Franz Hall Room 8548
Los Angeles, CA 90095
Work Phone Number:
My research goal is to use and advance sophisticated behavioral paradigms, coupled with neuropharmacology and neurochemical monitoring techniques, to elucidate the precise neural mechanisms and systems that underlie discrete aspects of motivated learning and decision-making. Moreover, my goals extend to understanding how disorders, such as obesity and addiction, marked by maladaptive decision-making result in such aberrant motivated behavior. Towards this goal my lab uses several approaches in parallel and often in combination:
In vivo electrochemistry
Fast-scan cyclic voltammetry for real time online monitoring of dopamine;
Biosensors for near-real time neurotransmitter measurement (i.e. glutamate);
Wassum Kate M, Ostlund Sean B, Balleine Bernard W, Maidment Nigel T Differential dependence of Pavlovian incentive motivation and
instrumental incentive learning processes on dopamine signaling..
Learning & memory (Cold Spring Harbor, N.Y.)
Wassum KM, Cely IC, Ostlund SB, Maidment NT, Balleine BW. Disruption of endogenous opioid activity during instrumental learning enhances habit acquisition.
Wassum KM, Ostlund SB, Maidment NT, Balleine BW. Distinct opioid circuits determine the palatability and the desirability of rewarding events.
Proc Natl Acad Sci USA
Wassum Kate M, Tolosa Vanessa M, Wang Jianjun, Walker Eric, Monbouquette Harold G, Maidment Nigel T Silicon Wafer-Based Platinum Microelectrode Array Biosensor for Near
Real-Time Measurement of Glutamate in Vivo..
Sensors (Basel, Switzerland)
Wightman R Mark, Heien Michael L A V, Wassum Kate M, Sombers Leslie A, Aragona Brandon J, Khan Amina S, Ariansen Jennifer L, Cheer Joseph F, Phillips Paul E M, Carelli Regina M Dopamine release is heterogeneous within microenvironments of the rat
The European journal of neuroscience
Cheer Joseph F, Wassum Kate M, Wightman R Mark Cannabinoid modulation of electrically evoked pH and oxygen transients
in the nucleus accumbens of awake rats..
Journal of neurochemistry