Work Address:
200 Stein Plaza Los Angeles, CA 90095 UNITED STATES
Fax Number:
310 206-7826
Work Phone Number:
310 794-5400
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Professor,
Neuroscience IDP,
Ophthalmology,
Human Genetics
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Member,
ACCESS Program: Dept. of Human Genetics,
Brain Research Institute,
CTSI,
Jules Stein Eye Institute,
Regulatory Knowledge and Support, Industry Relations, and Research Ethics
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Faculty,
ACCESS Program
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The major emphasis of our laboratory studies since coming to UCLA has been focused on light associated allodynia (LAA), a condition in which pain arises from exposure to normal levels of light. This problem is especially relevant for translational clinical studies since avoidance of light exposure can seriously compromise one?s ability to function and quality of life. The pain can be a minor annoyance for some or so severe as to be totally disabling, forcing individuals to spend their days in near complete darkness. Sustained LAA is seen in a number of neurodegenerative conditions of the eye, including age-related macular degeneration and dystrophies predominantly involving cone photoreceptors. Certain medications, migraines and rarely, central brain lesions, can also be major causes of LAA. Dr. Anna Matynia and I are undertaking the first behavioral and molecular studies of the neural pathway and biological basis of LAA by characterizing mouse genetic and pharmacologic models of LAA in order to ultimately find new treatments that will not interfere with an individual?s ability to see. We seek to improve the quality of life for those individuals suffering from LAA, whether or not they are experiencing vision loss from their underlying eye disease.
My ongoing research areas include the molecular genetics of hereditary eye disorders, particularly age-related macular degeneration (AMD), retinitis pigmentosa and Stargardt disease. I also investigate monogenic disorders such as hereditary retinal degenerations, glaucoma, cataracts and ocular syndromes. Other basic research areas include genetic modifiers of disease and ocular toxicities of systemic medications. Applied research interests include bioinformatics in clinical ophthalmic practice and research, new diagnostic technologies for retinal disorders, diabetic retinopathy.
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Michael B. Gorin, MD, PhD, is the currently the first recipient of the Harold and Pauline Price Chair in Ophthalmology and Professor of Ophthalmology in the Retina and Vision Science Divisions in the Department of Ophthalmology at the David Geffen School of Medicine ? UCLA and Jules Stein Eye Institute. He also holds an appointment in the Vision Research Division at the Jules Stein Eye Institute.
Dr. Gorin obtained his medical and doctor of philosophy degrees from the University of Pennsylvania at Philadelphia and completed his internship at the Center for Health Sciences at the University of California at Los Angeles (UCLA). He stayed on at UCLA for postdoctoral research fellowship and ophthalmology residency training at the Jules Stein Eye Institute, and then finished a clinical fellowship in Medical Retina and Genetics at Moorfields Eye Hospital in London, England.
Dr. Gorin returned to UCLA from the University of Pittsburgh, where he served as Assistant Vice Chancellor for Strategic Initiatives for the six graduate health sciences schools. He joined the Pittsburgh campus in 1990, rising to the rank of Professor in the Department of Ophthalmology in the School of Medicine and the Department of Human Genetics in the Graduate School of Public Health and serving as interim chair for both departments. He was founding director of the Center for Human Genetics and a founding senior associate of the Center for Biomedical Informatics at the University. Throughout his 16 years in Pittsburgh, he has provided clinical care on a regular basis in medical retina particularly in the fields of hereditary disorders, retinal diagnostics, drug-related ocular toxicity, and ophthalmic genetics. During 2005-2007, he was named one of the top physicians in the United States by Castle Connolly Medical Ltd.
As a full-time faculty member at the Jules Stein Eye Institute, Dr. Gorin divides his time between patient care for diseases of the retina, research into the genetics of inherited eye disorders and training young ophthalmologists and medical students.
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Thiels, E. Hoffman, E. K. Gorin, M. B. A reliable behavioral assay for the assessment of sustained photophobia in mice.
Curr Eye Res.
2008; 33(5):
483-91.
Jakobsdottir, J. Conley, Y. P. Weeks, D. E. Ferrell, R. E. Gorin, M. B. C2 and CFB genes in age-related maculopathy and joint action with CFH and LOC387715 genes.
PLoS ONE.
2008; 3(5):
e2199.
Gorin, M. B. A clinician's view of the molecular genetics of age-related maculopathy.
Arch Ophthalmol.
2007; 125(1):
21-9.
Ghajarnia, M. Gorin, M. B. Acetazolamide in the treatment of X-linked retinoschisis maculopathy.
Arch Ophthalmol.
2007; 125(4):
571-3.
