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Robert Prins, Ph.D.

Work Email Address:
rprins@mednet.ucla.edu

Laboratory Address:
Brain Tumor Immunology Lab
Factor 13-560

UNITED STATES

Mailing Address:
UCLA Pharmacology
10833 Le Conte Avenue
CHS 74-145
Box 956901
Los Angeles, CA 90095
UNITED STATES

Fax Number:
310-206-2093
Work Phone Number:
310-794-5663
310-825-4207



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Department / Division Affiliations
Associate Professor, Department of Medicine, Neurosurgery

Research Interest:

Study of T lymphocyte-mediated immune surveillance for malignant brain tumors

Primary interest interested in the study of T lymphocyte-mediated immune surveillance for malignant brain tumors. My early studies focused on distinct immune defects that occur during experimental brain tumor progression. More recently, I have begun to apply my basic immunology experience towards developing new immunotherapeutic treatments for malignant gliomas. As such, our group focuses on trying to manipulate the immune system to target tumors arising within the brain, and then translate our findings to the treatment of patients with the same diseases.

Bio:

Robert M. Prins is a tumor immunologist with joint faculty appointments in the Departments of Neurosurgery and Molecular and Medical Pharmacology. Dr. Prins earned his B.S. in Kinesiology and his M.S. in Physiological Science from the University of California, Los Angeles. He earned his Ph.D. in Anatomy and Immunology from the Medical College of Virginia. He completed post-doctoral fellowships at the Cedars-Sinai Neurosurgical Institute and the UCLA Division of Neurosurgery before joining the faculty at UCLA in 2006. Dr. Prins is a member of the Jonsson Comprehensive Cancer Center, the Brain Research Institute, and the Institute of Molecular Medicine. Dr. Prins is currently the Director of the Brain Tumor Immunology Research Lab and Clinical Trials for dendritic cell immunotherapy. His research centers on understanding the immunology of malignant brain tumors and devising new immune-based therapies to treat these deadly tumors.

Publications:

Williams Kevin J, Argus Joseph P, Zhu Yue, Wilks Moses Q, Marbois Beth N, York Autumn G, Kidani Yoko, Pourzia Alexandra L, Akhavan David, Lisiero Dominique N, Komisopoulou Evangelia, Henkin Amy H, Soto Horacio, Chamberlain Brian T, Vergnes Laurent, Jung Michael E, Torres Jorge Z, Liau Linda M, Christofk Heather R, Prins Robert M, Mischel Paul S, Reue Karen, Graeber Thomas G, Bensinger Steven J An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity. Cancer research. 2013; 73(9): 2850-2862.
Lasky Joseph L, Panosyan Eduard H, Plant Ashley, Davidson Tom, Yong William H, Prins Robert M, Liau Linda M, Moore Theodore B Autologous Tumor Lysate-pulsed Dendritic Cell Immunotherapy for Pediatric Patients with Newly Diagnosed or Recurrent High-grade Gliomas. Anticancer research. 2013; 33(5): 2047-56.
Prins Robert M, Wang Xiaoyan, Soto Horacio, Young Emma, Lisiero Dominique N, Fong Brendan, Everson Richard, Yong William H, Lai Albert, Li Gang, Cloughesy Timothy F, Liau Linda M Comparison of glioma-associated antigen peptide-loaded versus autologous tumor lysate-loaded dendritic cell vaccination in malignant glioma patients. Journal of immunotherapy (Hagerstown, Md. : 1997). 2013; 36(2): 152-7.
Lazovic Jelena, Soto Horacio, Piccioni David, Lou Jerry R, Li Sichen, Mirsadraei Leili, Yong William, Prins Robert, Liau Linda M, Ellingson Benjamin M, Cloughesy Timothy F, Lai Albert, Pope Whitney B Detection of 2-hydroxyglutaric acid in vivo by proton magnetic resonance spectroscopy in U87 glioma cells overexpressing isocitrate dehydrogenase-1 mutation. Neuro-oncology. 2012; 14(12): 1465-72.
Yang Jian, Nagasawa Daniel T, Spasic Marko, Amolis Misha, Choy Winward, Garcia Heather M, Prins Robert M, Liau Linda M, Yang Isaac Endogenous vaults and bioengineered vault nanoparticles for treatment of glioblastomas: implications for future targeted therapies. Neurosurgery clinics of North America. 2012; 23(3): 451-8.
Chou Arthur P, Chowdhury Reshmi, Li Sichen, Chen Weidong, Kim Andrew J, Piccioni David E, Selfridge Julia M, Mody Reema R, Chang Stephen, Lalezari Shadi, Lin Jeffrey, Sanchez Desiree E, Wilson Ryan W, Garrett Matthew C, Harry Bret, Mottahedeh Jack, Nghiemphu Phioanh L, Kornblum Harley I, Mischel Paul S, Prins Robert M, Yong William H, Cloughesy Timothy, Nelson Stanley F, Liau Linda M, Lai Albert Identification of retinol binding protein 1 promoter hypermethylation in isocitrate dehydrogenase 1 and 2 mutant gliomas. Journal of the National Cancer Institute. 2012; 104(19): 1458-69.
Hickey Michelle J, Malone Colin C, Erickson Kate E, Gomez German G, Young Emma L, Liau Linda M, Prins Robert M, Kruse Carol A Implementing preclinical study findings to protocol design: translational studies with alloreactive CTL for gliomas. American journal of translational research. 2012; 4(1): 114-26.
Fong Brendan, Jin Richard, Wang Xiaoyan, Safaee Michael, Lisiero Dominique N, Yang Isaac, Li Gang, Liau Linda M, Prins Robert M Monitoring of regulatory T cell frequencies and expression of CTLA-4 on T cells, before and after DC vaccination, can predict survival in GBM patients. PloS one. 2012; 7(4): e32614.
Pope Whitney B, Prins Robert M, Albert Thomas M, Nagarajan Rajakumar, Yen Katharine E, Bittinger Mark A, Salamon Noriko, Chou Arthur P, Yong William H, Soto Horacio, Wilson Neil, Driggers Edward, Jang Hyun G, Su Shinsan M, Schenkein David P, Lai Albert, Cloughesy Timothy F, Kornblum Harley I, Wu Hong, Fantin Valeria R, Liau Linda M Non-invasive detection of 2-hydroxyglutarate and other metabolites in IDH1 mutant glioma patients using magnetic resonance spectroscopy. Journal of neuro-oncology. 2012; 107(1): 197-205.
Guo Deliang, Reinitz Felicia, Youssef Mary, Hong Cynthia, Nathanson David, Akhavan David, Kuga Daisuke, Amzajerdi Ali Nael, Soto Horacio, Zhu Shaojun, Babic Ivan, Tanaka Kazuhiro, Dang Julie, Iwanami Akio, Gini Beatrice, Dejesus Jason, Lisiero Dominique D, Huang Tiffany T, Prins Robert M, Wen Patrick Y, Robins H Ian, Prados Michael D, Deangelis Lisa M, Mellinghoff Ingo K, Mehta Minesh P, James C David, Chakravarti Arnab, Cloughesy Timothy F, Tontonoz Peter, Mischel Paul S An LXR agonist promotes glioblastoma cell death through inhibition of an EGFR/AKT/SREBP-1/LDLR-dependent pathway. Cancer discovery. 2011; 1(5): 442-56.
Konkankit Veerauo V, Kim Won, Koya Richard C, Eskin Ascia, Dam Mai-Anh, Nelson Stanley, Ribas Antoni, Liau Linda M, Prins Robert M Decitabine immunosensitizes human gliomas to NY-ESO-1 specific T lymphocyte targeting through the Fas/Fas ligand pathway. Journal of translational medicine. 2011; 9(4): 192.
