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Liana Apostolova, M.D.

Work Email Address:
lapostolova@mednet.ucla.edu

Mailing Address:
Mary S. Easton Center for Alzheimer's Disease Research
10911 Weyburn Ave, 2nd Floor
Los Angeles, CA 90095
United States

UNITED STATES

10911 Weyburn Ave
2nd floor
Los Angeles, CA 90064
UNITED STATES

Fax Number:
310-794-3148
Work Phone Number:
310-794-3665



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Department / Division Affiliations
Director, UCLA/Easton NeuroImaging Laboratory
Associate Professor In-Residence, Neuroscience IDP
Associate Clinical Professor, Neurology
Member, ACCESS Program, Access Genetics and Genomics Home Area, Access Neuroscience Home Area, Brain Research Institute, CTSI

Research Interest:

Neuroimaging research in Alzheimer's disease (AD), mild cognitive impairment (MCI) and other neurodegenerative disorders

Dr. Liana Apostolova conducts neuroimaging research in Alzheimer's disease (AD), mild cognitive impairment (MCI) and other neurodegenerative disorders. She is presently investigating the magnetic resonance imaging markers predictive of conversion of MCI to AD, as well as functional localization and functional connectivity in normal and abnormal cognition.

Bio:

Dr. Apostolova conducts clinical and neuroimaging research in Alzheimer's disease, mild cognitive impairment and other neurodegenerative disorders. Her main research focus is the development and validation structural imaging biomarkers in Alzheimerís disease and mild cognitive impairment both from an epidemiological and pharmacotherapeutic perspective. This important research dimension is in line with the increased interest in disease-associated biomarkers that will allow us to diagnose and treat dementia as early as possible. Dr. Apostolova also studies the brain-behavior correlations and imaging genetic associations in Alzheimerís disease, Parkinsonís disease and other dementias. Dr. Apostolova is the recipient of the 2010 American Academy of Neurology Research Award in Geriatric Neurology, the 2010 American Federation for Aging Research GE-Healthcare Junior Investigator Award for Excellence in Imaging and Aging Research and the 2007 Turken Research Award.

Publications:

Apostolova Liana, Alves Guido, Hwang Kristy S, Babakchanian Sona, Bronnick Kolbjorn S, Larsen Jan Petter, Thompson Paul M, Chou Yi-Yu, Tysnes Ole B, Vefring Hege K, Beyer Mona K Hippocampal and ventricular changes in Parkinson's disease mild cognitive impairment. Neurobiology of aging. 2011; .
Ringman John M, Gylys Karen H, Medina Luis D, Fox Michelle, Kepe Vladimir, Flores Deborah L, Apostolova Liana G, Barrio Jorge R, Small Gary, Silverman Daniel H, Siu Erin, Cederbaum Stephen, Hecimovic Silva, Malnar Martina, Chakraverty Suma, Goate Alison M, Bird Thomas D, Leverenz James B Biochemical, neuropathological, and neuroimaging characteristics of early-onset Alzheimer's disease due to a novel PSEN1 mutation. Neuroscience letters. 2011; 487(3): 287-92.
Apostolova Liana G, Hwang Kristy S, Medina Luis D, Green Amity E, Braskie Meredith N, Dutton Rebecca A, Lai Jeffrey, Geschwind Daniel H, Cummings Jeffrey L, Thompson Paul M, Ringman John M Cortical and hippocampal atrophy in patients with autosomal dominant familial Alzheimer's disease. Dementia and geriatric cognitive disorders. 2011; 32(2): 118-25.
Andrawis John P, Hwang Kristy S, Green Amity E, Kotlerman Jenny, Elashoff David, Morra Jonathan H, Cummings Jeffrey L, Toga Arthur W, Thompson Paul M, Apostolova Liana G Effects of ApoE4 and maternal history of dementia on hippocampal atrophy. Neurobiology of aging. 2010; 32(2): .
Apostolova Liana G, Hwang Kristy S, Andrawis John P, Green Amity E, Babakchanian Sona, Morra Jonathan H, Cummings Jeffrey L, Toga Arthur W, Trojanowski John Q, Shaw Leslie M, Jack Clifford R, Petersen Ronald C, Aisen Paul S, Jagust William J, Koeppe Robert A, Mathis Chester A, Weiner Michael W, Thompson Paul M, Thompson Paul M 3D PIB and CSF biomarker associations with hippocampal atrophy in ADNI subjects. Neurobiology of aging. 2010; 31(8): 1284-303.
Apostolova Liana G, Mosconi Lisa, Thompson Paul M, Green Amity E, Hwang Kristy S, Ramirez Anthony, Mistur Rachel, Tsui Wai H, de Leon Mony J Subregional hippocampal atrophy predicts Alzheimer's dementia in the cognitively normal. Neurobiology of aging. 2010; 31(7): 1077-88.
Apostolova Liana G, Thompson Paul M, Green Amity E, Hwang Kristy S, Zoumalan Charleen, Jack Clifford R, Harvey Danielle J, Petersen Ronald C, Thal Leon J, Aisen Paul S, Toga Arthur W, Cummings Jeffrey L, Decarli Charles S 3D comparison of low, intermediate, and advanced hippocampal atrophy in MCI. Human brain mapping. 2010; 31(5): 786-97.
Apostolova Liana G, Morra Jonathan H, Green Amity E, Hwang Kristy S, Avedissian Christina, Woo Ellen, Cummings Jeffrey L, Toga Arthur W, Jack Clifford R, Weiner Michael W, Thompson Paul M, Thompson Paul M Automated 3D mapping of baseline and 12-month associations between three verbal memory measures and hippocampal atrophy in 490 ADNI subjects. NeuroImage. 2010; 51(1): 488-99.
Apostolova Liana G, Beyer Mona, Green Amity E, Hwang Kristy S, Morra Jonathan H, Chou Yi-Yu, Avedissian Christina, Aarsland Dag, Janvin Carmen C, Larsen Jan P, Cummings Jeffrey L, Thompson Paul M Hippocampal, caudate, and ventricular changes in Parkinson's disease with and without dementia. Movement disorders : official journal of the Movement Disorder Society. 2010; 25(6): 687-95.
Apostolova Liana G, Thompson Paul M, Rogers Steve A, Dinov Ivo D, Zoumalan Charleen, Steiner Calen A, Siu Erin, Green Amity E, Small Gary W, Toga Arthur W, Cummings Jeffrey L, Phelps Michael E, Silverman Daniel H Surface feature-guided mapping of cerebral metabolic changes in cognitively normal and mildly impaired elderly. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 2010; 12(2): 218-24.
Morra Jonathan H, Tu Zhuowen, Apostolova Liana G, Green Amity E, Toga Arthur W, Thompson Paul M Comparison of AdaBoost and support vector machines for detecting Alzheimer's disease through automated hippocampal segmentation. IEEE transactions on medical imaging. 2010; 29(1): 30-43.
Morra Jonathan H, Tu Zhuowen, Apostolova Liana G, Green Amity E, Avedissian Christina, Madsen Sarah K, Parikshak Neelroop, Hua Xue, Toga Arthur W, Jack Clifford R, Schuff Norbert, Weiner Michael W, Thompson Paul M, Thompson Paul M Automated 3D mapping of hippocampal atrophy and its clinical correlates in 400 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. Human brain mapping. 2009; 30(9): 2766-88.