Tikellis, G. Sun, C. Gorin, M. B. Klein, R. Klein, B. E. Larsen, E. K. Siscovick, D. S. Hubbard, L. D. Wong, T. Y. Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study.
Arch Ophthalmol.
2007; 125(1):
68-73.
Young, T. A. Burgess, B. L. Rao, N. P. Gorin, M. B. Straatsma, B. R. High-density genome array is superior to fluorescence in-situ hybridization analysis of monosomy 3 in choroidal melanoma fine needle aspiration biopsy.
Mol Vis.
2007; 13(number):
2328-33.
Thomas, G. Grassi, M. A. Lee, J. R. Edwards, A. O. Gorin, M. B. Klein, R. Casavant, T. L. Scheetz, T. E. Stone, E. M. Williams, A. B. IDOCS: intelligent distributed ontology consensus system--the use of machine learning in retinal drusen phenotyping.
Invest Ophthalmol Vis Sci.
2007; 48(5):
2278-84.
Yellore, V. S. Khan, M. A. Bourla, N. Rayner, S. A. Chen, M. C. Sonmez, B. Momi, R. S. Sampat, K. M. Gorin, M. B. Aldave, A. J. Identification of mutations in UBIAD1 following exclusion of coding mutations in the chromosome 1p36 locus for Schnyder crystalline corneal dystrophy.
Mol Vis.
2007; 13(number):
1777-82.
Finn, D. A. Beadles-Bohling, A. S. Beckley, E. H. Ford, M. M. Gililland, K. R. Gorin-Meyer, R. E. Wiren, K. M. A new look at the 5alpha-reductase inhibitor finasteride.
CNS Drug Rev.
2006; 12(1):
53-76.
Demirci, F. Y. Rigatti, B. W. Mah, T. S. Gorin, M. B. A novel RPGR exon ORF15 mutation in a family with X-linked retinitis pigmentosa and Coats'-like exudative vasculopathy.
Am J Ophthalmol.
2006; 141(1):
208-10.
Demirci, F. Y. Chang, M. H. Mah, T. S. Romero, M. F. Gorin, M. B. Proximal renal tubular acidosis and ocular pathology: a novel missense mutation in the gene (SLC4A4) for sodium bicarbonate cotransporter protein (NBCe1).
Mol Vis.
2006; 12(number):
324-30.
Gorin, M. B. A new vision for age-related macular degeneration.
Eur J Hum Genet.
2005; 13(7):
793-4.
Demirci, F. Y. Gupta, N. Radak, A. L. Rigatti, B. W. Mah, T. S. Milam, A. H. Gorin, M. B. Histopathologic study of X-linked cone-rod dystrophy (CORDX1) caused by a mutation in the RPGR exon ORF15.
Am J Ophthalmol.
2005; 139(2):
386-8.
Gorin, M. B. Costantino, J. P. Kulacoglu, D. N. Demirci, F. Y. Wickerham, D. L. Fisher, B. Wolmark, N. Is tamoxifen a risk factor for retinal vaso-occlusive disease?.
Retina.
2005; 25(4):
523-6.
Jakobsdottir, J. Conley, Y. P. Weeks, D. E. Mah, T. S. Ferrell, R. E. Gorin, M. B. Susceptibility genes for age-related maculopathy on chromosome 10q26.
Am J Hum Genet.
2005; 77(3):
389-407.
Gorin, M. B. The coming of age for age-related macular degeneration genetics.
Ophthalmic Genet.
2005; 26(2):
57-9.
Demirci, F. Y. Rigatti, B. W. Mah, T. S. Gorin, M. B. A novel compound heterozygous mutation in the cellular retinaldehyde-binding protein gene (RLBP1) in a patient with retinitis punctata albescens.
Am J Ophthalmol.
2004; 138(1):
171-3.
Demirci, F. Y. Radak, A. L. Rigatti, B. W. Mah, T. S. Gorin, M. B. A presumed missense mutation of RPGR causes abnormal RNA splicing with exon skipping.
Am J Ophthalmol.
2004; 138(3):
504-5.
Weeks, D. E. Conley, Y. P. Tsai, H. J. Mah, T. S. Schmidt, S. Postel, E. A. Agarwal, A. Haines, J. L. Pericak-Vance, M. A. Rosenfeld, P. J. Paul, T. O. Eller, A. W. Morse, L. S. Dailey, J. P. Ferrell, R. E. Gorin, M. B. Age-related maculopathy: a genomewide scan with continued evidence of susceptibility loci within the 1q31, 10q26, and 17q25 regions.
Am J Hum Genet.
2004; 75(2):
174-89.
