim P S, Novitch B G, Lassar A B Cyclin-mediated inhibition of muscle gene expression via a mechanism that is independent of pRB hyperphosphorylation. Molecular and cellular biology. 1996; 16(12): 7043-53.
Novitch B G, Mulligan G J, Jacks T, Lassar A B Skeletal muscle cells lacking the retinoblastoma protein display defects in muscle gene expression and accumulate in S and G2 phases of the cell cycle. The Journal of cell biology. 1996; 135(2): 441-56.
Halevy O, Novitch B G, Spicer D B, Skapek S X, Rhee J, Hannon G J, Beach D, Lassar A B Correlation of terminal cell cycle arrest of skeletal muscle with induction of p21 by MyoD. Science (New York, N.Y.). 1995; 267(5200): 1018-21.
Lassar A B, Skapek S X, Novitch B Regulatory mechanisms that coordinate skeletal muscle differentiation and cell cycle withdrawal. Current opinion in cell biology. 1994; 6(6): 788-94.