Lisiero Dominique N, Soto Horacio, Liau Linda M, Prins Robert M Enhanced sensitivity to IL-2 signaling regulates the clinical responsiveness of IL-12-primed CD8(+) T cells in a melanoma model. Journal of immunology (Baltimore, Md. : 1950). 2011; 186(9): 5068-77.
Prins Robert M, Soto Horacio, Konkankit Vera, Odesa Sylvia K, Eskin Ascia, Yong William H, Nelson Stanley F, Liau Linda M Gene expression profile correlates with T-cell infiltration and relative survival in glioblastoma patients vaccinated with dendritic cell immunotherapy. Clinical cancer research : an official journal of the American Association for Cancer Research. 2011; 17(6): 1603-15.
Dang Lenny, White David W, Gross Stefan, Bennett Bryson D, Bittinger Mark A, Driggers Edward M, Fantin Valeria R, Jang Hyun Gyung, Jin Shengfang, Keenan Marie C, Marks Kevin M, Prins Robert M, Ward Patrick S, Yen Katharine E, Liau Linda M, Rabinowitz Joshua D, Cantley Lewis C, Thompson Craig B, Vander Heiden Matthew G, Su Shinsan M Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2010; 465(7300): 966.
Hickey Michelle J, Malone Colin C, Erickson Kate L, Jadus Martin R, Prins Robert M, Liau Linda M, Kruse Carol A Cellular and vaccine therapeutic approaches for gliomas. Journal of translational medicine. 2010; 8(2): 100.
Dang Lenny, White David W, Gross Stefan, Bennett Bryson D, Bittinger Mark A, Driggers Edward M, Fantin Valeria R, Jang Hyun Gyung, Jin Shengfang, Keenan Marie C, Marks Kevin M, Prins Robert M, Ward Patrick S, Yen Katharine E, Liau Linda M, Rabinowitz Joshua D, Cantley Lewis C, Thompson Craig B, Vander Heiden Matthew G, Su Shinsan M Cancer-associated IDH1 mutations produce 2-hydroxyglutarate. Nature. 2009; 462(7274): 739-44.
Guo Deliang, Prins Robert M, Dang Julie, Kuga Daisuke, Iwanami Akio, Soto Horacio, Lin Kelly Y, Huang Tiffany T, Akhavan David, Hock M Benjamin, Zhu Shaojun, Kofman Ava A, Bensinger Steve J, Yong William H, Vinters Harry V, Horvath Steve, Watson Andrew D, Kuhn John G, Robins H Ian, Mehta Minesh P, Wen Patrick Y, DeAngelis Lisa M, Prados Michael D, Mellinghoff Ingo K, Cloughesy Timothy F, Mischel Paul S EGFR signaling through an Akt-SREBP-1-dependent, rapamycin-resistant pathway sensitizes glioblastomas to antilipogenic therapy. Science signaling. 2009; 2(101): ra82.
Vo Dan D, Prins Robert M, Begley Jonathan L, Donahue Timothy R, Morris Lilah F, Bruhn Kevin W, de la Rocha Pilar, Yang Meng-Yin, Mok Stephen, Garban Hermes J, Craft Noah, Economou James S, Marincola Francesco M, Wang Ena, Ribas Antoni Enhanced antitumor activity induced by adoptive T-cell transfer and adjunctive use of the histone deacetylase inhibitor LAQ824. Cancer research. 2009; 69(22): 8693-9.
Begley Jonathan, Vo Dan D, Morris Lilah F, Bruhn Kevin W, Prins Robert M, Mok Stephen, Koya Richard C, Garban Hermes J, Comin-Anduix Begonya, Craft Noah, Ribas Antoni Immunosensitization with a Bcl-2 small molecule inhibitor. Cancer immunology, immunotherapy : CII. 2009; 58(5): 699-708.
Shu Chengyi J, Radu Caius G, Shelly Stephanie M, Vo Dan D, Prins Robert, Ribas Antoni, Phelps Michael E, Witte Owen N Quantitative PET reporter gene imaging of CD8+ T cells specific for a melanoma-expressed self-antigen. International immunology. 2009; 21(2): 155-65.
Guo Deliang, Hildebrandt Isabel J, Prins Robert M, Soto Horacio, Mazzotta Mary M, Dang Julie, Czernin Johannes, Shyy John Y-J, Watson Andrew D, Phelps Michael, Radu Caius G, Cloughesy Timothy F, Mischel Paul S The AMPK agonist AICAR inhibits the growth of EGFRvIII-expressing glioblastomas by inhibiting lipogenesis. Proceedings of the National Academy of Sciences of the United States of America. 2009; 106(31): 12932-7.
Prins Robert M, Shu Chengyi J, Radu Caius G, Vo Dan D, Khan-Farooqi Haumith, Soto Horacio, Yang Meng-Yin, Lin Muh-Shi, Shelly Stephanie, Witte Owen N, Ribas Antoni, Liau Linda M Anti-tumor activity and trafficking of self, tumor-specific T cells against tumors located in the brain. Cancer immunology, immunotherapy : CII. 2008; 57(9): 1279-89.
Prins Robert M, Cloughesy Timothy F, Liau Linda M Cytomegalovirus immunity after vaccination with autologous glioblastoma lysate. The New England journal of medicine. 2008; 359(5): 539-41.
Kimura Takahiro, Koya Richard C, Anselmi Laura, Sternini Catia, Wang He-Jing, Comin-Anduix Begonya, Prins Robert M, Faure-Kumar Emmanuelle, Rozengurt Nora, Cui Yan, Kasahara Noriyuki, Stripecke Renata Lentiviral vectors with CMV or MHCII promoters administered in vivo: immune reactivity versus persistence of expression. Molecular therapy : the journal of the American Society of Gene Therapy. 2007; 15(7): 1390-9.