Morra Jonathan H, Tu Zhuowen, Apostolova Liana G, Green Amity E, Avedissian Christina, Madsen Sarah K, Parikshak Neelroop, Toga Arthur W, Jack Clifford R, Schuff Norbert, Weiner Michael W, Thompson Paul M, Thompson Paul M Automated mapping of hippocampal atrophy in 1-year repeat MRI data from 490 subjects with Alzheimer's disease, mild cognitive impairment, and elderly controls. NeuroImage. 2009; 45(1 Suppl): S3-15.
Apostolova Liana G Use of magnetic resonance imaging to identify mild cognitive impairment: who should be imaged?. CNS spectrums. 2008; 13(10 Suppl 16): 18-20.
Morra Jonathan H, Tu Zhuowen, Apostolova Liana G, Green Amity E, Avedissian Christina, Madsen Sarah K, Parikshak Neelroop, Hua Xue, Toga Arthur W, Jack Clifford R, Weiner Michael W, Thompson Paul M, Thompson Paul M Validation of a fully automated 3D hippocampal segmentation method using subjects with Alzheimer's disease mild cognitive impairment, and elderly controls. NeuroImage. 2008; 43(1): 59-68.
Apostolova Liana G, Lu Po, Rogers Steve, Dutton Rebecca A, Hayashi Kiralee M, Toga Arthur W, Cummings Jeffrey L, Thompson Paul M 3D mapping of language networks in clinical and pre-clinical Alzheimer's disease. Brain and language. 2008; 104(1): 33-41.
Morra Jonathan H, Tu Zhuowen, Apostolova Liana G, Green Amity E, Toga Arthur W, Thompson Paul M Automatic subcortical segmentation using a contextual model. Medical image computing and computer-assisted intervention : MICCAI ... International Conference on Medical Image Computing and Computer-Assisted Intervention. 2008; 11(Pt 1): 194-201.
Apostolova Liana G, Thompson Paul M Mapping progressive brain structural changes in early Alzheimer's disease and mild cognitive impairment. Neuropsychologia. 2008; 46(6): 1597-612.
Apostolova Liana G, Cummings Jeffrey L Neuropsychiatric manifestations in mild cognitive impairment: a systematic review of the literature. Dementia and geriatric cognitive disorders. 2008; 25(2): 115-26.
Apostolova Liana G, Steiner Calen A, Akopyan Gohar G, Dutton Rebecca A, Hayashi Kiralee M, Toga Arthur W, Cummings Jeffrey L, Thompson Paul M Three-dimensional gray matter atrophy mapping in mild cognitive impairment and mild Alzheimer disease. Archives of neurology. 2007; 64(10): 1489-95.
Apostolova Liana G, Thompson Paul M Brain mapping as a tool to study neurodegeneration. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics. 2007; 4(3): 387-400.
Ringman John M, O'Neill Joseph, Geschwind Daniel, Medina Luis, Apostolova Liana G, Rodriguez Yaneth, Schaffer Barbara, Varpetian Arousiak, Tseng Benjamin, Ortiz Freddy, Fitten Jaime, Cummings Jeffrey L, Bartzokis George Diffusion tensor imaging in preclinical and presymptomatic carriers of familial Alzheimer's disease mutations. Brain : a journal of neurology. 2007; 130(Pt 7): 1767-76.
Apostolova Liana G, Akopyan Gohar G, Partiali Negar, Steiner Calen A, Dutton Rebecca A, Hayashi Kiralee M, Dinov Ivo D, Toga Arthur W, Cummings Jeffrey L, Thompson Paul M Structural correlates of apathy in Alzheimer's disease. Dementia and geriatric cognitive disorders. 2007; 24(2): 91-7.
Apostolova Liana G, Dinov Ivo D, Dutton Rebecca A, Hayashi Kiralee M, Toga Arthur W, Cummings Jeffrey L, Thompson Paul M 3D comparison of hippocampal atrophy in amnestic mild cognitive impairment and Alzheimer's disease. Brain : a journal of neurology. 2006; 129(Pt 11): 2867-73.
Apostolova Liana G, Lu Po H, Rogers Steve, Dutton Rebecca A, Hayashi Kiralee M, Toga Arthur W, Cummings Jeffrey L, Thompson Paul M 3D mapping of mini-mental state examination performance in clinical and preclinical Alzheimer disease. Alzheimer disease and associated disorders. 2006; 20(4): 224-31.
Monien Bernhard H, Apostolova Liana G, Bitan Gal Early diagnostics and therapeutics for Alzheimer's disease--how early can we get there?. Expert review of neurotherapeutics. 2006; 6(9): 1293-306.
Apostolova Liana G, Dutton Rebecca A, Dinov Ivo D, Hayashi Kiralee M, Toga Arthur W, Cummings Jeffrey L, Thompson Paul M Conversion of mild cognitive impairment to Alzheimer disease predicted by hippocampal atrophy maps. Archives of neurology. 2006; 63(5): 693-9.
Apostolova Liana G, White Matthew, Moore Steven A, Davis Patricia H Deep white matter pathologic features in watershed regions: a novel pattern of central nervous system involvement in MELAS. Archives of neurology. 2005; 62(7): 1154-6.