Jalkanen, R. Demirci, F. Y. Tyynismaa, H. Bech-Hansen, T. Meindl, A. Peippo, M. Mantyjarvi, M. Gorin, M. B. Alitalo, T. A new genetic locus for X linked progressive cone-rod dystrophy.
J Med Genet.
2003; 40(6):
418-23.
Telmer, C. A. Retchless, A. C. Kinsey, A. D. Conley, Y. Rigatti, B. Gorin, M. B. Jarvik, J. W. Detection and assignment of mutations and minihaplotypes in human DNA using peptide mass signature genotyping (PMSG): application to the human RDS/peripherin gene.
Genome Res.
2003; 13(8):
1944-51.
Demirci, F. Y. Ramser, J. White, N. J. Rigatti, B. W. Meindl, A. Lewis, K. F. Wen, G. Gorin, M. B. Refinement of the physical location and the genomic characterization of the CRSP2 (EXLM1) gene on Xp11.4.
DNA Seq.
2003; 14(2):
123-7.
Conley, Y. P. Gorin, M. B. The genetics of age-related macular degeneration.
Medsurg Nurs.
2003; 12(4):
238-41, 259.
Schmidt, S. Klaver, C. Saunders, A. Postel, E. De La Paz, M. Agarwal, A. Small, K. Udar, N. Ong, J. Chalukya, M. Nesburn, A. Kenney, C. Domurath, R. Hogan, M. Mah, T. Conley, Y. Ferrell, R. Weeks, D. de Jong, P. T. van Duijn, C. Haines, J. Pericak-Vance, M. Gorin, M. A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy.
Ophthalmic Genet.
2002; 23(4):
209-23.
Weeks, D. E. Conley, Y. P. Ferrell, R. E. Mah, T. S. Gorin, M. B. A tale of two genotypes: consistency between two high-throughput genotyping centers.
Genome Res.
2002; 12(3):
430-5.
Gordon, Y. J. Mann, R. K. Mah, T. S. Gorin, M. B. Fluorescein-potentiated argon laser therapy improves symptoms and appearance of corneal neovascularization.
Cornea.
2002; 21(8):
770-3.
Demirci, F. Y. Rigatti, B. W. Wen, G. Radak, A. L. Mah, T. S. Baic, C. L. Traboulsi, E. I. Alitalo, T. Ramser, J. Gorin, M. B. X-linked cone-rod dystrophy (locus COD1): identification of mutations in RPGR exon ORF15.
Am J Hum Genet.
2002; 70(4):
1049-53.
Ayyagari, R. Demirci, F. Y. Liu, J. Bingham, E. L. Stringham, H. Kakuk, L. E. Boehnke, M. Gorin, M. B. Richards, J. E. Sieving, P. A. X-linked recessive atrophic macular degeneration from RPGR mutation.
Genomics.
2002; 80(2):
166-71.
Weeks, D. E. Conley, Y. P. Tsai, H. J. Mah, T. S. Rosenfeld, P. J. Paul, T. O. Eller, A. W. Morse, L. S. Dailey, J. P. Ferrell, R. E. Gorin, M. B. Age-related maculopathy: an expanded genome-wide scan with evidence of susceptibility loci within the 1q31 and 17q25 regions.
Am J Ophthalmol.
2001; 132(5):
682-92.
Milam, A. H. De Castro, E. B. Smith, J. E. Tang, W. X. John, S. K. Gorin, M. B. Stone, E. M. Aguirre, G. D. Jacobson, S. G. Concentric retinitis pigmentosa: clinicopathologic correlations.
Exp Eye Res.
2001; 73(4):
493-508.
Gorin, M. B. The ABCA4 gene and age-related macular degeneration: innocence or guilt by association.
Arch Ophthalmol.
2001; 119(5):
752-3.
Conley, Y. P. Erturk, D. Keverline, A. Mah, T. S. Keravala, A. Barnes, L. R. Bruchis, A. Hess, J. F. FitzGerald, P. G. Weeks, D. E. Ferrell, R. E. Gorin, M. B. A juvenile-onset, progressive cataract locus on chromosome 3q21-q22 is associated with a missense mutation in the beaded filament structural protein-2.
Am J Hum Genet.
2000; 66(4):
1426-31.
Kniazeva, M. Traboulsi, E. I. Yu, Z. Stefko, S. T. Gorin, M. B. Shugart, Y. Y. O'Connell, J. R. Blaschak, C. J. Cutting, G. Han, M. Zhang, K. A new locus for dominant drusen and macular degeneration maps to chromosome 6q14.
Am J Ophthalmol.
2000; 130(2):
197-202.
