Lab Number:
310-794-5625
|
|
|
How does the activity of a neuronal ensemble encode the association of a sensory cue with a rewarding stimulus? This phenomenon is critical to our survival and relevant to understanding various neuropsychiatric disorders such as addiction. We are interested in understanding associative reward learning mechanisms at the level of large networks of interacting neurons in the basal ganglia and limbic system. But accessing network-level dynamic phenomena requires substantial innovations in the ability to simultaneously monitor electrophysiological activity across large populations of neurons, with high spatiotemporal resolution. The capabilities of existing recording techniques fall short of this objective. We are addressing this challenge with advances in nanotechnology, by deploying minimally invasive instrumentation for large-scale neuronal recordings from deep brain structures.
|
Du J, Blanche TJ, Harrison RR, Lester HA, Masmanidis SC Multiplexed, high density electrophysiology with nanofabricated neural probes..
PloS one.
2011; 6(10):
e26204.
Sadek AS, Karabalin RB, Du J, Roukes ML, Koch C, Masmanidis SC Wiring nanoscale biosensors with piezoelectric nanomechanical resonators..
Nano letters.
2010; 10(5):
1769-73.
Du J, Riedel-Kruse IH, Nawroth JC, Roukes ML, Laurent G, Masmanidis SC High-resolution three-dimensional extracellular recording of neuronal activity with microfabricated electrode arrays..
Journal of neurophysiology.
2009; 101(3):
1671-8.
Masmanidis SC, Karabalin RB, De Vlaminck I, Borghs G, Freeman MR, Roukes ML Multifunctional nanomechanical systems via tunably coupled piezoelectric actuation..
Science.
2007; 317(5839):
780-3.
|
|
|
