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Brent Fogel, M.D., Ph.D.

Email Address:
bfogel@ucla.edu

Work Address:
695 Charles E. Young Drive South, Gonda Room 1206
Los Angeles, CA 90095
UNITED STATES

Work Phone Number:
310-825-6816



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Department / Division Affiliations
Assistant Professor, Neurology
Member, ACCESS Program, Access Gene Regulation Home Area, Access Genetics and Genomics Home Area, Access Neuroscience Home Area
Assistant Professor In-Residence, Brain Research Institute, Neuroscience IDP

Research Interest:

Exploring the Molecular Basis of Neurodevelopmental and Neurodegenerative Disease

My research seeks to understand the basic and fundamental molecular mechanisms underlying human neurodevelopment and neurodegenerative disease. We are currently examining how specific genes and genetic pathways influence the development of two classes of neurogenetic disease: 1) autism spectrum disorder and 2) cerebellar ataxia. Our goal is to better understand the molecular etiologies behind these diseases to improve diagnosis and develop new strategies for better clinical treatments for patients and their families.

Publications:

Fogel Brent L, Vickrey Barbara G, Walton-Wetzel Jenny, Lieber Eli, Browner Carole H Utilization of Genetic Testing Prior to Subspecialist Referral for Cerebellar Ataxia. Genetic testing and molecular biomarkers. 2013; .
Giorgio Elisa, Rolyan Harshvardhan, Kropp Laura, Chakka Anish Baswanth, Yatsenko Svetlana, Gregorio Eleonora Di, Lacerenza Daniela, Vaula Giovanna, Talarico Flavia, Mandich Paola, Toro Camilo, Pierre Eleonore Eymard, Labauge Pierre, Capellari Sabina, Cortelli Pietro, Vairo Filippo Pinto, Miguel Diego, Stubbolo Danielle, Marques Lourenco Charles, Gahl William, Boespflug-Tanguy Odile, Melberg Atle, Hassin-Baer Sharon, Cohen Oren S, Pjontek Rastislav, Grau Armin, Klopstock Thomas, Fogel Brent, Meijer Inge, Rouleau Guy, Bouchard Jean-Pierre L, Ganapathiraju Madhavi, Vanderver Adeline, Dahl Niklas, Hobson Grace, Brusco Alfredo, Brussino Alessandro, Padiath Quasar Saleem Analysis of LMNB1 Duplications in Autosomal Dominant Leukodystrophy Provides Insights into Duplication Mechanisms and Allele-Specific Expression. Human mutation. 2013; .
Hsu Sandy Chan, Sears Renee L, Lemos Roberta R, Quintáns Beatriz, Huang Alden, Spiteri Elizabeth, Nevarez Lisette, Mamah Catherine, Zatz Mayana, Pierce Kerrie D, Fullerton Janice M, Adair John C, Berner Jon E, Bower Matthew, Brodaty Henry, Carmona Olga, Dobrici? Valerija, Fogel Brent L, García-Estevez Daniel, Goldman Jill, Goudreau John L, Hopfer Suellen, Jankovi? Milena, Jaumà Serge, Jen Joanna C, Kirdlarp Suppachok, Klepper Joerg, Kosti? Vladimir, Lang Anthony E, Linglart Agnès, Maisenbacher Melissa K, Manyam Bala V, Mazzoni Pietro, Miedzybrodzka Zofia, Mitarnun Witoon, Mitchell Philip B, Mueller Jennifer, Novakovi? Ivana, Paucar Martin, Paulson Henry, Simpson Sheila A, Svenningsson Per, Tuite Paul, Vitek Jerrold, Wetchaphanphesat Suppachok, Williams Charles, Yang Michele, Schofield Peter R, de Oliveira João R M, Sobrido María-Jesús, Geschwind Daniel H, Coppola Giovanni Mutations in SLC20A2 are a major cause of familial idiopathic basal ganglia calcification. Neurogenetics. 2013; 14(1): 11-22.
Fogel Brent L, Baker Cameron, Curnow Andrew, Perlman Susan L, Geschwind Daniel H, Coppola Giovanni Mutations in PDYN are not responsible for multiple system atrophy. Journal of neurology. 2013; 14(1): .
Fogel Brent L, Pribadi Mochtar, Pi Sarah, Perlman Susan L, Geschwind Daniel H, Coppola Giovanni C9ORF72 expansion is not a significant cause of sporadic spinocerebellar ataxia. Movement disorders : official journal of the Movement Disorder Society. 2012; .