Brown, J., Jr. Kimura, A. E. Gorin, M. B. Clinical and electroretinographic findings of female carriers and affected males in a progressive X-linked cone-rod dystrophy (COD-1) pedigree.
Ophthalmology.
2000; 107(6):
1104-10.
Stefko, S. T. Zhang, K. Gorin, M. B. Traboulsi, E. I. Clinical spectrum of chromosome 6-linked autosomal dominant drusen and macular degeneration.
Am J Ophthalmol.
2000; 130(2):
203-8.
Hardcastle, A. J. Thiselton, D. L. Zito, I. Ebenezer, N. Mah, T. S. Gorin, M. B. Bhattacharya, S. S. Evidence for a new locus for X-linked retinitis pigmentosa (RP23).
Invest Ophthalmol Vis Sci.
2000; 41(8):
2080-6.
Pieke-Dahl, S. Moller, C. G. Kelley, P. M. Astuto, L. M. Cremers, C. W. Gorin, M. B. Kimberling, W. J. Genetic heterogeneity of Usher syndrome type II: localisation to chromosome 5q.
J Med Genet.
2000; 37(4):
256-62.
Astuto, L. M. Weston, M. D. Carney, C. A. Hoover, D. M. Cremers, C. W. Wagenaar, M. Moller, C. Smith, R. J. Pieke-Dahl, S. Greenberg, J. Ramesar, R. Jacobson, S. G. Ayuso, C. Heckenlively, J. R. Tamayo, M. Gorin, M. B. Reardon, W. Kimberling, W. J. Genetic heterogeneity of Usher syndrome: analysis of 151 families with Usher type I.
Am J Hum Genet.
2000; 67(6):
1569-74.
Zito, I. Gorin, M. B. Plant, C. Bird, A. C. Bhattacharya, S. S. Hardcastle, A. J. Novel mutations of the RPGR gene in RP3 families.
Hum Mutat.
2000; 15(4):
386.
Zito, I. Thiselton, D. L. Gorin, M. B. Stout, J. T. Plant, C. Bird, A. C. Bhattacharya, S. S. Hardcastle, A. J. Identification of novel RPGR (retinitis pigmentosa GTPase regulator) mutations in a subset of X-linked retinitis pigmentosa families segregating with the RP3 locus.
Hum Genet.
1999; 105(1-2):
57-62.
Feng, L. Seymour, A. B. Jiang, S. To, A. Peden, A. A. Novak, E. K. Zhen, L. Rusiniak, M. E. Eicher, E. M. Robinson, M. S. Gorin, M. B. Swank, R. T. The beta3A subunit gene (Ap3b1) of the AP-3 adaptor complex is altered in the mouse hypopigmentation mutant pearl, a model for Hermansky-Pudlak syndrome and night blindness.
Hum Mol Genet.
1999; 8(2):
323-30.
Keverline, M. R. Mah, T. S. Keverline, P. O. Gorin, M. B. A practice-based survey of familial age-related maculopathy.
Ophthalmic Genet.
1998; 19(1):
19-26.
Seymour, A. B. Dash-Modi, A. O'Connell, J. R. Shaffer-Gordon, M. Mah, T. S. Stefko, S. T. Nagaraja, R. Brown, J. Kimura, A. E. Ferrell, R. E. Gorin, M. B. Linkage analysis of X-linked cone-rod dystrophy: localization to Xp11.4 and definition of a locus distinct from RP2 and RP3.
Am J Hum Genet.
1998; 62(1):
122-9.
Gorin, M. B. Day, R. Costantino, J. P. Fisher, B. Redmond, C. K. Wickerham, L. Gomolin, J. E. Margolese, R. G. Mathen, M. K. Bowman, D. M. Kaufman, D. I. Dimitrov, N. V. Singerman, L. J. Bornstein, R. Wolmark, N. Long-term tamoxifen citrate use and potential ocular toxicity.
Am J Ophthalmol.
1998; 125(4):
493-501.
Andersen, J. S. Pralea, A. M. DelBono, E. A. Haines, J. L. Gorin, M. B. Schuman, J. S. Mattox, C. G. Wiggs, J. L. A gene responsible for the pigment dispersion syndrome maps to chromosome 7q35-q36.
Arch Ophthalmol.
1997; 115(3):
384-8.
Seymour, A. B. Yanak, B. L. O'Brien, E. P. Rusiniak, M. E. Novak, E. K. Pinto, L. H. Swank, R. T. Gorin, M. B. An integrated genetic map of the pearl locus of mouse chromosome 13.
Genome Res.
1996; 6(6):
538-44.
