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Seema Tiwari-Woodruff, Ph.D.

Email Address:

Laboratory Address:
635 Charles E Young Drive
Los Angeles, CA 91411

Work Phone Number:
310 206 6777
310 267 4778

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Department / Division Affiliations
Assistant Professor, Neurology
Member, Brain Research Institute


Seema K Tiwari-Woodruff is a neurobiologist who has served on the UCLA School of Medicine faculty since she joined the Department of Neurology in 2006. Dr. Tiwari-Woodruff earned her M.S. in Chemistry and Biochemistry and Ph.D. in Physiology at the Southern Illinois University, Carbondale. She was a postdoctoral fellow at the UCLA School of Medicine. Her laboratory research is focused on understanding the molecular events involved in neurodegeneration and neuroprotection in demyelinating central nervous system. In addition, her lab is testing various compounds as therapeutic agents in mouse models of multiple sclerosis. Other projects include the role of gender specific hormones and sex chromosomes on oligodendrocyte function during developmental myelination and during remyelination. Her lab uses a combination of transgenic mice and two different mouse models of demyelination. Techniques employed in her lab include various behavioral tests, electrophysiology, immunohistochemistry, quantitative morphometry, protein an gene analysis.


Khalaj Anna J, Yoon Jaehee, Nakai Jaspreet, Winchester Zachary, Moore Spencer M, Yoo Timothy, Martinez-Torres Leonardo, Kumar Shalini, Itoh Noriko, Tiwari-Woodruff Seema Kaushalya Estrogen receptor (ER) B expression in oligodendrocytes is required for attenuation of clinical disease by an ERβ ligand. Proceedings of the National Academy of Sciences of the United States of America. 2013; .
Kumar Shalini, Patel Rhusheet, Moore Spencer, Crawford Daniel K, Suwanna Nirut, Mangiardi Mario, Tiwari-Woodruff Seema K Estrogen receptor B ligand therapy activates PI3K/Akt/mTOR signaling in oligodendrocytes and promotes remyelination in a mouse model of multiple sclerosis. Neurobiology of disease. 2013; .
Moore S, Patel R, Hannsun G, Yang J, Tiwari-Woodruff S K Sex chromosome complement influences functional callosal myelination. Neuroscience. 2013; .
Patel Rhusheet, Moore Spencer, Crawford Daniel K, Hannsun Gemmy, Sasidhar Manda V, Tan Kevin, Molaie Donna, Tiwari-Woodruff Seema K Attenuation of Corpus Callosum Axon Myelination and Remyelination in the Absence of Circulating Sex Hormones. Brain pathology (Zurich, Switzerland). 2013; .
Bankston Andrew N, Li Wenqi, Zhang Hui, Ku Li, Liu Guanglu, Papa Filomena, Zhao Lixia, Bibb James A, Cambi Franca, Tiwari-Woodruff Seema K, Feng Yue P39, the Primary Activator for Cyclin-dependent Kinase 5 (Cdk5) in Oligodendroglia, Is Essential for Oligodendroglia Differentiation and Myelin Repair. The Journal of biological chemistry. 2013; .
Mangiardi Mario, Crawford Daniel K, Xia Xiaoyu, Du Sienmi, Simon-Freeman Rebecca, Voskuhl Rhonda R, Tiwari-Woodruff Seema K An Animal Model of Cortical and Callosal Pathology in Multiple Sclerosis. Brain pathology (Zurich, Switzerland). 2011; 21(3): .
Ziehn Marina O, Avedisian Andrea A, Tiwari-Woodruff Seema, Voskuhl Rhonda R Hippocampal CA1 atrophy and synaptic loss during experimental autoimmune encephalomyelitis, EAE. Laboratory investigation; a journal of technical methods and pathology. 2010; 90(5): 774-86.
Crawford Daniel K, Mangiardi Mario, Song Bingbing, Patel Rhusheet, Du Sienmi, Sofroniew Michael V, Voskuhl Rhonda R, Tiwari-Woodruff Seema K Oestrogen receptor beta ligand: a novel treatment to enhance endogenous functional remyelination. Brain : a journal of neurology. 2010; 133(10): 2999-3016.
Gold Stefan M, Sasidhar Manda V, Morales Laurie B, Du Sienmi, Sicotte Nancy L, Tiwari-Woodruff Seema K, Voskuhl Rhonda R Estrogen treatment decreases matrix metalloproteinase (MMP)-9 in autoimmune demyelinating disease through estrogen receptor alpha (ERalpha). Laboratory investigation; a journal of technical methods and pathology. 2009; 89(10): 1076-83.
Crawford, Mangiardi, Xia, López-Valdés, Tiwari-Woodruff Functional recovery of callosal axons following demyelination: a critical window. Neuroscience. 2009; .
