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Peyman Golshani, M.D.

Email Address:
pgolshani@yahoo.com
Work Email Address:
pgolshani@mednet.ucla.edu

Mailing Address:
UCLA neuro
BOX 951769, 10833 Le Conte Ave, LA CA
Los Angeles, CA 90095
UNITED STATES

Work Phone Number:
(310) 794-1195



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Department / Division Affiliations
Assistant Professor, Neurology, Brain Research Institute
Assistant Professor In-Residence, Neuroscience IDP

Research Interest:

Focus on discovering the role of different GABAergic neuronal types in the cerebral cortex and hippocampus during perception and learning in awake behaving mice

My laboratory is focused on discovering the role of different GABAergic neuronal types in the cerebral cortex and hippocampus during perception and learning in awake behaving mice. We use in-vivo two photon calcium imaging, and in-vivo whole-cell patch clamp recordings from identified interneurons and excitatory neurons in mice as they perform a perceptual learning task. We are also interested in understanding how distinct GABAergic interneuron networks malfunction in models of autism and developmental epilepsy. We are currently performing recordings in the neuroligin-3, PTEN and CNTNAP2 mutant mice, to understand how altered excitability or connectivity in cortical networks leads to abnormal network oscillations and ultimately abnormal behavior.

Publications:

Golshani Peyman, Gonçalves J Tiago, Khoshkhoo Sattar, Mostany Ricardo, Smirnakis Stelios, Portera-Cailliau Carlos Internally mediated developmental desynchronization of neocortical network activity. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009; 29(35): 10890-9.
Golshani Peyman, Hutnick Leah, Schweizer Felix, Fan Guoping Conditional Dnmt1 deletion in dorsal forebrain disrupts development of somatosensory barrel cortex and thalamocortical long-term potentiation. Thalamus & related systems. 2005; 3(3): 227-233.
Golshani P, Liu X B, Jones E G Differences in quantal amplitude reflect GluR4- subunit number at corticothalamic synapses on two populations of thalamic neurons. Proceedings of the National Academy of Sciences of the United States of America. 2001; 98(7): 4172-7.