Weston, M. D. Kelley, P. M. Overbeck, L. D. Wagenaar, M. Orten, D. J. Hasson, T. Chen, Z. Y. Corey, D. Mooseker, M. Sumegi, J. Cremers, C. Moller, C. Jacobson, S. G. Gorin, M. B. Kimberling, W. J. Myosin VIIA mutation screening in 189 Usher syndrome type 1 patients.
Am J Hum Genet.
1996; 59(5):
1074-83.
Xu, H. P. Yanak, B. L. Wigler, M. H. Gorin, M. B. New polymorphic markers in the vicinity of the pearl locus on mouse chromosome 13.
Mamm Genome.
1996; 7(1):
16-9.
Ip, M. Gorin, M. B. Recurrence of a choroidal neovascular membrane in a patient with punctate inner choroidopathy treated with daily doses of thalidomide.
Am J Ophthalmol.
1996; 122(4):
594-5.
Nayfield, S. G. Gorin, M. B. Tamoxifen-associated eye disease. A review.
J Clin Oncol.
1996; 14(3):
1018-26.
Gorin, M. B. Jackson, K. E. Ferrell, R. E. Sheffield, V. C. Jacobson, S. G. Gass, J. D. Mitchell, E. Stone, E. M. A peripherin/retinal degeneration slow mutation (Pro-210-Arg) associated with macular and peripheral retinal degeneration.
Ophthalmology.
1995; 102(2):
246-55.
Day, R. Gorin, M. B. Eller, A. W. Prevalence of lens changes in Ukrainian children residing around Chernobyl.
Health Phys.
1995; 68(5):
632-42.
Parker, L. S. Gorin, M. B. Preventive ethics in the management of ophthalmic genetic disorders.
Semin Ophthalmol.
1995; 10(4):
331-43.
Gorin, M. B. The interplay of genetics and surgery in ophthalmic care.
Semin Ophthalmol.
1995; 10(4):
303-17.
Gorin, M. B. Paul, T. O. Rader, D. J. Angioid streaks associated with abetalipoproteinemia.
Ophthalmic Genet.
1994; 15(3-4):
151-9.
Hong, H. K. Ferrell, R. E. Gorin, M. B. Clinical diversity and chromosomal localization of X-linked cone dystrophy (COD1).
Am J Hum Genet.
1994; 55(6):
1173-81.
Brown, D. L. Gorin, M. B. Weeks, D. E. Efficient strategies for genomic searching using the affected-pedigree-member method of linkage analysis.
Am J Hum Genet.
1994; 54(3):
544-52.
Donahue, S. P. Wenger, S. L. Steele, M. W. Gorin, M. B. Broad-spectrum Mobius syndrome associated with a 1;11 chromosome translocation.
Ophthalmic Paediatr Genet.
1993; 14(1):
17-21.
Pieke Dahl, S. Kimberling, W. J. Gorin, M. B. Weston, M. D. Furman, J. M. Pikus, A. Moller, C. Genetic heterogeneity of Usher syndrome type II.
J Med Genet.
1993; 30(10):
843-8.
Rikke, B. A. Pinto, L. H. Gorin, M. B. Hardies, S. C. Mus spretus-specific LINE-1 DNA probes applied to the cloning of the murine pearl locus.
Genomics.
1993; 15(2):
291-6.
Gorin, M. B. Snyder, S. To, A. Narfstrom, K. Curtis, R. The cat RDS transcript: candidate gene analysis and phylogenetic sequence analysis.
Mamm Genome.
1993; 4(9):
544-8.
Filling-Katz, M. R. Fink, J. K. Gorin, M. B. Caruso, R. Carl, J. B. Fitzgibbon, E. J. Barton, N. W. Katz, N. N. Ophthalmologic manifestations of type B Niemann-Pick diseases.
Metab Pediatr Syst Ophthalmol.
1992; 15(1-3):
16-20.
Gorin, M. B. Von Hippel-Lindau disease: clinical considerations and the use of fluorescein-potentiated argon laser therapy for treatment of retinal angiomas.
Semin Ophthalmol.
1992; 7(3):
182-91.
Filling-Katz, M. R. Choyke, P. L. Oldfield, E. Charnas, L. Patronas, N. J. Glenn, G. M. Gorin, M. B. Morgan, J. K. Linehan, W. M. Seizinger, B. R. et al., Central nervous system involvement in Von Hippel-Lindau disease.
Neurology.
1991; 41(1):
41-6.
Glenn, G. M. Daniel, L. N. Choyke, P. Linehan, W. M. Oldfield, E. Gorin, M. B. Hosoe, S. Latif, F. Weiss, G. Walther, M. et al., Von Hippel-Lindau (VHL) disease: distinct phenotypes suggest more than one mutant allele at the VHL locus.
