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Maria Castro, Ph.D.

Email Address:
castromg@cshs.org
Work Email Address:
castromg@cshs.org

Work Address:
8700 Beverly Blvd.
Davis 5090
Los Angeles, CA 90048
UNITED STATES

Fax Number:
310-423-7308
Work Phone Number:
(310) 423-7303



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Department / Division Affiliations
Professor, Medicine, Molecular & Medical Pharmacology
Member, ACCESS, ACCESS Program: Dept. of Molecular & Medical Pharmacology, Brain Research Institute, JCCC Tumor Immunology Program Area
ACCESS Affinity - Molecular & Medical Pharmacology

Research Interest:

Cellular and molecular mechanisms underlying brain tumor regression and immunological long term memory

Dr. Maria G Castro's group is investigating the cellular and molecular mechanisms underlying brain tumor regression and immunological long term memory in pre-clinical models of glioblastoma (GBM). Her group has uncovered the role of plasmocitoid dendritic cells (pDC) in mediating tumor regression and initiating both the innate and adaptive arms of the immune response against intracranial tumors. Dr. Castro's lab is currently working with knock out mice to establish the phenotype of immune cells responsible for long term memory in the syngeneic GBM models. Dr. Castro's group is establishing gutless and lentivirus vectors with the aim of imaging in vivo and non-invasively the trafficking of activated immune cells in and out of the central nervous system.

Bio:

Dr. Castro is Co-Director of the Board of Governors Gene Therapeutics Research Institute at Cedars-Sinai. Dr. Castro is also Professor of Medicine and Professor of Molecular and Medical Pharmacology at the David Geffen School of Medicine at the University of California, Los Angeles (UCLA). Dr Castro has recently been awarded the Medallion's Group Endowed Chair in Gene Therapeutics at Cedars Sinai Medical Center. She currently serves as a permanent member and consultant at a study section of the National Institute of Neurological Disorders and Stroke, National Institutes of Health. Dr Castro previously served as Professor of Molecular Medicine at the University of Manchester in England. She was a member of the Neuroscience Panel (Study Section) of the Welcome Trust, UK and is an expert member on the Neuroscience Panel for Evaluators of the European Commission. Dr. Castro is the recipient of RO-1 and R0-3 grants from the National Institutes of Health to develop novel gene therapy approaches to treat chronic neurodegenerative brain diseases, such as Parkinson's disease and brain cancer. Dr Castro's research program focuses on the molecular and cellular mechanisms which mediate brain tumor regression in response to immune-stimulatory and cytotoxic gene therapeutics. Dr Castro has published over 200 research articles, reviews and book chapters in high impact peer-reviewed journals, e.g. Nature Medicine, Nature Biotechnology, Proceedings of the National Academy of Medicine USA, The Journal of Experimental Medicine, The Journal of Virology, The Journal of Neuroscience, and Cancer Research amongst many others. Dr Castro serves on the editorial boards of Gene Therapy, Current Gene Therapy, Journal of Endocrinology, Journal of Molecular Endocrinology and Journal of Neuromolecular Medicine.

Publications:

Curtin JF, King GD, Barcia C, Liu C, Hubert FX, Guillonneau C, Josien R, Anegon I, Lowenstein PR, Castro MG. Fms-like tyrosine kinase 3 ligand recruits plasmacytoid dendritic cells to the brain.. Journal of Immunology. 2006; 176(6): 3566-77.
Ali S, King GD, Curtin JF, Candolfi M, Xiong W, Liu C, Puntel M, Cheng Q, Prieto J, Ribas A, Kupiec-Weglinski J, van Rooijen N, Lassmann H, Lowenstein PR, Castro MG. Combined immunostimulation and conditional cytotoxic gene therapy provide long-term survival in a large glioma model.. Cancer Research. 2005; 65(16): 7194-204.