Mochel Fanny, Schiffmann Raphael, Steenweg Marjan E, Akman Hasan O, Wallace Mary, Sedel Frédéric, Laforêt Pascal, Levy Richard, Powers J Michael, Demeret Sophie, Maisonobe Thierry, Froissart Roseline, Da Nobrega Bruno Barcelos, Fogel Brent L, Natowicz Marvin R, Lubetzki Catherine, Durr Alexandra, Brice Alexis, Rosenmann Hanna, Barash Varda, Kakhlon Or, Gomori J Moshe, van der Knaap Marjo S, Lossos Alexander Adult polyglucosan body disease: Natural History and Key Magnetic Resonance Imaging Findings. Annals of neurology. 2012; 72(3): 433-41.
Cho Ellen, Fogel Brent L A Family with Spinocerebellar Ataxia Type 5 Found to Have a Novel Missense Mutation within a SPTBN2 Spectrin Repeat. Cerebellum (London, England). 2012; 72(3): .
Fogel Brent L Childhood Cerebellar Ataxia. Journal of child neurology. 2012; .
Fogel Brent L, Wexler Eric, Wahnich Amanda, Friedrich Tara, Vijayendran Chandran, Gao Fuying, Parikshak Neelroop, Konopka Genevieve, Geschwind Daniel H RBFOX1 Regulates Both Splicing and Transcriptional Networks in Human Neuronal Development. Human molecular genetics. 2012; .
Fogel Brent L, Lee Ji Yong, Lane Jessica, Wahnich Amanda, Chan Sandy, Huang Alden, Osborn Greg E, Klein Eric, Mamah Catherine, Perlman Susan, Geschwind Daniel H, Coppola Giovanni Mutations in rare ataxia genes are uncommon causes of sporadic cerebellar ataxia. Movement disorders : official journal of the Movement Disorder Society. 2012; 27(3): 442-6.
Wexler Eric, Fogel Brent L New-onset psychosis in a patient with spinocerebellar ataxia type 10. The American journal of psychiatry. 2011; 168(12): 1339-40.
Becker Esther B E, Fogel Brent L, Rajakulendran Sanjeev, Dulneva Anna, Hanna Michael G, Perlman Susan L, Geschwind Daniel H, Davies Kay E Candidate screening of the TRPC3 gene in cerebellar ataxia. Cerebellum (London, England). 2011; 10(2): 296-9.
Fogel Brent L Interpretation of genetic testing: variants of unknown significance. Continuum (Minneapolis, Minn.). 2011; 17(2 Neurogenetics): 347-52.
Fogel Brent L, Lee Ji Yong, Perlman Susan Aberrant splicing of the senataxin gene in a patient with ataxia with oculomotor apraxia type 2. Cerebellum (London, England). 2009; 8(4): 448-53.
Fogel Brent L, Young Pari, Thompson Arthur R, Perlman Susan A family with combined mutations of the hemophilia A and X-linked adrenoleukodystrophy genes. Neurogenetics. 2008; 9(3): 215-8.
Fogel Brent L, Perlman Susan Clinical features and molecular genetics of autosomal recessive cerebellar ataxias. Lancet neurology. 2007; 6(3): 245-57.
Fogel Brent L, Perlman Susan Novel mutations in the senataxin DNA/RNA helicase domain in ataxia with oculomotor apraxia 2. Neurology. 2006; 67(11): 2083-4.
Fogel Brent L, Perlman Susan An approach to the patient with late-onset cerebellar ataxia. Nature clinical practice. Neurology. 2006; 2(11): 629-35; quiz 1 p following 635.
Fogel Brent, Cardenas Doris, Ovbiagele Bruce Magnetic resonance imaging abnormalities in the corpus callosum of a patient with neuropsychiatric lupus. The neurologist. 2006; 12(5): 271-3.
Fogel Brent, Wu Mark, Kremen Sarah, Murthy Kolar, Jackson George, Vanek Zeba Creutzfeldt-Jakob disease presenting with alien limb sign. Movement disorders : official journal of the Movement Disorder Society. 2006; 21(7): 1040-2.
Fogel Brent L, McNally Lisa M, McNally Mark T Efficient polyadenylation of Rous sarcoma virus RNA requires the negative regulator of splicing element. Nucleic acids research. 2002; 30(3): 810-7.
Fogel B L, McNally M T A cellular protein, hnRNP H, binds to the negative regulator of splicing element from Rous sarcoma virus. The Journal of biological chemistry. 2000; 275(41): 32371-8.
Fogel B L, McNally M T Trace contamination following reuse of anion-exchange DNA purification resins. BioTechniques. 2000; 28(2): 299-302.