Hum Genet.
1991; 87(2):
207-10.
Hosoe, S. Brauch, H. Latif, F. Glenn, G. Daniel, L. Bale, S. Choyke, P. Gorin, M. Oldfield, E. Berman, A. et al., Localization of the von Hippel-Lindau disease gene to a small region of chromosome 3.
Genomics.
1990; 8(4):
634-40.
Choyke, P. L. Filling-Katz, M. R. Shawker, T. H. Gorin, M. B. Travis, W. D. Chang, R. Seizinger, B. R. Dwyer, A. J. Linehan, W. M. von Hippel-Lindau disease: radiologic screening for visceral manifestations.
Radiology.
1990; 174(3 Pt 1):
815-20.
Gibbons, I. Gorin, M. Yassinzadeh, Z. Peterson, P. Besemer, D. Dillon, K. Burd, T. Hillman, R. Smoluk, G. Cobb, M. Patient-side immunoassay system with a single-use cartridge for measuring analytes in blood.
Clin Chem.
1989; 35(9):
1869-73.
Filling-Katz, M. R. Choyke, P. L. Patronas, N. J. Gorin, M. B. Barba, D. Chang, R. Doppman, J. L. Seizinger, B. Oldfield, E. H. Radiologic screening for von Hippel-Lindau disease: the role of Gd-DTPA enhanced MR imaging of the CNS.
J Comput Assist Tomogr.
1989; 13(5):
743-55.
Barrett, D. J. Sparkes, R. S. Gorin, M. B. Bhat, S. P. Spence, M. A. Marazita, M. L. Bateman, J. B. Genetic linkage analysis of autosomal dominant congenital cataracts with lens-specific DNA probes and polymorphic phenotypic markers.
Ophthalmology.
1988; 95(4):
538-44.
Hogg, D. Gorin, M. B. Heinzmann, C. Zollman, S. Mohandas, T. Klisak, I. Sparkes, R. S. Breitman, M. Tsui, L. C. Horwitz, J. Nucleotide sequence for the cDNA of the bovine beta B2 crystallin and assignment of the orthologous human locus to chromosome 22.
Curr Eye Res.
1987; 6(11):
1335-42.
Sparkes, R. S. Mohandas, T. Heinzmann, C. Gorin, M. B. Zollman, S. Horwitz, J. Assignment of a human beta-crystallin gene to 17cen-q23.
Hum Genet.
1986; 74(2):
133-6.
Sparkes, R. S. Mohandas, T. Heinzmann, C. Gorin, M. B. Horwitz, J. Law, M. L. Jones, C. A. Bateman, J. B. The gene for the major intrinsic protein (MIP) of the ocular lens is assigned to human chromosome 12cen-q14.
Invest Ophthalmol Vis Sci.
1986; 27(9):
1351-4.
Gorin, M. B. Horwitz, J. Cloning and characterization of a cow beta crystallin cDNA.
Curr Eye Res.
1984; 3(7):
939-48.
Gorin, M. B. Yancey, S. B. Cline, J. Revel, J. P. Horwitz, J. The major intrinsic protein (MIP) of the bovine lens fiber membrane: characterization and structure based on cDNA cloning.
Cell.
1984; 39(1):
49-59.
Gorin, M. B. Tilghman, S. M. Structure of the alpha-fetoprotein gene in the mouse.
Proc Natl Acad Sci U S A.
1980; 77(3):
1351-5.
Hansch, C. Nakamoto, K. Gorin, M. Denisevich, P. Garret, E. R. Heman-Ackah, S. M. Won, C. H. Structure-activity relationship of chloramphenicols.
J Med Chem.
1973; 16(8):
917-22.
Choi Daniel Y, Ortube Maria Carolina, McCannel Colin A, Sarraf David, Hubschman Jean-Pierre, McCannel Tara A, Gorin Michael B Sustained elevated intraocular pressures after intravitreal injection
of bevacizumab, ranibizumab, and pegaptanib..
Retina (Philadelphia, Pa.).
2011; 31(6):
1028-35.
Aldave Anthony J, Rosenwasser George O D, Yellore Vivek S, Papp Jeanette C, Sobel Eric M, Pham Michele N, Chen Michael C, Dandekar Sugandha, Sripracha Ram, Rayner Sylvia A, Sassani Joseph W, Gorin Michael B Linkage of posterior amorphous corneal dystrophy to chromosome
12q21.33 and exclusion of coding region mutations in KERA, LUM, DCN,
and EPYC..
Investigative ophthalmology & visual science.
2010; 51(8):
4006-12.