Prins Robert M, Bruhn Kevin W, Craft Noah, Lin Jia Wei, Kim Choong-Hyun, Odesa Sylvia K, Miller Jeff F, Liau Linda M Central nervous system tumor immunity generated by a recombinant listeria monocytogenes vaccine targeting tyrosinase related protein-2 and real-time imaging of intracranial tumor burden. Neurosurgery. 2006; 58(1): 169-78; discussion 169-78.
Yang Meng-Yin, Zetler Paul M, Prins Robert M, Khan-Farooqi Haumith, Liau Linda M Immunotherapy for patients with malignant glioma: from theoretical principles to clinical applications. Expert review of neurotherapeutics. 2006; 6(10): 1481-94.
Prins Robert M, Vo Dan D, Khan-Farooqi Haumith, Yang Meng-Yin, Soto Horacio, Economou James S, Liau Linda M, Ribas Antoni NK and CD4 cells collaborate to protect against melanoma tumor formation in the brain. Journal of immunology (Baltimore, Md. : 1950). 2006; 177(12): 8448-55.
Prins Robert M, Craft Noah, Bruhn Kevin W, Khan-Farooqi Haumith, Koya Richard C, Stripecke Renata, Miller Jeff F, Liau Linda M The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor antigen-specific T cell priming: relation to central nervous system antitumor immunity. Journal of immunology (Baltimore, Md. : 1950). 2006; 176(1): 157-64.
Craft Noah, Bruhn Kevin W, Nguyen Bidong D, Prins Robert, Liau Linda M, Collisson Eric A, De Abhijit, Kolodney Michael S, Gambhir Sanjiv S, Miller Jeff F Bioluminescent imaging of melanoma in live mice. The Journal of investigative dermatology. 2005; 125(1): 159-65.
Liau Linda M, Prins Robert M, Kiertscher Sylvia M, Odesa Sylvia K, Kremen Thomas J, Giovannone Adrian J, Lin Jia-Wei, Chute Dennis J, Mischel Paul S, Cloughesy Timothy F, Roth Michael D Dendritic cell vaccination in glioblastoma patients induces systemic and intracranial T-cell responses modulated by the local central nervous system tumor microenvironment. Clinical cancer research : an official journal of the American Association for Cancer Research. 2005; 11(15): 5515-25.
Craft Noah, Bruhn Kevin W, Nguyen Bidong D, Prins Robert, Lin Jia Wei, Liau Linda M, Miller Jeffery F The TLR7 agonist imiquimod enhances the anti-melanoma effects of a recombinant Listeria monocytogenes vaccine. Journal of immunology (Baltimore, Md. : 1950). 2005; 175(3): 1983-90.
Khan-Farooqi Haumith R, Prins Robert M, Liau Linda M Tumor immunology, immunomics and targeted immunotherapy for central nervous system malignancies. Neurological research. 2005; 27(7): 692-702.
Prins Robert M, Liau Linda M Cellular immunity and immunotherapy of brain tumors. Frontiers in bioscience : a journal and virtual library. 2004; 9(1): 3124-36.
Prins Robert M, Incardona Francesca, Lau Regan, Lee Paul, Claus Sarah, Zhang Wenxuan, Black Keith L, Wheeler Christopher J Characterization of defective CD4-CD8- T cells in murine tumors generated independent of antigen specificity. Journal of immunology (Baltimore, Md. : 1950). 2004; 172(3): 1602-11.
Yang Isaac, Kremen Thomas J, Giovannone Adrian J, Paik Elena, Odesa Sylvia K, Prins Robert M, Liau Linda M Modulation of major histocompatibility complex Class I molecules and major histocompatibility complex-bound immunogenic peptides induced by interferon-alpha and interferon-gamma treatment of human glioblastoma multiforme. Journal of neurosurgery. 2004; 100(2): 310-9.
Prins Robert M, Graf Martin R, Merchant Randall E, Black Keith L, Wheeler Christopher J Thymic function and output of recent thymic emigrant T cells during intracranial glioma progression. Journal of neuro-oncology. 2004; 64(1-2): 45-54.
Graf Martin R, Prins Robert M, Poulsen Gail A, Merchant Randall E Contrasting effects of interleukin-2 secretion by rat glioma cells contingent upon anatomical location: accelerated tumorigenesis in the central nervous system and complete rejection in the periphery. Journal of neuroimmunology. 2003; 140(1-2): 49-60.
Prins Robert M, Liau Linda M Immunology and immunotherapy in neurosurgical disease. Neurosurgery. 2003; 53(1): 144-52; discussion 152-3.
Prins Robert M, Odesa Sylvia K, Liau Linda M Immunotherapeutic targeting of shared melanoma-associated antigens in a murine glioma model. Cancer research. 2003; 63(23): 8487-91.
Graf Martin R, Prins Robert M, Hawkins William T, Merchant Randall E Irradiated tumor cell vaccine for treatment of an established glioma. I. Successful treatment with combined radiotherapy and cellular vaccination. Cancer immunology, immunotherapy : CII. 2002; 51(4): 179-89.
Prins Robert M, Scott Gail P, Merchant Randall E, Graf Martin R Irradiated tumor cell vaccine for treatment of an established glioma. II. Expansion of myeloid suppressor cells that promote tumor progression. Cancer immunology, immunotherapy : CII. 2002; 51(4): 190-9.