MacKenzie-Graham Allan, Tiwari-Woodruff Seema K, Sharma Gaurav, Aguilar Cynthia, Vo Kieumai T, Strickland Lauren V, Morales Laurie, Fubara Boma, Martin Melanie, Jacobs Russell E, Johnson G Allan, Toga Arthur W, Voskuhl Rhonda R Purkinje cell loss in experimental autoimmune encephalomyelitis. NeuroImage. 2009; 48(4): 637-51.
Crawford Daniel K, Mangiardi Mario, Tiwari-Woodruff Seema K Assaying the functional effects of demyelination and remyelination: revisiting field potential recordings. Journal of neuroscience methods. 2009; 182(1): 25-33.
Voskuhl Rhonda R, Peterson R Scott, Song Bingbing, Ao Yan, Morales Laurie Beth J, Tiwari-Woodruff Seema, Sofroniew Michael V Reactive astrocytes form scar-like perivascular barriers to leukocytes during adaptive immune inflammation of the CNS. The Journal of neuroscience : the official journal of the Society for Neuroscience. 2009; 29(37): 11511-22.
Tiwari-Woodruff Seema K, Voskuhl Seema K Neuroprotective and anti-inflammatory effects of estrogen receptor ligand treatment in mice. Journal of the neurological sciences. 2009; 182(1): .
Smith-Bouvier Deborah L, Divekar Anagha A, Sasidhar Manda, Du Sienmi, Tiwari-Woodruff Seema K, King Jennifer K, Arnold Arthur P, Singh Ram Raj, Voskuhl Rhonda R A role for sex chromosome complement in the female bias in autoimmune disease. The Journal of experimental medicine. 2008; 205(5): 1099-108.
Tiwari-Woodruff, S. Morales, L. B. Lee, R. Voskuhl, R. R. Differential neuroprotective and antiinflammatory effects of estrogen receptor (ER)alpha and ERbeta ligand treatment. Proc Natl Acad Sci U S A. 2007; 104(37): 14813-8.
Tiwari-Woodruff, S. Beltran-Parrazal, L. Charles, A. Keck, T. Vu, T. Bronstein, J. K+ channel KV3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development. Am J Physiol Cell Physiol. 2006; 291(4): C687-98.
Morales, L. B. Loo, K. K. Liu, H. B. Peterson, C. Tiwari-Woodruff, S. Voskuhl, R. R. Treatment with an estrogen receptor alpha ligand is neuroprotective in experimental autoimmune encephalomyelitis. J Neurosci. 2006; 26(25): 6823-33.
Tiwari-Woodruff, S. K. Beltran-Parrazal, L. Charles, A. Keck, T. Vu, T. Bronstein, J. K+ channel Kv3.1 associates with OSP/claudin-11 and regulates oligodendrocyte development. Am J Physiol Cell Physiol. 2006; .
Tiwari-Woodruff, S. K. Myers, L. W. Bronstein, J. M. Cerebrospinal fluid immunoglobulin G promotes oligodendrocyte progenitor cell migration. J Neurosci Res. 2004; 77(3): 363-6.
Tiwari-Woodruff, S. K. Kaplan, R. Kornblum, H. I. Bronstein, J. M. Developmental expression of OAP-1/Tspan-3, a member of the tetraspanin superfamily. J Neurosci Res. 2004; 77(2): 166-73.
Papazian, D. M. Silverman, W. R. Lin, M. C. Tiwari-Woodruff, S. K. Tang, C. Y. Structural organization of the voltage sensor in voltage-dependent potassium channels. Novartis Found Symp. 2002; 245: 178-90; discussion 190-2, 261-4.
Tiwari-Woodruff, S. K. Buznikov, A. G. Vu, T. Q. Micevych, P. E. Chen, K. Kornblum, H. I. Bronstein, J. M. OSP/claudin-11 forms a complex with a novel member of the tetraspanin super family and beta1 integrin and regulates proliferation and migration of oligodendrocytes. J Cell Biol. 2001; 153(2): 295-305.
Tiwari-Woodruff, S. K. Lin, M. A. Schulteis, C. T. Papazian, D. M. Voltage-dependent structural interactions in the Shaker K(+) channel. J Gen Physiol. 2000; 115(2): 123-38.
Bronstein, J. M. Chen, K. Tiwari-Woodruff, S. Kornblum, H. I. Developmental expression of OSP/claudin-11. J Neurosci Res. 2000; 60(3): 284-90.
Bronstein, J. M. Tiwari-Woodruff, S. Buznikov, A. G. Stevens, D. B. Involvement of OSP/claudin-11 in oligodendrocyte membrane interactions: role in biology and disease. J Neurosci Res. 2000; 59(6): 706-11.
Tiwari-Woodruff, S. K. Schulteis, C. T. Mock, A. F. Papazian, D. M. Electrostatic interactions between transmembrane segments mediate folding of Shaker K+ channel subunits. Biophys J. 1997; 72(4): 1489-500.
Tiwari-Woodruff, S. K. Cox, T. C. Boar sperm plasma membrane Ca(2+)-selective channels in planar lipid bilayers. Am J Physiol. 1995; 268(5 Pt 1): C1284-94.
Moore Spencer, Khalaj Anna J, Yoon Jaehee, Patel Rhusheet, Hannsun Gemmy, Yoo Timothy, Sasidhar Manda, Martinez-Torres Leonardo, Hayardeny Liat, Tiwari-Woodruff Seema K Therapeutic laquinimod treatment decreases inflammation, initiates axon remyelination, and improves motor deficit in a mouse model of multiple sclerosis. Brain and behavior. 2013; 3(6): 664-82.