Tosha Chinatsu, Gorin Michael B, Nusinowitz Steven Test-retest reliability and inter-ocular symmetry of multi-focal
electroretinography in Stargardt disease..
Current eye research.
2010; 35(1):
63-72.
Aldave Anthony J, Yellore Vivek S, Vo Rosalind C, Kamal Khairidzan M, Rayner Sylvia A, Plaisier Christopher L, Chen Michael C, Damani Mausam R, Pham Michele N, Gorin Michael B, Sobel Eric, Papp Jeanette Exclusion of positional candidate gene coding region mutations in the
common posterior polymorphous corneal dystrophy 1 candidate gene
interval..
Cornea.
2009; 28(7):
801-7.
Jakobsdottir Johanna, Gorin Michael B, Conley Yvette P, Ferrell Robert E, Weeks Daniel E Interpretation of genetic association studies: markers with replicated
highly significant odds ratios may be poor classifiers..
PLoS genetics.
2009; 5(2):
e1000337.
Thiels Edda, Hoffman Eric K, Gorin Michael B A reliable behavioral assay for the assessment of sustained
photophobia in mice..
Current eye research.
2008; 33(5):
483-91.
Jakobsdottir Johanna, Conley Yvette P, Weeks Daniel E, Ferrell Robert E, Gorin Michael B C2 and CFB genes in age-related maculopathy and joint action with CFH
and LOC387715 genes..
PloS one.
2008; 3(5):
e2199.
Yellore Vivek S, Khan M Ali, Bourla Nirit, Rayner Sylvia A, Chen Michael C, Sonmez Baris, Momi Rominder S, Sampat Kapil M, Gorin Michael B, Aldave Anthony J Identification of mutations in UBIAD1 following exclusion of coding
mutations in the chromosome 1p36 locus for Schnyder crystalline
corneal dystrophy..
Molecular vision.
2007; 13(5):
1777-82.
Gorin Michael B A clinician's view of the molecular genetics of age-related
maculopathy..
Archives of ophthalmology.
2007; 125(1):
21-9.
Young Tara A, Burgess Barry L, Rao Nagesh P, Gorin Michael B, Straatsma Bradley R High-density genome array is superior to fluorescence in-situ
hybridization analysis of monosomy 3 in choroidal melanoma fine needle
aspiration biopsy..
Molecular vision.
2007; 13(1):
2328-33.
Conley Yvette P, Jakobsdottir Johanna, Mah Tammy, Weeks Daniel E, Klein Ronald, Kuller Lewis, Ferrell Robert E, Gorin Michael B CFH, ELOVL4, PLEKHA1 and LOC387715 genes and susceptibility to
age-related maculopathy: AREDS and CHS cohorts and meta-analyses..
Human molecular genetics.
2006; 15(21):
3206-18.
Demirci F Yesim K, Chang Min-Hwang, Mah Tammy S, Romero Michael F, Gorin Michael B Proximal renal tubular acidosis and ocular pathology: a novel missense
mutation in the gene (SLC4A4) for sodium bicarbonate cotransporter
protein (NBCe1)..
Molecular vision.
2006; 12(21):
324-30.
Jakobsdottir Johanna, Conley Yvette P, Weeks Daniel E, Mah Tammy S, Ferrell Robert E, Gorin Michael B Susceptibility genes for age-related maculopathy on chromosome 10q26..
American journal of human genetics.
2005; 77(3):
389-407.
Conley Yvette P, Thalamuthu Anbupalam, Jakobsdottir Johanna, Weeks Daniel E, Mah Tammy, Ferrell Robert E, Gorin Michael B Candidate gene analysis suggests a role for fatty acid biosynthesis
and regulation of the complement system in the etiology of age-related
maculopathy..
Human molecular genetics.
2005; 14(14):
1991-2002.
Demirci F Yesim K, Gupta Nisha, Radak Amy L, Rigatti Brian W, Mah Tammy S, Milam Ann H, Gorin Michael B Histopathologic study of X-linked cone-rod dystrophy (CORDX1) caused
by a mutation in the RPGR exon ORF15..
American journal of ophthalmology.
2005; 139(2):
386-8.
Weeks Daniel E, Conley Yvette P, Tsai Hui-Ju, Mah Tammy S, Schmidt Silke, Postel Eric A, Agarwal Anita, Haines Jonathan L, Pericak-Vance Margaret A, Rosenfeld Philip J, Paul T Otis, Eller Andrew W, Morse Lawrence S, Dailey J P, Ferrell Robert E, Gorin Michael B Age-related maculopathy: a genomewide scan with continued evidence of
susceptibility loci within the 1q31, 10q26, and 17q25 regions..
