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Marie-Francoise Chesselet, M.D., Ph.D.

Email Address:
mchesselet@mednet.ucla.edu

Laboratory Address:
Laboratory
B117 Reed

UNITED STATES

Work Address:
Office
B114 Reed

UNITED STATES

Fax Number:
(310) 267-1786
Work Phone Number:
(310) 267-1781


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Department / Division Affiliations
Chair, Neurobiology
Professor, Neurology, Neurobiology
Member, ACCESS Program: Dept. of Neurobiology, Neuroengineering Training Program, Neuroscience Graduate Program, Brain Research Institute, Center for Neurodegenerative Disease Studies
ACCESS Affinity - Neurobiology

Bio:

Dr. Marie-Francoise Chesselet received her MD and PhD degrees from the University of Paris VI, in France. She completed her internship at the Hopital de l'Hotel Dieu in Paris and her PhD thesis in the laboratory of Jacques Glowinski at the College of France. After obtaining a position at the CNRS, she joined the laboratory of Ann Graybiel at MIT and the laboratory of Michael Bronstein at the NIH as a Visiting Scientist. She held faculty appointments at the Medical College of Pennsylvania and the University of Pennsylvania before joining UCLA as the Charles H. Markham Professor of Neurology in 1996. She is currently Chair of the Department of Neurobiology in the David Geffen School of Medicine at UCLA. She is also Director of the APDA Advanced Center for Parkinson's Disease Research, Morris K. Udall Center of Excellence for Parkinson's Disease Research and the Center for Gene Environment Studies in Parkinson's Disease at UCLA.
Publications:

Wang Lixin, Fleming Sheila M, Chesselet Marie-Françoise, Taché Yvette Abnormal colonic motility in mice overexpressing human wild-type alpha-synuclein.. Neuroreport. 2008; 19(8): 873-6.
Meredith Gloria E, Sonsalla Patricia K, Chesselet Marie-Francoise Animal models of Parkinson's disease progression.. Acta neuropathologica. 2008; 115(4): 385-98.
Reliene Ramune, Fleming Sheila M, Chesselet Marie-Françoise, Schiestl Robert H Effects of antioxidants on cancer prevention and neuromotor performance in Atm deficient mice.. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association. 2008; 46(4): 1371-7.
Chesselet Marie-Francoise In vivo alpha-synuclein overexpression in rodents: a useful model of Parkinson's disease?. Experimental neurology. 2008; 209(1): 22-7.
Fleming Sheila M, Tetreault Nicole A, Mulligan Caitlin K, Hutson Ché B, Masliah Eliezer, Chesselet Marie-Françoise Olfactory deficits in mice overexpressing human wildtype alpha-synuclein.. The European journal of neuroscience. 2008; 28(2): 247-56.
Effros Rita B, Austad Steven, Blau Helen, Chesselet Marie-Francoise, Ingram Donald, Johnson Thomas E, Kaeberlein Matt, Lundblad Vicki, McCarter Roger, McElhaney Janet, Saag Michael The biological sciences section program at the 60th Annual Meeting of the Gerontological Society of America.. The journals of gerontology. Series A, Biological sciences and medical sciences. 2008; 63(4): 331-7.
Chesselet MF, Plotkin JL, Wu N, Levine MS. Development of striatal fast-spiking GABAergic interneurons.. Prog Brain Res 2007; 160: 261-72.
Litvan Irene, Chesselet Marie-Francoise, Gasser Thomas, Di Monte Donato A, Parker Davis, Hagg Theo, Hardy John, Jenner Peter, Myers Richard H, Price Donald, Hallett Mark, Langston William J, Lang Anthony E, Halliday Glenda, Rocca Walter, Duyckaerts Charles, Dickson Dennis W, Ben-Shlomo Yoav, Goetz Christopher G, Melamed Eldad The etiopathogenesis of Parkinson disease and suggestions for future research. Part II.. Journal of neuropathology and experimental neurology. 2007; 66(5): 329-36.
Litvan Irene, Halliday Glenda, Hallett Mark, Goetz Christopher G, Rocca Walter, Duyckaerts Charles, Ben-Shlomo Yoav, Dickson Dennis W, Lang Anthony E, Chesselet Marie-Francoise, Langston William J, Di Monte Donato A, Gasser Thomas, Hagg Theo, Hardy John, Jenner Peter, Melamed Eldad, Myers Richard H, Parker Davis, Price Donald L The etiopathogenesis of Parkinson disease and suggestions for future research. Part I.. Journal of neuropathology and experimental neurology. 2007; 66(4): 251-7.
Fleming, SM., Salcedo, J., Hutson, CB., Rockenstein, E., Masliah, E., Levine, MS., Chesselet, MF. Behavioral effects of dopaminergic agonists in transgenic mice overexpressing human wildtype alpha-synuclein. Neuroscience 2006; 142: 1245-1253.
Fleming SM, Chesselet MF. Behavioral phenotypes and pharmacology in genetic mouse models of Parkinsonism.. Behav Pharmacol 2006; 17(5-6): 383-91.
Dewing P, Chiang CW, Sinchak K, Sim H, Fernagut PO, Kelly S, Chesselet MF, Micevych PE, Albrecht KH, Harley VR, Vilain E. Direct regulation of adult brain function by the male-specific factor SRY.. Curr Biol 2006; 16(4): 415-20.
Riban Veronique, Chesselet Marie-Françoise Region-specific sprouting of crossed corticofugal fibers after unilateral cortical lesions in adult mice.. Experimental neurology. 2006; 197(2): 451-7.
Hwang, DY Fleming, SM Ardayfio, P Moran-Gates, T Kim, H Tarazi, FI Chesselet, MF Kim, KS 3,4-dihydroxyphenylalanine reverses the motor deficits in Pitx3-deficient aphakia mice: behavioral characterization of a novel genetic model of Parkinson's disease.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2005; 25(8): 2132-7.
Chesselet MF. Animal models of neurological disorders.. NeuroRx 2005; 2(3): 395.
Hickey, M.A., Gallant, K., Gross, G., Levine, M.S., and Chesselet, M-F. Early behavioural deficits in R6/2 mice suitable for use in preclinical drug testing.. Neurobiology of Disease 2005; 20: 1-11.
Plotkin, J., Wu, N., Chesselet, M-F, and Levine, M.S. Functional and molecular development of striatal fast-spiking GABAergic interneurons and their cortical inputs. European Journal of Neuroscience 2005; 22: 1097-108.
Fleming, S.M., Fernagut, P-O., Chesselet, M-F. Genetic Mouse Models of Parkinsonism: Strengths and Limitations.. NeuroRx 2005; Vol. 2 : 495-503.
Chesselet, M-F., Fernagut, P-O, Fleming, SM. Parkinson���s disease models: from toxins to genes. Drug Discovery Today: Disease Models 2005; Vol. 2 (No. 4): 299-303.
Fleming, SM Zhu, C Fernagut, PO Mehta, A DiCarlo, CD Seaman, RL Chesselet, MF Behavioral and immunohistochemical effects of chronic intravenous and subcutaneous infusions of varying doses of rotenone.. Experimental neurology. . 2004; 187(2): 418-29.
Fleming, SM Salcedo, J Fernagut, PO Rockenstein, E Masliah, E Levine, MS Chesselet, MF Early and progressive sensorimotor anomalies in mice overexpressing wild-type human alpha-synuclein.. The Journal of neuroscience : the official journal of the Society for Neuroscience. . 2004; 24(42): 9434-40.
Levine, MS Cepeda, C Hickey, MA Fleming, SM Chesselet, MF Genetic mouse models of Huntington's and Parkinson's diseases: illuminating but imperfect.. Trends in neurosciences. . 2004; 27(11): 691-7.
Zhu, C Vourc'h, P Fernagut, PO Fleming, SM Lacan, S Dicarlo, CD Seaman, RL Chesselet, MF Variable effects of chronic subcutaneous administration of rotenone on striatal histology.. The Journal of comparative neurology. . 2004; 478(4): 418-26.
Menalled, LB Sison, JD Dragatsis, I Zeitlin, S Chesselet, MF Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats.. The Journal of comparative neurology. . 2003; 465(1): 11-26.