American journal of human genetics.
2004; 75(2):
174-89.
Demirci F Yesim K, Rigatti Brian W, Wen Gaiping, Radak Amy L, Mah Tammy S, Baic Corrine L, Traboulsi Elias I, Alitalo Tiina, Ramser Juliane, Gorin Michael B X-linked cone-rod dystrophy (locus COD1): identification of mutations
in RPGR exon ORF15..
American journal of human genetics.
2002; 70(4):
1049-53.
Demirci, F. Y. White, N. J. Rigatti, B. W. Lewis, K. F. Gorin, M. B. Identification, genomic structure, and screening of the vacuolar proton-ATPase membrane sector-associated protein M8-9 gene within the COD1 critical region (Xp11.4).
Mol Vis.
2001; 7(number):
234-9.
Feng, L. Rigatti, B. W. Novak, E. K. Gorin, M. B. Swank, R. T. Genomic structure of the mouse Ap3b1 gene in normal and pearl mice.
Genomics.
2000; 69(3):
370-9.
Weeks, D. E. Conley, Y. P. Mah, T. S. Paul, T. O. Morse, L. Ngo-Chang, J. Dailey, J. P. Ferrell, R. E. Gorin, M. B. A full genome scan for age-related maculopathy.
Hum Mol Genet.
2000; 9(9):
1329-49.
Gorin, M. B. Breitner, J. C. De Jong, P. T. Hageman, G. S. Klaver, C. C. Kuehn, M. H. Seddon, J. M. The genetics of age-related macular degeneration.
Mol Vis.
1999; 5(number):
29.
Zhen, L. Jiang, S. Feng, L. Bright, N. A. Peden, A. A. Seymour, A. B. Novak, E. K. Elliott, R. Gorin, M. B. Robinson, M. S. Swank, R. T. Abnormal expression and subcellular distribution of subunit proteins of the AP-3 adaptor complex lead to platelet storage pool deficiency in the pearl mouse.
Blood.
1999; 94(1):
146-55.
Nwokoro, N. A. Korytkowski, M. T. Rose, S. Gorin, M. B. Penles Stadler, M. Witchel, S. F. Mulvihill, J. J. Spectrum of malignancy and premalignancy in Carney syndrome.
Am J Med Genet.
1997; 73(4):
369-77.
Gorin, M. B. To, A. C. Narfstrom, K. Sequence analysis and exclusion of phosducin as the gene for the recessive retinal degeneration of the Abyssinian cat.
Biochim Biophys Acta.
1995; 1260(3):
323-7.
Sigman, D. S. Chen, C. H. Gorin, M. B. Sequence-specific scission of DNA by RNAs linked to a chemical nuclease.
Nature.
1993; 363(6428):
474-5.
Chen, C. B. Gorin, M. B. Sigman, D. S. Sequence-specific scission of DNA by the chemical nuclease activity of 1,10-phenanthroline-copper(I) targeted by RNA.
Proc Natl Acad Sci U S A.
1993; 90(9):
4206-10.
Glenn, G. M. Linehan, W. M. Hosoe, S. Latif, F. Yao, M. Choyke, P. Gorin, M. B. Chew, E. Olfield, E. Manolatos, C. et al., Screening for von Hippel-Lindau disease by DNA polymorphism analysis.
JAMA.
1992; 267(9):
1226-31.
Arden, G. B. Gorin, M. B. Polkinghorne, P. J. Jay, M. Bird, A. C. Detection of the carrier state of X-linked retinoschisis.
Am J Ophthalmol.
1988; 105(6):
590-5.
Hogg, D. Tsui, L. C. Gorin, M. Breitman, M. L. Characterization of the human beta-crystallin gene Hu beta A3/A1 reveals ancestral relationships among the beta gamma-crystallin superfamily.
J Biol Chem.
1986; 261(26):
12420-7.
Gorin, M. B. Cooper, D. L. Eiferman, F. van de Rijn, P. Tilghman, S. M. The evolution of alpha-fetoprotein and albumin. I. A comparison of the primary amino acid sequences of mammalian alpha-fetoprotein and albumin.
J Biol Chem.
1981; 256(4):
1954-9.
Kioussis, D. Eiferman, F. van de Rijn, P. Gorin, M. B. Ingram, R. S. Tilghman, S. M. The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse.
J Biol Chem.
1981; 256(4):
1960-7.
Tilghman, S. M. Kioussis, D. Gorin, M. B. Ruiz, J. P. Ingram, R. S. The presence of intervening sequences in the alpha-fetoprotein gene of the mouse.
J Biol Chem.
1979; 254(15):
7393-9.
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